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Inhibitory nucleic acid molecules targeting cyclin D1 mRNA

Inhibition of non-canonical functions of cyclin D1 as a potential therapy for liver diseases.

Mouse model for studying SARS-CoV-2

A gene replacement mouse model incorporating human ACE2 and TMPRSS2 genes for authentic SARS-CoV-2 replication and virus entry studies.

Broadspectrum potentially therapeutic nanobodies against COVID-19

A class of nanobodies (Nanosota-2, -3, and -4) offering broadspectrum therapeutic potential against COVID-19.

Soluble, active DNA cytosine deaminase for use as a research tool

A method to produce soluble DNA cytosine deaminase for assays of potential inhibitors of HIV-1 and as a tool for biotech applications

Nanorings for cell-mediated drug delivery

Farnesylated chemically self-assembled nanorings that facilitate targeted drug delivery between cells.

Artificial gut/absorption simulator for evaluation of drug formulations dissolution

A device and method for simulating a digestive gut to evaluate drug delivery that incorporates simultaneous absorption with dissolution

Efficient CRISPR-based gene editing for stem cells

A CRISPR-based gene editing protocol for induced pluripotent stem cells (iPSCs) with improved editing efficiency and cell survival.

Dual frequency RF coil for magnetic resonance imaging

A novel RF resonant coil that can operate at both X-nuclear and proton frequencies.

Single-cell Integration and DrUg Response PrediCtion (scIDUC)

A computational pipeline that predicts drug response scores for individual cells using single-cell RNA sequencing data.

2 licensing options
Pharmacological enhancement of CD8 T cell effector function using TEPP46

A clinically viable strategy for preventing mitochondria-mediated T cell exhaustion and enhancing effector T cell function.

First-in-class drug lead candidate (A229) for treating ocular diseases

PPARα agonist, A229, exhibits strong potency and demonstrates efficacy in in-vitro models of diabetic retinopathy.

Bacterial histidine kinase inhibitors for treating Staphylococcus infections

Small molecule bacterial histidine kinase inhibitors that significantly diminish staphylococcal virulence.

Small molecule inhibitors for treating alcoholic hepatitis

Bromodomain inhibitor, UMN627, reduces inflammation in mice models of alcoholic hepatitis.

T Cell Receptor Exchange (TRex) Mice

A mouse model for studying physiological antigen-specific T cell behavior.

Bisubstrate inhibitors for treating SARS-CoV-2 infections

Bisubstrate inhibitors that target the active site of SARS-CoV-2 Nsp14 methyltransferase (MTase) for treating SARS-CoV-2 infections.

Novel compounds for treatment of neurodegenerative disease and chronic pain

Novel alpha2-adrenergic agonists with neuroprotective and/or analgesic properties.

First-generation degraders for class I bromodomain-containing proteins

A bromodomain-targeting degrader of CECR2, an epigenetic regulator that drives cancer metastasis.

NOD-2-active carboxamide compounds as vaccine adjuvants

Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.

Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines

A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.

High-throughput screening assay for sickle cell disease drug discovery

A high-throughput screening assay for discovering small molecules that directly inhibit sickle hemoglobin oligomerization.

Conditional DUXC knockout mouse model

A conditional DUXC knockout mouse model for use as a basic research tool.

Direct elution caps for reducing autosampler cross-vial contamination

A screw cap that interfaces a pipette tip and autosampler vial, creating a sturdy connection and an elevated pipette tip position within the vial.

Fast 3-dimensional reciprocal space imaging with laboratory X-ray diffraction: RSLab

A software that adds fast 3D reciprocal space imaging capabilities to laboratory X-ray diffractometers with 2D detectors.

1 licensing option
Mouse-derived FSHD muscle cell lines

Primary skeletal muscle cell lines isolated from DUX4 expressing FSHD mice.

Generating teratoma-derived skeletal muscle stem cells

A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.

Rapid non-invasive portable system for monitoring deterioration of plastics

A system comprising a portable device and image processing software for superficial non-destructive determination of plastic deterioration

Steerable magneto-photonic particles for targeted delivery and collection of light

An embeddable magneto-photonic microparticle that can be externally positioned and orientated for targeted delivery and collection of light.

