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Combined targeted and untargeted proteomics
A method to conduct simultaneous targeted and unbiased mass spectrometry-based proteomics in a sample-sparring manner.
Method for treating P300/CBP-dependent tumors using combined P300/CBP inhibition/ degradation, and senolytic therapy
A method for treating P300/CBP-dependent tumors, such as Ewing sarcoma, by selectively eliminating senescence-induced cancer cells through P300/CBP inactivation.
Derivation of human T-(progenitor) cells from human T-cells derived induced pluripotent stem cells (T-iPSCs)
A method for generating T cells from patient-derived induced pluripotent stem cells, enabling scalable and customizable immunotherapies for cancer and other diseases.
MoonTag and plant-derived activation domains for improved genetic engineering
A novel programmable transcriptional activator that can work with plant-derived activation domains to enable precise and robust gene activation in plants.
Intraoral sustained-release device for treatment of Parkinson’s and other neurological disorders
A novel intraoral device for sustained and controlled medication delivery for the treatment of neurological disorders.
Modified myeloid-derived suppressor cells for treating GvHD
A novel cell therapy and associated methods for treating GvHD after allogenic hematopoietic cell transplantation.
A minipromoter for gene therapies
A mini-promoter to accommodate larger therapeutic genes of interest in gene therapy programs
A method for dynamic anchoring of soft exoskeletons using localized active compression
A system of local active compression anchors to enhance exoskeleton mobility and functionality
Allogeneic extracellular vesicles for enhancing CD8+ T cell response in colorectal cancer
Allogeneic tumor-derived extracellular vesicles (TEVs) that stimulate CD8+ T cell response and reduce tumor growth in colorectal cancer.
Non-invasive imaging of cardiac electrical activity
A novel method for noninvasive cardiac imaging that localizes the origins of cardiac arrhythmias.
Improved method for the synthesis of flurprimidol
A novel method for the synthesis of flurprimidol and other 5-subsituted pyrimidines.
Accessible clothing technologies, systems, and methods using integrated soft robotics
A collection of tools to self-tighten clothing for individuals with physical impairments
Compounds that lead to degradation of cancer relevant proteins
Compounds target and degrade kinases, specifically Aurora A and CDK4/6, for effective cancer treatment.
A tau antibody for detecting and treating Alzheimer's disease
An antibody for detecting, screening, and inhibiting Tau products critical in Alzheimer’s disease
Web-based software for clinical laboratory training
A suite of web-based software designed to enhance training in Medical Laboratory Sciences.
Anti-viral phosphoramidates for treating SARS-CoV and influenza
A method for treating an influenza viral infection or a severe acute respiratory syndrome
Novel small molecule inhibitor to target metabolic plasticity
A novel pharmaceutical candidate with potent MPC and MCT1 inhibition.
Temporal sparse imaging of cardiac electric activity
A novel cardiac imaging technique that enables high-resolution, noninvasive imaging of cardiac electrical activity.
Detection of liver cancer by AI analysis of ultrasound Doppler waves
A novel method to detect hepatocellular carcinoma via ultrasound examination and AI analysis of the portal vein.
Alternative slice ordering for improved MRI perfusion imaging
A novel method for the alternative ordering of slices in multi-band echo planar imaging arterial spin labeling (MB-EPI ASL) imaging for improved image quality.
Dpath: a novel software for classification and quantification of cellular states in single-cell transcriptomics
A software for classification and quantification of cell types during stage transitions from stem cells to differentiated cells. This software can further classify and quantify the progenitor and committed states in single-cell RNA-sequence data in a non-biased manner.
Zika as an oncolytic virus to treat brain tumors
A method to treat aggressive brain cancers using Zika as an oncolytic virus combined with anti-cancer vaccinations.
Atrial fibrillation complexity score for enhanced risk stratification and management
A novel scoring system that integrates multiple metrics to evaluate the severity of atrial fibrillation.
Single-pathogen detection via liposome-amplified plasmonic immunoassay
A novel colorimetric assay with single pathogen detection capabilities.
Motion robust magnetic resonance imaging (MOTOR-MRI)
A method for suppressing motion artifacts in anatomical magnetic resonance imaging
Didehydro-nucleoside antiviral agents
A broad-spectrum antiviral agent platform
Plasma cell-free DNA sequencing assay for advanced prostate cancer
A liquid biopsy assay for predicting survival outcomes of castration-resistant prostate cancer
Stable glutathione analog for the treatment of Alzheimer’s disease
A metabolically stable glutathione analog that resists degradation and offers protection against oxidative stress.
