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Method for treating P300/CBP-dependent tumors using combined P300/CBP inhibition/ degradation, and senolytic therapy
A method for treating P300/CBP-dependent tumors, such as Ewing sarcoma, by selectively eliminating senescence-induced cancer cells through P300/CBP inactivation.
Derivation of human T-(progenitor) cells from human T-cells derived induced pluripotent stem cells (T-iPSCs)
A method for generating T cells from patient-derived induced pluripotent stem cells, enabling scalable and customizable immunotherapies for cancer and other diseases.
Modified myeloid-derived suppressor cells for treating GvHD
A novel cell therapy and associated methods for treating GvHD after allogenic hematopoietic cell transplantation.
A minipromoter for gene therapies
A mini-promoter to accommodate larger therapeutic genes of interest in gene therapy programs
Improved method for the synthesis of flurprimidol
A novel method for the synthesis of flurprimidol and other 5-subsituted pyrimidines.
Compounds that lead to degradation of cancer relevant proteins
Compounds target and degrade kinases, specifically Aurora A and CDK4/6, for effective cancer treatment.
Anti-viral phosphoramidates for treating SARS-CoV and influenza
A method for treating an influenza viral infection or a severe acute respiratory syndrome
Novel small molecule inhibitor to target metabolic plasticity
A novel pharmaceutical candidate with potent MPC and MCT1 inhibition.
Zika as an oncolytic virus to treat brain tumors
A method to treat aggressive brain cancers using Zika as an oncolytic virus combined with anti-cancer vaccinations.
Didehydro-nucleoside antiviral agents
A broad-spectrum antiviral agent platform
Stable glutathione analog for the treatment of Alzheimer’s disease
A metabolically stable glutathione analog that resists degradation and offers protection against oxidative stress.
Therapeutic target for treatment of ataxia
A newly identified pathway that represents a therapeutic target for the prevention and treatment of ataxia.
Use of extracellular vesicles to enhance colorectal cancer therapeutics
Cancer-derived extracellular vesicles (EVs) that enhance the efficacy of checkpoint inhibitor therapeutics for colorectal tumors.
Hyperstable synthetic miniproteins as ligand scaffolds
Hyperstable synthetic miniproteins as modular ligand scaffolds for advanced therapeutics and diagnostics.
Progesterone receptor detection for breast cancer therapy
A test to detect phosphorylated progesterone receptors for patient stratification
CDK2 inhibitors for cancer therapy and male contraception
CDK2 inhibitors for cancer therapy and non-hormonal male contraception with high selectivity and reduced side effects.
Nanorings for cell-mediated drug delivery
Farnesylated chemically self-assembled nanorings that facilitate targeted drug delivery between cells.
Artificial gut/absorption simulator for evaluation of drug formulations dissolution
A device and method for simulating a digestive gut to evaluate drug delivery that incorporates simultaneous absorption with dissolution
Efficient CRISPR-based gene editing for stem cells
A CRISPR-based gene editing protocol for induced pluripotent stem cells (iPSCs) with improved editing efficiency and cell survival.
Single-cell Integration and DrUg Response PrediCtion (scIDUC)
A computational pipeline that predicts drug response scores for individual cells using single-cell RNA sequencing data.
Pharmacological enhancement of CD8 T cell effector function using TEPP46
A clinically viable strategy for preventing mitochondria-mediated T cell exhaustion and enhancing effector T cell function.
First-in-class drug lead candidate (A229) for treating ocular diseases
PPARα agonist, A229, exhibits strong potency and demonstrates efficacy in in-vitro models of diabetic retinopathy.
Bacterial histidine kinase inhibitors for treating Staphylococcus infections
Small molecule bacterial histidine kinase inhibitors that significantly diminish staphylococcal virulence.
Small molecule inhibitors for treating alcoholic hepatitis
Bromodomain inhibitor, UMN627, reduces inflammation in mice models of alcoholic hepatitis.
InTERACCT Program: Occupational health and safety training
Training courses for occupational health and safety workers aimed to equip them to handle risks associated with emerging technologies.
Ovarian cancer prognostic test for predicting response to chemotherapy and bevacizumab
A prognostic molecular test for predicting ovarian cancer patient response to platinum-based chemotherapy and/or treatment with bevacizumab.
Bisubstrate inhibitors for treating SARS-CoV-2 infections
Bisubstrate inhibitors that target the active site of SARS-CoV-2 Nsp14 methyltransferase (MTase) for treating SARS-CoV-2 infections.
Novel compounds for treatment of neurodegenerative disease and chronic pain
Novel alpha2-adrenergic agonists with neuroprotective and/or analgesic properties.
