NOD-2-active carboxamide compounds as vaccine adjuvants
Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.
Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines
A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.
High-throughput screening assay for sickle cell disease drug discovery
A high-throughput screening assay for discovering small molecules that directly inhibit sickle hemoglobin oligomerization.
Mouse-derived FSHD muscle cell lines
Primary skeletal muscle cell lines isolated from DUX4 expressing FSHD mice.
Generating teratoma-derived skeletal muscle stem cells
A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.
Small molecules with antiproliferative activity against pancreatic cancer cells
Small molecules that show antiproliferative activity against the pancreatic cancer cell line MiaPaca-2.
Steerable magneto-photonic particles for targeted delivery and collection of light
An embeddable magneto-photonic microparticle that can be externally positioned and orientated for targeted delivery and collection of light.
AgRP-Derived melanocortin-5 receptor peptide antagonists
AgRP derived scaffolds composed of natural (Tyr, Ala, Val, Asn) and unnatural amino acids (Dap) with antagonist activity at the mouse MC5R
Novel Anti-microbial Peptide GL13K
Family of antimicrobial peptides, based on the core peptide GL13, that directly attack the bacterial cell membrane.
Methods for Modifying Proteins and Peptides.
Production of alpha-N-methylated peptides for improved pharmacological properties.
Surface markers for identification and isolation of skeletal muscle stem cells
A list of cell surface marker antibodies that can identify and isolate (or purify) human skeletal muscle stem cells.
Treating trauma-induced acute blood loss
Novel formulations of D-β-hydroxybutyrate and melatonin improve survival from hemorrhagic shock.
Cell-free selection of site-specific polypeptide binders via tethering
In vitro selection method for the engineering of protein-based high-affinity binders to targets of interest with potential pharmacological value
Compound with selective inhibition potential against P300 and CBT
A compound to treat pediatric sarcoma through the inhibition of P300 and CBT
Live cell assay to quantify the activity of SARS-CoV-2 main protease, Mpro
Fluorescence-based method to effectively screen for protease inhibitors
Camelid single domain antibody phage display library
Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target
T cell receptors for engineered T cell therapy
Mesothelin-specific T cell receptors for cell engineering and cancer therapy
A system for unattended delivery of cognitive neuromodulation therapy
Non-invasive interactive system with specialized equipment and customizable stimulation unit to deliver unattended cognitive neuromodulation therapy. The system supports training of prescribers and clinical staff leading to certification
AGRP-derived melanocortin receptor ligands
Identifying a selective MC4R antagonist for appetite modulation
Chimeric melanocortin receptor ligands
Melanocortin-4 receptor ligand reduces food intake in mice
Selective melanocortin receptor ligands
Potential dual-ligand approach to weight management
Lateral flow assay for respiratory viruses
CRISPR/Cas9-based point-of-care diagnosis for SARS-CoV-2
Semi-solid polymer drug delivery system
A polymer-based material that is semi-solid material at room and physiological temperatures enabling easy formulation of drugs (e.g. by simple mixing) and delivery (e.g. topical cream).
A novel approach for bioprinting complex tissue models
A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.
Novel anti-cancer agents that target the epigenetic reader protein
Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.
Use of sulfanegen and its analogs for prevention and treatment for neurodegenerative disorders
A 3-mercaptopyruvate prodrug, sulfanegen, that reduces neuroinflammation and oxidative stress for therapeutic use in neurodegenerative diseases.
A method to identify cell-free biomarkers of cancers and other diseases
A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.
Assessing tumor behavior and response to therapy
A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.
Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction
Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.
Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)
An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.
Pharmacological agents to prevent recurrent C. diff infection (20150362)
Cholic and bile acid derivatives that inhibit Clostridium difficile spore germination to prevent or treat C. diff infection.
A method to genetically engineer monocytes (20180236)
The first and only method available to create genetically modified CD14+ monocytes for use in research or therapy.
A streamlined method to isolate Fibroadipogenic progenitor cells from muscle (2020-195)
A method to isolate fibroadipogenic progenitor cells (FAPs) based on the presence of a single surface marker (CD73).
PEGylated Fibrin Biomatrix for Treatment of Acute Myocardial Infarction
Genetic Modification of Endostatin: An Anti-Angiogenic Therapeutic
More Stable and Potent Cyclic ADP-Ribose Analogs
Treating Neurodegenerative Diseases with Nicotine Receptor Ligands
Modified Sleeping Beauty Transposon Gene Transfer System
Novel process to obtain large quantities of primary cells for transplantation
A method to isolate large quantities of high quality primary cells for therapeutic transplantation through freezing and thawing organs, including organs typically considered suboptimal for donation.
Dental stem cells to treat spinal cord injury
A method of treating nervous tissue damage using dental pulp stem cells that leads to neuro-regeneration with a high safety profile and low probability of patient rejection.
CoFe nanowires for remote heating using an alternating magnetic field
A nanowire material for remote, rapid and uniform heating of biological samples.
Novel small molecules for chemotherapy sensitization
Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.
MHC Class II Molecules with Enhanced Co-receptor Affinity
Microinjection for Single Cell Gene Manipulation
Tosedostat (CHR-2797) as a Potential Analgesic
Engineering Human CD64 Chimeric Receptors for Immune Therapy
Real-Time Reporter and Efficient Enzymes for DNA Editing
Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC
Optimizing Gene Editing in NK Cells for Therapy and Research
Efficient release of affinity-captured cells
A method to effectively release affinity-captured cells.
Peptide Activation of T Cells for Cancer Immunotherapy
Increased efficiency of CRISPR-Cas9 genome editing (Dr. Wendy Gordon)
An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.
Cryopreservation without Dimethyl Sulfoxide (20140289, Dr. Allison Hubel)
Bacterial Biofilms Targeted with Microbial Drone Therapeutics (20140281, Dr. Christine Salomon)
Mesoporous Silica-coated Iron Oxide Nanoparticle (20140249, Dr. Christy Haynes)
ssDNA Amphiphile Self-Assembly Forms DNA Nanotubes (20140227, Dr. Efie Kokkoli)
Small RNA Amplification and Library Preparation (20140020, Dr. Subree Subramanian)
Mesoporous silica nanoparticles with ultra high porosity
Novel mesoporous silica nanoparticles with high pore volume and open pore structure, displaying high thermal stability and mechanical sturdiness
Cerebral Amyloid Angiopathy and Alzheimer’s Disease Diagnosis and Treatment (20130341, Dr. Karunya Kandimalla)
Blood Sugar Regulation with D-serine (20130320, Dr. Amber Lockridge)
Reagent for Dual Protein Labeling (20130255, Dr. Mark Distefano)
Immunosuppression Augmented by CD200 Derived Peptide (20130229, Dr. Michael Olin)
Molecular Probe Measures Nucleosides and Differentiation of ATP and ADP (20120272, Dr. Valerie Pierre)
Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)
Controlled Drug Release with Drug Delivery System (20120102, Dr. Chun Wang)
Nanoparticle Chemotherapy with Anticancer Prodrugs (20110152, Dr. Thomas Hoye)
Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)
Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.