Inhibitors of Cell Adhesion by Nectin Peptides
Peptides that functionally block ovarian cancer cell adhesion by targeting Nectin-4
Self-Supervision via Data Undersampling (SSDU) Software- Evaluation License
Self-supervised physics-based deep learning reconstruction without fully-sampled data for MRI
Hamster CD4 and CD8 antibodies
Monoclonal antibodies against Syrian golden hamster CD4 and CD8
3D printing of organisms
A 3D printing system with multiple nozzles to automatically pick-and-place single and multiple living organisms in desired 3D locations.
Treating epilepsy via targeted therapy to the endopiriform nucleus (EPN)
A system and method for treating epilepsy and other neurological disorders by deep brain stimulation targeted to the EPN using ultrahigh field MRI.
Therapeutic target for treatment of ataxia
A newly identified pathway that represents a therapeutic target for the prevention and treatment of ataxia.
Use of extracellular vesicles to enhance colorectal cancer therapeutics
Cancer-derived extracellular vesicles (EVs) that enhance the efficacy of checkpoint inhibitor therapeutics for colorectal tumors.
Glycoengineered mesenchymal stem cells as targeted therapeutic carriers
A targeted therapeutic delivery system utilizing glycoengineered mesenchymal stem cells for reduced toxicity and increased treatment residence time
An anti-CD133 hybridoma
A hybridoma for manufacturing anti-CD133 antibodies capable of recognizing glycosylated and non-glycosylated epitopes
Hands-free immunoblot washing device
A low-cost, automated method to wash immunoblots
Serum-based extracellular vesicle panel for detection for glioblastoma
A blood-based panel for diagnosing and tracking glioblastoma to improve patient outcomes
Hyperstable synthetic miniproteins as ligand scaffolds
Hyperstable synthetic miniproteins as modular ligand scaffolds for advanced therapeutics and diagnostics.
DeepPTx: parallel transmission MRI using deep learning
A novel deep neural network to enhance MRI image reconstruction.
Keratin hydrogels for intravenous embolization
A rapid onset, non-toxic, hybrid hydrogel network for the safe and rapid embolization of blood vessels.
Progesterone receptor detection for breast cancer therapy
A test to detect phosphorylated progesterone receptors for patient stratification
CDK2 inhibitors for cancer therapy and male contraception
CDK2 inhibitors for cancer therapy and non-hormonal male contraception with high selectivity and reduced side effects.
SSDU software for non-Cartesian trajectories- Evaluation License
Non-Cartesian implementation of a self-supervised physics-based deep learning reconstruction without fully-sampled data
Seizure Behavioral Testing Protocol (ROAR)
A standardized seizure behavioral testing protocol (ROAR) for enhanced diagnosis and care during video EEG monitoring.
Inhibitory nucleic acid molecules targeting cyclin D1 mRNA
Inhibition of non-canonical functions of cyclin D1 as a potential therapy for liver diseases.
Mouse model for studying SARS-CoV-2
A gene replacement mouse model incorporating human ACE2 and TMPRSS2 genes for authentic SARS-CoV-2 replication and virus entry studies.
Broadspectrum potentially therapeutic nanobodies against COVID-19
A class of nanobodies (Nanosota-2, -3, and -4) offering broadspectrum therapeutic potential against COVID-19.
Soluble, active DNA cytosine deaminase for use as a research tool
A method to produce soluble DNA cytosine deaminase for assays of potential inhibitors of HIV-1 and as a tool for biotech applications
Image processing technique for improved MRI image fidelity
A novel technique to improve MRI image fidelity via the combination of a denoising and deep learning-based reconstruction.
Nanorings for cell-mediated drug delivery
Farnesylated chemically self-assembled nanorings that facilitate targeted drug delivery between cells.
Artificial gut/absorption simulator for evaluation of drug formulations dissolution
A device and method for simulating a digestive gut to evaluate drug delivery that incorporates simultaneous absorption with dissolution
Encapsulated supported anaerobic biofilms for enhanced methane production
Encapsulated anaerobic biofilms for treating wastewater and generating desirable products such as methane or hydrogen gas.
Efficient CRISPR-based gene editing for stem cells
A CRISPR-based gene editing protocol for induced pluripotent stem cells (iPSCs) with improved editing efficiency and cell survival.
Wearable ultrasound sensors for imaging and sensing
Novel wearable ultrasound transducers designed to integrate real-time imaging, sensing, and treatment functions for application in therapeutics and diagnostics.
Quantitative ultrasound for fatty tissue imaging
A signal processing method to enhance ultrasound imaging of fatty tissue.
Dual frequency RF coil for magnetic resonance imaging
A novel RF resonant coil that can operate at both X-nuclear and proton frequencies.
Neonatal pneumothorax decompression device
A rapidly deployable, self-contained device to evacuate air from the pleural space of a neonate.
Single-cell Integration and DrUg Response PrediCtion (scIDUC)
A computational pipeline that predicts drug response scores for individual cells using single-cell RNA sequencing data.