Small molecules promoting differentiation/maturation of stem cell-derived myogenic cells

A combinatorial small molecule treatment that promotes differentiation and maturation of myotubes derived from pluripotent stem cells.

Minnesota Assessment of Pharmacogenomic Literacy (MAPL™)

A questionnaire to assess pharmacogenomic knowledge among patients in research studies or clinical care.

2 licensing options
Human Myotonic Dystrophy Induced Pluripotent Stem Cell Lines

HUH fusion enzymes for multiplex protein labeling

HUH fusion tags are novel, robust endonucleases that allow proteins and DNA to be linked covalently in one simple step

Camelid single domain antibody phage display library

Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target

Targeted Artificial DNA Replisome (TADR) a Tool for Targeted Mutagenesis

TADR is a protein-complex designed to target and mutate specific genes on plasmid in vivo

Immortalized clonal human myoblast line "M007"

Immortalized human myoblast cell line obtained from a healthy individual

Immortalized clonal human fibroblast line "F007"

Immortalized human fibroblast cell line obtained from a healthy individual

Cryopreservation method for millimeter scale biological samples using Cryomesh

A cryopreservation method that uses cryomesh and cryopreservation agents to preserve Drosophila embryos.

Risk-free in situ non animal (RISNA) surrogate assay for African swine fever virus

A method of using a surrogate virus to confirm inactivation of African Swine Fever Virus(ASFV)

A novel approach for bioprinting complex tissue models

A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.

Novel anti-cancer agents that target the epigenetic reader protein

Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.

HapShared - a software for pedigree reconstruction

A Python script for performing complex pedigree analysis with high sensitivity.

1 licensing option
A method to identify cell-free biomarkers of cancers and other diseases

A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.

Community-based antibiotic screening method for polymicrobial infections (2020-090)

An improved antibiotic susceptibility test (AST) that determines minimal inhibitory concentration (MIC) with high physiological relevance for polymicrobial infections.

Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)

An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.

Device for extracting long genomic DNA from human cells

A microfluidic device for automated cell lysis and extraction of long DNA strands.

UEMtomaton: Software for automating image acquisition in electron microscope

Software files for automating image acquisition in TEM

1 licensing option
SARS-CoV-2 N-protein for use in COVID-19 serological assays (2020-323)

Full length SARS-CoV-2 Nucleocapsid (N) protein expressed by bacteria for use in serological assays to detect previous COVID-19 infection in humans and animals.

SARS-CoV-2 spike receptor-binding domain for use in COVID-19 assays (2020-301)

Stably transfected mammalian cell lines that express the receptor-binding domain of the SARS-CoV-2 spike protein for use in assays and research relevant to COVID-19 and potential therapies.

Continuous honey bee cell-line, AmE-711 (2020-240)

The first and only honey bee cell-line available for use in research and experimental testing.

Adenovirus Vector Generating System (20110090)

Siderophore-based diagnosis of bacterial infections (20150206)

Biofeedback Hand Grip Exercise Device for Assessing Muscle Function (20170200)

A method to genetically engineer monocytes (20180236)

The first and only method available to create genetically modified CD14+ monocytes for use in research or therapy.

A streamlined method to isolate Fibroadipogenic progenitor cells from muscle (2020-195)

A method to isolate fibroadipogenic progenitor cells (FAPs) based on the presence of a single surface marker (CD73).

Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)

A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.

Antagomir to prevent cardiac arrhythmia (2019-069)

A novel small molecule screening platform for tauopathies (2019-123)

FRET-based biosensors that identify early toxic states of tau for use in basic research and clinical development of therapeutics for tauopathies including Alzheimer’s Disease.