First-generation degraders for class I bromodomain-containing proteins
A bromodomain-targeting degrader of CECR2, an epigenetic regulator that drives cancer metastasis.
NOD-2-active carboxamide compounds as vaccine adjuvants
Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.
Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines
A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.
High-throughput screening assay for sickle cell disease drug discovery
A high-throughput screening assay for discovering small molecules that directly inhibit sickle hemoglobin oligomerization.
Mouse-derived FSHD muscle cell lines
Primary skeletal muscle cell lines isolated from DUX4 expressing FSHD mice.
Small molecules with antiproliferative activity against pancreatic cancer cells
Small molecules that show antiproliferative activity against the pancreatic cancer cell line MiaPaca-2.
Steerable magneto-photonic particles for targeted delivery and collection of light
An embeddable magneto-photonic microparticle that can be externally positioned and orientated for targeted delivery and collection of light.
AgRP-Derived melanocortin-5 receptor peptide antagonists
AgRP derived scaffolds composed of natural (Tyr, Ala, Val, Asn) and unnatural amino acids (Dap) with antagonist activity at the mouse MC5R
Methods for Modifying Proteins and Peptides.
Production of alpha-N-methylated peptides for improved pharmacological properties.
Pain therapy without the risk of respiratory depression, addiction or abuse
An analgesic combination of peripherally restricted opioids that eliminates the risk of respiratory depression, chemical addiction or abuse.
Cell-free selection of site-specific polypeptide binders via tethering
In vitro selection method for the engineering of protein-based high-affinity binders to targets of interest with potential pharmacological value
Compound with selective inhibition potential against P300 and CBT
A compound to treat pediatric sarcoma through the inhibition of P300 and CBT
Live cell assay to quantify the activity of SARS-CoV-2 main protease, Mpro
Fluorescence-based method to effectively screen for protease inhibitors
T cell receptors for engineered T cell therapy
Mesothelin-specific T cell receptors for cell engineering and cancer therapy
Nanominne-1: novel virus-like particle (nanoparticle) vaccines to prevent SARS-CoV-2 infections
Series of novel vaccines containing 60 copies of SARS-CoV-2 antigens displayed in ordered array on a virus-like particle scaffold (nanoparticle)
AGRP-derived melanocortin receptor ligands
Identifying a selective MC4R antagonist for appetite modulation
Chimeric melanocortin receptor ligands
Melanocortin-4 receptor ligand reduces food intake in mice
Selective melanocortin receptor ligands
Potential dual-ligand approach to weight management
Novel anti-cancer agents that target the epigenetic reader protein
Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.
Assessing tumor behavior and response to therapy
A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.
Machine learning for early cancer detection
A machine learning method to train and validate algorithms to classify cancer risk based on a blood sample.
Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction
Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.
Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)
An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.
Adenovirus Vector Generating System (20110090)
Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)
A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.
Antagomir to prevent cardiac arrhythmia (2019-069)
A novel small molecule screening platform for tauopathies (2019-123)
FRET-based biosensors that identify early toxic states of tau for use in basic research and clinical development of therapeutics for tauopathies including Alzheimer’s Disease.
Opioid and Analgesic Chemical Compound Library (z09208)
Carcinoma Immunotoxin Targeting Epidermal Growth Factor and Interleukin-4 Receptors
Kappa Receptor Agonists and Delta Receptor Antagonists
More Stable and Potent Cyclic ADP-Ribose Analogs
Treating Neurodegenerative Diseases with Nicotine Receptor Ligands
Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ)
The Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ) is a validated patient-oriented measure of the adverse effects of heart failure on a patient's life.
Minnesota Solvation (MNSOL) Database
An extensive and vetted database of free energies of solvation.
Living with Pulmonary Hypertension Questionnaire (LPHQ)
The Living with Pulmonary Hypertension Questionnaire (LPHQ) is a reliable and validated measure of the adverse effects of pulmonary hypertension on a patient’s life.
Selective bromodomain protein inhibitors that reduce cancer cell viability
Small molecules systematically designed as highly selective bromodomain inhibitors for development as cancer and inflammatory disease therapeutics.
Reduce contamination from grains and powdered food
A method for scalable, non-thermal or low temperature pasteurization of powdered or particulate food.
A synergistic therapy for multi-drug resistant cancers
A synthetic polymer that targets cancer cell membranes and works synergistically with existing chemotherapeutic drugs to treat drug-resistant solid tumors.
3D tumor models for accurate testing of therapeutics
A method to create a 3D tumor model that accurately mimics both tumor behavior and environment for use in anti-cancer drug development.
A TLR-2 stimulatory molecule for use as a vaccine adjuvant
A small molecule that serves as an adjuvant in vaccines through stimulation of the immune receptor, TLR-2
Antibody based treatment for Type 1 Diabetes
A humanized monoclonal antibody against Serpin B13 to treat Type 1 Diabetes.