Medical device for the treatment of Raynaud’s phenomenon
A novel therapeutic device that applies blue light and warmth for the treatment of Raynaud’s phenomenon.
Pharmacological enhancement of CD8 T cell effector function using TEPP46
A clinically viable strategy for preventing mitochondria-mediated T cell exhaustion and enhancing effector T cell function.
First-in-class drug lead candidate (A229) for treating ocular diseases
PPARα agonist, A229, exhibits strong potency and demonstrates efficacy in in-vitro models of diabetic retinopathy.
3D printed organ models with integrated sensing capabilities
A method to 3D print patient-specific organ models with tissue-mimicking properties and integrated sensing capabilities.
Bacterial histidine kinase inhibitors for treating Staphylococcus infections
Small molecule bacterial histidine kinase inhibitors that significantly diminish staphylococcal virulence.
Catheter to measure intra-arterial pressure gradients
A catheter coated in carbon nanotubes and pressure membranes that measures intra-arterial pressure changes.
Small molecule inhibitors for treating alcoholic hepatitis
Bromodomain inhibitor, UMN627, reduces inflammation in mice models of alcoholic hepatitis.
Novel biliary stent and deployment device
A novel device for managing difficult strictures of the pancreatic and biliary ducts.
InTERACCT Program: Occupational health and safety training
Training courses for occupational health and safety workers aimed to equip them to handle risks associated with emerging technologies.
A catheter-based intravenous respirator
A device for direct gas exchange with the venous system to deliver oxygen and support critically ill patients.
Device to deliver large volumes of oxygen intravenously
A device for infusing large volumes of oxygen directly into the bloodstream via an oxygenated and pressurized saline solution.
T Cell Receptor Exchange (TRex) Mice
A mouse model for studying physiological antigen-specific T cell behavior.
Ovarian cancer prognostic test for predicting response to chemotherapy and bevacizumab
A prognostic molecular test for predicting ovarian cancer patient response to platinum-based chemotherapy and/or treatment with bevacizumab.
Highly fluorinated compounds for magnetic resonance-based temperature sensing
Novel fluorinated molecules for temperature sensing by MRI thermometry.
Bisubstrate inhibitors for treating SARS-CoV-2 infections
Bisubstrate inhibitors that target the active site of SARS-CoV-2 Nsp14 methyltransferase (MTase) for treating SARS-CoV-2 infections.
Early detection of ovarian cancer using a multiprotein classifier
A blood test for detecting ovarian cancer with over 90% accuracy by monitoring key protein levels.
Novel compounds for treatment of neurodegenerative disease and chronic pain
Novel alpha2-adrenergic agonists with neuroprotective and/or analgesic properties.
First-generation degraders for class I bromodomain-containing proteins
A bromodomain-targeting degrader of CECR2, an epigenetic regulator that drives cancer metastasis.
Endotracheal intubation with computer vision
A machine learning-based intubation tube for autonomous or computer-assisted endotracheal intubation.
NOD-2-active carboxamide compounds as vaccine adjuvants
Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.
Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines
A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.
High-throughput screening assay for sickle cell disease drug discovery
A high-throughput screening assay for discovering small molecules that directly inhibit sickle hemoglobin oligomerization.
Self-Efficacy to Reduce Sedentary Behavior (SRSB) Questionnaire
A 9-item questionnaire designed to evaluate self-efficacy to reduce sedentary behavior.
Autonomous high-accuracy analysis of prostate cancer biopsies
A framework for automated detection of prostate cancer on histopathology slides.
Conditional DUXC knockout mouse model
A conditional DUXC knockout mouse model for use as a basic research tool.
Direct elution caps for reducing autosampler cross-vial contamination
A screw cap that interfaces a pipette tip and autosampler vial, creating a sturdy connection and an elevated pipette tip position within the vial.
Fast 3-dimensional reciprocal space imaging with laboratory X-ray diffraction: RSLab
A software that adds fast 3D reciprocal space imaging capabilities to laboratory X-ray diffractometers with 2D detectors.
Mouse-derived FSHD muscle cell lines
Primary skeletal muscle cell lines isolated from DUX4 expressing FSHD mice.
Generating teratoma-derived skeletal muscle stem cells
A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.
Small molecules with antiproliferative activity against pancreatic cancer cells
Small molecules that show antiproliferative activity against the pancreatic cancer cell line MiaPaca-2.
Genetically modified endophyte with biofertilizer potential
A genetically modified bacteria (G. diazotrophicus) that is an established plant endophyte and releases high amounts of ammonium when grown on simple sugars
Rapid non-invasive portable system for monitoring deterioration of plastics
A system comprising a portable device and image processing software for superficial non-destructive determination of plastic deterioration
Steerable magneto-photonic particles for targeted delivery and collection of light
An embeddable magneto-photonic microparticle that can be externally positioned and orientated for targeted delivery and collection of light.
