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Broadspectrum potentially therapeutic nanobodies against COVID-19

A class of nanobodies (Nanosota-2, -3, and -4) offering broadspectrum therapeutic potential against COVID-19.

Soluble, active DNA cytosine deaminase for use as a research tool

A method to produce soluble DNA cytosine deaminase for assays of potential inhibitors of HIV-1 and as a tool for biotech applications

Image processing technique for improved MRI image fidelity

A novel technique to improve MRI image fidelity via the combination of a denoising and deep learning-based reconstruction step.

Nanorings for cell-mediated drug delivery

Farnesylated chemically self-assembled nanorings that facilitate targeted drug delivery between cells.

Artificial gut/absorption simulator for evaluation of drug formulations dissolution

A device and method for simulating a digestive gut to evaluate drug delivery that incorporates simultaneous absorption with dissolution

Encapsulated supported anaerobic biofilms for enhanced methane production

Encapsulated anaerobic biofilms for treating wastewater and generating desirable products such as methane or hydrogen gas.

Novel Antimicrobial Peptide DGL13K

An antimicrobial peptide DGL13 that exhibits several desirable characteristics for a novel antibiotic.

Efficient CRISPR-based gene editing for stem cells

A CRISPR-based gene editing protocol for induced pluripotent stem cells (iPSCs) with improved editing efficiency and cell survival.

Wearable ultrasound sensors for imaging and sensing

Novel wearable ultrasound transducers designed to integrate real-time imaging, sensing, and treatment functions for application in therapeutics and diagnostics.

Quantitative ultrasound for fatty tissue imaging

A signal processing method to enhance ultrasound imaging of fatty tissue.

Dual frequency RF coil for magnetic resonance imaging

A novel RF resonant coil that can operate at both X-nuclear and proton frequencies.

Neonatal pneumothorax decompression device

A rapidly deployable, self-contained device to evacuate air from the pleural space of a neonate.

Single-cell Integration and DrUg Response PrediCtion (scIDUC)

A computational pipeline that predicts drug response scores for individual cells using single-cell RNA sequencing data.

2 licensing options
Medical device for the treatment of Raynaud’s phenomenon

A novel therapeutic device that applies blue light and warmth for the treatment of Raynaud’s phenomenon.

Pharmacological enhancement of CD8 T cell effector function using TEPP46

A clinically viable strategy for preventing mitochondria-mediated T cell exhaustion and enhancing effector T cell function.

First-in-class drug lead candidate (A229) for treating ocular diseases

PPARα agonist, A229, exhibits strong potency and demonstrates efficacy in in-vitro models of diabetic retinopathy.

3D printed organ models with integrated sensing capabilities

A method to 3D print patient-specific organ models with tissue-mimicking properties and integrated sensing capabilities.

Bacterial histidine kinase inhibitors for treating Staphylococcus infections

Small molecule bacterial histidine kinase inhibitors that significantly diminish staphylococcal virulence.

Catheter to measure intra-arterial pressure gradients

A catheter coated in carbon nanotubes and pressure membranes that measures intra-arterial pressure changes.

Small molecule inhibitors for treating alcoholic hepatitis

Bromodomain inhibitor, UMN627, reduces inflammation in mice models of alcoholic hepatitis.

Novel biliary stent and deployment device

A novel device for managing difficult strictures of the pancreatic and biliary ducts.

InTERACCT Program: Occupational health and safety training

Training courses for occupational health and safety workers aimed to equip them to handle risks associated with emerging technologies.

1 licensing option
A catheter-based intravenous respirator

A device for direct gas exchange with the venous system to deliver oxygen and support critically ill patients.

Device to deliver large volumes of oxygen intravenously

A device for infusing large volumes of oxygen directly into the bloodstream via an oxygenated and pressurized saline solution.

T Cell Receptor Exchange (TRex) Mice

A mouse model for studying physiological antigen-specific T cell behavior.

Ovarian cancer prognostic test for predicting response to chemotherapy and bevacizumab

A prognostic molecular test for predicting ovarian cancer patient response to platinum-based chemotherapy and/or treatment with bevacizumab.

Highly fluorinated compounds for magnetic resonance-based temperature sensing

Novel fluorinated molecules for temperature sensing by MRI thermometry.

Bisubstrate inhibitors for treating SARS-CoV-2 infections

Bisubstrate inhibitors that target the active site of SARS-CoV-2 Nsp14 methyltransferase (MTase) for treating SARS-CoV-2 infections.

