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Advanced manufacturing method to fabricate removable partial denture

A series of methods and designs to quickly and accurately fabricate partial dentures from intraoral scanning without stone or printed models. The methods include harnessing the abilities of 3d printing, milling, and scanning technology to allow for the most efficient clinical and laboratory outcomes.

Cryopreservation method for millimeter scale biological samples using Cryomesh

A cryopreservation method that uses cryomesh and cryopreservation agents to preserve Drosophila embryos.

Multi-faceted glue for long-term survival of osseointegrated prosthetic devices

A multi-functional photopolymerizable glue that enhances the physical and biological adhesion between soft skin and a metal prosthetic device.

AI-enabled support tool for COVID-19 diagnosis using chest x-rays

A deep learning model for screening COVID-19 patients using chest x-rays with >98% accuracy.

Network curvature as a hallmark of brain structural connectivity

A novel method to quantify robustness for brain networks against damage caused by lesions, traumatic brain injury, or aging.

Risk-free in situ non animal (RISNA) surrogate assay for African swine fever virus

A method of using a surrogate virus to confirm inactivation of African Swine Fever Virus(ASFV)

Rapid infuser purge valve

A one-way purge valve that allows for quick removal of air from IV fluid bags with a single spike.

Network Neuromodulation

A closed-loop deep brain stimulation device that exploits new mechanisms of action to control brain networks

Algorithm to improve left ventricular assist device implantation

An image processing algorithm to determine ideal, patient-specific location parameters for LVAD implantation.

3D printed microfluidic devices

An extrusion-based 3D-printing method to create enclosed microfluidic channels on freeform surfaces.

Semi-solid polymer drug delivery system

A polymer-based material that is semi-solid material at room and physiological temperatures enabling easy formulation of drugs (e.g. by simple mixing) and delivery (e.g. topical cream).

Accelerating MRI data acquisition with segmented 2D pulses

A method for accelerating MRI data acquisition with segmented 2D pulses using virtual coils.

Non-Cartesian k-space reconstruction to improve acquisition efficiency

A non‐Cartesian k‐space reconstruction method using self-calibrated, region‐specific interpolation kernels for highly accelerated acquisitions in MRI.

MRI RF coil for improved field efficiency and image quality

A novel RF coil design with high dielectric constant materials to improve B1+ efficiency in MRI systems.

A hybrid machine learning-based magnetic resonance image reconstruction

A machine learning-based magnetic resonance image reconstruction algorithm that combines the benefits of both linear GRAPPA and nonlinear RAKI methods.

Assay for detecting misfolded proteins

A simple, onsite diagnostic assay for detecting misfolded proteins using nanoparticles.

Urinary Catheter Stabilization Device

A urinary catheter support device that prevents penile erosion arising from the use of indwelling catheters.

Rapid microbial diagnostics

A method for rapid detection of microorganisms using chemiluminescence.

Autonomous, high accuracy classification of cancer in tissue samples

A machine learning-based algorithm for cancer detection and classification.

PhysiAware - continuous monitoring of physiological signals

An app for continuous monitoring of physiological signals from sensors worn by patients.

Quantitative relaxation mapping

Pulse sequence for MRI scanners

1 licensing option
A novel approach for bioprinting complex tissue models

A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.

Novel anti-cancer agents that target the epigenetic reader protein

Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.

HapShared - a software for pedigree reconstruction

A Python script for performing complex pedigree analysis with high sensitivity.

1 licensing option
Chaotic desynchronization of neural populations with non-pulsatile inputs

A method to identify stimulation parameters for desynchronizing a set of neurons.

Software for dual-mode ultrasound array driver and imaging platform (DMUA-DIP)

A software to drive dual-mode ultrasound arrays in imaging and therapy modes in a synchronized fashion.

Utilizing periodic irradiation to enhance sensitivity of magnetic resonance detection

A periodic irradiation method for measuring exchange-induced relaxation rate constants to characterize tissue properties using MR spectroscopy.

Central airway stent removal device

A medical device for manipulation and removal of airway stents.

Use of sulfanegen and its analogs for prevention and treatment for neurodegenerative disorders

A 3-mercaptopyruvate prodrug, sulfanegen, that reduces neuroinflammation and oxidative stress for therapeutic use in neurodegenerative diseases.