Small molecules promoting differentiation/maturation of stem cell-derived myogenic cells
A combinatorial small molecule treatment that promotes differentiation and maturation of myotubes derived from pluripotent stem cells.
Engineered bacteria for the synthesis of a biodegradable polymer coating
Genetically modified bacteria for the synthesis of a biodegradable polymer to coat fertilizer pellets, allowing nitrogen to be slowly released over time.
AgRP-Derived melanocortin-5 receptor peptide antagonists
AgRP derived scaffolds composed of natural (Tyr, Ala, Val, Asn) and unnatural amino acids (Dap) with antagonist activity at the mouse MC5R
Scale of Alopecia Areata Distress (SAAD)
A tool (e.g., scale) for assessing the psychosocial impact of Alopecia Areata/Totalis/Universalis on patients' lifes.
Self-navigation to enable efficient 3D DWI SE-EPI multi-slab multi-band imaging
A method for correcting MRI data from corruption due to physiological changes.
3D-printed skin-wearable photodetector device
Fully 3D-printed flexible skin-wearable device for real-time measurements of UV-visible exposures.
The Mindful Movement for Physical Activity (MMPA) Program
An eight-week, research-tested mindful physical activity educational program
The Keys to Health & Wellbeing Program (KHW) for adults 50+ years of age
An eight-week, research-tested health & wellbeing educational program for adults over 50
Long-stroke rolling diaphragm cylinder for passive hydraulic rehabilitation robot
Novel fabric-elastomer long-stroke rolling diaphragm (LSRD) cylinder displaying low friction and zero leakage for small and passive hydraulic systems.
Minnesota Assessment of Pharmacogenomic Literacy (MAPL™)
A questionnaire to assess pharmacogenomic knowledge among patients in research studies or clinical care.
Methods for Modifying Proteins and Peptides.
Production of alpha-N-methylated peptides for improved pharmacological properties.
Human Myotonic Dystrophy Induced Pluripotent Stem Cell Lines
Treating trauma-induced acute blood loss
Novel formulations of D-β-hydroxybutyrate and melatonin improve survival from hemorrhagic shock.
Pain therapy without the risk of respiratory depression, addiction or abuse
An analgesic combination of peripherally restricted opioids that eliminates the risk of respiratory depression, chemical addiction or abuse.
Medical Device for Chronic Sinusitis
The technology is a design of a medical device that can be placed in the ostium between the maxillary sinus and nasal passageway for treatment of chronic sinusitis.
HUH fusion enzymes for multiplex protein labeling
HUH fusion tags are novel, robust endonucleases that allow proteins and DNA to be linked covalently in one simple step
Cell-free selection of site-specific polypeptide binders via tethering
In vitro selection method for the engineering of protein-based high-affinity binders to targets of interest with potential pharmacological value
Compound with selective inhibition potential against P300 and CBT
A compound to treat pediatric sarcoma through the inhibition of P300 and CBT
Live cell assay to quantify the activity of SARS-CoV-2 main protease, Mpro
Fluorescence-based method to effectively screen for protease inhibitors
Camelid single domain antibody phage display library
Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target
T cell receptors for engineered T cell therapy
Mesothelin-specific T cell receptors for cell engineering and cancer therapy
Nanominne-1: novel virus-like particle (nanoparticle) vaccines to prevent SARS-CoV-2 infections
Series of novel vaccines containing 60 copies of SARS-CoV-2 antigens displayed in ordered array on a virus-like particle scaffold (nanoparticle)
Targeted Artificial DNA Replisome (TADR) a Tool for Targeted Mutagenesis
TADR is a protein-complex designed to target and mutate specific genes on plasmid in vivo
Augmented reality transjugular intrahepatic portosystemic shunt (AR-TIPS) set and other interventional devices
An augmented reality (AR) system to assist clinicians in performing medical procedures inside the body where 3D anatomical information is important
Immortalized clonal human myoblast line "M007"
Immortalized human myoblast cell line obtained from a healthy individual
Immortalized clonal human fibroblast line "F007"
Immortalized human fibroblast cell line obtained from a healthy individual
Electron paramagnetic resonance (EPR) imaging without magnet
A method which produces low cost EPR imaging with better receiver isolation and no magnet requirement
Engineered SARS-CoV-2 spike ectodomain for COVID-19 diagnostic assays
Engineered SARS-CoV-2 spike ectodomain expressed from stably transfected mammalian cell lines to be used as an effective diagnostic antigen against different SARS-CoV-2 variants
A system for unattended delivery of cognitive neuromodulation therapy
Non-invasive interactive system with specialized equipment and customizable stimulation unit to deliver unattended cognitive neuromodulation therapy. The system supports training of prescribers and clinical staff leading to certification
Method for mass production of high performance magnetic nanoparticles for biomedical applications
Iron nitride nanoparticles are post-processed by applying a wet ball milling method in conjunction with different surface-active media and centrifugation steps to obtain ultra-stable, monodispersed, uniformly sized, surface-functionalized, and sub-100-nm iron nitride nanoparticles suitable for biomedical applications
Functionalized filters for high efficiency bioseparation
A bioseparation device using a novel filter to facilitate collection and extraction in large volumes and at high flow rates.
