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A novel approach for bioprinting complex tissue models

A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.

HapShared - a software for pedigree reconstruction

A Python script for performing complex pedigree analysis with high sensitivity.

1 licensing option
Triumph™ Brand Apples

The latest apple cultivar from the renowned University of Minnesota apple breeding team.

Minimally invasive diagnostic for osteosarcoma in dogs

A panel of six definitive biomarkers that can be isolated from a canine blood sample for the detection of minimal residual disease and monitoring remission in dogs treated for osteosarcoma.

A method to identify cell-free biomarkers of cancers and other diseases

A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.

Assessing tumor behavior and response to therapy

A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.

Machine learning for early cancer detection

A machine learning method to train and validate algorithms to classify cancer risk based on a blood sample.

Remote sensing based classification of soybean aphid-induced stress in soybean

A method for identification of soybean aphid infestation and classification based level of infestation.

Detection of toxic small molecules using polymers and Raman scattering

A method to capture small molecules using polymers for quantitative detection using surface-enhanced Raman scattering.

Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)

An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.

Juicy Jewel™ Brand Pears

An early-ripening Asian-type pear that produces sweet, crisp fruits with yellow-green skin and the occasional orange-pink blush.

Golden Sunset™ Grass

An attractive grass variety with olive-green foliage and yellow-gold flowers.

SARS-CoV-2 N-protein for use in COVID-19 serological assays (2020-323)

Full length SARS-CoV-2 Nucleocapsid (N) protein expressed by bacteria for use in serological assays to detect previous COVID-19 infection in humans and animals.

Continuous honey bee cell-line, AmE-711 (2020-240)

The first and only honey bee cell-line available for use in research and experimental testing.

Pharmacological agents to prevent recurrent C. diff infection (20150362)

Cholic and bile acid derivatives that inhibit Clostridium difficile spore germination to prevent or treat C. diff infection.

Siderophore-based diagnosis of bacterial infections (20150206)

Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)

A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.

Food Supply Chain Risk Assessment and Mitigation Tools (20180173)

Technology #20180173-20180174-20180175-20180176-20180177-20180178

E. Coli Fermentation of Glycerol from Biodiesel Waste into Ethanol

Geothermal Power Generation from Carbon Dioxide Sequestration Uses Renewable Resources

Geothermal Power Generation: Clean Energy from Carbon Dioxide Sequestration

Corn Stover Agglomerates for Oil Absorption

High Yield Ammonia Production

Ammonia Production without Molecular Hydrogen for use in Fertilizer Production

Bactericidal Lanbiotic Inhibits Gram-negative Bacteria

Cold Hardy Marquette Grape Variety

2 licensing options
MRI of Amyloid Plaque in the Brain

Biodiesel and Enriched Animal Feed from Dry Distillers Grains with Solubles Created in Ethanol Production

SnowSweet® Apple, Cold Hardy with Sweet Tart Taste

2 licensing options
Mammalian Cell Culture System for Anaplasmosis Vaccine Development

Mutated Opioid Receptors Block Chronic Pain Signals

Cold Hardy Frontenac gris Grape Variety

2 licensing options
Nonlinear Post Beamforming Filter for Imaging

Ecdysteroid Biosynthetic Enzyme Inhibitors

Blue Heaven Ornamental Grass

1 licensing option
Cold Hardy La Crescent Grape Variety

2 licensing options
Turkey Production Improvements

Bifidobacteria Strain Depletes Iron-Dependent Bacteria

Nematode Biocontrol Agent

Nutrition Data System for Research – Nutritional Analysis Software

Food and Nutrient Database for Application Development and Nutrition Research

Zestar!® Cold Hardy, Early Season Apple Variety

2 licensing options
FINPACK® Financial Software for Agricultural and Farm Management

FINPACK® is the credit analysis solution that can help lenders work smarter and serve customers better.

Honeycrisp Apples - Cold Hardy, Minnesota Apple

Explosively Crisp!

Decontamination of food and surfaces from viral contamination using photodynamic treatment

An inexpensive, non-thermal method for decontamination of foods from viral contaminants without affecting their quality.