Minimally invasive diagnostic for osteosarcoma in dogs

A panel of six definitive biomarkers that can be isolated from a canine blood sample for the detection of minimal residual disease and monitoring remission in dogs treated for osteosarcoma.

A method to identify cell-free biomarkers of cancers and other diseases

A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.

Assessing tumor behavior and response to therapy

A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.

Machine learning for early cancer detection

A machine learning method to train and validate algorithms to classify cancer risk based on a blood sample.

Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction

Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.

Biodegradable elastomers for 3D printing at low temperatures

A method of using a block copolymer comprising PCL and a stretchable amorphous block such as P(βMδVL) or random P(CL-co-DLLA) for creating extruded structures with bioactive ingredients.

High throughput cryopreservation system for up to millimeter-sized samples

A method for cryopreservation of large (100-1000micron dia.) biological samples while improving cell viability.

1 licensing option
Community-based antibiotic screening method for polymicrobial infections (2020-090)

An improved antibiotic susceptibility test (AST) that determines minimal inhibitory concentration (MIC) with high physiological relevance for polymicrobial infections.

Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)

An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.

Device for extracting long genomic DNA from human cells

A microfluidic device for automated cell lysis and extraction of long DNA strands.

Device to Expand Soft Tissue

UEMtomaton: Software for automating image acquisition in electron microscope

SARS-CoV-2 N-protein for use in COVID-19 serological assays (2020-323)

Full length SARS-CoV-2 Nucleocapsid (N) protein expressed by bacteria for use in serological assays to detect previous COVID-19 infection in humans and animals.

SARS-CoV-2 spike receptor-binding domain for use in COVID-19 assays (2020-301)

Stably transfected mammalian cell lines that express the receptor-binding domain of the SARS-CoV-2 spike protein for use in assays and research relevant to COVID-19 and potential therapies.

Multifunctional, flexible sensor array for urethral catheters (20140233)

A new urethral catheter for simultaneous measurement of pressure distribution and neural activity.

Continuous honey bee cell-line, AmE-711 (2020-240)

The first and only honey bee cell-line available for use in research and experimental testing.

Wearable laryngeal vibration system for Spasmodic Dysphonia (20170400)

A non-invasive neuromodulation device and method for the treatment of spasmodic dysphonia.

Orthodontic teeth aligners enabling deeper analysis and personalized treatment plans (2020-227, Dr. Alex Fok)

A system and method for measuring stress and strain distribution of invisible orthodontic teeth aligners.

Pharmacological agents to prevent recurrent C. diff infection (20150362)

Cholic and bile acid derivatives that inhibit Clostridium difficile spore germination to prevent or treat C. diff infection.

3D Spine Registration Software for Computational Thoracic Volume Modeling (20160071)

Circulating tumor biomarkers for meningiomas (2020-164)

A biomarker panel for early diagnosis of meningiomas with the potential to improve patient outcomes.

Adenovirus Vector Generating System (20110090)

Siderophore-based diagnosis of bacterial infections (20150206)

Deep Brain Stimulators (DBS) to Treat Glioblastoma (20180080)

A device and method for treating tumors using optimized electromagnetic signals.

Biofeedback Hand Grip Exercise Device for Assessing Muscle Function (20170200)

A method to genetically engineer monocytes (20180236)

The first and only method available to create genetically modified CD14+ monocytes for use in research or therapy.

A streamlined method to isolate Fibroadipogenic progenitor cells from muscle (2020-195)

A method to isolate fibroadipogenic progenitor cells (FAPs) based on the presence of a single surface marker (CD73).

Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)

A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.

Antagomir to prevent cardiac arrhythmia (2019-069)

A novel small molecule screening platform for tauopathies (2019-123)

FRET-based biosensors that identify early toxic states of tau for use in basic research and clinical development of therapeutics for tauopathies including Alzheimer’s Disease.

Acceleration of heterogeneous catalysis through dynamic resonance (2019-226)

A method to dynamically vary binding rates to drastically increase rate of chemical reactions involving heterogeneous catalysts.

