Nanorings for cell-mediated drug delivery
Farnesylated chemically self-assembled nanorings that facilitate targeted drug delivery between cells.
Novel Antimicrobial Peptide DGL13K
An antimicrobial peptide DGL13 that exhibits several desirable characteristics for a novel antibiotic.
Efficient CRISPR-based gene editing for stem cells
A CRISPR-based gene editing protocol for induced pluripotent stem cells (iPSCs) with improved editing efficiency and cell survival.
Single-cell Integration and DrUg Response PrediCtion (scIDUC)
A computational pipeline that predicts drug response scores for individual cells using single-cell RNA sequencing data.
Pharmacological enhancement of CD8 T cell effector function using TEPP46
A clinically viable strategy for preventing mitochondria-mediated T cell exhaustion and enhancing effector T cell function.
First-in-class drug lead candidate (A229) for treating ocular diseases
PPARα agonist, A229, exhibits strong potency and demonstrates efficacy in in-vitro models of diabetic retinopathy.
Bacterial histidine kinase inhibitors for treating Staphylococcus infections
Small molecule bacterial histidine kinase inhibitors that significantly diminish staphylococcal virulence.
Catheter to measure intra-arterial pressure gradients
A catheter coated in carbon nanotubes and pressure membranes that measures intra-arterial pressure changes.
Small molecule inhibitors for treating alcoholic hepatitis
Bromodomain inhibitor, UMN627, reduces inflammation in mice models of alcoholic hepatitis.
Novel biliary stent and deployment device
A novel device for managing difficult strictures of the pancreatic and biliary ducts.
A catheter-based intravenous respirator
A device for direct gas exchange with the venous system to deliver oxygen and support critically ill patients.
Device to deliver large volumes of oxygen intravenously
A device for infusing large volumes of oxygen directly into the bloodstream via an oxygenated and pressurized saline solution.
T Cell Receptor Exchange (TRex) Mice
A mouse model for studying physiological antigen-specific T cell behavior.
Ovarian cancer prognostic test for predicting response to chemotherapy and bevacizumab
A prognostic molecular test for predicting ovarian cancer patient response to platinum-based chemotherapy and/or treatment with bevacizumab.
Bisubstrate inhibitors for treating SARS-CoV-2 infections
Bisubstrate inhibitors that target the active site of SARS-CoV-2 Nsp14 methyltransferase (MTase) for treating SARS-CoV-2 infections.
Early detection of ovarian cancer using a multiprotein classifier
A blood test for detecting ovarian cancer with over 90% accuracy by monitoring key protein levels.
Novel compounds for treatment of neurodegenerative disease and chronic pain
Novel alpha2-adrenergic agonists with neuroprotective and/or analgesic properties.
First-generation degraders for class I bromodomain-containing proteins
A bromodomain-targeting degrader of CECR2, an epigenetic regulator that drives cancer metastasis.
NOD-2-active carboxamide compounds as vaccine adjuvants
Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.
Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines
A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.
High-throughput screening assay for sickle cell disease drug discovery
A high-throughput screening assay for discovering small molecules that directly inhibit sickle hemoglobin oligomerization.
Mouse-derived FSHD muscle cell lines
Primary skeletal muscle cell lines isolated from DUX4 expressing FSHD mice.
Generating teratoma-derived skeletal muscle stem cells
A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.
Small molecules with antiproliferative activity against pancreatic cancer cells
Small molecules that show antiproliferative activity against the pancreatic cancer cell line MiaPaca-2.
Steerable magneto-photonic particles for targeted delivery and collection of light
An embeddable magneto-photonic microparticle that can be externally positioned and orientated for targeted delivery and collection of light.
Small molecules promoting differentiation/maturation of stem cell-derived myogenic cells
A combinatorial small molecule treatment that promotes differentiation and maturation of myotubes derived from pluripotent stem cells.
AgRP-Derived melanocortin-5 receptor peptide antagonists
AgRP derived scaffolds composed of natural (Tyr, Ala, Val, Asn) and unnatural amino acids (Dap) with antagonist activity at the mouse MC5R
Surface Coating with Novel Antimicrobial Peptide DGL13K
Family of antimicrobial peptides, based on the core peptide GL13, that directly attack the bacterial cell membrane.
3D-printed skin-wearable photodetector device
Fully 3D-printed flexible skin-wearable device for real-time measurements of UV-visible exposures.