Opioid and Analgesic Chemical Compound Library (z09208)

Functional Analysis of Networks in the Neural System

Iron Deficiency Mouse Model

Ultra-smooth Patterned Metal Films for Plasmonics

Ultra-smooth Patterned Metal Films for Plasmonics and Metamaterials

SALSA - Automated Speech Assessment

For Quantitative Neuropsychological Cognitive Assessment

MRI Contrast Software Based on RAFF-n

Reverse Plug Cytometer for Cell Tracking

Three Dimensional Dental Anatomy Software Program for Dentistry Students

1 licensing option
3D Video from 2D Using a Single Camera System

Mammalian Cell Culture System for Anaplasmosis Vaccine Development

Biological Imaging Provides Full Imaging of Samples

Cellulosic Biofuel, Chemical, and Ethanol Production

Organism Design for Cellulosic Biofuel, Cellulosic Chemical, and Cellulosic Ethanol Production

Kappa Receptor Agonists and Delta Receptor Antagonists

Target for Acaricides and Cattle Tick Vaccines

More Stable and Potent Cyclic ADP-Ribose Analogs

Risk assessment for repeated hospital admission: Pra and PraPlus

1 licensing option
Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ)

The Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ) is a validated patient-oriented measure of the adverse effects of heart failure on a patient's life.

7 licensing options
3D printed deer head and neck model

Peripheral Artery Disease Quality of Life (PADQOL) Questionnaire

A validated instrument to assess the physical, psychosocial and emotional effects on patients suffering from peripheral artery disease.

4 licensing options
Living with Pulmonary Hypertension Questionnaire (LPHQ)

The Living with Pulmonary Hypertension Questionnaire (LPHQ) is a reliable and validated measure of the adverse effects of pulmonary hypertension on a patient’s life.

2 licensing options
Mouse models of tau variants linked to neurodegenerative disease

An improved and controlled mouse model expressing human tau P301L protein, a common mutation linked to neurodegeneration.

Click-Chemistry Reagent for Mass Cytometry

Nesocodin: A natural red colorant that’s easily synthesized

A method to synthesize a novel, natural red colorant that is biodegradable and likely non-toxic.

Fluorescence-based assay for probing lipid transfer activity

A sensitive, reproducible and quantitative assay to study lipid transfer using bicelles as model membranes.

CoFe nanowires for remote heating using an alternating magnetic field

A nanowire material for remote, rapid and uniform heating of biological samples.

3D tumor models for accurate testing of therapeutics

A method to create a 3D tumor model that accurately mimics both tumor behavior and environment for use in anti-cancer drug development.

Immunostimulatory conjugates for targeted delivery as adjuvants

Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure

An accurate, high throughput method to measure site-specific ubiquitin abundance

Isotopically balanced quantification of ubiquitination (IBAQ-Ub): A rapid, sensitive method to measure site-specific ubiquitination abundance

CMRR - Center for Magnetic Resonance Research Software for Siemens MRI Scanners

9 licensing options
Assay to measure intrinsic efficiency of GPCR ligands

FRET-based GPCR biosensors to measure specific ligand activation in a cell independent manner.

MHC Class II Molecules with Enhanced Co-receptor Affinity

Automated De-Identification of Distributional Semantics Models

1 licensing option
Microinjection for Single Cell Gene Manipulation

Segmenting 3D Bone Computed Tomography Data

An effective media for difficult-to-culture mouse epithelial cells

A novel cell culture media formula that facilitates the expansion and cultivation of typically challenging mouse keratinocytes.

Chewing Simulator Provides Sensory Information

Real-Time Reporter and Efficient Enzymes for DNA Editing

Versatile Biocatalyst System for Synthesizing Chemicals, Pharmaceuticals and Food Ingredients

Specific kinase biosensors to probe cancer metabolism

Substrate peptides for Ser/Thr kinases to investigate the metabolic processes of cancer cells.

3D Microscale Isotropic Metamaterials

An approach to identify allosteric modulators of kinases

Protein-based sensor for detecting kinase-substrate interactions suitable for screening therapeutically-relevant inhibitors.

Probes for Biosynthesis of Bacterial Cell Wall

Universal tyrosine kinase substrates

Non-selective, universal substrates for tyrosine kinases that couple with a fluorescent readout mechanism to serve as quantity and quality control (internally and/or between samples). 