Active Knit Compression Garment Portfolio (20170290)

A portfolio of shape memory alloy (SMA) functional active knits offers several types of wearable compression garments as well as a novel process for creating them. Technology #20170290-20180107-20180120-20180298

Opioid and Analgesic Chemical Compound Library (z09208)

E. Coli Fermentation of Glycerol from Biodiesel Waste into Ethanol

Dental Implant Bone Cement for Stabilizing Dental Implants and Bone Osseointegration

Calcium Based Dental Bone Cement for Dental Implant Osseointegration

Functional Analysis of Networks in the Neural System

Infection Control System for Sterilization of Catheter Access Points with Ultraviolet (UV) Light

Geothermal Power Generation from Carbon Dioxide Sequestration Uses Renewable Resources

Geothermal Power Generation: Clean Energy from Carbon Dioxide Sequestration

Iron Deficiency Mouse Model

Ultra-smooth Patterned Metal Films for Plasmonics

Ultra-smooth Patterned Metal Films for Plasmonics and Metamaterials

Artificial Cornea Made From Silica Composite

Improved Impedance Measurements for Pulmonary Edema from Pacemaker or CRT-ICD Leads

Improved Monitoring of Heart Failure Using Bioimpedance

SALSA - Automated Speech Assessment

For Quantitative Neuropsychological Cognitive Assessment

Transposon Induction of Glioma Brain Tumors and Cancer Stem

The Savvy Caregiver™ Program for Alzheimer Caregiver Training

Ritonavir Analog with Anticancer Activity

MRI Contrast Software Based on RAFF-n

Ammonia Production without Molecular Hydrogen for use in Fertilizer Production

Bactericidal Lanbiotic Inhibits Gram-negative Bacteria

Syncope Warnings with Minimally Invasive Medical Device for Monitoring Blood Flow

Monitoring Blood Flow and Predicting Syncope with Minimally Invasive Medical Device

Biosynthesis of Biodiesel without Glycerin By-Product

Cellulosic Ethanol Production from Starch or Cellulose Derived Sugars

Reverse Plug Cytometer for Cell Tracking

Carcinoma Immunotoxin Targeting Epidermal Growth Factor and Interleukin-4 Receptors

Syngas Production Using a Biomass Gasification Process

Cardiac Test Provides Three Dimensional Model of the Heart and Locates Heart Problems

Lupus Treatments Possible with Identification of High Risk Haplotype

Drug Resistant Tuberculosis Treatment

Navigation Aid for the Visually Impaired

On-Demand Production of Peracetic Acid

Early Pulmonary Edema and Atrial Fibrillation Detection Using Implantable Devices

Algorithm for Non-invasive Source Localization of Neural Activity

Complementary Therapies and Alternative Medicine Online Learning Modules

Three Dimensional Dental Anatomy Software Program for Dentistry Students

1 licensing option
MRI of Amyloid Plaque in the Brain

Pulmonary Edema Measurement Provides Alert to Worsening Heart Failure

Microbial Biosynthesis Produces Unique Flavonoids, Chalcones and Stilbenes Used in Nutraceuticals

Biodiesel and Enriched Animal Feed from Dry Distillers Grains with Solubles Created in Ethanol Production

High Quality Digital Image Restoration Provides Faster Downloads with Less Storage and Bandwidth Requirements

3D Video from 2D Using a Single Camera System

Fabric Sleeve for Percutaneous Transluminal Device Provides Embolic Protection

Mammalian Cell Culture System for Anaplasmosis Vaccine Development

PEGylated Fibrin Biomatrix for Treatment of Acute Myocardial Infarction

Mutated Opioid Receptors Block Chronic Pain Signals

Nonlinear Post Beamforming Filter for Imaging

Reelin Protein Diagnostic Test for Mental Disorders

Biological Imaging Provides Full Imaging of Samples

Biological Imaging and Analyzing DNA Chips

Cellulosic Biofuel, Chemical, and Ethanol Production

Organism Design for Cellulosic Biofuel, Cellulosic Chemical, and Cellulosic Ethanol Production

Implantable Microvalve Device for Controlled Insulin Delivery in Type 1 Diabetes Patients

Targeting uPAR Overexpression on Human Glioblastoma

Ecdysteroid Biosynthetic Enzyme Inhibitors

Human Brain Anatomy Software for Interactive Neuroanatomy Study

Biological Imaging using a CMOS or CCD Image Sensor

Direct Application of Antibiotics to Middle Ear for Ear Infection Treatment

Kappa Receptor Agonists and Delta Receptor Antagonists

Histology Software Atlas for Anatomy and Cell Biology Study

Computer-based Histology Atlas for Human Anatomy and Cell Study

Catheter for Cell Delivery in Tissue

Inhibition of Zebrafish Gene Expression

Turkey Production Improvements

Improved Nuclear Magnetic Resonance Spectroscopy Using Half-Spin Echo Data Recovery

