Conditional DUXC knockout mouse model
A conditional DUXC knockout mouse model for use as a basic research tool.
Technology No. 2023-164
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Applications
- Basic research tool
Technology Overview
Organism: Mus musculus, mouse
Background: C57BL/6
Product format: Live animals
Description: The Double homeobox (Dux) gene is a repeated gene array in humans and mice. In a C57BL/6 mouse background, this array was replaced with a single copy of the repeat containing the DUXC gene flanked by loxP sites at both ends. This created a conditional allele that can be deleted with Cre expression. Briefly, mouse Dux is not essential for viability or fertilization nor for zygotic genome activation, however the knockout embryos exhibit post-implantation development failures.
Phase of Development
TRL: 7-8Conditional DUXC knockout mice have been generated, characterized, and published.
Desired Partnerships
This technology is now available for:- License
- Sponsored research
- Co-development
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Researchers
- Michael Kyba, PhD, Pofessor, Department of Pediatrics
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swap_vertical_circlelibrary_booksReferences (1)
- Darko Bosnakovski, Micah D Gearhart, Si Ho Choi, Michael Kyba (January 2021), Dux facilitates post-implantation development, but is not essential for zygotic genome activation, Biology of Reproduction, 104, 83–93
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