Early detection of ovarian cancer using a multiprotein classifier

A blood test for detecting ovarian cancer with over 90% accuracy by monitoring key protein levels.

Novel compounds for treatment of neurodegenerative disease and chronic pain

Novel alpha2-adrenergic agonists with neuroprotective and/or analgesic properties.

First-generation degraders for class I bromodomain-containing proteins

A bromodomain-targeting degrader of CECR2, an epigenetic regulator that drives cancer metastasis.

Endotracheal intubation with computer vision

A machine learning-based intubation tube for autonomous or computer-assisted endotracheal intubation.

NOD-2-active carboxamide compounds as vaccine adjuvants

Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.

Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines

A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.

High-throughput screening assay for sickle cell disease drug discovery

A high-throughput screening assay for discovering small molecules that directly inhibit sickle hemoglobin oligomerization.

Self-Efficacy to Reduce Sedentary Behavior (SRSB) Questionnaire

A 9-item questionnaire designed to evaluate self-efficacy to reduce sedentary behavior.

2 licensing options
Autonomous high-accuracy analysis of prostate cancer biopsies

A framework for automated detection of prostate cancer on histopathology slides.

Conditional DUXC knockout mouse model

A conditional DUXC knockout mouse model for use as a basic research tool.

Direct elution caps for reducing autosampler cross-vial contamination

A screw cap that interfaces a pipette tip and autosampler vial, creating a sturdy connection and an elevated pipette tip position within the vial.

Fast 3-dimensional reciprocal space imaging with laboratory X-ray diffraction: RSLab

A software that adds fast 3D reciprocal space imaging capabilities to laboratory X-ray diffractometers with 2D detectors.

1 licensing option
Mouse-derived FSHD muscle cell lines

Primary skeletal muscle cell lines isolated from DUX4 expressing FSHD mice.

Generating teratoma-derived skeletal muscle stem cells

A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.

Small molecules with antiproliferative activity against pancreatic cancer cells

Small molecules that show antiproliferative activity against the pancreatic cancer cell line MiaPaca-2.

Genetically modified endophyte with biofertilizer potential

A genetically modified bacteria (G. diazotrophicus) that is an established plant endophyte and releases high amounts of ammonium when grown on simple sugars

Rapid non-invasive portable system for monitoring deterioration of plastics

A system comprising a portable device and image processing software for superficial non-destructive determination of plastic deterioration

Steerable magneto-photonic particles for targeted delivery and collection of light

An embeddable magneto-photonic microparticle that can be externally positioned and orientated for targeted delivery and collection of light.

Small molecules promoting differentiation/maturation of stem cell-derived myogenic cells

A combinatorial small molecule treatment that promotes differentiation and maturation of myotubes derived from pluripotent stem cells.

Engineered bacteria for the synthesis of a biodegradable polymer coating

Genetically modified bacteria for the synthesis of a biodegradable polymer to coat fertilizer pellets, allowing nitrogen to be slowly released over time.

AgRP-Derived melanocortin-5 receptor peptide antagonists

AgRP derived scaffolds composed of natural (Tyr, Ala, Val, Asn) and unnatural amino acids (Dap) with antagonist activity at the mouse MC5R

Surface Coating with Novel Antimicrobial Peptide DGL13K

Family of antimicrobial peptides, based on the core peptide GL13, that directly attack the bacterial cell membrane.

Scale of Alopecia Areata Distress (SAAD)

A tool (e.g., scale) for assessing the psychosocial impact of Alopecia Areata/Totalis/Universalis on patients' lifes.

1 licensing option
Self-navigation to enable efficient 3D DWI SE-EPI multi-slab multi-band imaging

A method for correcting MRI data from corruption due to physiological changes.

3D-printed skin-wearable photodetector device

Fully 3D-printed flexible skin-wearable device for real-time measurements of UV-visible exposures.

The Mindful Movement for Physical Activity (MMPA) Program

An eight-week, research-tested mindful physical activity educational program

The Keys to Health & Wellbeing Program (KHW) for adults 50+ years of age

An eight-week, research-tested health & wellbeing educational program for adults over 50

Long-stroke rolling diaphragm cylinder for passive hydraulic rehabilitation robot

Novel fabric-elastomer long-stroke rolling diaphragm (LSRD) cylinder displaying low friction and zero leakage for small and passive hydraulic systems.

Minnesota Assessment of Pharmacogenomic Literacy (MAPL™)

A questionnaire to assess pharmacogenomic knowledge among patients in research studies or clinical care.

2 licensing options
Methods for Modifying Proteins and Peptides.

