Inhibitory nucleic acid molecules targeting cyclin D1 mRNA

Inhibition of non-canonical functions of cyclin D1 as a potential therapy for liver diseases.

Broadspectrum potentially therapeutic nanobodies against COVID-19

A class of nanobodies (Nanosota-2, -3, and -4) offering broadspectrum therapeutic potential against COVID-19.

Nanorings for cell-mediated drug delivery

Farnesylated chemically self-assembled nanorings that facilitate targeted drug delivery between cells.

Novel Antimicrobial Peptide DGL13K

An antimicrobial peptide DGL13 that exhibits several desirable characteristics for a novel antibiotic.

Efficient CRISPR-based gene editing for stem cells

A CRISPR-based gene editing protocol for induced pluripotent stem cells (iPSCs) with improved editing efficiency and cell survival.

Single-cell Integration and DrUg Response PrediCtion (scIDUC)

A computational pipeline that predicts drug response scores for individual cells using single-cell RNA sequencing data.

2 licensing options
Pharmacological enhancement of CD8 T cell effector function using TEPP46

A clinically viable strategy for preventing mitochondria-mediated T cell exhaustion and enhancing effector T cell function.

First-in-class drug lead candidate (A229) for treating ocular diseases

PPARα agonist, A229, exhibits strong potency and demonstrates efficacy in in-vitro models of diabetic retinopathy.

Bacterial histidine kinase inhibitors for treating Staphylococcus infections

Small molecule bacterial histidine kinase inhibitors that significantly diminish staphylococcal virulence.

Small molecule inhibitors for treating alcoholic hepatitis

Bromodomain inhibitor, UMN627, reduces inflammation in mice models of alcoholic hepatitis.

InTERACCT Program: Occupational health and safety training

Training courses for occupational health and safety workers aimed to equip them to handle risks associated with emerging technologies.

1 licensing option
Ovarian cancer prognostic test for predicting response to chemotherapy and bevacizumab

A prognostic molecular test for predicting ovarian cancer patient response to platinum-based chemotherapy and/or treatment with bevacizumab.

Bisubstrate inhibitors for treating SARS-CoV-2 infections

Bisubstrate inhibitors that target the active site of SARS-CoV-2 Nsp14 methyltransferase (MTase) for treating SARS-CoV-2 infections.

Novel compounds for treatment of neurodegenerative disease and chronic pain

Novel alpha2-adrenergic agonists with neuroprotective and/or analgesic properties.

First-generation degraders for class I bromodomain-containing proteins

A bromodomain-targeting degrader of CECR2, an epigenetic regulator that drives cancer metastasis.

NOD-2-active carboxamide compounds as vaccine adjuvants

Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.

Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines

A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.

High-throughput screening assay for sickle cell disease drug discovery

A high-throughput screening assay for discovering small molecules that directly inhibit sickle hemoglobin oligomerization.

Mouse-derived FSHD muscle cell lines

Primary skeletal muscle cell lines isolated from DUX4 expressing FSHD mice.

Generating teratoma-derived skeletal muscle stem cells

A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.

Small molecules with antiproliferative activity against pancreatic cancer cells

Small molecules that show antiproliferative activity against the pancreatic cancer cell line MiaPaca-2.

Steerable magneto-photonic particles for targeted delivery and collection of light

An embeddable magneto-photonic microparticle that can be externally positioned and orientated for targeted delivery and collection of light.

AgRP-Derived melanocortin-5 receptor peptide antagonists

AgRP derived scaffolds composed of natural (Tyr, Ala, Val, Asn) and unnatural amino acids (Dap) with antagonist activity at the mouse MC5R

Surface Coating with Novel Antimicrobial Peptide DGL13K

Family of antimicrobial peptides, based on the core peptide GL13, that directly attack the bacterial cell membrane.

Methods for Modifying Proteins and Peptides.

Production of alpha-N-methylated peptides for improved pharmacological properties.

Surface markers for identification and isolation of skeletal muscle stem cells

A list of cell surface marker antibodies that can identify and isolate (or purify) human skeletal muscle stem cells.

Treating trauma-induced acute blood loss

Novel formulations of D-β-hydroxybutyrate and melatonin improve survival from hemorrhagic shock.