3D printable deer head and neck model

Chronic wasting disease transmission and progression e-booklet

An informative and captivating e-booklet on chronic wasting disease transmission and progression.

2 licensing options
S100A4 inhibitor “Minnetamide” for prostate cancer treatment

Sustainable triblock copolymers as strong, tunable, and degradable pressure sensitive adhesives

A method to produce strong, tunable, and degradable pressure sensitive adhesives from by-products of the cashew industry.

Nanoparticle bio-pesticide to improve crop health, germination, and overall yield

A material and method of application for improving crop health and yield.

Novel process to obtain large quantities of primary cells for transplantation

A method to isolate large quantities of high quality primary cells for therapeutic transplantation through freezing and thawing organs, including organs typically considered suboptimal for donation.

Fully-biodegradable controlled release coatings for fertilizer

A new, fully-biodegradable material and method of preparation of slow release fertilizers.

Method for genetic engineering of legume species (2019-351, Dr. Daniel Voytas, Dr. Feng Zhang)

A method to genetically modify a variety of legume species that is efficient, fast and doesn’t require technical skills such as traditional tissue culture.

Selective bromodomain protein inhibitors that reduce cancer cell viability

Small molecules systematically designed as highly selective bromodomain inhibitors for development as cancer and inflammatory disease therapeutics.

Augmented sgRNAs for enhanced plant genome engineering (2019-322, Dr. Daniel Voytas)

The Voytas Lab has developed augmented sgRNAs that improve somatic cell genome editing and produce heritable modifications in plants using CRISPR/Cas9.

3D printed bionic skull for multimodal neural sensing

Reduce contamination from grains and powdered food

A method for scalable, non-thermal or low temperature pasteurization of powdered or particulate food.

Simplified, Single-Vessel Synthesis and Separation of Ammonia

An apparatus and process for simplified, high yield production of ammonia using a single vessel, isothermal reactor.

Nesocodin: A natural red colorant that’s easily synthesized

A method to synthesize a novel, natural red colorant that is biodegradable and likely non-toxic.

Fluorescence-based assay for probing lipid transfer activity

A sensitive, reproducible and quantitative assay to study lipid transfer using bicelles as model membranes.

A synergistic therapy for multi-drug resistant cancers

A synthetic polymer that targets cancer cell membranes and works synergistically with existing chemotherapeutic drugs to treat drug-resistant solid tumors.

Heart’s Desire™ Brand Redbud Spring Flowering Tree

Novel anticancer compound that targets metabolic plasticity

F-MN-D1 compound targets metabolic plasticity common to many solid tumors through inhibition of glycolysis and oxidative phosphorylation facilitating tumor growth reduction.

CoFe nanowires for remote heating using an alternating magnetic field

A nanowire material for remote, rapid and uniform heating of biological samples.

Subfield Level Model for Improved Nitrogen Fertilizer Recommendations

Biodegradable lactose-based hydrogel

A method to produce biodegradable lactose-based hydrogel from lactose-containing dairy waste.

A TLR-2 stimulatory molecule for use as a vaccine adjuvant

A small molecule that serves as an adjuvant in vaccines through stimulation of the immune receptor, TLR-2

Delivery of developmental regulators to whole plants for the induction of genetically altered meristematic tissue (Dr. Voytas)

Research out of the Voytas Lab provides a method for the creation of genetically-altered seeds within one generation via the induction of new plant meristems.

Unique small molecule modulators of GPCRs

Novel small molecules that bind and modulate G-protein coupled receptors (specifically Sigma 1 and 5-HT7) for therapeutic development.

Antibody based treatment for Type 1 Diabetes

A humanized monoclonal antibody against Serpin B13 to treat Type 1 Diabetes.

Immunostimulatory conjugates for targeted delivery as adjuvants

Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure

Cancer preventative for at risk individuals

An approach to prevent cancers through blocking the transcription factor STAT3 that leads to an 80% tumor reduction in a mouse model of disease.

