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SARS-CoV-2 N-protein for use in COVID-19 serological assays (2020-323)

Full length SARS-CoV-2 Nucleocapsid (N) protein expressed by bacteria for use in serological assays to detect previous COVID-19 infection in humans and animals.

Pharmacological agents to prevent recurrent C. diff infection (20150362)

Cholic and bile acid derivatives that inhibit Clostridium difficile spore germination to prevent or treat C. diff infection.

Adenovirus Vector Generating System (20110090)

A method to genetically engineer monocytes (20180236)

The first and only method available to create genetically modified CD14+ monocytes for use in research or therapy.

Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)

A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.

Antagomir to prevent cardiac arrhythmia (2019-069)

A novel small molecule screening platform for tauopathies (2019-123)

FRET-based biosensors that identify early toxic states of tau for use in basic research and clinical development of therapeutics for tauopathies including Alzheimer’s Disease.

Opioid and Analgesic Chemical Compound Library (z09208)

Ritonavir Analog with Anticancer Activity

Carcinoma Immunotoxin Targeting Epidermal Growth Factor and Interleukin-4 Receptors

Lupus Treatments Possible with Identification of High Risk Haplotype

Drug Resistant Tuberculosis Treatment

Targeting uPAR Overexpression on Human Glioblastoma

Direct Application of Antibiotics to Middle Ear for Ear Infection Treatment

Kappa Receptor Agonists and Delta Receptor Antagonists

Genetic Modification of Endostatin: An Anti-Angiogenic Therapeutic

Multimeric Immunotoxins for Cancer Treatment and Graft vs Host Disease

More Stable and Potent Cyclic ADP-Ribose Analogs

Treating Neurodegenerative Diseases with Nicotine Receptor Ligands

Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ)

The Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ) is a reliable and valid patient-oriented measure of the adverse effects of heart failure on a patient's life.

7 licensing options
Minnesota Solvation (MNSOL) Database

An extensive and vetted database of free energies of solvation.

1 licensing option
S100A4 inhibitor “Minnetamide” for prostate cancer treatment

Living with Pulmonary Hypertension Questionnaire (LPHQ)

The Living with Pulmonary Hypertension Questionnaire (LPHQ) is a reliable and validated measure of the adverse effects of pulmonary hypertension on a patient’s life.

1 licensing option
Novel process to obtain large quantities of primary cells for transplantation

A method to isolate large quantities of high quality primary cells for therapeutic transplantation through freezing and thawing organs, including organs typically considered suboptimal for donation.

Nanosota-1: A series of nanobody drugs to combat COVID-19

A series of camelid nanobodies that bind to SARS-CoV-2 (COVID-19) spike protein to block infection of human cells.

Selective bromodomain protein inhibitors that reduce cancer cell viability

Small molecules systematically designed as highly selective bromodomain inhibitors for development as cancer and inflammatory disease therapeutics.

Dental stem cells to treat spinal cord injury

A method of treating nervous tissue damage using dental pulp stem cells that leads to neuro-regeneration with a high safety profile and low probability of patient rejection.

Reduce contamination from grains and powdered food

A method for scalable, non-thermal or low temperature pasteurization of powdered or particulate food.

A synergistic therapy for multi-drug resistant cancers

A synthetic polymer that targets cancer cell membranes and works synergistically with existing chemotherapeutic drugs to treat drug-resistant solid tumors.

Novel anticancer compound that targets metabolic plasticity

F-MN-D1 compound targets metabolic plasticity common to many solid tumors through inhibition of glycolysis and oxidative phosphorylation facilitating tumor growth reduction.

3D tumor models for accurate testing of therapeutics

A method to create a 3D tumor model that accurately mimics both tumor behavior and environment for use in anti-cancer drug development.

A TLR-2 stimulatory molecule for use as a vaccine adjuvant

A small molecule that serves as an adjuvant in vaccines through stimulation of the immune receptor, TLR-2

Unique small molecule modulators of GPCRs

Novel small molecules that bind and modulate G-protein coupled receptors (specifically Sigma 1 and 5-HT7) for therapeutic development.

Antibody based treatment for Type 1 Diabetes

A humanized monoclonal antibody against Serpin B13 to treat Type 1 Diabetes.

Immunostimulatory conjugates for targeted delivery as adjuvants

Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure

Cancer preventative for at risk individuals

An approach to prevent cancers through blocking the transcription factor STAT3 that leads to an 80% tumor reduction in a mouse model of disease.

Drug Delivery Device for Oral Topical Medicine

Bioink composition suitable for creating cardiac tissues

A material composition suitable for 3D printing of biological structures containing stem cells.

Novel small molecules for chemotherapy sensitization

Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.

New Prodrugs for Preventing and Treating Alzheimer's Disease

Cost Effective Preparation of Highly Stable, Reusable Whole Cell Biocatalysts

A novel method to immobilize, stabilize, and enhance the reactivity of whole cell biocatalysts.

Assay to measure intrinsic efficiency of GPCR ligands

FRET-based GPCR biosensors to measure specific ligand activation in a cell independent manner.

MHC Class II Molecules with Enhanced Co-receptor Affinity

A novel chemotherapy drug with reduced patient side-effects

A novel anti-cancer compound that inhibits translation and induces p53 in a DNA-damage independent manner to cause cell cycle arrest and apoptosis.

Tosedostat (CHR-2797) as a Potential Analgesic

Engineering Human CD64 Chimeric Receptors for Immune Therapy

Specific kinase biosensors to probe cancer metabolism

Substrate peptides for Ser/Thr kinases to investigate the metabolic processes of cancer cells.

