Electron paramagnetic resonance (EPR) imaging without magnet
A method which produces low cost EPR imaging with better receiver isolation and no magnet requirement
- In-vivo portable EPR imaging system
- Relaxation time measurement – for material science instrumentation, or detecting whether drug-loaded iron oxide nanoparticles (NPs) have reached their target in targeted drug-delivery
- Concentration calibration in cryopreservation – calibration of iron oxide NP concentration in cryopreserved organs
- Magnetic Particle Imaging (MPI) – comparable resolution with 10x less gradient strength. May expand usage to human applications. With appropriate tracer, it may be an alternative to positron emission tomography (PET)
- Dosimetry – both external beam radiotherapy and brachytherapy
- Hyperthymia – higher heating efficiency for cancer therapy or for thawing cryopreserved organs
This EPR imaging technique is low cost and portable due to the absence of a magnet requirement. This method makes use of geometrical isolation and frequency separation where the receive coil is vertical to the transmit coils, and transmit carrier frequency and receive frequency are tuned to different values. This provides better receiver isolation than the conventional Continuous Wave (CW) EPR systems.
Phase of DevelopmentTRL: 4-5
Working prototype. One-dimensional (1D) imaging system has been built.
Desired PartnershipsThis technology is now available for:
- Sponsored research
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- Michael Garwood, Ph.D., Professor, Department of Radiology
- Tang, Xueyan, Steven Suddarth, Guhan Qian, and Michael Garwood. , Ultra-low frequency EPR using longitudinal detection and fictitious-field modulation, Journal of Magnetic Resonance
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