Soluble, Active DNA Cytosine Deaminase for use as a Research Tool
A method to produce soluble DNA cytosine deaminase for assays of potential inhibitors of HIV-1 and as a tool for biotech applications
Nanorings for cell-mediated drug delivery
Farnesylated chemically self-assembled nanorings that facilitate targeted drug delivery between cells.
Novel Antimicrobial Peptide DGL13K
An antimicrobial peptide DGL13 that exhibits several desirable characteristics for a novel antibiotic.
Efficient CRISPR-based gene editing for stem cells
A CRISPR-based gene editing protocol for induced pluripotent stem cells (iPSCs) with improved editing efficiency and cell survival.
Single-cell Integration and DrUg Response PrediCtion (scIDUC)
A computational pipeline that predicts drug response scores for individual cells using single-cell RNA sequencing data.
Pharmacological enhancement of CD8 T cell effector function using TEPP46
A clinically viable strategy for preventing mitochondria-mediated T cell exhaustion and enhancing effector T cell function.
First-in-class drug lead candidate (A229) for treating ocular diseases
PPARĪ± agonist, A229, exhibits strong potency and demonstrates efficacy in in-vitro models of diabetic retinopathy.
Bacterial histidine kinase inhibitors for treating Staphylococcus infections
Small molecule bacterial histidine kinase inhibitors that significantly diminish staphylococcal virulence.
Small molecule inhibitors for treating alcoholic hepatitis
Bromodomain inhibitor, UMN627, reduces inflammation in mice models of alcoholic hepatitis.
Ovarian cancer prognostic test for predicting response to chemotherapy and bevacizumab
A prognostic molecular test for predicting ovarian cancer patient response to platinum-based chemotherapy and/or treatment with bevacizumab.
Bisubstrate inhibitors for treating SARS-CoV-2 infections
Bisubstrate inhibitors that target the active site of SARS-CoV-2 Nsp14 methyltransferase (MTase) for treating SARS-CoV-2 infections.
Novel compounds for treatment of neurodegenerative disease and chronic pain
Novel alpha2-adrenergic agonists with neuroprotective and/or analgesic properties.
First-generation degraders for class I bromodomain-containing proteins
A bromodomain-targeting degrader of CECR2, an epigenetic regulator that drives cancer metastasis.
NOD-2-active carboxamide compounds as vaccine adjuvants
Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.
Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines
A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.
High-throughput screening assay for sickle cell disease drug discovery
A high-throughput screening assay for discovering small molecules that directly inhibit sickle hemoglobin oligomerization.
Small molecules with antiproliferative activity against pancreatic cancer cells
Small molecules that show antiproliferative activity against the pancreatic cancer cell line MiaPaca-2.
Small molecules promoting differentiation/maturation of stem cell-derived myogenic cells
A combinatorial small molecule treatment that promotes differentiation and maturation of myotubes derived from pluripotent stem cells.
Surface Coating with Novel Antimicrobial Peptide DGL13K
Family of antimicrobial peptides, based on the core peptide GL13, that directly attack the bacterial cell membrane.
HUH fusion enzymes for multiplex protein labeling
HUH fusion tags are novel, robust endonucleases that allow proteins and DNA to be linked covalently in one simple step
Compound with selective inhibition potential against P300 and CBT
A compound to treat pediatric sarcoma through the inhibition of P300 and CBT
Nanominne-1: novel virus-like particle (nanoparticle) vaccines to prevent SARS-CoV-2 infections
Series of novel vaccines containing 60 copies of SARS-CoV-2 antigens displayed in ordered array on a virus-like particle scaffold (nanoparticle)
Multi-faceted glue for long-term survival of osseointegrated prosthetic devices
A multi-functional photopolymerizable glue that enhances the physical and biological adhesion between soft skin and a metal prosthetic device.
Novel anti-cancer agents that target the epigenetic reader protein
Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.
Use of sulfanegen and its analogs for prevention and treatment for neurodegenerative disorders
A 3-mercaptopyruvate prodrug, sulfanegen, that reduces neuroinflammation and oxidative stress for therapeutic use in neurodegenerative diseases.
Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction
Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.
Detection of toxic small molecules using polymers and Raman scattering
A method to capture one or more analytes using polymers to enable multiplex quantitative detection by surface-enhanced Raman scattering