An approach to identify allosteric modulators of kinases

Protein-based sensor for detecting kinase-substrate interactions suitable for screening therapeutically-relevant inhibitors.

Biased Unmatched Bivalent LigandsTargeting Asymmetrically Signaling GPCR Homodimers

Probes for Biosynthesis of Bacterial Cell Wall

Unique compounds to treat obesity

Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.

Bacterial Histidine Kinase Inhibitor

Tau-targeting Peptides Treat Neurodegenerative Diseases

Universal tyrosine kinase substrates

Non-selective, universal substrates for tyrosine kinases that couple with a fluorescent readout mechanism to serve as quantity and quality control (internally and/or between samples). 

Skin Care Formulations for Preventing and Treating Skin Cancer

Solar UV-Induced Skin Cancer Inhibitor

Fluorescence-based Detection of Kinase Allostery for High-throughput Allosteric Inhibitor Discovery

Adaptive Immune Response Stimulated with TLR8 and Dual TLR7/TLR8 Agonists

Kinase assay to aid in development of therapeutics for acute myeloid leukemia

Peptide substrates to sensitively and specifically measure the real-time activity of FLT3, a kinase linked to acute myeloid leukemia.

PDAC Treatment with High Antiproliferative Activity Against MiaPaca-2

Novel inhibitors of HINT1 to treat neuropathic pain and addiction

Small-molecule inhibitors of hHint1 (and their synthesis) for use in basic CNS research and treatment of neuropathic pain and addiction.

Optimizing Gene Editing in NK Cells for Therapy and Research

Biosynthetic Route to Serofendic Acid

Anti-obesity and Weight Control Drugs Target Melanocortin Receptor

Weight Management Drugs using Selective Melanocortin Ligands

Efficient release of affinity-captured cells

A method to effectively release affinity-captured cells.

Nonsurgical Method for Restoring Tooth Enamel

Peptide Activation of T Cells for Cancer Immunotherapy

Biomarker for Diagnosis of Aggressive Breast Cancer

Improved Pertussis Vaccine

Algorithm for Discovering Genetic Interactions in Genome-Wide Association Studies (BridGE)

1 licensing option
Live Attenuated Viral Vaccines

Nucleic Acid Delivery to the Liver for Hemophilia and Lysosomal Storage Disease Treatment (20150339, Dr. Reineke)

Improved Thiourea Catalysts (20150314, Dr. Steven Kass)

HerdIn:Form(er): Mobile Questionnaire for Livestock Epidemiology Research (20150194, Dr. Andres Perez)

1 licensing option
Midazolam Lysine Prodrug Rapid Delivery System (20150121, Dr. Ronald Siegel)

Potent HIV Integrase Inhibitor (20150106, Dr. Zhengqiang Wang)

High-efficiency Pyrrole Synthesis (20150075, Dr. Ian Tonks)

Therapeutic compound for chronic inflammatory pain without dependence or tolerance (20140357, Dr. Philip Portoghese)

An analgesic compound without side effects that relieves chronic pain associated with arthritis, sickle cell disease, chemotherapy, AIDs and inflammation.

Circulating Tumor Cell Detection with New Reagents (20140299, Dr. Jayanth Panyam)

Mesoporous Silica-coated Iron Oxide Nanoparticle (20140249, Dr. Christy Haynes)

Biguanide Compounds for Estrogen Receptor Positive Breast Cancer Treatment (20140240, Dr. David Potter)

Beta-Catenin Inhibitors

Protein Scaffold for Molecular Targeting Ligands (20140059, Dr. Benjamin Hackel)

Nanoparticles Made of Ultra-Porous Silica (20140012, Dr. Christy Haynes)

FRET Based Assay to Discover Modulators of RyR Calcium Channels (20130323, Dr. Razvan Cornea)

Blood Sugar Regulation with D-serine (20130320, Dr. Amber Lockridge)

Prodrug with Enzyme Increases Absorption of Hydrophobic Drugs (20130297, Dr. Ronald Siegel)

Reagent for Dual Protein Labeling (20130255, Dr. Mark Distefano)

Improved SERCA Assay (20130193, Dr. David Thomas)

Analgesics for Inflammatory Pain (20130119, Dr. Philip Portoghese)

Aurora Kinase Inhibitors for Cancer Treatment (20120305, Dr. Zigang Dong)

Molecular Probe Measures Nucleosides and Differentiation of ATP and ADP (20120272, Dr. Valerie Pierre)

Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)

Analogs of Cabergoline Lessen Side Effects (20120228, Dr. Peter Dosa)

Functionalized Nanoparticles Provide More Effective Anticancer Drug Delivery (20120116, Dr. Jayanth Panyam)

Small Aromatic Molecule Synthesis at Ambient Conditions Using Diels-Alder Reactions and Benzyne Intermediates

Controlled Drug Release with Drug Delivery System (20120102, Dr. Chun Wang)

Fractalkine Binding Aptamers for Drug Delivery (20120074, Dr. Efrosini Kokkoli)

Monocarboxylate Transporter (MCT) Inhibitors to Treat Hypoxic Tumors (20120012)

Bacteriostatic Treatment for Staph Infections (20110209, Dr. Patrick Schlievert)

Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)

Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.

Toxoid Vaccine for Antibiotic Resistant Staphylococcus aureus (20110070, Dr. Patrick Schlievert)

Cancer Treatment Uses Ornithine Decarboxylase Inhibitor (20110052, Dr. Zigang Dong, Dr. Ann Bode)

Treating Carcinomas Using Immunotoxin Specific for Cancer Stem Cells (20110014, Dr. John Ohlfest)

Cancer Vaccine Adjuvant: Annexin II (20100242)

Lysosomal Storage Disease Enzyme Delivery System (20100076)