Production of alpha-N-methylated peptides for improved pharmacological properties.

Surface markers for identification and isolation of skeletal muscle stem cells

A list of cell surface marker antibodies that can identify and isolate (or purify) human skeletal muscle stem cells.

Human Myotonic Dystrophy Induced Pluripotent Stem Cell Lines

Treating trauma-induced acute blood loss

Novel formulations of D-β-hydroxybutyrate and melatonin improve survival from hemorrhagic shock.

Pain therapy without the risk of respiratory depression, addiction or abuse

An analgesic combination of peripherally restricted opioids that eliminates the risk of respiratory depression, chemical addiction or abuse.

Medical Device for Chronic Sinusitis

The technology is a design of a medical device that can be placed in the ostium between the maxillary sinus and nasal passageway for treatment of chronic sinusitis.

HUH fusion enzymes for multiplex protein labeling

HUH fusion tags are novel, robust endonucleases that allow proteins and DNA to be linked covalently in one simple step

Cell-free selection of site-specific polypeptide binders via tethering

In vitro selection method for the engineering of protein-based high-affinity binders to targets of interest with potential pharmacological value

Compound with selective inhibition potential against P300 and CBT

A compound to treat pediatric sarcoma through the inhibition of P300 and CBT

Live cell assay to quantify the activity of SARS-CoV-2 main protease, Mpro

Fluorescence-based method to effectively screen for protease inhibitors

Camelid single domain antibody phage display library

Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target

T cell receptors for engineered T cell therapy

Mesothelin-specific T cell receptors for cell engineering and cancer therapy

A process to make ultra-high purity urea at low cost by using enzymes

Low cost enzyme-processed ultra-high purity urea for high-grade fertilizer, diesel emissions fluid and pharmaceuticals

Nanominne-1: novel virus-like particle (nanoparticle) vaccines to prevent SARS-CoV-2 infections

Series of novel vaccines containing 60 copies of SARS-CoV-2 antigens displayed in ordered array on a virus-like particle scaffold (nanoparticle)

Targeted Artificial DNA Replisome (TADR) a Tool for Targeted Mutagenesis

TADR is a protein-complex designed to target and mutate specific genes on plasmid in vivo

Augmented reality transjugular intrahepatic portosystemic shunt (AR-TIPS) set and other interventional devices

An augmented reality (AR) system to assist clinicians in performing medical procedures inside the body where 3D anatomical information is important

Immortalized clonal human myoblast line "M007"

Immortalized human myoblast cell line obtained from a healthy individual

Immortalized clonal human fibroblast line "F007"

Immortalized human fibroblast cell line obtained from a healthy individual

Electron paramagnetic resonance (EPR) imaging without magnet

A method which produces low cost EPR imaging with better receiver isolation and no magnet requirement

Bacteriophage cocktail for food decontamination

A cocktail of bacteriophages for specific targeting and eradication of foodborne Salmonella and Shiga toxigenic E.coli.

Engineered SARS-CoV-2 spike ectodomain for COVID-19 diagnostic assays

Engineered SARS-CoV-2 spike ectodomain expressed from stably transfected mammalian cell lines to be used as an effective diagnostic antigen against different SARS-CoV-2 variants

A system for unattended delivery of cognitive neuromodulation therapy

Non-invasive interactive system with specialized equipment and customizable stimulation unit to deliver unattended cognitive neuromodulation therapy. The system supports training of prescribers and clinical staff leading to certification

Method for mass production of high performance magnetic nanoparticles for biomedical applications

Iron nitride nanoparticles are post-processed by applying a wet ball milling method in conjunction with different surface-active media and centrifugation steps to obtain ultra-stable, monodispersed, uniformly sized, surface-functionalized, and sub-100-nm iron nitride nanoparticles suitable for biomedical applications

Functionalized filters for high efficiency bioseparation

A bioseparation device using a novel filter to facilitate collection and extraction in large volumes and at high flow rates.

AGRP-derived melanocortin receptor ligands

Identifying a selective MC4R antagonist for appetite modulation

Chimeric melanocortin receptor ligands

Melanocortin-4 receptor ligand reduces food intake in mice

Selective melanocortin receptor ligands

Potential dual-ligand approach to weight management

Lateral flow assay for respiratory viruses

CRISPR/Cas9-based point-of-care diagnosis for SARS-CoV-2

Just One Thing (JOT): custom care plans for people with cognitive challenges

A simple, customizable clinical care guide and worksheet to promote at-home therapy for people with cognitive challenges and their caregivers.