AGRP-derived melanocortin receptor ligands
Identifying a selective MC4R antagonist for appetite modulation
Chimeric melanocortin receptor ligands
Melanocortin-4 receptor ligand reduces food intake in mice
Selective melanocortin receptor ligands
Potential dual-ligand approach to weight management
Lateral flow assay for respiratory viruses
CRISPR/Cas9-based point-of-care diagnosis for SARS-CoV-2
Just One Thing (JOT): custom care plans for people with cognitive challenges
A simple, customizable clinical care guide and worksheet to promote at-home therapy for people with cognitive challenges and their caregivers.
Sugar-secreting green microalga
A microalgae strain that secretes simple sugars in conditions favorable for co-culture schemes and fermentation processes.
Advanced manufacturing method to fabricate removable partial denture
A series of methods and designs to quickly and accurately fabricate partial dentures from intraoral scanning without stone or printed models. The methods include harnessing the abilities of 3d printing, milling, and scanning technology to allow for the most efficient clinical and laboratory outcomes.
Cryopreservation method for millimeter scale biological samples using Cryomesh
A cryopreservation method that uses cryomesh and cryopreservation agents to preserve Drosophila embryos.
Risk-free in situ non animal (RISNA) surrogate assay for African swine fever virus
A method of using a surrogate virus to confirm inactivation of African Swine Fever Virus(ASFV)
Rapid infuser purge valve
A one-way purge valve that allows for quick removal of air from IV fluid bags with a single spike.
Network Neuromodulation
A closed-loop deep brain stimulation device that exploits new mechanisms of action to control brain networks
Algorithm to improve left ventricular assist device implantation
An image processing algorithm to determine ideal, patient-specific location parameters for LVAD implantation.
Accelerating MRI data acquisition with segmented 2D pulses
A method for accelerating MRI data acquisition with segmented 2D pulses using virtual coils.
Non-Cartesian k-space reconstruction to improve acquisition efficiency
A non‐Cartesian k‐space reconstruction method using self-calibrated, region‐specific interpolation kernels for highly accelerated acquisitions in MRI.
MRI RF coil for improved field efficiency and image quality
A novel RF coil design with high dielectric constant materials to improve B1+ efficiency in MRI systems.
A hybrid machine learning-based magnetic resonance image reconstruction
A machine learning-based magnetic resonance image reconstruction algorithm that combines the benefits of both linear GRAPPA and nonlinear RAKI methods.
Urinary Catheter Stabilization Device
A urinary catheter support device that prevents penile erosion arising from the use of indwelling catheters.
Rapid microbial diagnostics
A method for rapid detection of microorganisms using chemiluminescence.
Autonomous, high accuracy classification of cancer in tissue samples
A machine learning-based algorithm for cancer detection and classification.
PhysiAware - continuous monitoring of physiological signals
An app for continuous monitoring of physiological signals from sensors worn by patients.
Quantitative relaxation mapping
Pulse sequence for MRI scanners
A novel approach for bioprinting complex tissue models
A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.
Novel anti-cancer agents that target the epigenetic reader protein
Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.
HapShared - a software for pedigree reconstruction
A Python script for performing complex pedigree analysis with high sensitivity.
Chaotic desynchronization of neural populations with non-pulsatile inputs
A method to identify stimulation parameters for desynchronizing a set of neurons.
Software for dual-mode ultrasound array driver and imaging platform (DMUA-DIP)
A software to drive dual-mode ultrasound arrays in imaging and therapy modes in a synchronized fashion.
Utilizing periodic irradiation to enhance sensitivity of magnetic resonance detection
A periodic irradiation method for measuring exchange-induced relaxation rate constants to characterize tissue properties using MR spectroscopy.
Central airway stent removal device
A medical device for manipulation and removal of airway stents.
Use of sulfanegen and its analogs for prevention and treatment for neurodegenerative disorders
A 3-mercaptopyruvate prodrug, sulfanegen, that reduces neuroinflammation and oxidative stress for therapeutic use in neurodegenerative diseases.
Minimally invasive diagnostic for osteosarcoma in dogs
A panel of six definitive biomarkers that can be isolated from a canine blood sample for the detection of minimal residual disease and monitoring remission in dogs treated for osteosarcoma.
A method to identify cell-free biomarkers of cancers and other diseases
A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.
Assessing tumor behavior and response to therapy
A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.