The Mindful Movement for Physical Activity (MMPA) Program
An eight-week, research-tested mindful physical activity educational program
The Keys to Health & Wellbeing Program (KHW) for adults 50+ years of age
An eight-week, research-tested health & wellbeing educational program for adults over 50
Minnesota Assessment of Pharmacogenomic Literacy (MAPL™)
A questionnaire to assess pharmacogenomic knowledge among patients in research studies or clinical care.
Human Myotonic Dystrophy Induced Pluripotent Stem Cell Lines
Pain therapy without the risk of respiratory depression, addiction or abuse
An analgesic combination of peripherally restricted opioids that eliminates the risk of respiratory depression, chemical addiction or abuse.
Compound with selective inhibition potential against P300 and CBT
A compound to treat pediatric sarcoma through the inhibition of P300 and CBT
Live cell assay to quantify the activity of SARS-CoV-2 main protease, Mpro
Fluorescence-based method to effectively screen for protease inhibitors
Camelid single domain antibody phage display library
Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target
T cell receptors for engineered T cell therapy
Mesothelin-specific T cell receptors for cell engineering and cancer therapy
Nanominne-1: novel virus-like particle (nanoparticle) vaccines to prevent SARS-CoV-2 infections
Series of novel vaccines containing 60 copies of SARS-CoV-2 antigens displayed in ordered array on a virus-like particle scaffold (nanoparticle)
Augmented reality transjugular intrahepatic portosystemic shunt (AR-TIPS) set and other interventional devices
An augmented reality (AR) system to assist clinicians in performing medical procedures inside the body where 3D anatomical information is important
Immortalized clonal human myoblast line "M007"
Immortalized human myoblast cell line obtained from a healthy individual
Immortalized clonal human fibroblast line "F007"
Immortalized human fibroblast cell line obtained from a healthy individual
Bacteriophage cocktail for food decontamination
A cocktail of bacteriophages for specific targeting and eradication of foodborne Salmonella and Shiga toxigenic E.coli.
Engineered SARS-CoV-2 spike ectodomain for COVID-19 diagnostic assays
Engineered SARS-CoV-2 spike ectodomain expressed from stably transfected mammalian cell lines to be used as an effective diagnostic antigen against different SARS-CoV-2 variants
A system for unattended delivery of cognitive neuromodulation therapy
Non-invasive interactive system with specialized equipment and customizable stimulation unit to deliver unattended cognitive neuromodulation therapy. The system supports training of prescribers and clinical staff leading to certification
AGRP-derived melanocortin receptor ligands
Identifying a selective MC4R antagonist for appetite modulation
Chimeric melanocortin receptor ligands
Melanocortin-4 receptor ligand reduces food intake in mice
Selective melanocortin receptor ligands
Potential dual-ligand approach to weight management
Lateral flow assay for respiratory viruses
CRISPR/Cas9-based point-of-care diagnosis for SARS-CoV-2
Just One Thing (JOT): custom care plans for people with cognitive challenges
A simple, customizable clinical care guide and worksheet to promote at-home therapy for people with cognitive challenges and their caregivers.
AI-enabled support tool for COVID-19 diagnosis using chest x-rays
A deep learning model for screening COVID-19 patients using chest x-rays with >98% accuracy.
Urinary Catheter Stabilization Device
A urinary catheter support device that prevents penile erosion arising from the use of indwelling catheters.
A novel approach for bioprinting complex tissue models
A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.
Novel anti-cancer agents that target the epigenetic reader protein
Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.
Use of sulfanegen and its analogs for prevention and treatment for neurodegenerative disorders
A 3-mercaptopyruvate prodrug, sulfanegen, that reduces neuroinflammation and oxidative stress for therapeutic use in neurodegenerative diseases.
Minimally invasive diagnostic for osteosarcoma in dogs
A panel of six definitive biomarkers that can be isolated from a canine blood sample for the detection of minimal residual disease and monitoring remission in dogs treated for osteosarcoma.
A method to identify cell-free biomarkers of cancers and other diseases
A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.
Assessing tumor behavior and response to therapy
A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.
Machine learning for early cancer detection
A machine learning method to train and validate algorithms to classify cancer risk based on a blood sample.
Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction
Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.
Community-based antibiotic screening method for polymicrobial infections (2020-090)
An improved antibiotic susceptibility test (AST) that determines minimal inhibitory concentration (MIC) with high physiological relevance for polymicrobial infections.
Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)
An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.