1 licensing option
Sugar-secreting green microalga

A microalgae strain that secretes simple sugars in conditions favorable for co-culture schemes and fermentation processes.

Advanced manufacturing method to fabricate removable partial denture

A series of methods and designs to quickly and accurately fabricate partial dentures from intraoral scanning without stone or printed models. The methods include harnessing the abilities of 3d printing, milling, and scanning technology to allow for the most efficient clinical and laboratory outcomes.

Cryopreservation method for millimeter scale biological samples using Cryomesh

A cryopreservation method that uses cryomesh and cryopreservation agents to preserve Drosophila embryos.

Multi-faceted glue for long-term survival of osseointegrated prosthetic devices

A multi-functional photopolymerizable glue that enhances the physical and biological adhesion between soft skin and a metal prosthetic device.

AI-enabled support tool for COVID-19 diagnosis using chest x-rays

A deep learning model for screening COVID-19 patients using chest x-rays with >98% accuracy.

Risk-free in situ non animal (RISNA) surrogate assay for African swine fever virus

A method of using a surrogate virus to confirm inactivation of African Swine Fever Virus(ASFV)

Rapid infuser purge valve

A one-way purge valve that allows for quick removal of air from IV fluid bags with a single spike.

Network Neuromodulation

A closed-loop deep brain stimulation device that exploits new mechanisms of action to control brain networks

Algorithm to improve left ventricular assist device implantation

An image processing algorithm to determine ideal, patient-specific location parameters for LVAD implantation.

Accelerating MRI data acquisition with segmented 2D pulses

A method for accelerating MRI data acquisition with segmented 2D pulses using virtual coils.

Non-Cartesian k-space reconstruction to improve acquisition efficiency

A non‐Cartesian k‐space reconstruction method using self-calibrated, region‐specific interpolation kernels for highly accelerated acquisitions in MRI.

MRI RF coil for improved field efficiency and image quality

A novel RF coil design with high dielectric constant materials to improve B1+ efficiency in MRI systems.

A hybrid machine learning-based magnetic resonance image reconstruction

A machine learning-based magnetic resonance image reconstruction algorithm that combines the benefits of both linear GRAPPA and nonlinear RAKI methods.

Urinary Catheter Stabilization Device

A urinary catheter support device that prevents penile erosion arising from the use of indwelling catheters.

Rapid microbial diagnostics

A method for rapid detection of microorganisms using chemiluminescence.

Autonomous, high accuracy classification of cancer in tissue samples

A machine learning-based algorithm for cancer detection and classification.

PhysiAware - continuous monitoring of physiological signals

An app for continuous monitoring of physiological signals from sensors worn by patients.

Quantitative relaxation mapping

Pulse sequence for MRI scanners

1 licensing option
A novel approach for bioprinting complex tissue models

A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.

Novel anti-cancer agents that target the epigenetic reader protein

Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.

HapShared - a software for pedigree reconstruction

A Python script for performing complex pedigree analysis with high sensitivity.

1 licensing option
Chaotic desynchronization of neural populations with non-pulsatile inputs

A method to identify stimulation parameters for desynchronizing a set of neurons.

Software for dual-mode ultrasound array driver and imaging platform (DMUA-DIP)

A software to drive dual-mode ultrasound arrays in imaging and therapy modes in a synchronized fashion.

Utilizing periodic irradiation to enhance sensitivity of magnetic resonance detection

A periodic irradiation method for measuring exchange-induced relaxation rate constants to characterize tissue properties using MR spectroscopy.

Central airway stent removal device

A medical device for manipulation and removal of airway stents.

Use of sulfanegen and its analogs for prevention and treatment for neurodegenerative disorders

A 3-mercaptopyruvate prodrug, sulfanegen, that reduces neuroinflammation and oxidative stress for therapeutic use in neurodegenerative diseases.

Minimally invasive diagnostic for osteosarcoma in dogs

A panel of six definitive biomarkers that can be isolated from a canine blood sample for the detection of minimal residual disease and monitoring remission in dogs treated for osteosarcoma.

A method to identify cell-free biomarkers of cancers and other diseases

A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.

Assessing tumor behavior and response to therapy

A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.

Machine learning for early cancer detection

A machine learning method to train and validate algorithms to classify cancer risk based on a blood sample.

Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction

Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.

Biodegradable elastomers for 3D printing at low temperatures

A method of using a block copolymer comprising PCL and a stretchable amorphous block such as P(βMδVL) or random P(CL-co-DLLA) for creating extruded structures with bioactive ingredients.