Machine learning for early cancer detection
A machine learning method to train and validate algorithms to classify cancer risk based on a blood sample.
Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction
Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.
Biodegradable elastomers for 3D printing at low temperatures
A method of using a block copolymer comprising PCL and a stretchable amorphous block such as P(βMδVL) or random P(CL-co-DLLA) for creating extruded structures with bioactive ingredients.
High throughput cryopreservation system for up to millimeter-sized samples
A method for cryopreservation of large (100-1000micron dia.) biological samples while improving cell viability.
Detection of toxic small molecules using polymers and Raman scattering
A method to capture one or more analytes using polymers to enable multiplex quantitative detection by surface-enhanced Raman scattering
Community-based antibiotic screening method for polymicrobial infections (2020-090)
An improved antibiotic susceptibility test (AST) that determines minimal inhibitory concentration (MIC) with high physiological relevance for polymicrobial infections.
Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)
An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.
Device for extracting long genomic DNA from human cells
A microfluidic device for automated cell lysis and extraction of long DNA strands.
Device to Expand Soft Tissue
UEMtomaton: Software for automating image acquisition in electron microscope
Software files for automating image acquisition in TEM
SARS-CoV-2 spike receptor-binding domain for use in COVID-19 assays (2020-301)
Stably transfected mammalian cell lines that express the receptor-binding domain of the SARS-CoV-2 spike protein for use in assays and research relevant to COVID-19 and potential therapies.
Multifunctional, flexible sensor array for urethral catheters (20140233)
A new urethral catheter for simultaneous measurement of pressure distribution and neural activity.
Continuous honey bee cell-line, AmE-711 (2020-240)
The first and only honey bee cell-line available for use in research and experimental testing.
Orthodontic teeth aligners enabling deeper analysis and personalized treatment plans (2020-227, Dr. Alex Fok)
A system and method for measuring stress and strain distribution of invisible orthodontic teeth aligners.
3D Spine Registration Software for Computational Thoracic Volume Modeling (20160071)
Circulating tumor biomarkers for meningiomas (2020-164)
A biomarker panel for early diagnosis of meningiomas with the potential to improve patient outcomes.
Adenovirus Vector Generating System (20110090)
Siderophore-based diagnosis of bacterial infections (20150206)
Biofeedback Hand Grip Exercise Device for Assessing Muscle Function (20170200)
A streamlined method to isolate Fibroadipogenic progenitor cells from muscle (2020-195)
A method to isolate fibroadipogenic progenitor cells (FAPs) based on the presence of a single surface marker (CD73).
Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)
A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.
Antagomir to prevent cardiac arrhythmia (2019-069)
A novel small molecule screening platform for tauopathies (2019-123)
FRET-based biosensors that identify early toxic states of tau for use in basic research and clinical development of therapeutics for tauopathies including Alzheimer’s Disease.
Active Knit Compression Garment Portfolio (20170290)
A portfolio of shape memory alloy (SMA) functional active knits offers several types of wearable compression garments as well as a novel process for creating them. Technology #20170290-20180107-20180120-20180298
Opioid and Analgesic Chemical Compound Library (z09208)
E. Coli Fermentation of Glycerol from Biodiesel Waste into Ethanol
Functional Analysis of Networks in the Neural System
Infection Control System for Sterilization of Catheter Access Points with Ultraviolet (UV) Light
Iron Deficiency Mouse Model
Ultra-smooth Patterned Metal Films for Plasmonics
Ultra-smooth Patterned Metal Films for Plasmonics and Metamaterials
Improved Impedance Measurements for Pulmonary Edema from Pacemaker or CRT-ICD Leads
Improved Monitoring of Heart Failure Using Bioimpedance
SALSA - Automated Speech Assessment
For Quantitative Neuropsychological Cognitive Assessment
MRI Contrast Software Based on RAFF-n
Ammonia Production without Molecular Hydrogen for use in Fertilizer Production
Bactericidal Lanbiotic Inhibits Gram-negative Bacteria
Biosynthesis of Biodiesel without Glycerin By-Product
Cellulosic Ethanol Production from Starch or Cellulose Derived Sugars
Carcinoma Immunotoxin Targeting Epidermal Growth Factor and Interleukin-4 Receptors
Imaging of Cardiac Electrical Activation
A novel cardiac electrophysiological 3D imaging algorithm.
