Mammalian Cell Culture System for Anaplasmosis Vaccine Development
Anaplasmosis is a disease caused by Anaplasma phagocytophilium. This intracellular bacterium is transmitted via infected tick bites, and infects humans and animals in North America, Europe, Australia, and Africa. A method of propagating Anaplasma species stably in mammalian cells would assist both industry and academia research and development.
Culturing Anaplasma for Antigen Use
A way to propagate Anaplasma species in mammalian cells has been developed at the University of Minnesota. An Anaplasma species stably infects a mammalian endothelial cell, which is propagated then isolated. This culturing system allows for genetic analysis and provides a source of Anaplasma for use as an antigen for potential anaplasmosis diagnostics or treatments.
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BENEFITS AND FEATURES OF CELL LINES FOR PROPAGATING ANAPLASMA:
- Provides cells that are stably infected with Anaplasma species
- Allows for propagation of Anaplasma species in mammalian cells for at least 8 weeks
- Isolation of Anaplasma species for research use
Licensee will receive rights to practice the intellectual property (Patent) for the purposes of developing and manufacturing a commercial product.
Phase of Development
In Vitro Assessment