Target for Acaricides and Cattle Tick Vaccines

Genetic Modification of Endostatin: An Anti-Angiogenic Therapeutic

Bifidobacteria Strain Depletes Iron-Dependent Bacteria

MRI Compatible Surgical Table

Nematode Biocontrol Agent

Multimeric Immunotoxins for Cancer Treatment and Graft vs Host Disease

Nutrition Data System for Research – Nutritional Analysis Software

Food and Nutrient Database for Application Development and Nutrition Research

Biological Sample Imaging Device

More Stable and Potent Cyclic ADP-Ribose Analogs

Virtual Dental Simulation Software for Dental Assessment

Treating Neurodegenerative Diseases with Nicotine Receptor Ligands

Infusion Micropump for Drug Delivery for Treatment of Neurological Disorders and Pain Management

Medical Probe Deflection Device

Needle Placement System Provides Details for Tissue Model

Modified Sleeping Beauty Transposon Gene Transfer System

Intracranial Endoscopy System Fiber-Optic Biopsy Needle Minimizes Hemorrhaging Risk

Cell Cryopreservation for Lymphocytes Improves Hematopietic Cell Survival

Assessing the Risk of Repeated Hospital Admission for Elderly Patients (97145)

Vertebrates: Sleeping Beauty Transposon for Efficient DNA Delivery into Wide Array of Cells

Continuous-Text Reading Chart for Eye Examinations Measures Reading Acuity and Speed

Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ)

The Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ) is a validated patient-oriented measure of the adverse effects of heart failure on a patient's life.

7 licensing options
3D printable deer head and neck model

1 licensing option
A positive pressure testing booth for sample collection

Design files for a portable testing booth that facilitates safe practice of sample collection procedures on patients with infectious pathogens.

1 licensing option
A Gown for U Project - level 1 isolation gown for emergency use

Design files for a low cost, rapidly producible, one-size-fits-all level 1 isolation gown.

1 licensing option
Storage box to facilitate decontamination and reuse of face masks

A safe and well-ventilated storage box for N95 masks - design files and instruction videos.

1 licensing option
MNmask Emergency-Use Face Masks

A design package for three styles of emergency-use face masks.

1 licensing option
Minnesota Solvation (MNSOL) Database

An extensive and vetted database of free energies of solvation.

1 licensing option
Portable aerosol hood to reduce spread of pathogens during medical procedures

A portable, transparent isolation box that facilitates safe practice of medical procedures on patients with infectious pathogens.

Coventor Emergency Ventilator - Adult Manual Resuscitator Compressor

A design package for an emergency, rapid-deployment ventilator system.

1 licensing option
S100A4 inhibitor “Minnetamide” for prostate cancer treatment

Sustainable triblock copolymers as strong, tunable, and degradable pressure sensitive adhesives

A method to produce strong, tunable, and degradable pressure sensitive adhesives from by-products of the cashew industry.

Machine learning algorithm for 3D particle field reconstruction

A machine learning algorithm for accurately reconstructing 3D particle fields.

Peripheral Artery Disease Quality of Life (PADQOL) Questionnaire

A validated instrument to assess the physical, psychosocial and emotional effects on patients suffering from peripheral artery disease.

3 licensing options
Living with Pulmonary Hypertension Questionnaire (LPHQ)

The Living with Pulmonary Hypertension Questionnaire (LPHQ) is a reliable and validated measure of the adverse effects of pulmonary hypertension on a patient’s life.

2 licensing options
Visualization of intracardiac electrograms on 3D heart model (VIEgram)

A software for easy visualization of intracardiac electrograms on 3D heart models.

1 licensing option
Improving photovoltaic cell efficiency by employing highly stable, earth-abundant nanoparticle system

A novel nanomaterial for applications involving photon upconversion.

Self-supervised physics-based deep learning reconstruction without fully-sampled data

Methods for training machine learning algorithms without fully-sampled reference data for inverse problems.

Mouse models of tau variants linked to neurodegenerative disease

An improved and controlled mouse model expressing human tau P301L protein, a common mutation linked to neurodegeneration.