Plant Biometric Estimation Using 3D Models

3D Plant Reconstruction and Biometric Measurement

Trotter or Pacer? Accurate Method to Detect Preferred Gait in Standardbred Horses

A genetic testing method to accurately (>99%) predict gait profile of Standardbred horses around the globe.

Novel small molecules for chemotherapy sensitization

Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.

Quality Control Test for Pathogenic Bacteria Contaminated Water

Patient Controlled Dynamic Therapeutic Compression Tension Garment

MHC Class II Molecules with Enhanced Co-receptor Affinity

High Yield Synthesis of Bio-based Acrylic Acid and Acrylate Monomers from Lactic Acid (20180106, Dr. Marc Hillmyer)

A novel chemotherapy drug with reduced patient side-effects

A novel anti-cancer compound that inhibits translation and induces p53 in a DNA-damage independent manner to cause cell cycle arrest and apoptosis.

High Ammonia Absorbing Corn Stover Hydrochar for use in Horse Bedding

Microinjection for Single Cell Gene Manipulation

Referenceless Nyquist Ghost Correction for Echo Planar Imaging (EPI)

Segmenting 3D Bone Computed Tomography Data

Tosedostat (CHR-2797) as a Potential Analgesic

Engineering Human CD64 Chimeric Receptors for Immune Therapy

Integrated Traumatic Brain Injury Catheter (iTBI)

Chewing Simulator Provides Sensory Information

Real-Time Reporter and Efficient Enzymes for DNA Editing

Versatile Biocatalyst System for Synthesizing Chemicals, Pharmaceuticals and Food Ingredients

Optimized Radio Frequency Pulses Generated From Magnetic Resonance User Defined Parameters

Scan-Specific Machine Learning Reconstruction for MRI

Sliding Windowed Infinite Fourier Transform (SWIFT)

MRI and Spectroscopy Multi-part Body Coil

3D Microscale Isotropic Metamaterials

Biased Unmatched Bivalent LigandsTargeting Asymmetrically Signaling GPCR Homodimers

Probes for Biosynthesis of Bacterial Cell Wall

Unique compounds to treat obesity

Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.

Increase Signal-to-noise Ratio in Imaging Data

Bacterial Histidine Kinase Inhibitor

Faster MRI Acquistion with Motion Robustness

Tunable Neural Electrodes for MRI-Compatible Brain Signal Recordings

Biomass Absorbs Phosphates and Phosphate-Containing Herbicide (Organophosphates)

Myocardial Viability Functional Assessment

Dynamic Quantification of Myocardial Tissue MRI

Orthopedic Meniscus Repair Implant, Introducer and Delivery System

Conformable Dual-mode Ultrasound Transducers for Neuromodulation

Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC

Single Voxel MR Spectroscopy of Human Brain with Automatic Voxel Positioning

Solar UV-Induced Skin Cancer Inhibitor

Magnetization Transfer Contrast Preparation

Multi-modal Neuromodulation Therapy Promotes Sleep

Pediatric Tracheo-bronchomalacia Stent and Deployment System

Fluorescence-based Detection of Kinase Allostery for High-throughput Allosteric Inhibitor Discovery

Mimicked Calcified Annulus Model for Preclinical Assessment of TAVR Devices

1 licensing option
Motion-Robust Cardiac B1+ Mapping of the Transmit Field

Imaging Source Distribution from Electromagnetic Signals

High-voltage, Fully-integrated, High-density Microstimulator with Charge Balancing

Predicting Crop Yield and Quality Using Canopy Reflectance and LiDAR Sensors

Simultaneous RF Signal Transmission and Reception in MRI (20160420)

Neural Recording under Electrical Microstimulation

Adaptive Immune Response Stimulated with TLR8 and Dual TLR7/TLR8 Agonists

Black-Blood T1 Myocardial Mapping to Remove Partial Voluming Effects

PDAC Treatment with High Antiproliferative Activity Against MiaPaca-2

Lung Biopsy Tool

Treating Tumors with High Intensity Focused Ultrasound

Novel inhibitors of HINT1 to treat neuropathic pain and addiction

Small-molecule inhibitors of hHint1 (and their synthesis) for use in basic CNS research and treatment of neuropathic pain and addiction.

