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Pulsed electric field processing of dairy proteins

A method of using pulsed electric field processing to modify functional properties of dairy proteins

Silica-coated polymeric nanoparticles for silicic acid delivery

Novel silica-coated nanoparticles with a stimulus-responsive core that can swell and fracture the surrounding silica shell, leading to the release of silicic acid.

Clarion Grape Variety

1 licensing option
Rapid detection and prediction of functional characteristics of dairy powders using near-infrared spectroscopy

A model for predicting the functional properties of dairy powders characterized using NIR spectroscopy

Therapeutic target for treatment of ataxia

A newly identified pathway that represents a therapeutic target for the prevention and treatment of ataxia.

Use of extracellular vesicles to enhance colorectal cancer therapeutics

Cancer-derived extracellular vesicles (EVs) that enhance the efficacy of checkpoint inhibitor therapeutics for colorectal tumors.

Kudos® Apple Variety

1 licensing option
Inverse modeling based approach for land cover mapping

A modeling approach for generating land cover maps for crop growth predictions utilizing satellite images and weather data

An assay for detecting Palmer amaranth DNA in individual and mixed samples

A method and kit for determining whether a sample contains Amaranthus palmeri, a prohibited noxious seed in multiple states, plant material.

Encapsulated supported anaerobic biofilms for enhanced methane production

Encapsulated anaerobic biofilms for treating wastewater and generating desirable products such as methane or hydrogen gas.

Phytoremediation of PFAS with ultraporous silica nanoparticles

A method for the phytoremediation of PFAS from contaminated soil using ultraporous mesostructured silica nanoparticles.

Fixation of nitrogen from renewable resources using non-thermal plasma

A system that fixates nitrogen from air and water to produce nitrate-rich liquids using non-thermal plasma-assisted catalytic reactions.

Generating teratoma-derived skeletal muscle stem cells

A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.

Small molecules with antiproliferative activity against pancreatic cancer cells

Small molecules that show antiproliferative activity against the pancreatic cancer cell line MiaPaca-2.

Genetically modified endophyte with biofertilizer potential

A genetically modified bacteria (G. diazotrophicus) that is an established plant endophyte and releases high amounts of ammonium when grown on simple sugars

Engineered bacteria for the synthesis of a biodegradable polymer coating

Genetically modified bacteria for the synthesis of a biodegradable polymer to coat fertilizer pellets, allowing nitrogen to be slowly released over time.

AgRP-Derived melanocortin-5 receptor peptide antagonists

AgRP derived scaffolds composed of natural (Tyr, Ala, Val, Asn) and unnatural amino acids (Dap) with antagonist activity at the mouse MC5R

Automatic Evaluation of Wheat Resistance to Fusarium Head Blight Using Dual Mask

A method that enables the rapid recognition of wheat spikes and the fungus Fusarium Head Blight diseased areas in wheat.

Method to produce pea protein with improved functionality

A novel method to produce soluble pulse proteins with longer shelf-life that features a clean label and does not compromise nutritional value.

Treating trauma-induced acute blood loss

Novel formulations of D-β-hydroxybutyrate and melatonin improve survival from hemorrhagic shock.

Pain therapy without the risk of respiratory depression, addiction or abuse

An analgesic combination of peripherally restricted opioids that eliminates the risk of respiratory depression, chemical addiction or abuse.

A process to make ultra-high purity urea at low cost by using enzymes

Low cost enzyme-processed ultra-high purity urea for high-grade fertilizer, diesel emissions fluid and pharmaceuticals

3D printable bovine head model

AGRP-derived melanocortin receptor ligands

Identifying a selective MC4R antagonist for appetite modulation

Chimeric melanocortin receptor ligands

Melanocortin-4 receptor ligand reduces food intake in mice

Selective melanocortin receptor ligands

Potential dual-ligand approach to weight management

Sugar-secreting green microalga

A microalgae strain that secretes simple sugars in conditions favorable for co-culture schemes and fermentation processes.