Nanoparticle bio-pesticide to improve crop health, germination, and overall yield

A material and method of application for improving crop health and yield.

Novel process to obtain large quantities of primary cells for transplantation

A method to isolate large quantities of high quality primary cells for therapeutic transplantation through freezing and thawing organs, including organs typically considered suboptimal for donation.

Topographically conforming self-fitting garments made of active materials

A method to design and manufacture knitted garments that dynamically conforms to complex surfaces.

Nanosota-1: A series of nanobody drugs to combat COVID-19

A series of camelid nanobodies that bind to SARS-CoV-2 (COVID-19) spike protein to block infection of human cells.

Six-month mortality risk estimation from electronic medical record

Selective bromodomain protein inhibitors that reduce cancer cell viability

Small molecules systematically designed as highly selective bromodomain inhibitors for development as cancer and inflammatory disease therapeutics.

Wound closure device

Dental stem cells to treat spinal cord injury

A method of treating nervous tissue damage using dental pulp stem cells that leads to neuro-regeneration with a high safety profile and low probability of patient rejection.

3D printed bionic skull for multimodal neural sensing

Elderly Mortality After Trauma (EMAT) score

A validated scoring method for predicting mortality after trauma in elderly patients at admission.

Reduce contamination from grains and powdered food

A method for scalable, non-thermal or low temperature pasteurization of powdered or particulate food.

Machine learning-based sleep quality monitoring

Click-Chemistry Reagent for Mass Cytometry

A Single Device for Vaginal Dilation and Flushing

Nesocodin: A natural red colorant that’s easily synthesized

A method to synthesize a novel, natural red colorant that is biodegradable and likely non-toxic.

Fluorescence-based assay for probing lipid transfer activity

A sensitive, reproducible and quantitative assay to study lipid transfer using bicelles as model membranes.

A synergistic therapy for multi-drug resistant cancers

A synthetic polymer that targets cancer cell membranes and works synergistically with existing chemotherapeutic drugs to treat drug-resistant solid tumors.

Novel anticancer compound that targets metabolic plasticity

F-MN-D1 compound targets metabolic plasticity common to many solid tumors through inhibition of glycolysis and oxidative phosphorylation facilitating tumor growth reduction.

CoFe nanowires for remote heating using an alternating magnetic field

A nanowire material for remote, rapid and uniform heating of biological samples.

Biodegradable lactose-based hydrogel

A method to produce biodegradable lactose-based hydrogel from lactose-containing dairy waste.

3D tumor models for accurate testing of therapeutics

A method to create a 3D tumor model that accurately mimics both tumor behavior and environment for use in anti-cancer drug development.

Minnesota Nursing Informatics Leadership Inventory (MNILI)

A TLR-2 stimulatory molecule for use as a vaccine adjuvant

A small molecule that serves as an adjuvant in vaccines through stimulation of the immune receptor, TLR-2

Delivery of developmental regulators to whole plants for the induction of genetically altered meristematic tissue (Dr. Voytas)

Research out of the Voytas Lab provides a method for the creation of genetically-altered seeds within one generation via the induction of new plant meristems.

Machine Learning-based Dynamic Activity Recommendation System

A deep learning architecture for wearable devices to evaluate, predict, and improve the quality of sleep by recommending personalized activities.

Unique small molecule modulators of GPCRs

Novel small molecules that bind and modulate G-protein coupled receptors (specifically Sigma 1 and 5-HT7) for therapeutic development.

Point-of-care Concussion Therapy

Antibody based treatment for Type 1 Diabetes

A humanized monoclonal antibody against Serpin B13 to treat Type 1 Diabetes.

Immunostimulatory conjugates for targeted delivery as adjuvants

Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure

iTorsion - Smartphone App for Ocular Torsion Diagnosis

An accurate, high throughput method to measure site-specific ubiquitin abundance

Isotopically balanced quantification of ubiquitination (IBAQ-Ub): A rapid, sensitive method to measure site-specific ubiquitination abundance

Cancer preventative for at risk individuals

An approach to prevent cancers through blocking the transcription factor STAT3 that leads to an 80% tumor reduction in a mouse model of disease.

