MoonTag and plant-derived activation domains for improved genetic engineering
A novel programmable transcriptional activator that can work with plant-derived activation domains to enable precise and robust gene activation in plants.
A minipromoter for gene therapies
A mini-promoter to accommodate larger therapeutic genes of interest in gene therapy programs
Compounds that lead to degradation of cancer relevant proteins
Compounds target and degrade kinases, specifically Aurora A and CDK4/6, for effective cancer treatment.
Dpath: a novel software for classification and quantification of cellular states in single-cell transcriptomics
A software for classification and quantification of cell types during stage transitions from stem cells to differentiated cells. This software can further classify and quantify the progenitor and committed states in single-cell RNA-sequence data in a non-biased manner.
Inhibitors of Cell Adhesion by Nectin Peptides
Peptides that functionally block ovarian cancer cell adhesion by targeting Nectin-4
Hamster CD4 and CD8 antibodies
Monoclonal antibodies against Syrian golden hamster CD4 and CD8
Therapeutic target for treatment of ataxia
A newly identified pathway that represents a therapeutic target for the prevention and treatment of ataxia.
An anti-CD133 hybridoma
A hybridoma for manufacturing anti-CD133 antibodies capable of recognizing glycosylated and non-glycosylated epitopes
Hands-free immunoblot washing device
A low-cost, automated method to wash immunoblots
Hyperstable synthetic miniproteins as ligand scaffolds
Hyperstable synthetic miniproteins as modular ligand scaffolds for advanced therapeutics and diagnostics.
Progesterone receptor detection for breast cancer therapy
A test to detect phosphorylated progesterone receptors for patient stratification
CDK2 inhibitors for cancer therapy and male contraception
CDK2 inhibitors for cancer therapy and non-hormonal male contraception with high selectivity and reduced side effects.
Seizure Behavioral Testing Protocol (ROAR)
A standardized seizure behavioral testing protocol (ROAR) for enhanced diagnosis and care during video EEG monitoring.
Inhibitory nucleic acid molecules targeting cyclin D1 mRNA
Inhibition of non-canonical functions of cyclin D1 as a potential therapy for liver diseases.
Mouse model for studying SARS-CoV-2
A gene replacement mouse model incorporating human ACE2 and TMPRSS2 genes for authentic SARS-CoV-2 replication and virus entry studies.
Broadspectrum potentially therapeutic nanobodies against COVID-19
A class of nanobodies (Nanosota-2, -3, and -4) offering broadspectrum therapeutic potential against COVID-19.
Soluble, active DNA cytosine deaminase for use as a research tool
A method to produce soluble DNA cytosine deaminase for assays of potential inhibitors of HIV-1 and as a tool for biotech applications
Nanorings for cell-mediated drug delivery
Farnesylated chemically self-assembled nanorings that facilitate targeted drug delivery between cells.
Artificial gut/absorption simulator for evaluation of drug formulations dissolution
A device and method for simulating a digestive gut to evaluate drug delivery that incorporates simultaneous absorption with dissolution
Efficient CRISPR-based gene editing for stem cells
A CRISPR-based gene editing protocol for induced pluripotent stem cells (iPSCs) with improved editing efficiency and cell survival.
Dual frequency RF coil for magnetic resonance imaging
A novel RF resonant coil that can operate at both X-nuclear and proton frequencies.
Single-cell Integration and DrUg Response PrediCtion (scIDUC)
A computational pipeline that predicts drug response scores for individual cells using single-cell RNA sequencing data.
Pharmacological enhancement of CD8 T cell effector function using TEPP46
A clinically viable strategy for preventing mitochondria-mediated T cell exhaustion and enhancing effector T cell function.
First-in-class drug lead candidate (A229) for treating ocular diseases
PPARα agonist, A229, exhibits strong potency and demonstrates efficacy in in-vitro models of diabetic retinopathy.
Bacterial histidine kinase inhibitors for treating Staphylococcus infections
Small molecule bacterial histidine kinase inhibitors that significantly diminish staphylococcal virulence.
Small molecule inhibitors for treating alcoholic hepatitis
Bromodomain inhibitor, UMN627, reduces inflammation in mice models of alcoholic hepatitis.
T Cell Receptor Exchange (TRex) Mice
A mouse model for studying physiological antigen-specific T cell behavior.