Optimizing Gene Editing in NK Cells for Therapy and Research

Anti-obesity and Weight Control Drugs Target Melanocortin Receptor

Porcine B lymphoma cell lines

Three porcine B cell lines (Murtaugh001, Murtaugh002, Murtaugh003) established by 3 rounds of limiting dilution from splenic and subiliac lymph node lymphomas.

Weight Management Drugs using Selective Melanocortin Ligands

Smart Clothing with Dynamically Controlled Compression

Engineered enzymes to disrupt bacterial communication and reduce virulence

Engineered enzymes that inhibit bacterial virulence factors by breaking down bacterial communication molecules.

Engineered enzymes to disrupt and prevent biofilms

Engineered enzymes that inhibit hazardous and infectious biofilms by breaking down bacterial communication molecules.

Environmentally-friendly, enzymatic anticorrosion and antifouling coating

A method to reduce microbial-caused corrosion and biofouling through the use of an enzymatic coating to disrupt bacterial communication

Multiplex Plant Gene Targeting through Homologous Recombination (20160266, Dr. Daniel Voytas)

Designing 2D and 3D Adiabatic Pulses

Neuromodulator for Simultaneous Stimulation and Signal Reception

Colorimetric Assay for Microbial Screening

Improved Craniotome to Prevent Dural Tear

Efficient release of affinity-captured cells

A method to effectively release affinity-captured cells.

Efficient Bio-intensive Gardening Tool Design

Developing Highly Specific Monoclonal Antibodies to Peptide in the Context of MHC II

Nonsurgical Method for Restoring Tooth Enamel

Peptide Activation of T Cells for Cancer Immunotherapy

Radiofrequency Antenna Array with Electric Dipole and Loop Elements

Biomarker for Diagnosis of Aggressive Breast Cancer

Warming of Cryopreserved Biomaterials using Laser Assisted Gold Nanorods

Improved Pertussis Vaccine

Bee Squad Varroa Mite Testing Kit

Algorithm for Discovering Genetic Interactions in Genome-Wide Association Studies (BridGE)

1 licensing option
Hydrophobic Surfaces for Tooth Tissues

High Quality Mosaics from UAV Obtained Images

Automated Detection of Nitrogen Deficiency in Corn

Glyphosate Resistance from Altered EPSPS Plant Genes (20160028, Dr. Daniel Voytas)

Adaptive Refocusing of Ultrasound Arrays Using Synthetic Aperture Imaging Data

Live Attenuated Viral Vaccines

Nucleic Acid Delivery to the Liver for Hemophilia and Lysosomal Storage Disease Treatment (20150339, Dr. Reineke)

Catheter System with Guidewire Compartmentalization (20150223, Dr. Rumi Faizer)

HerdIn:Form(er): Mobile Questionnaire for Livestock Epidemiology Research (20150194, Dr. Andres Perez)

1 licensing option
Lower Extremity Edema Monitor (20150192, Dr. Rajesh Rajamani)

Deep Brain Stimulation Using Magnetic Brain Array (20150177, Dr. Jian-Ping Wang)

Improved Deep Brain Stimulation Target Selectivity (20150170, Dr. Shalom Michaeli)

Increased efficiency of CRISPR-Cas9 genome editing (20150143, Dr. Wendy Gordon)

An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.

Improved MRI Quality with Gradient Modulation Pulse Sequence (20150133, Dr. Kobayashi, Dr. Garwood)

Acousto-electromagnetic Imaging of the Brain (20150126, Dr. Bin He)

Phytate Extraction from Corn Ethanol Coproducts (20150123, Dr. Bo Hu)

HILAGE: Haploid Inducer Line for Accelerated Genome Editing (20150117, Dr. Robert Stupar)

Biodiesel from Scum Oil and Waste Oil (20150113, Dr. Roger Ruan)

Time Efficient Arterial Spin Labeling Imaging with Segmented Multiband-acquisition (20150097, Dr. Greg Metzger)

Cold Hardy Itasca Grape Variety

2 licensing options
Improved MRI Method Uses Temperature Rise Contraints (20150061, Dr. Moortele)

LJ-1000 Apple Variety (20150018, Dr. Bedford)

1 licensing option
Therapeutic compound for chronic inflammatory pain without dependence or tolerance (20140357, Dr. Philip Portoghese)

An analgesic compound without side effects that relieves chronic pain associated with arthritis, sickle cell disease, chemotherapy, AIDs and inflammation.