Device for extracting long genomic DNA from human cells
A microfluidic device for automated cell lysis and extraction of long DNA strands.
SARS-CoV-2 N-protein for use in COVID-19 serological assays (2020-323)
Full length SARS-CoV-2 Nucleocapsid (N) protein expressed by bacteria for use in serological assays to detect previous COVID-19 infection in humans and animals.
SARS-CoV-2 spike receptor-binding domain for use in COVID-19 assays (2020-301)
Stably transfected mammalian cell lines that express the receptor-binding domain of the SARS-CoV-2 spike protein for use in assays and research relevant to COVID-19 and potential therapies.
Multifunctional, flexible sensor array for urethral catheters (20140233)
A new urethral catheter for simultaneous measurement of pressure distribution and neural activity.
Circulating tumor biomarkers for meningiomas (2020-164)
A biomarker panel for early diagnosis of meningiomas with the potential to improve patient outcomes.
Siderophore-based diagnosis of bacterial infections (20150206)
Biofeedback Hand Grip Exercise Device for Assessing Muscle Function (20170200)
A method to genetically engineer monocytes (20180236)
The first and only method available to create genetically modified CD14+ monocytes for use in research or therapy.
A streamlined method to isolate Fibroadipogenic progenitor cells from muscle (2020-195)
A method to isolate fibroadipogenic progenitor cells (FAPs) based on the presence of a single surface marker (CD73).
Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)
A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.
Antagomir to prevent cardiac arrhythmia (2019-069)
A novel small molecule screening platform for tauopathies (2019-123)
FRET-based biosensors that identify early toxic states of tau for use in basic research and clinical development of therapeutics for tauopathies including Alzheimer’s Disease.
MRI of Amyloid Plaque in the Brain
Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ)
The Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ) is a validated patient-oriented measure of the adverse effects of heart failure on a patient's life.
A positive pressure testing booth for sample collection
Design files for a portable testing booth that facilitates safe practice of sample collection procedures on patients with infectious pathogens.
A Gown for U Project - level 1 isolation gown for emergency use
Design files for a low cost, rapidly producible, one-size-fits-all level 1 isolation gown.
Storage box to facilitate decontamination and reuse of face masks
A safe and well-ventilated storage box for N95 masks - design files and instruction videos.
Portable aerosol hood to reduce spread of pathogens during medical procedures
A portable, transparent isolation box that facilitates safe practice of medical procedures on patients with infectious pathogens.
Peripheral Artery Disease Quality of Life (PADQOL) Questionnaire
A validated instrument to assess the physical, psychosocial and emotional effects on patients suffering from peripheral artery disease.
Living with Pulmonary Hypertension Questionnaire (LPHQ)
The Living with Pulmonary Hypertension Questionnaire (LPHQ) is a reliable and validated measure of the adverse effects of pulmonary hypertension on a patient’s life.
Visualization of intracardiac electrograms on 3D heart model (VIEgram)
A software for easy visualization of intracardiac electrograms on 3D heart models.
Mouse models of tau variants linked to neurodegenerative disease
An improved and controlled mouse model expressing human tau P301L protein, a common mutation linked to neurodegeneration.
Selective bromodomain protein inhibitors that reduce cancer cell viability
Small molecules systematically designed as highly selective bromodomain inhibitors for development as cancer and inflammatory disease therapeutics.
Dental stem cells to treat spinal cord injury
A method of treating nervous tissue damage using dental pulp stem cells that leads to neuro-regeneration with a high safety profile and low probability of patient rejection.
Elderly Mortality After Trauma (EMAT) score
A validated scoring method for predicting mortality after trauma in elderly patients at admission.
Machine learning-based sleep quality monitoring
Fluorescence-based assay for probing lipid transfer activity
A sensitive, reproducible and quantitative assay to study lipid transfer using bicelles as model membranes.
A synergistic therapy for multi-drug resistant cancers
A synthetic polymer that targets cancer cell membranes and works synergistically with existing chemotherapeutic drugs to treat drug-resistant solid tumors.
3D tumor models for accurate testing of therapeutics
A method to create a 3D tumor model that accurately mimics both tumor behavior and environment for use in anti-cancer drug development.
A TLR-2 stimulatory molecule for use as a vaccine adjuvant
A small molecule that serves as an adjuvant in vaccines through stimulation of the immune receptor, TLR-2
Machine Learning-based Dynamic Activity Recommendation System
A deep learning architecture for wearable devices to evaluate, predict, and improve the quality of sleep by recommending personalized activities.