High throughput cryopreservation system for up to millimeter-sized samples

A method for cryopreservation of large (100-1000micron dia.) biological samples while improving cell viability.

1 licensing option
Detection of toxic small molecules using polymers and Raman scattering

A method to capture one or more analytes using polymers to enable multiplex quantitative detection by surface-enhanced Raman scattering

Community-based antibiotic screening method for polymicrobial infections (2020-090)

An improved antibiotic susceptibility test (AST) that determines minimal inhibitory concentration (MIC) with high physiological relevance for polymicrobial infections.

Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)

An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.

Device for extracting long genomic DNA from human cells

A microfluidic device for automated cell lysis and extraction of long DNA strands.

Device to Expand Soft Tissue

UEMtomaton: Software for automating image acquisition in electron microscope

Software files for automating image acquisition in TEM

1 licensing option
SARS-CoV-2 N-protein for use in COVID-19 serological assays (2020-323)

Full length SARS-CoV-2 Nucleocapsid (N) protein expressed by bacteria for use in serological assays to detect previous COVID-19 infection in humans and animals.

SARS-CoV-2 spike receptor-binding domain for use in COVID-19 assays (2020-301)

Stably transfected mammalian cell lines that express the receptor-binding domain of the SARS-CoV-2 spike protein for use in assays and research relevant to COVID-19 and potential therapies.

Multifunctional, flexible sensor array for urethral catheters (20140233)

A new urethral catheter for simultaneous measurement of pressure distribution and neural activity.

Continuous honey bee cell-line, AmE-711 (2020-240)

The first and only honey bee cell-line available for use in research and experimental testing.

Orthodontic teeth aligners enabling deeper analysis and personalized treatment plans (2020-227, Dr. Alex Fok)

A system and method for measuring stress and strain distribution of invisible orthodontic teeth aligners.

3D Spine Registration Software for Computational Thoracic Volume Modeling (20160071)

Circulating tumor biomarkers for meningiomas (2020-164)

A biomarker panel for early diagnosis of meningiomas with the potential to improve patient outcomes.

Adenovirus Vector Generating System (20110090)

Siderophore-based diagnosis of bacterial infections (20150206)

Biofeedback Hand Grip Exercise Device for Assessing Muscle Function (20170200)

A method to genetically engineer monocytes (20180236)

The first and only method available to create genetically modified CD14+ monocytes for use in research or therapy.

A streamlined method to isolate Fibroadipogenic progenitor cells from muscle (2020-195)

A method to isolate fibroadipogenic progenitor cells (FAPs) based on the presence of a single surface marker (CD73).

Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)

A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.

Antagomir to prevent cardiac arrhythmia (2019-069)

A novel small molecule screening platform for tauopathies (2019-123)

FRET-based biosensors that identify early toxic states of tau for use in basic research and clinical development of therapeutics for tauopathies including Alzheimer’s Disease.

Active Knit Compression Garment Portfolio (20170290)

A portfolio of shape memory alloy (SMA) functional active knits offers several types of wearable compression garments as well as a novel process for creating them. Technology #20170290-20180107-20180120-20180298

Opioid and Analgesic Chemical Compound Library (z09208)

E. Coli Fermentation of Glycerol from Biodiesel Waste into Ethanol

Functional Analysis of Networks in the Neural System

Infection Control System for Sterilization of Catheter Access Points with Ultraviolet (UV) Light

Iron Deficiency Mouse Model

Ultra-smooth Patterned Metal Films for Plasmonics

Ultra-smooth Patterned Metal Films for Plasmonics and Metamaterials

Artificial Cornea Made From Silica Composite

Improved Impedance Measurements for Pulmonary Edema from Pacemaker or CRT-ICD Leads

Improved Monitoring of Heart Failure Using Bioimpedance

SALSA - Automated Speech Assessment

For Quantitative Neuropsychological Cognitive Assessment

Ritonavir Analog with Anticancer Activity

MRI Contrast Software Based on RAFF-n

Ammonia Production without Molecular Hydrogen for use in Fertilizer Production

Bactericidal Lanbiotic Inhibits Gram-negative Bacteria

Biosynthesis of Biodiesel without Glycerin By-Product

Cellulosic Ethanol Production from Starch or Cellulose Derived Sugars

Reverse Plug Cytometer for Cell Tracking

Carcinoma Immunotoxin Targeting Epidermal Growth Factor and Interleukin-4 Receptors