Enhanced Brain Structural Connectivity Mapping

Suture-free Chest Tube Stabilizing Device

Drug Delivery Device for Oral Topical Medicine

Plant Biometric Estimation Using 3D Models

3D Plant Reconstruction and Biometric Measurement

Trotter or Pacer? Accurate Method to Detect Preferred Gait in Standardbred Horses

A genetic testing method to accurately (>99%) predict gait profile of Standardbred horses around the globe.

Bioink composition suitable for creating cardiac tissues

A material composition suitable for 3D printing of biological structures containing stem cells.

Multi-compartment Biopsy Syringe

MRI Pre-Scan Method for Imaging Metallic Devices

Durable, Water Resistant Wood-Based Energy Pellets

Select Optimal Therapeutic Parameters for Medical Stimulation Devices

Novel small molecules for chemotherapy sensitization

Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.

3D printing on Moving Freeform Surfaces

Quality Control Test for Pathogenic Bacteria Contaminated Water

New Prodrugs for Preventing and Treating Alzheimer's Disease

CMRR - Center for Magnetic Resonance Research Software for Siemens MRI Scanners

9 licensing options
Cost Effective Preparation of Highly Stable, Reusable Whole Cell Biocatalysts

A novel method to immobilize, stabilize, and enhance the reactivity of whole cell biocatalysts.

Assay to measure intrinsic efficiency of GPCR ligands

FRET-based GPCR biosensors to measure specific ligand activation in a cell independent manner.

Patient Controlled Dynamic Therapeutic Compression Tension Garment

Improving Biodiesel Production Efficiency via Methyl Ester Recovery

Efficient Ammonia Production Using Stable Absorbents

MHC Class II Molecules with Enhanced Co-receptor Affinity

High Yield Synthesis of Bio-based Acrylic Acid and Acrylate Monomers from Lactic Acid (20180106, Dr. Marc Hillmyer)

A novel chemotherapy drug with reduced patient side-effects

A novel anti-cancer compound that inhibits translation and induces p53 in a DNA-damage independent manner to cause cell cycle arrest and apoptosis.

Non-invasive Neuromodulation for Reversible Modulation of Neural Activity

A method for targeted modulation of neural activity using transcranial low intensity focused ultrasound.

MyStrengths MyHealth™

2 licensing options
Automated De-Identification of Distributional Semantics Models

1 licensing option
High Ammonia Absorbing Corn Stover Hydrochar for use in Horse Bedding

Microinjection for Single Cell Gene Manipulation

Referenceless Nyquist Ghost Correction for Echo Planar Imaging (EPI)

Segmenting 3D Bone Computed Tomography Data

Directional Coordinated Reset Deep Brain Stimulation (DBS) (20180061)

Tosedostat (CHR-2797) as a Potential Analgesic

An effective media for difficult-to-culture mouse epithelial cells

A novel cell culture media formula that facilitates the expansion and cultivation of typically challenging mouse keratinocytes.

Engineering Human CD64 Chimeric Receptors for Immune Therapy

Integrated Traumatic Brain Injury Catheter (iTBI)

Localization of Cardiac Arrhythmia Origins from ECG

Chewing Simulator Provides Sensory Information

Real-Time Reporter and Efficient Enzymes for DNA Editing

Active Knit Compression Stockings

Versatile Biocatalyst System for Synthesizing Chemicals, Pharmaceuticals and Food Ingredients

Optimized Radio Frequency Pulses Generated From Magnetic Resonance User Defined Parameters

Physical-layer cross-technology communication via signal emulation (AllBee)

A method to enable high-throughput cross-technology communication using physical-level emulation without hardware or firmware modifications.

Scan-Specific Machine Learning Reconstruction for MRI

Augmented non-invasive hearing system

3D Printed Stretchable Tactile Sensors with Electronic Ink

Specific kinase biosensors to probe cancer metabolism

Substrate peptides for Ser/Thr kinases to investigate the metabolic processes of cancer cells.

Sliding Windowed Infinite Fourier Transform (SWIFT)

MRI and Spectroscopy Multi-part Body Coil

3D Microscale Isotropic Metamaterials

Compressed Sensing Coronary MRI Sequence

Enhanced Resolution Cardiac MRI

Remote-Controlled Microscale 3D Self-Assembly

An approach to identify allosteric modulators of kinases

Protein-based sensor for detecting kinase-substrate interactions suitable for screening therapeutically-relevant inhibitors.