Large 3D Printed Skull Window for Neuroscience Research

Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC

Single Voxel MR Spectroscopy of Human Brain with Automatic Voxel Positioning

1 licensing option
Magnetization Transfer Contrast Preparation

Particle Swarm Optimization for Programming Neuromodulation Systems

Image-Based Fiber Orientation and Alignment Calculator

3 licensing options
Mimicked Calcified Annulus Model for Preclinical Assessment of TAVR Devices

1 licensing option
Predicting Crop Yield and Quality Using Canopy Reflectance and LiDAR Sensors

CG-TARGET Interpretation of Chemical-Genetic Interaction Profiles

4 licensing options
BEAN-Counter Quantitative Scoring of Chemical-Genetic Interactions

4 licensing options
Kinase assay to aid in development of therapeutics for acute myeloid leukemia

Peptide substrates to sensitively and specifically measure the real-time activity of FLT3, a kinase linked to acute myeloid leukemia.

Biosynthetic Route to Serofendic Acid

Porcine B lymphoma cell lines

Three porcine B cell lines (Murtaugh001, Murtaugh002, Murtaugh003) established by 3 rounds of limiting dilution from splenic and subiliac lymph node lymphomas.

Efficient release of affinity-captured cells

A method to effectively release affinity-captured cells.

Developing Highly Specific Monoclonal Antibodies to Peptide in the Context of MHC II

Warming of Cryopreserved Biomaterials using Laser Assisted Gold Nanorods

Algorithm for Discovering Genetic Interactions in Genome-Wide Association Studies (BridGE)

1 licensing option
Kinase biosensor for individualized cancer therapy (20150289, Dr. Laurie Parker)

A method to sensitively and specifically detect the activity of multiple kinases, from multiple samples in a traceable manner.

HerdIn:Form(er): Mobile Questionnaire for Livestock Epidemiology Research (20150194, Dr. Andres Perez)

1 licensing option
Increased efficiency of CRISPR-Cas9 genome editing (Dr. Wendy Gordon)

An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.

Improved MRI Method Uses Temperature Rise Contraints (20150061, Dr. Moortele)

Multi-purpose Arm Ergometer Design (20140266, Dr. Gary Goldish)

In-vivo MRI Radiofrequency Pulses Robust against Respiration Induced Errors (20140236, Dr. Kamil Ugurbil)

Multi-band SWIFT Improves MRI (20140121, Dr. Idiyatullin, Dr. Garwood)

Dystrophin Gene Targeting Method and Tools (20140040, Dr. Perlingeiro, Dr. Daniel Voytas)

Small RNA Amplification and Library Preparation (20140020, Dr. Subree Subramanian)

Anti-arrhythmic Effect of Cardiac Pacing Without Feedback (20130273, Dr. Alena Talkachova)

Magnetic Resonance Electrical Properties Tomography (20130259, Dr. Bin He)

Reagent for Dual Protein Labeling (20130255, Dr. Mark Distefano)

Matrix for Storage of Biofluid Specimens and Biological Drugs at Room Temperature (20130180, Dr. Alpetkin Aksan)

This technology is a novel biopreservation sponge for storage of biofluid specimens and biological drugs at room temperature that prevents degradation and aggregation of biomolecules.

Sanfilippo Syndrome Behavior Rating Scale (SBRS) (20130141, Dr. Elsa Shapiro)

5 licensing options
Long-term whole organ cryopreservation and transplantation

A method for long-term whole organ cryopreservation and transplantation using vitrification and nanowarming techniques.

Valve Control System for Decellularization and Recellularization of Organs (20130112, Dr. Angela Panoskaltsis-Mortari)

2 licensing options
Mass Spectrometry Software Improves Data Evaluation (20120293, Dr. Timothy Griffin)

2 licensing options
Avian Cell Lines: Clonal Variant Cell Line for Improved Vaccine Virus Propagation

Shuttle Vector for Rickettsia Species

Canine Cell Lines

Lower Specific Absorption Rate for Multiband MRI (20110093, Dr. Kamil Ugurbil)

GFP Displaying Transgenic Mouse for Antigen Receptors

Digital Pathology Virtual Microscope Slides with Online Database (20110025, Dr. Stephen Wiesner)

The Digital Pathology Virtual Microscope Slides allow medical students and allied health professionals to access hematology, body fluids, bacteriology and parasitology microscope slides through an online database for distance learning and enhanced curriculum delivery.

3 licensing options
Acute Lymphoblastic Leukemia Cell Line and Mouse Model (20100059)

Sarcoma miRNA Expression Database for Cancer Treatment