Navigation Aid for the Visually Impaired

On-Demand Production of Peracetic Acid

Algorithm for Non-invasive Source Localization of Neural Activity

Three Dimensional Dental Anatomy Software Program for Dentistry Students

1 licensing option
MRI of Amyloid Plaque in the Brain

Microbial Biosynthesis Produces Unique Flavonoids, Chalcones and Stilbenes Used in Nutraceuticals

Biodiesel and Enriched Animal Feed from Dry Distillers Grains with Solubles Created in Ethanol Production

High Quality Digital Image Restoration Provides Faster Downloads with Less Storage and Bandwidth Requirements

3D Video from 2D Using a Single Camera System

Fabric Sleeve for Percutaneous Transluminal Device Provides Embolic Protection

Mammalian Cell Culture System for Anaplasmosis Vaccine Development

Mutated Opioid Receptors Block Chronic Pain Signals

Biological Imaging Provides Full Imaging of Samples

Cellulosic Biofuel, Chemical, and Ethanol Production

Organism Design for Cellulosic Biofuel, Cellulosic Chemical, and Cellulosic Ethanol Production

Implantable Microvalve Device for Controlled Insulin Delivery in Type 1 Diabetes Patients

Kappa Receptor Agonists and Delta Receptor Antagonists

Improved Nuclear Magnetic Resonance Spectroscopy Using Half-Spin Echo Data Recovery

Target for Acaricides and Cattle Tick Vaccines

Bifidobacteria Strain Depletes Iron-Dependent Bacteria

Nematode Biocontrol Agent

Biological Sample Imaging Device

More Stable and Potent Cyclic ADP-Ribose Analogs

Treating Neurodegenerative Diseases with Nicotine Receptor Ligands

Risk assessment for repeated hospital admission: Pra and PraPlus

1 licensing option
Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ)

The Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ) is a validated patient-oriented measure of the adverse effects of heart failure on a patient's life.

7 licensing options
3D printed deer head and neck model

A positive pressure testing booth for sample collection

Design files for a portable testing booth that facilitates safe practice of sample collection procedures on patients with infectious pathogens.

1 licensing option
A Gown for U Project - level 1 isolation gown for emergency use

Design files for a low cost, rapidly producible, one-size-fits-all level 1 isolation gown.

1 licensing option
Storage box to facilitate decontamination and reuse of face masks

A safe and well-ventilated storage box for N95 masks - design files and instruction videos.

1 licensing option
MNmask Emergency-Use Face Masks

A design package for three styles of emergency-use face masks.

1 licensing option
Minnesota Solvation (MNSOL) Database

An extensive and vetted database of free energies of solvation.

1 licensing option
Portable aerosol hood to reduce spread of pathogens during medical procedures

A portable, transparent isolation box that facilitates safe practice of medical procedures on patients with infectious pathogens.

Coventor Emergency Ventilator - Adult Manual Resuscitator Compressor

A design package for an emergency, rapid-deployment ventilator system.

1 licensing option
Sustainable triblock copolymers as strong, tunable, and degradable pressure sensitive adhesives

A method to produce strong, tunable, and degradable pressure sensitive adhesives from by-products of the cashew industry.

Machine learning algorithm for 3D particle field reconstruction

A machine learning algorithm for accurately reconstructing 3D particle fields.

Peripheral Artery Disease Quality of Life (PADQOL) Questionnaire

A validated instrument to assess the physical, psychosocial and emotional effects on patients suffering from peripheral artery disease.

4 licensing options
Living with Pulmonary Hypertension Questionnaire (LPHQ)

The Living with Pulmonary Hypertension Questionnaire (LPHQ) is a reliable and validated measure of the adverse effects of pulmonary hypertension on a patient’s life.

2 licensing options
Visualization of intracardiac electrograms on 3D heart model (VIEgram)

A software for easy visualization of intracardiac electrograms on 3D heart models.

1 licensing option
Improving photovoltaic cell efficiency by employing highly stable, earth-abundant nanoparticle system

A novel nanomaterial for applications involving photon upconversion.

Self-supervised physics-based deep learning reconstruction without fully-sampled data

Methods for training machine learning algorithms without fully-sampled reference data for inverse problems.

Mouse models of tau variants linked to neurodegenerative disease

An improved and controlled mouse model expressing human tau P301L protein, a common mutation linked to neurodegeneration.

Nanoparticle bio-pesticide to improve crop health, germination, and overall yield

A material and method of application for improving crop health and yield.

Topographically conforming self-fitting garments made of active materials

A method to design and manufacture knitted garments that dynamically conforms to complex surfaces.