Biased Unmatched Bivalent LigandsTargeting Asymmetrically Signaling GPCR Homodimers

One-Year Mortality Risk Estimates from Electronic Medical Record Data

Probes for Biosynthesis of Bacterial Cell Wall

Unique compounds to treat obesity

Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.

Denoising Magnetic Resonance Imaging Data

NOise reduction with DIstribution Corrected (NORDIC) technique for improving MRI imaging.

Bacterial Histidine Kinase Inhibitor

Faster MRI Acquistion with Motion Robustness

Tau-targeting Peptides Treat Neurodegenerative Diseases

Gender Affirmative Lifespan Approach (GALA)

1 licensing option
Tunable Neural Electrodes for MRI-Compatible Brain Signal Recordings

A discrete and effective wearable breast pump for nursing mothers

A quiet and concealed wearable breast pump that mimics infant suckling using mechanical compression and heat; increasing milk expression as well as convenience and comfort.

Universal tyrosine kinase substrates

Non-selective, universal substrates for tyrosine kinases that couple with a fluorescent readout mechanism to serve as quantity and quality control (internally and/or between samples). 

Biomass Absorbs Phosphates and Phosphate-Containing Herbicide (Organophosphates)

Myocardial Viability Functional Assessment

Dynamic Quantification of Myocardial Tissue MRI

Skin Care Formulations for Preventing and Treating Skin Cancer

Orthopedic Meniscus Repair Implant, Introducer and Delivery System

Remedy for Heart Failure with Preserved Ejection Fraction

Large 3D Printed Skull Window for Neuroscience Research

Conformable Dual-mode Ultrasound Transducers for Neuromodulation

Microstructure Imaging of Crossing White Matter Fibers from Diffusion MRI

Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC

Single Voxel MR Spectroscopy of Human Brain with Automatic Voxel Positioning

Solar UV-Induced Skin Cancer Inhibitor

Magnetization Transfer Contrast Preparation

Particle Swarm Optimization for Programming Neuromodulation Systems

Multi-modal Neuromodulation Therapy Promotes Sleep

Image-Based Fiber Orientation and Alignment Calculator

3 licensing options
Scaffolds for Cancer Cell Ablation

Pediatric Tracheo-bronchomalacia Stent and Deployment System

Fluorescence-based Detection of Kinase Allostery for High-throughput Allosteric Inhibitor Discovery

Mimicked Calcified Annulus Model for Preclinical Assessment of TAVR Devices

1 licensing option
Motion-Robust Cardiac B1+ Mapping of the Transmit Field

Imaging Source Distribution from Electromagnetic Signals

High-voltage, Fully-integrated, High-density Microstimulator with Charge Balancing

Predicting Crop Yield and Quality Using Canopy Reflectance and LiDAR Sensors

Clinical Quality MRI Image under Inhomogeneous Magnetic Field

CG-TARGET Interpretation of Chemical-Genetic Interaction Profiles

4 licensing options
BEAN-Counter Quantitative Scoring of Chemical-Genetic Interactions

4 licensing options
Simultaneous RF Signal Transmission and Reception in MRI (20160420)

Bio-based Elastomers from Recoverable Methyl Valerolactone (20160418, Dr. Marc Hillmyer)

Neural Recording under Electrical Microstimulation

Adaptive Immune Response Stimulated with TLR8 and Dual TLR7/TLR8 Agonists

Compliant Aortic Stent Graft

Black-Blood T1 Myocardial Mapping to Remove Partial Voluming Effects

Kinase assay to aid in development of therapeutics for acute myeloid leukemia

Peptide substrates to sensitively and specifically measure the real-time activity of FLT3, a kinase linked to acute myeloid leukemia.

PDAC Treatment with High Antiproliferative Activity Against MiaPaca-2

Lung Biopsy Tool

Treating Tumors with High Intensity Focused Ultrasound

Novel inhibitors of HINT1 to treat neuropathic pain and addiction

Small-molecule inhibitors of hHint1 (and their synthesis) for use in basic CNS research and treatment of neuropathic pain and addiction.

3D Shoulder Motion Measurement System

Optimizing Gene Editing in NK Cells for Therapy and Research

Ultrasound-based Hearing Aid

Biosynthetic Route to Serofendic Acid

ThermoDome Thermodilution Cardiac Output Catheter