Immunostimulatory conjugates for targeted delivery as adjuvants
Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure
Drug Delivery Device for Oral Topical Medicine
Novel small molecules for chemotherapy sensitization
Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.
Assay to measure intrinsic efficiency of GPCR ligands
FRET-based GPCR biosensors to measure specific ligand activation in a cell independent manner.
MHC Class II Molecules with Enhanced Co-receptor Affinity
A novel dual-action drug targeting cancer and respiratory syndromes
A novel compound inhibiting translation and inducing p53 independently of DNA damage, with potential for treating both cancer and acute respiratory syndromes.
Tosedostat (CHR-2797) as a Potential Analgesic
Specific kinase biosensors to probe cancer metabolism
Substrate peptides for Ser/Thr kinases to investigate the metabolic processes of cancer cells.
Probes for Biosynthesis of Bacterial Cell Wall
Unique compounds to treat obesity
Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.
Bacterial Histidine Kinase Inhibitor
Universal tyrosine kinase substrates
Non-selective, universal substrates for tyrosine kinases that couple with a fluorescent readout mechanism to serve as quantity and quality control (internally and/or between samples).
Solar UV-Induced Skin Cancer Inhibitor
Adaptive Immune Response Stimulated with TLR8 and Dual TLR7/TLR8 Agonists
Kinase assay to aid in development of therapeutics for acute myeloid leukemia
Peptide substrates to sensitively and specifically measure the real-time activity of FLT3, a kinase linked to acute myeloid leukemia.
PDAC Treatment with High Antiproliferative Activity Against MiaPaca-2
Novel inhibitors of HINT1 to treat neuropathic pain and addiction
Small-molecule inhibitors of hHint1 (and their synthesis) for use in basic CNS research and treatment of neuropathic pain and addiction.
Biosynthetic Route to Serofendic Acid
Efficient release of affinity-captured cells
A method to effectively release affinity-captured cells.
Nonsurgical Method for Restoring Tooth Enamel
Peptide Activation of T Cells for Cancer Immunotherapy
Improved Pertussis Vaccine
Algorithm for Discovering Genetic Interactions in Genome-Wide Association Studies (BridGE)
Live Attenuated Viral Vaccines
HerdIn:Form(er): Mobile Questionnaire for Livestock Epidemiology Research (20150194, Dr. Andres Perez)
Midazolam Lysine Prodrug Rapid Delivery System (20150121, Dr. Ronald Siegel)
Potent HIV Integrase Inhibitor (20150106, Dr. Zhengqiang Wang)
High-efficiency Pyrrole Synthesis (20150075, Dr. Ian Tonks)
Therapeutic compound for chronic inflammatory pain without dependence or tolerance (20140357, Dr. Philip Portoghese)
An analgesic compound without side effects that relieves chronic pain associated with arthritis, sickle cell disease, chemotherapy, AIDs and inflammation.
Circulating Tumor Cell Detection with New Reagents (20140299, Dr. Jayanth Panyam)
Mesoporous Silica-coated Iron Oxide Nanoparticle (20140249, Dr. Christy Haynes)
Biguanide Compounds for Estrogen Receptor Positive Breast Cancer Treatment (20140240, Dr. David Potter)
Protein Scaffold for Molecular Targeting Ligands (20140059, Dr. Benjamin Hackel)
Mesoporous silica nanoparticles with ultra high porosity
Novel mesoporous silica nanoparticles with high pore volume and open pore structure, displaying high thermal stability and mechanical sturdiness
Prodrug with Enzyme Increases Absorption of Hydrophobic Drugs (20130297, Dr. Ronald Siegel)
Reagent for Dual Protein Labeling (20130255, Dr. Mark Distefano)
Analgesics for Inflammatory Pain (20130119, Dr. Philip Portoghese)
Aurora Kinase Inhibitors for Cancer Treatment (20120305, Dr. Zigang Dong)
Molecular Probe Measures Nucleosides and Differentiation of ATP and ADP (20120272, Dr. Valerie Pierre)
Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)
Analogs of Cabergoline Lessen Side Effects (20120228, Dr. Peter Dosa)
Functionalized Nanoparticles Provide More Effective Anticancer Drug Delivery (20120116, Dr. Jayanth Panyam)
Small Aromatic Molecule Synthesis at Ambient Conditions Using Diels-Alder Reactions and Benzyne Intermediates
Fractalkine Binding Aptamers for Drug Delivery (20120074, Dr. Efrosini Kokkoli)
Monocarboxylate Transporter (MCT) Inhibitors to Treat Hypoxic Tumors (20120012)
Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)
Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.