Bisubstrate inhibitors for treating SARS-CoV-2 infections
Bisubstrate inhibitors that target the active site of SARS-CoV-2 Nsp14 methyltransferase (MTase) for treating SARS-CoV-2 infections.
Novel compounds for treatment of neurodegenerative disease and chronic pain
Novel alpha2-adrenergic agonists with neuroprotective and/or analgesic properties.
First-generation degraders for class I bromodomain-containing proteins
A bromodomain-targeting degrader of CECR2, an epigenetic regulator that drives cancer metastasis.
NOD-2-active carboxamide compounds as vaccine adjuvants
Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.
Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines
A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.
High-throughput screening assay for sickle cell disease drug discovery
A high-throughput screening assay for discovering small molecules that directly inhibit sickle hemoglobin oligomerization.
Conditional DUXC knockout mouse model
A conditional DUXC knockout mouse model for use as a basic research tool.
Direct elution caps for reducing autosampler cross-vial contamination
A screw cap that interfaces a pipette tip and autosampler vial, creating a sturdy connection and an elevated pipette tip position within the vial.
Fast 3-dimensional reciprocal space imaging with laboratory X-ray diffraction: RSLab
A software that adds fast 3D reciprocal space imaging capabilities to laboratory X-ray diffractometers with 2D detectors.
Mouse-derived FSHD muscle cell lines
Primary skeletal muscle cell lines isolated from DUX4 expressing FSHD mice.
Generating teratoma-derived skeletal muscle stem cells
A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.
Rapid non-invasive portable system for monitoring deterioration of plastics
A system comprising a portable device and image processing software for superficial non-destructive determination of plastic deterioration
Steerable magneto-photonic particles for targeted delivery and collection of light
An embeddable magneto-photonic microparticle that can be externally positioned and orientated for targeted delivery and collection of light.
Small molecules promoting differentiation/maturation of stem cell-derived myogenic cells
A combinatorial small molecule treatment that promotes differentiation and maturation of myotubes derived from pluripotent stem cells.
Minnesota Assessment of Pharmacogenomic Literacy (MAPL™)
A questionnaire to assess pharmacogenomic knowledge among patients in research studies or clinical care.
Human Myotonic Dystrophy Induced Pluripotent Stem Cell Lines
HUH fusion enzymes for multiplex protein labeling
HUH fusion tags are novel, robust endonucleases that allow proteins and DNA to be linked covalently in one simple step
Camelid single domain antibody phage display library
Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target
Targeted Artificial DNA Replisome (TADR) a Tool for Targeted Mutagenesis
TADR is a protein-complex designed to target and mutate specific genes on plasmid in vivo
Immortalized clonal human myoblast line "M007"
Immortalized human myoblast cell line obtained from a healthy individual
Immortalized clonal human fibroblast line "F007"
Immortalized human fibroblast cell line obtained from a healthy individual
Cryopreservation method for millimeter scale biological samples using Cryomesh
A cryopreservation method that uses cryomesh and cryopreservation agents to preserve Drosophila embryos.
Risk-free in situ non animal (RISNA) surrogate assay for African swine fever virus
A method of using a surrogate virus to confirm inactivation of African Swine Fever Virus(ASFV)
A novel approach for bioprinting complex tissue models
A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.
Novel anti-cancer agents that target the epigenetic reader protein
Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.
HapShared - a software for pedigree reconstruction
A Python script for performing complex pedigree analysis with high sensitivity.
A method to identify cell-free biomarkers of cancers and other diseases
A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.
Community-based antibiotic screening method for polymicrobial infections (2020-090)
An improved antibiotic susceptibility test (AST) that determines minimal inhibitory concentration (MIC) with high physiological relevance for polymicrobial infections.
Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)
An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.
Device for extracting long genomic DNA from human cells
A microfluidic device for automated cell lysis and extraction of long DNA strands.
UEMtomaton: Software for automating image acquisition in electron microscope
Software files for automating image acquisition in TEM
SARS-CoV-2 spike receptor-binding domain for use in COVID-19 assays (2020-301)
Stably transfected mammalian cell lines that express the receptor-binding domain of the SARS-CoV-2 spike protein for use in assays and research relevant to COVID-19 and potential therapies.
Continuous honey bee cell-line, AmE-711 (2020-240)
The first and only honey bee cell-line available for use in research and experimental testing.