Six-month mortality risk estimation from electronic medical record

Selective bromodomain protein inhibitors that reduce cancer cell viability

Small molecules systematically designed as highly selective bromodomain inhibitors for development as cancer and inflammatory disease therapeutics.

Wound closure device

Dental stem cells to treat spinal cord injury

A method of treating nervous tissue damage using dental pulp stem cells that leads to neuro-regeneration with a high safety profile and low probability of patient rejection.

3D printed bionic skull for multimodal neural sensing

Elderly Mortality After Trauma (EMAT) score

A validated scoring method for predicting mortality after trauma in elderly patients at admission.

Reduce contamination from grains and powdered food

A method for scalable, non-thermal or low temperature pasteurization of powdered or particulate food.

Machine learning-based sleep quality monitoring

Click-Chemistry Reagent for Mass Cytometry

Nesocodin: A natural red colorant that’s easily synthesized

A method to synthesize a novel, natural red colorant that is biodegradable and likely non-toxic.

Fluorescence-based assay for probing lipid transfer activity

A sensitive, reproducible and quantitative assay to study lipid transfer using bicelles as model membranes.

A synergistic therapy for multi-drug resistant cancers

A synthetic polymer that targets cancer cell membranes and works synergistically with existing chemotherapeutic drugs to treat drug-resistant solid tumors.

CoFe nanowires for remote heating using an alternating magnetic field

A nanowire material for remote, rapid and uniform heating of biological samples.

Biodegradable lactose-based hydrogel

A method to produce biodegradable lactose-based hydrogel from lactose-containing dairy waste.

3D tumor models for accurate testing of therapeutics

A method to create a 3D tumor model that accurately mimics both tumor behavior and environment for use in anti-cancer drug development.

Minnesota Nursing Informatics Leadership Inventory (MNILI)

A TLR-2 stimulatory molecule for use as a vaccine adjuvant

A small molecule that serves as an adjuvant in vaccines through stimulation of the immune receptor, TLR-2

Delivery of developmental regulators to whole plants for the induction of genetically altered meristematic tissue (Dr. Voytas)

Research out of the Voytas Lab provides a method for the creation of genetically-altered seeds within one generation via the induction of new plant meristems.

Machine Learning-based Dynamic Activity Recommendation System

A deep learning architecture for wearable devices to evaluate, predict, and improve the quality of sleep by recommending personalized activities.

Antibody based treatment for Type 1 Diabetes

A humanized monoclonal antibody against Serpin B13 to treat Type 1 Diabetes.

Immunostimulatory conjugates for targeted delivery as adjuvants

Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure

iTorsion - Smartphone App for Ocular Torsion Diagnosis

An accurate, high throughput method to measure site-specific ubiquitin abundance

Isotopically balanced quantification of ubiquitination (IBAQ-Ub): A rapid, sensitive method to measure site-specific ubiquitination abundance

Suture-free Chest Tube Stabilizing Device

Drug Delivery Device for Oral Topical Medicine

Plant Biometric Estimation Using 3D Models

3D Plant Reconstruction and Biometric Measurement

Multi-compartment Biopsy Syringe

MRI Pre-Scan Method for Imaging Metallic Devices

Durable, Water Resistant Wood-Based Energy Pellets

Novel small molecules for chemotherapy sensitization

Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.

3D printing on Moving Freeform Surfaces

CMRR - Center for Magnetic Resonance Research Software for Siemens MRI Scanners

9 licensing options
Cost Effective Preparation of Highly Stable, Reusable Whole Cell Biocatalysts

A novel method to immobilize, stabilize, and enhance the reactivity of whole cell biocatalysts.

Assay to measure intrinsic efficiency of GPCR ligands

FRET-based GPCR biosensors to measure specific ligand activation in a cell independent manner.

Patient Controlled Dynamic Therapeutic Compression Tension Garment

Efficient Ammonia Production Using Stable Absorbents

MHC Class II Molecules with Enhanced Co-receptor Affinity

High Yield Synthesis of Bio-based Acrylic Acid and Acrylate Monomers from Lactic Acid (20180106, Dr. Marc Hillmyer)

A novel dual-action drug targeting cancer and respiratory syndromes

A novel compound inhibiting translation and inducing p53 independently of DNA damage, with potential for treating both cancer and acute respiratory syndromes.

Non-invasive Neuromodulation for Reversible Modulation of Neural Activity

A method for targeted modulation of neural activity using transcranial low intensity focused ultrasound.