Immunostimulatory conjugates for targeted delivery as adjuvants
Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure
iTorsion - Smartphone App for Ocular Torsion Diagnosis
Drug Delivery Device for Oral Topical Medicine
Novel small molecules for chemotherapy sensitization
Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.
Assay to measure intrinsic efficiency of GPCR ligands
FRET-based GPCR biosensors to measure specific ligand activation in a cell independent manner.
Patient Controlled Dynamic Therapeutic Compression Tension Garment
MHC Class II Molecules with Enhanced Co-receptor Affinity
A novel chemotherapy drug with reduced patient side-effects
A novel anti-cancer compound that inhibits translation and induces p53 in a DNA-damage independent manner to cause cell cycle arrest and apoptosis.
Non-invasive Neuromodulation for Reversible Modulation of Neural Activity
A method for targeted modulation of neural activity using transcranial low intensity focused ultrasound.
MyStrengths MyHealth™
Microinjection for Single Cell Gene Manipulation
Segmenting 3D Bone Computed Tomography Data
Tosedostat (CHR-2797) as a Potential Analgesic
Real-Time Reporter and Efficient Enzymes for DNA Editing
Optimized Radio Frequency Pulses Generated From Magnetic Resonance User Defined Parameters
Scan-Specific Machine Learning Reconstruction for MRI
Augmented non-invasive hearing system
3D Printed Stretchable Tactile Sensors with Electronic Ink
Specific kinase biosensors to probe cancer metabolism
Substrate peptides for Ser/Thr kinases to investigate the metabolic processes of cancer cells.
Sliding Windowed Infinite Fourier Transform (SWIFT)
3D Microscale Isotropic Metamaterials
One-Year Mortality Risk Estimates from Electronic Medical Record Data
Probes for Biosynthesis of Bacterial Cell Wall
Unique compounds to treat obesity
Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.
Denoising Magnetic Resonance Imaging Data
NOise reduction with DIstribution Corrected (NORDIC) technique for improving MRI imaging.
Bacterial Histidine Kinase Inhibitor
Faster MRI Acquistion with Motion Robustness
Tunable Neural Electrodes for MRI-Compatible Brain Signal Recordings
A discrete and effective wearable breast pump for nursing mothers
A quiet and concealed wearable breast pump that mimics infant suckling using mechanical compression and heat; increasing milk expression as well as convenience and comfort.
Myocardial Viability Functional Assessment
Dynamic Quantification of Myocardial Tissue MRI
Orthopedic Meniscus Repair Implant, Introducer and Delivery System
Remedy for Heart Failure with Preserved Ejection Fraction
Conformable Dual-mode Ultrasound Transducers for Neuromodulation
Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC
Single Voxel MR Spectroscopy of Human Brain with Automatic Voxel Positioning
Solar UV-Induced Skin Cancer Inhibitor
Magnetization Transfer Contrast Preparation
Particle Swarm Optimization for Programming Neuromodulation Systems
Multi-modal Neuromodulation Therapy Promotes Sleep
Scaffolds for Cancer Cell Ablation
Pediatric Tracheo-bronchomalacia Stent and Deployment System
Mimicked Calcified Annulus Model for Preclinical Assessment of TAVR Devices
Motion-Robust Cardiac B1+ Mapping of the Transmit Field
Imaging Source Distribution from Electromagnetic Signals
Adaptive Immune Response Stimulated with TLR8 and Dual TLR7/TLR8 Agonists
Compliant Aortic Stent Graft
Black-Blood T1 Myocardial Mapping to Remove Partial Voluming Effects
Kinase assay to aid in development of therapeutics for acute myeloid leukemia
Peptide substrates to sensitively and specifically measure the real-time activity of FLT3, a kinase linked to acute myeloid leukemia.
PDAC Treatment with High Antiproliferative Activity Against MiaPaca-2
Lung Biopsy Tool
Novel inhibitors of HINT1 to treat neuropathic pain and addiction
Small-molecule inhibitors of hHint1 (and their synthesis) for use in basic CNS research and treatment of neuropathic pain and addiction.
3D Shoulder Motion Measurement System
Ultrasound-based Hearing Aid
Biosynthetic Route to Serofendic Acid
Smart Clothing with Dynamically Controlled Compression
Improved Lumbar Puncture And Epidural Accuracy
Designing 2D and 3D Adiabatic Pulses
Neuromodulator for Simultaneous Stimulation and Signal Reception
Improved Craniotome to Prevent Dural Tear
Efficient release of affinity-captured cells
A method to effectively release affinity-captured cells.
