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Semi-solid polymer drug delivery system

A polymer-based material that is semi-solid material at room and physiological temperatures enabling easy formulation of drugs (e.g. by simple mixing) and delivery (e.g. topical cream).

A novel approach for bioprinting complex tissue models

A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.

Novel anti-cancer agents that target the epigenetic reader protein

Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.

Use of sulfanegen and its analogs for prevention and treatment for neurodegenerative disorders

A 3-mercaptopyruvate prodrug, sulfanegen, that reduces neuroinflammation and oxidative stress for therapeutic use in neurodegenerative diseases.

A method to identify cell-free biomarkers of cancers and other diseases

A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.

Assessing tumor behavior and response to therapy

A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.

Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction

Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.

Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)

An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.

Pharmacological agents to prevent recurrent C. diff infection (20150362)

Cholic and bile acid derivatives that inhibit Clostridium difficile spore germination to prevent or treat C. diff infection.

A method to genetically engineer monocytes (20180236)

The first and only method available to create genetically modified CD14+ monocytes for use in research or therapy.

A streamlined method to isolate Fibroadipogenic progenitor cells from muscle (2020-195)

A method to isolate fibroadipogenic progenitor cells (FAPs) based on the presence of a single surface marker (CD73).

PEGylated Fibrin Biomatrix for Treatment of Acute Myocardial Infarction

Genetic Modification of Endostatin: An Anti-Angiogenic Therapeutic

More Stable and Potent Cyclic ADP-Ribose Analogs

Treating Neurodegenerative Diseases with Nicotine Receptor Ligands

Modified Sleeping Beauty Transposon Gene Transfer System

Cell Cryopreservation for Lymphocytes Improves Hematopietic Cell Survival

Novel process to obtain large quantities of primary cells for transplantation

A method to isolate large quantities of high quality primary cells for therapeutic transplantation through freezing and thawing organs, including organs typically considered suboptimal for donation.

Dental stem cells to treat spinal cord injury

A method of treating nervous tissue damage using dental pulp stem cells that leads to neuro-regeneration with a high safety profile and low probability of patient rejection.

CoFe nanowires for remote heating using an alternating magnetic field

A nanowire material for remote, rapid and uniform heating of biological samples.

Novel small molecules for chemotherapy sensitization

Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.

MHC Class II Molecules with Enhanced Co-receptor Affinity

Microinjection for Single Cell Gene Manipulation

Tosedostat (CHR-2797) as a Potential Analgesic

Engineering Human CD64 Chimeric Receptors for Immune Therapy

Real-Time Reporter and Efficient Enzymes for DNA Editing

Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC

Optimizing Gene Editing in NK Cells for Therapy and Research

Efficient release of affinity-captured cells

A method to effectively release affinity-captured cells.

Peptide Activation of T Cells for Cancer Immunotherapy

Increased efficiency of CRISPR-Cas9 genome editing (20150143, Dr. Wendy Gordon)

An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.

Cryopreservation without Dimethyl Sulfoxide (20140289, Dr. Allison Hubel)

3 licensing options
Bacterial Biofilms Targeted with Microbial Drone Therapeutics (20140281, Dr. Christine Salomon)

Mesoporous Silica-coated Iron Oxide Nanoparticle (20140249, Dr. Christy Haynes)

ssDNA Amphiphile Self-Assembly Forms DNA Nanotubes (20140227, Dr. Efie Kokkoli)

Small RNA Amplification and Library Preparation (20140020, Dr. Subree Subramanian)

Cerebral Amyloid Angiopathy and Alzheimer’s Disease Diagnosis and Treatment (20130341, Dr. Karunya Kandimalla)

Blood Sugar Regulation with D-serine (20130320, Dr. Amber Lockridge)

Reagent for Dual Protein Labeling (20130255, Dr. Mark Distefano)

Immunosuppression Augmented by CD200 Derived Peptide (20130229, Dr. Michael Olin)

Molecular Probe Measures Nucleosides and Differentiation of ATP and ADP (20120272, Dr. Valerie Pierre)

Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)

Controlled Drug Release with Drug Delivery System (20120102, Dr. Chun Wang)

Nanoparticle Chemotherapy with Anticancer Prodrugs (20110152, Dr. Thomas Hoye)

Alzheimer’s and Neurodegenerative Disease Treatment (20110150, Dr. Robert Vince)

Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)

Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.

Cancer Treatment Uses Ornithine Decarboxylase Inhibitor (20110052, Dr. Zigang Dong, Dr. Ann Bode)

Treating Carcinomas Using Immunotoxin Specific for Cancer Stem Cells (20110014, Dr. John Ohlfest)

Cancer Vaccine Adjuvant: Annexin II (20100242)

Lysosomal Storage Disease Enzyme Delivery System (20100076)

Sarcoma miRNA Expression Database for Cancer Treatment