Cell-free selection of site-specific polypeptide binders via tethering

In vitro selection method for the engineering of protein-based high-affinity binders to targets of interest with potential pharmacological value

Compound with selective inhibition potential against P300 and CBT

A compound to treat pediatric sarcoma through the inhibition of P300 and CBT

Live cell assay to quantify the activity of SARS-CoV-2 main protease, Mpro

Fluorescence-based method to effectively screen for protease inhibitors

Camelid single domain antibody phage display library

Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target

T cell receptors for engineered T cell therapy

Mesothelin-specific T cell receptors for cell engineering and cancer therapy

A system for unattended delivery of cognitive neuromodulation therapy

Non-invasive interactive system with specialized equipment and customizable stimulation unit to deliver unattended cognitive neuromodulation therapy. The system supports training of prescribers and clinical staff leading to certification

AGRP-derived melanocortin receptor ligands

Identifying a selective MC4R antagonist for appetite modulation

Chimeric melanocortin receptor ligands

Melanocortin-4 receptor ligand reduces food intake in mice

Selective melanocortin receptor ligands

Potential dual-ligand approach to weight management

Lateral flow assay for respiratory viruses

CRISPR/Cas9-based point-of-care diagnosis for SARS-CoV-2

A novel approach for bioprinting complex tissue models

A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.

Novel anti-cancer agents that target the epigenetic reader protein

Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.

Use of sulfanegen and its analogs for prevention and treatment for neurodegenerative disorders

A 3-mercaptopyruvate prodrug, sulfanegen, that reduces neuroinflammation and oxidative stress for therapeutic use in neurodegenerative diseases.

A method to identify cell-free biomarkers of cancers and other diseases

A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.

Assessing tumor behavior and response to therapy

A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.

Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction

Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.

Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)

An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.

A method to genetically engineer monocytes (20180236)

The first and only method available to create genetically modified CD14+ monocytes for use in research or therapy.

A streamlined method to isolate Fibroadipogenic progenitor cells from muscle (2020-195)

A method to isolate fibroadipogenic progenitor cells (FAPs) based on the presence of a single surface marker (CD73).

More Stable and Potent Cyclic ADP-Ribose Analogs

Treating Neurodegenerative Diseases with Nicotine Receptor Ligands

Dental stem cells to treat spinal cord injury

A method of treating nervous tissue damage using dental pulp stem cells that leads to neuro-regeneration with a high safety profile and low probability of patient rejection.

CoFe nanowires for remote heating using an alternating magnetic field

A nanowire material for remote, rapid and uniform heating of biological samples.

Novel small molecules for chemotherapy sensitization

Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.

MHC Class II Molecules with Enhanced Co-receptor Affinity

Microinjection for Single Cell Gene Manipulation

Tosedostat (CHR-2797) as a Potential Analgesic

Real-Time Reporter and Efficient Enzymes for DNA Editing

Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC

Efficient release of affinity-captured cells

A method to effectively release affinity-captured cells.

Peptide Activation of T Cells for Cancer Immunotherapy

Increased efficiency of CRISPR-Cas9 genome editing (Dr. Wendy Gordon)

An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.

Bacterial Biofilms Targeted with Microbial Drone Therapeutics (20140281, Dr. Christine Salomon)

Mesoporous Silica-coated Iron Oxide Nanoparticle (20140249, Dr. Christy Haynes)

ssDNA Amphiphile Self-Assembly Forms DNA Nanotubes (20140227, Dr. Efie Kokkoli)

Small RNA Amplification and Library Preparation (20140020, Dr. Subree Subramanian)

Mesoporous silica nanoparticles with ultra high porosity

Novel mesoporous silica nanoparticles with high pore volume and open pore structure, displaying high thermal stability and mechanical sturdiness

Cerebral Amyloid Angiopathy and Alzheimer’s Disease Diagnosis and Treatment (20130341, Dr. Karunya Kandimalla)

Reagent for Dual Protein Labeling (20130255, Dr. Mark Distefano)

Molecular Probe Measures Nucleosides and Differentiation of ATP and ADP (20120272, Dr. Valerie Pierre)

Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)

Nanoparticle Chemotherapy with Anticancer Prodrugs (20110152, Dr. Thomas Hoye)

Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)

Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.

Cancer Treatment Uses Ornithine Decarboxylase Inhibitor (20110052, Dr. Zigang Dong, Dr. Ann Bode)

Treating Carcinomas Using Immunotoxin Specific for Cancer Stem Cells (20110014, Dr. John Ohlfest)

Lysosomal Storage Disease Enzyme Delivery System (20100076)

Sarcoma miRNA Expression Database for Cancer Treatment