Adenovirus Vector Generating System (20110090)
Siderophore-based diagnosis of bacterial infections (20150206)
Biofeedback Hand Grip Exercise Device for Assessing Muscle Function (20170200)
A streamlined method to isolate Fibroadipogenic progenitor cells from muscle (2020-195)
A method to isolate fibroadipogenic progenitor cells (FAPs) based on the presence of a single surface marker (CD73).
Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)
A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.
Antagomir to prevent cardiac arrhythmia (2019-069)
A novel small molecule screening platform for tauopathies (2019-123)
FRET-based biosensors that identify early toxic states of tau for use in basic research and clinical development of therapeutics for tauopathies including Alzheimer’s Disease.
Opioid and Analgesic Chemical Compound Library (z09208)
Functional Analysis of Networks in the Neural System
Iron Deficiency Mouse Model
Ultra-smooth Patterned Metal Films for Plasmonics
Ultra-smooth Patterned Metal Films for Plasmonics and Metamaterials
SALSA - Automated Speech Assessment
For Quantitative Neuropsychological Cognitive Assessment
MRI Contrast Software Based on RAFF-n
Three Dimensional Dental Anatomy Software Program for Dentistry Students
Mammalian Cell Culture System for Anaplasmosis Vaccine Development
Biological Imaging Provides Full Imaging of Samples
Cellulosic Biofuel, Chemical, and Ethanol Production
Organism Design for Cellulosic Biofuel, Cellulosic Chemical, and Cellulosic Ethanol Production
Kappa Receptor Agonists and Delta Receptor Antagonists
Target for Acaricides and Cattle Tick Vaccines
More Stable and Potent Cyclic ADP-Ribose Analogs
Risk assessment for repeated hospital admission: Pra and PraPlus
Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ)
The Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ) is a validated patient-oriented measure of the adverse effects of heart failure on a patient's life.
3D printed deer head and neck model
Peripheral Artery Disease Quality of Life (PADQOL) Questionnaire
A validated instrument to assess the physical, psychosocial and emotional effects on patients suffering from peripheral artery disease.
Living with Pulmonary Hypertension Questionnaire (LPHQ)
The Living with Pulmonary Hypertension Questionnaire (LPHQ) is a reliable and validated measure of the adverse effects of pulmonary hypertension on a patient’s life.
Mouse models of tau variants linked to neurodegenerative disease
An improved and controlled mouse model expressing human tau P301L protein, a common mutation linked to neurodegeneration.
Click-Chemistry Reagent for Mass Cytometry
Nesocodin: A natural red colorant that’s easily synthesized
A method to synthesize a novel, natural red colorant that is biodegradable and likely non-toxic.
Fluorescence-based assay for probing lipid transfer activity
A sensitive, reproducible and quantitative assay to study lipid transfer using bicelles as model membranes.
CoFe nanowires for remote heating using an alternating magnetic field
A nanowire material for remote, rapid and uniform heating of biological samples.
3D tumor models for accurate testing of therapeutics
A method to create a 3D tumor model that accurately mimics both tumor behavior and environment for use in anti-cancer drug development.
Immunostimulatory conjugates for targeted delivery as adjuvants
Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure
CMRR - Center for Magnetic Resonance Research Software for Siemens MRI Scanners
Assay to measure intrinsic efficiency of GPCR ligands
FRET-based GPCR biosensors to measure specific ligand activation in a cell independent manner.
MHC Class II Molecules with Enhanced Co-receptor Affinity
Automated De-Identification of Distributional Semantics Models
Microinjection for Single Cell Gene Manipulation
Segmenting 3D Bone Computed Tomography Data
An effective media for difficult-to-culture mouse epithelial cells
A novel cell culture media formula that facilitates the expansion and cultivation of typically challenging mouse keratinocytes.
Chewing Simulator Provides Sensory Information
Real-Time Reporter and Efficient Enzymes for DNA Editing
Versatile Biocatalyst System for Synthesizing Chemicals, Pharmaceuticals and Food Ingredients
Specific kinase biosensors to probe cancer metabolism
Substrate peptides for Ser/Thr kinases to investigate the metabolic processes of cancer cells.
3D Microscale Isotropic Metamaterials
Probes for Biosynthesis of Bacterial Cell Wall
Universal tyrosine kinase substrates
Non-selective, universal substrates for tyrosine kinases that couple with a fluorescent readout mechanism to serve as quantity and quality control (internally and/or between samples).