Biofertilizer from Genetically-modified Azotobacter vinelandii (20140348, Dr. Brett Barney)

Mapping Prostate Cancer from Multi-parametric MRI with Improved Predictive Models (20140287, Dr. Greg Metzger)

In-vivo MRI Radiofrequency Pulses Robust against Respiration Induced Errors (20140236, Dr. Kamil Ugurbil)

Microbiome Profiling Techninque for Improving Commercial Turkey Production (20140230, Dr. Timothy Johnson)

Physocarpus Opulifolius “Center Glow Ninebark” (20140201, Dr. Harold Pellett)

2 licensing options
Multi-band SWIFT Improves MRI (20140121, Dr. Idiyatullin, Dr. Garwood)

Generalized Multiband Slice Accelerated Imaging (20140093, Dr. Dingxin Wang)

Bovine Tuberculosis Screening (20140058, Dr. Srinand Sreevatsan)

Reduced-power SWIFT Magnetic Resonance Imaging (20140052, Dr. Jinjin Zhang, Dr. Garwood)

Precision Agriculture Drone Algorithms (20140013, Dr. Volkan Isler)

Wheat Variety Selection Tool for Wheat Farming (20140006, Dr. Jochum Wiersma)

Conferring Plant Resistance to Geminiviruses using CRISPR/Cas Systems (20130311, Dr. Daniel Voytas)

Hay Prices per Ton Calculator App (20130300, Dr. Krishona Martinson)

Healthy Horse App Calculates Weight (20130294, Dr. Krishona Martinson)

Multislice Multiband Excitation with Parallel Transmission for B1 Homogenization and Power Reduction (20130170)

IV Line Lifting Device (20130136, Dr. Mary Hooke)

Intraoral Dental MRI Coil (20130110, Dr. Michael Garwood)

MRI Signal Separation using Iterative Calibration (20130079, Dr. Kamil Ugurbil)

Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)

Immunotherapy for Dogs with Increased Immune Response (20120263, Dr. John Ohlfest)

Simultaneous RF Transmit and Receive in MRI Coils (20120123, Dr. Tommy Vaughan)

MRI Coil Amplifiers (20120122, Dr. Tommy Vaughan)

Human Whole-Body Imaging at 7T (20120120, Dr. Tommy Vaughan)

Electrical Auto-tuning for Ultra-High-Field MRI RF Coils (20120119, Dr. Tommy Vaughan)

MRI Method Reduces Peak Power for Multiband Images (20120077, Dr. Kamil Ugurbil)

Synchronized Multi-Modal Tinnitus Therapy (20120070, Dr. Hubert Lim)

A non-invasive or minimally-invasive method for the suppression of tinnitus using synchronized brain stimulation.

Canine Lymphoma Prognostic Classification (20120065, Dr. Jaime Modiano)

Beam Steering Resonance along a Spatiotemporal Trajectory for MRI (20120060, Dr. Michael Garwood)

MRI Pulse Sequence: Steering Resonance over the Object (20120049, Dr. Michael Garwood)

Faster Functional and Diffusion MRI of the Brain (20110139, Dr. Kamil Ugurbil)

Lower Specific Absorption Rate for Multiband MRI (20110093, Dr. Kamil Ugurbil)

Faster Whole Brain Imaging (20110092, Dr. Kamil Ugurbil)

Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)

Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.

Minnesota First Kiss™ Apple (MN55 Variety) (20110037, Dr. David Bedford)

Insulin Producing Cells from Pluripotent Stem Cells (20100245)

Ultrasound System for Characterization and Image-guided Therapy of Blood Vessel Diseases (20100155)

Tracking Deformation of Organs during Minimally Invasive Surgery