Navigation Aid for the Visually Impaired
On-Demand Production of Peracetic Acid
Algorithm for Non-invasive Source Localization of Neural Activity
Three Dimensional Dental Anatomy Software Program for Dentistry Students
MRI of Amyloid Plaque in the Brain
Microbial Biosynthesis Produces Unique Flavonoids, Chalcones and Stilbenes Used in Nutraceuticals
Biodiesel and Enriched Animal Feed from Dry Distillers Grains with Solubles Created in Ethanol Production
High Quality Digital Image Restoration Provides Faster Downloads with Less Storage and Bandwidth Requirements
Fabric Sleeve for Percutaneous Transluminal Device Provides Embolic Protection
Mammalian Cell Culture System for Anaplasmosis Vaccine Development
Mutated Opioid Receptors Block Chronic Pain Signals
Biological Imaging Provides Full Imaging of Samples
Cellulosic Biofuel, Chemical, and Ethanol Production
Organism Design for Cellulosic Biofuel, Cellulosic Chemical, and Cellulosic Ethanol Production
Implantable Microvalve Device for Controlled Insulin Delivery in Type 1 Diabetes Patients
Kappa Receptor Agonists and Delta Receptor Antagonists
Improved Nuclear Magnetic Resonance Spectroscopy Using Half-Spin Echo Data Recovery
Target for Acaricides and Cattle Tick Vaccines
Bifidobacteria Strain Depletes Iron-Dependent Bacteria
Nematode Biocontrol Agent
Biological Sample Imaging Device
More Stable and Potent Cyclic ADP-Ribose Analogs
Treating Neurodegenerative Diseases with Nicotine Receptor Ligands
Risk assessment for repeated hospital admission: Pra and PraPlus
Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ)
The Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ) is a validated patient-oriented measure of the adverse effects of heart failure on a patient's life.
3D printed deer head and neck model
A positive pressure testing booth for sample collection
Design files for a portable testing booth that facilitates safe practice of sample collection procedures on patients with infectious pathogens.
A Gown for U Project - level 1 isolation gown for emergency use
Design files for a low cost, rapidly producible, one-size-fits-all level 1 isolation gown.
Storage box to facilitate decontamination and reuse of face masks
A safe and well-ventilated storage box for N95 masks - design files and instruction videos.
MNmask Emergency-Use Face Masks
A design package for three styles of emergency-use face masks.
Minnesota Solvation (MNSOL) Database
An extensive and vetted database of free energies of solvation.
Portable aerosol hood to reduce spread of pathogens during medical procedures
A portable, transparent isolation box that facilitates safe practice of medical procedures on patients with infectious pathogens.
Coventor Emergency Ventilator - Adult Manual Resuscitator Compressor
A design package for an emergency, rapid-deployment ventilator system.
Sustainable triblock copolymers as strong, tunable, and degradable pressure sensitive adhesives
A method to produce strong, tunable, and degradable pressure sensitive adhesives from by-products of the cashew industry.
Machine learning algorithm for 3D particle field reconstruction
A machine learning algorithm for accurately reconstructing 3D particle fields.
Peripheral Artery Disease Quality of Life (PADQOL) Questionnaire
A validated instrument to assess the physical, psychosocial and emotional effects on patients suffering from peripheral artery disease.
Living with Pulmonary Hypertension Questionnaire (LPHQ)
The Living with Pulmonary Hypertension Questionnaire (LPHQ) is a reliable and validated measure of the adverse effects of pulmonary hypertension on a patient’s life.
Visualization of intracardiac electrograms on 3D heart model (VIEgram)
A software for easy visualization of intracardiac electrograms on 3D heart models.
Improving photovoltaic cell efficiency by employing highly stable, earth-abundant nanoparticle system
A novel nanomaterial for applications involving photon upconversion.
Self-supervised physics-based deep learning reconstruction without fully-sampled data
Methods for training machine learning algorithms without fully-sampled reference data for inverse problems.
Mouse models of tau variants linked to neurodegenerative disease
An improved and controlled mouse model expressing human tau P301L protein, a common mutation linked to neurodegeneration.
Nanoparticle bio-pesticide to improve crop health, germination, and overall yield
A material and method of application for improving crop health and yield.
Topographically conforming self-fitting garments made of active materials
A method to design and manufacture knitted garments that dynamically conforms to complex surfaces.
Six-month mortality risk estimation from electronic medical record
Selective bromodomain protein inhibitors that reduce cancer cell viability
Small molecules systematically designed as highly selective bromodomain inhibitors for development as cancer and inflammatory disease therapeutics.
Elderly Mortality After Trauma (EMAT) score
A validated scoring method for predicting mortality after trauma in elderly patients at admission.
Reduce contamination from grains and powdered food
A method for scalable, non-thermal or low temperature pasteurization of powdered or particulate food.
Machine learning-based sleep quality monitoring
Click-Chemistry Reagent for Mass Cytometry
Nesocodin: A natural red colorant that’s easily synthesized
A method to synthesize a novel, natural red colorant that is biodegradable and likely non-toxic.
Fluorescence-based assay for probing lipid transfer activity
A sensitive, reproducible and quantitative assay to study lipid transfer using bicelles as model membranes.
A synergistic therapy for multi-drug resistant cancers
A synthetic polymer that targets cancer cell membranes and works synergistically with existing chemotherapeutic drugs to treat drug-resistant solid tumors.