Large 3D Printed Skull Window for Neuroscience Research
Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC
Single Voxel MR Spectroscopy of Human Brain with Automatic Voxel Positioning
Magnetization Transfer Contrast Preparation
Particle Swarm Optimization for Programming Neuromodulation Systems
Image-Based Fiber Orientation and Alignment Calculator
Mimicked Calcified Annulus Model for Preclinical Assessment of TAVR Devices
Predicting Crop Yield and Quality Using Canopy Reflectance and LiDAR Sensors
CG-TARGET Interpretation of Chemical-Genetic Interaction Profiles
BEAN-Counter Quantitative Scoring of Chemical-Genetic Interactions
Kinase assay to aid in development of therapeutics for acute myeloid leukemia
Peptide substrates to sensitively and specifically measure the real-time activity of FLT3, a kinase linked to acute myeloid leukemia.
Biosynthetic Route to Serofendic Acid
Porcine B lymphoma cell lines
Three porcine B cell lines (Murtaugh001, Murtaugh002, Murtaugh003) established by 3 rounds of limiting dilution from splenic and subiliac lymph node lymphomas.
Efficient release of affinity-captured cells
A method to effectively release affinity-captured cells.
Developing Highly Specific Monoclonal Antibodies to Peptide in the Context of MHC II
Warming of Cryopreserved Biomaterials using Laser Assisted Gold Nanorods
A method for rapid, uniform warming of cryopreserved biomaterials using laser-assisted gold nanorods.
Algorithm for Discovering Genetic Interactions in Genome-Wide Association Studies (BridGE)
Kinase biosensor for individualized cancer therapy (20150289, Dr. Laurie Parker)
A method to sensitively and specifically detect the activity of multiple kinases, from multiple samples in a traceable manner.
HerdIn:Form(er): Mobile Questionnaire for Livestock Epidemiology Research (20150194, Dr. Andres Perez)
Increased efficiency of CRISPR-Cas9 genome editing (Dr. Wendy Gordon)
An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.
Improved MRI Method Uses Temperature Rise Contraints (20150061, Dr. Moortele)
In-vivo MRI Radiofrequency Pulses Robust against Respiration Induced Errors (20140236, Dr. Kamil Ugurbil)
Multi-band SWIFT Improves MRI (20140121, Dr. Idiyatullin, Dr. Garwood)
Dystrophin Gene Targeting Method and Tools (20140040, Dr. Perlingeiro, Dr. Daniel Voytas)
Small RNA Amplification and Library Preparation (20140020, Dr. Subree Subramanian)
Anti-arrhythmic Effect of Cardiac Pacing Without Feedback (20130273, Dr. Alena Talkachova)
Magnetic Resonance Electrical Properties Tomography (20130259, Dr. Bin He)
Reagent for Dual Protein Labeling (20130255, Dr. Mark Distefano)
Matrix for Storage of Biofluid Specimens and Biological Drugs at Room Temperature
This technology is a novel biopreservation sponge for storage of biofluid specimens and biological drugs at room temperature that prevents degradation and aggregation of biomolecules.
Sanfilippo Syndrome Behavior Rating Scale (SBRS) (20130141, Dr. Elsa Shapiro)
Long-term whole organ cryopreservation and transplantation
A method for long-term whole organ cryopreservation and transplantation using vitrification and nanowarming techniques.
Valve Control System for Decellularization and Recellularization of Organs (20130112, Dr. Angela Panoskaltsis-Mortari)
Mass Spectrometry Software Improves Data Evaluation (20120293, Dr. Timothy Griffin)
Avian Cell Lines: Clonal Variant Cell Line for Improved Vaccine Virus Propagation
Shuttle Vector for Rickettsia Species
Canine Cell Lines
Lower Specific Absorption Rate for Multiband MRI (20110093, Dr. Kamil Ugurbil)
GFP Displaying Transgenic Mouse for Antigen Receptors
Digital Pathology Virtual Microscope Slides with Online Database (20110025, Dr. Stephen Wiesner)
The Digital Pathology Virtual Microscope Slides allow medical students and allied health professionals to access hematology, body fluids, bacteriology and parasitology microscope slides through an online database for distance learning and enhanced curriculum delivery.