Developing Highly Specific Monoclonal Antibodies to Peptide in the Context of MHC II
Nonsurgical Method for Restoring Tooth Enamel
Radiofrequency Antenna Array with Electric Dipole and Loop Elements
Warming of Cryopreserved Biomaterials using Laser Assisted Gold Nanorods
Catheter Based Targeted Extracorporeal Membrane Oxygenator (ECMO)
Improved Pertussis Vaccine
Algorithm for Discovering Genetic Interactions in Genome-Wide Association Studies (BridGE)
Multimodal Synchronization, Sound & Electrical Stimulation, Hearing Aid (mSync-hEAR)
Hydrophobic Surfaces for Tooth Tissues
Adaptive Refocusing of Ultrasound Arrays Using Synthetic Aperture Imaging Data
Graphene Formaldehyde Sensor (20150354, Dr. Tianhong Cui)
Kinase biosensor for individualized cancer therapy (20150289, Dr. Laurie Parker)
A method to sensitively and specifically detect the activity of multiple kinases, from multiple samples in a traceable manner.
Lower Extremity Edema Monitor (20150192, Dr. Rajesh Rajamani)
Deep Brain Stimulation Using Magnetic Brain Array (20150177, Dr. Jian-Ping Wang)
Improved Deep Brain Stimulation Target Selectivity (20150170, Dr. Shalom Michaeli)
Increased efficiency of CRISPR-Cas9 genome editing (Dr. Wendy Gordon)
An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.
Improved MRI Quality with Gradient Modulation Pulse Sequence (20150133, Dr. Kobayashi, Dr. Garwood)
Time Efficient Arterial Spin Labeling Imaging with Segmented Multiband-acquisition (20150097, Dr. Greg Metzger)
Improved MRI Method Uses Temperature Rise Contraints (20150061, Dr. Moortele)
Therapeutic compound for chronic inflammatory pain without dependence or tolerance (20140357, Dr. Philip Portoghese)
An analgesic compound without side effects that relieves chronic pain associated with arthritis, sickle cell disease, chemotherapy, AIDs and inflammation.
Mapping Prostate Cancer from Multi-parametric MRI with Improved Predictive Models (20140287, Dr. Greg Metzger)
Multi-purpose Arm Ergometer Design (20140266, Dr. Gary Goldish)
In-vivo MRI Radiofrequency Pulses Robust against Respiration Induced Errors (20140236, Dr. Kamil Ugurbil)
Multi-band SWIFT Improves MRI (20140121, Dr. Idiyatullin, Dr. Garwood)
Generalized Multiband Slice Accelerated Imaging (20140093, Dr. Dingxin Wang)
Reduced-power SWIFT Magnetic Resonance Imaging (20140052, Dr. Jinjin Zhang, Dr. Garwood)
Magnetic Resonance Electrical Properties Tomography (20130259, Dr. Bin He)
Multislice Multiband Excitation with Parallel Transmission for B1 Homogenization and Power Reduction (20130170)
IV Line Lifting Device (20130136, Dr. Mary Hooke)
Long-term whole organ cryopreservation and transplantation
A method for long-term whole organ cryopreservation and transplantation using vitrification and nanowarming techniques.
Intraoral Dental MRI Coil (20130110, Dr. Michael Garwood)
MRI Signal Separation using Iterative Calibration (20130079, Dr. Kamil Ugurbil)
Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)
MRI Method Reduces Peak Power for Multiband Images (20120077, Dr. Kamil Ugurbil)
Synchronized Multi-Modal Tinnitus Therapy (20120070, Dr. Hubert Lim)
A non-invasive or minimally-invasive method for the suppression of tinnitus using synchronized brain stimulation.
MRI Pulse Sequence: Steering Resonance over the Object (20120049, Dr. Michael Garwood)
Faster Functional and Diffusion MRI of the Brain (20110139, Dr. Kamil Ugurbil)
Lower Specific Absorption Rate for Multiband MRI (20110093, Dr. Kamil Ugurbil)
Faster Whole Brain Imaging (20110092, Dr. Kamil Ugurbil)
Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)
Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.
Digital Pathology Quantitative Immunohistochemistry Software
Digital Pathology Quantitative Immunohistochemistry Software