CoFe nanowires for remote heating using an alternating magnetic field
A nanowire material for remote, rapid and uniform heating of biological samples.
Biodegradable lactose-based hydrogel
A method to produce biodegradable lactose-based hydrogel from lactose-containing dairy waste.
3D tumor models for accurate testing of therapeutics
A method to create a 3D tumor model that accurately mimics both tumor behavior and environment for use in anti-cancer drug development.
Minnesota Nursing Informatics Leadership Inventory (MNILI)
A TLR-2 stimulatory molecule for use as a vaccine adjuvant
A small molecule that serves as an adjuvant in vaccines through stimulation of the immune receptor, TLR-2
Delivery of developmental regulators to whole plants for the induction of genetically altered meristematic tissue (Dr. Voytas)
Research out of the Voytas Lab provides a method for the creation of genetically-altered seeds within one generation via the induction of new plant meristems.
Machine Learning-based Dynamic Activity Recommendation System
A deep learning architecture for wearable devices to evaluate, predict, and improve the quality of sleep by recommending personalized activities.
Antibody based treatment for Type 1 Diabetes
A humanized monoclonal antibody against Serpin B13 to treat Type 1 Diabetes.
Immunostimulatory conjugates for targeted delivery as adjuvants
Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure
iTorsion - Smartphone App for Ocular Torsion Diagnosis
Suture-free Chest Tube Stabilizing Device
Drug Delivery Device for Oral Topical Medicine
Plant Biometric Estimation Using 3D Models
3D Plant Reconstruction and Biometric Measurement
Multi-compartment Biopsy Syringe
MRI Pre-Scan Method for Imaging Metallic Devices
Novel small molecules for chemotherapy sensitization
Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.
3D printing on Moving Freeform Surfaces
CMRR - Center for Magnetic Resonance Research Software for Siemens MRI Scanners
Assay to measure intrinsic efficiency of GPCR ligands
FRET-based GPCR biosensors to measure specific ligand activation in a cell independent manner.
Patient Controlled Dynamic Therapeutic Compression Tension Garment
Efficient Ammonia Production Using Stable Absorbents
MHC Class II Molecules with Enhanced Co-receptor Affinity
High Yield Synthesis of Bio-based Acrylic Acid and Acrylate Monomers from Lactic Acid (20180106, Dr. Marc Hillmyer)
A novel dual-action drug targeting cancer and respiratory syndromes
A novel compound inhibiting translation and inducing p53 independently of DNA damage, with potential for treating both cancer and acute respiratory syndromes.
Non-invasive Neuromodulation for Reversible Modulation of Neural Activity
A method for targeted modulation of neural activity using transcranial low intensity focused ultrasound.
MyStrengths MyHealth™
Automated De-Identification of Distributional Semantics Models
High Ammonia Absorbing Corn Stover Hydrochar for use in Horse Bedding
Microinjection for Single Cell Gene Manipulation
Referenceless Nyquist Ghost Correction for Echo Planar Imaging (EPI)
Segmenting 3D Bone Computed Tomography Data
Directional Coordinated Reset Deep Brain Stimulation (DBS) (20180061)
Tosedostat (CHR-2797) as a Potential Analgesic
An effective media for difficult-to-culture mouse epithelial cells
A novel cell culture media formula that facilitates the expansion and cultivation of typically challenging mouse keratinocytes.
Chewing Simulator Provides Sensory Information
Real-Time Reporter and Efficient Enzymes for DNA Editing
Active Knit Compression Stockings
Versatile Biocatalyst System for Synthesizing Chemicals, Pharmaceuticals and Food Ingredients
Optimized Radio Frequency Pulses Generated From Magnetic Resonance User Defined Parameters
Physical-layer cross-technology communication via signal emulation (AllBee)
A method to enable high-throughput cross-technology communication using physical-level emulation without hardware or firmware modifications.
Scan-Specific Machine Learning Reconstruction for MRI
Augmented non-invasive hearing system
3D Printed Stretchable Tactile Sensors with Electronic Ink
Specific kinase biosensors to probe cancer metabolism
Substrate peptides for Ser/Thr kinases to investigate the metabolic processes of cancer cells.
Sliding Windowed Infinite Fourier Transform (SWIFT)
3D Microscale Isotropic Metamaterials
Compressed Sensing Coronary MRI Sequence
Enhanced Resolution Cardiac MRI
Remote-Controlled Microscale 3D Self-Assembly
One-Year Mortality Risk Estimates from Electronic Medical Record Data
Probes for Biosynthesis of Bacterial Cell Wall
Unique compounds to treat obesity
Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.
Denoising Magnetic Resonance Imaging Data
NOise reduction with DIstribution Corrected (NORDIC) technique for improving MRI imaging.