MyStrengths MyHealth™

2 licensing options
Automated De-Identification of Distributional Semantics Models

1 licensing option
High Ammonia Absorbing Corn Stover Hydrochar for use in Horse Bedding

Microinjection for Single Cell Gene Manipulation

Referenceless Nyquist Ghost Correction for Echo Planar Imaging (EPI)

Segmenting 3D Bone Computed Tomography Data

Directional Coordinated Reset Deep Brain Stimulation (DBS) (20180061)

Tosedostat (CHR-2797) as a Potential Analgesic

An effective media for difficult-to-culture mouse epithelial cells

A novel cell culture media formula that facilitates the expansion and cultivation of typically challenging mouse keratinocytes.

Chewing Simulator Provides Sensory Information

Real-Time Reporter and Efficient Enzymes for DNA Editing

Active Knit Compression Stockings

Versatile Biocatalyst System for Synthesizing Chemicals, Pharmaceuticals and Food Ingredients

Optimized Radio Frequency Pulses Generated From Magnetic Resonance User Defined Parameters

Physical-layer cross-technology communication via signal emulation (AllBee)

A method to enable high-throughput cross-technology communication using physical-level emulation without hardware or firmware modifications.

Scan-Specific Machine Learning Reconstruction for MRI

Augmented non-invasive hearing system

3D Printed Stretchable Tactile Sensors with Electronic Ink

Specific kinase biosensors to probe cancer metabolism

Substrate peptides for Ser/Thr kinases to investigate the metabolic processes of cancer cells.

Sliding Windowed Infinite Fourier Transform (SWIFT)

3D Microscale Isotropic Metamaterials

Compressed Sensing Coronary MRI Sequence

Enhanced Resolution Cardiac MRI

Remote-Controlled Microscale 3D Self-Assembly

An approach to identify allosteric modulators of kinases

Protein-based sensor for detecting kinase-substrate interactions suitable for screening therapeutically-relevant inhibitors.

One-Year Mortality Risk Estimates from Electronic Medical Record Data

Probes for Biosynthesis of Bacterial Cell Wall

Unique compounds to treat obesity

Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.

Denoising Magnetic Resonance Imaging Data

NOise reduction with DIstribution Corrected (NORDIC) technique for improving MRI imaging.

Bacterial Histidine Kinase Inhibitor

Faster MRI Acquistion with Motion Robustness

Tunable Neural Electrodes for MRI-Compatible Brain Signal Recordings

A discrete and effective wearable breast pump for nursing mothers

A quiet and concealed wearable breast pump that mimics infant suckling using mechanical compression and heat; increasing milk expression as well as convenience and comfort.

Universal tyrosine kinase substrates

Non-selective, universal substrates for tyrosine kinases that couple with a fluorescent readout mechanism to serve as quantity and quality control (internally and/or between samples). 

Myocardial Viability Functional Assessment

Dynamic Quantification of Myocardial Tissue MRI

Orthopedic Meniscus Repair Implant, Introducer and Delivery System

Remedy for Heart Failure with Preserved Ejection Fraction

Large 3D Printed Skull Window for Neuroscience Research

Conformable Dual-mode Ultrasound Transducers for Neuromodulation

Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC

Single Voxel MR Spectroscopy of Human Brain with Automatic Voxel Positioning

1 licensing option
Solar UV-Induced Skin Cancer Inhibitor

Magnetization Transfer Contrast Preparation

Particle Swarm Optimization for Programming Neuromodulation Systems

Multi-modal Neuromodulation Therapy Promotes Sleep

Image-Based Fiber Orientation and Alignment Calculator

3 licensing options
Scaffolds for Cancer Cell Ablation

Pediatric Tracheo-bronchomalacia Stent and Deployment System

Mimicked Calcified Annulus Model for Preclinical Assessment of TAVR Devices

1 licensing option
Motion-Robust Cardiac B1+ Mapping of the Transmit Field

Imaging Source Distribution from Electromagnetic Signals

Predicting Crop Yield and Quality Using Canopy Reflectance and LiDAR Sensors

Clinical Quality MRI Image under Inhomogeneous Magnetic Field

CG-TARGET Interpretation of Chemical-Genetic Interaction Profiles

4 licensing options
BEAN-Counter Quantitative Scoring of Chemical-Genetic Interactions

4 licensing options
Bio-based Elastomers from Recoverable Methyl Valerolactone (20160418, Dr. Marc Hillmyer)

Adaptive Immune Response Stimulated with TLR8 and Dual TLR7/TLR8 Agonists