Multi-faceted glue for long-term survival of osseointegrated prosthetic devices

A multi-functional photopolymerizable glue that enhances the physical and biological adhesion between soft skin and a metal prosthetic device.

Risk-free in situ non animal (RISNA) surrogate assay for African swine fever virus

A method of using a surrogate virus to confirm inactivation of African Swine Fever Virus(ASFV)

A novel approach for bioprinting complex tissue models

A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.

HapShared - a software for pedigree reconstruction

A Python script for performing complex pedigree analysis with high sensitivity.

1 licensing option
Triumph™ Brand Apples

The latest apple cultivar from the renowned University of Minnesota apple breeding team.

Minimally invasive diagnostic for osteosarcoma in dogs

A panel of six definitive biomarkers that can be isolated from a canine blood sample for the detection of minimal residual disease and monitoring remission in dogs treated for osteosarcoma.

A method to identify cell-free biomarkers of cancers and other diseases

A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.

Assessing tumor behavior and response to therapy

A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.

Machine learning for early cancer detection

A machine learning method to train and validate algorithms to classify cancer risk based on a blood sample.

Remote sensing based classification of soybean aphid-induced stress in soybean

A method for identification of soybean aphid infestation and classification based level of infestation.

Detection of toxic small molecules using polymers and Raman scattering

A method to capture one or more analytes using polymers to enable multiplex quantitative detection by surface-enhanced Raman scattering

Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)

An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.

Juicy Jewel™ Brand Pears

An early-ripening Asian-type pear that produces sweet, crisp fruits with yellow-green skin and the occasional orange-pink blush.

Golden Sunset™ Grass

An attractive grass variety with olive-green foliage and yellow-gold flowers.

Continuous honey bee cell-line, AmE-711 (2020-240)

The first and only honey bee cell-line available for use in research and experimental testing.

Siderophore-based diagnosis of bacterial infections (20150206)

Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)

A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.

Food Supply Chain Risk Assessment and Mitigation Tools (20180173)

Technology #20180173-20180174-20180175-20180176-20180177-20180178

E. Coli Fermentation of Glycerol from Biodiesel Waste into Ethanol

Corn Stover Agglomerates for Oil Absorption

High Yield Ammonia Production

Ammonia Production without Molecular Hydrogen for use in Fertilizer Production

Bactericidal Lanbiotic Inhibits Gram-negative Bacteria

Cold Hardy Marquette Grape Variety

2 licensing options
MRI of Amyloid Plaque in the Brain

Biodiesel and Enriched Animal Feed from Dry Distillers Grains with Solubles Created in Ethanol Production

SnowSweet® Apple, Cold Hardy with Sweet Tart Taste

2 licensing options
Mammalian Cell Culture System for Anaplasmosis Vaccine Development

Mutated Opioid Receptors Block Chronic Pain Signals

Cold Hardy Frontenac gris Grape Variety

2 licensing options
Blue Heaven Ornamental Grass

1 licensing option
Cold Hardy La Crescent Grape Variety

2 licensing options
Bifidobacteria Strain Depletes Iron-Dependent Bacteria

Nematode Biocontrol Agent

Zestar!® Cold Hardy, Early Season Apple Variety

2 licensing options
FINPACK® Financial Software for Agricultural and Farm Management

FINPACK® is the credit analysis solution that can help lenders work smarter and serve customers better.

Honeycrisp Apples - Cold Hardy, Minnesota Apple

Explosively Crisp!

Decontamination of food and surfaces from viral contamination using photodynamic treatment

An inexpensive, non-thermal method for decontamination of foods from viral contaminants without affecting their quality.

3D printed deer head and neck model

Chronic wasting disease transmission and progression e-booklet

An informative and captivating e-booklet on chronic wasting disease transmission and progression.

2 licensing options
Sustainable triblock copolymers as strong, tunable, and degradable pressure sensitive adhesives

A method to produce strong, tunable, and degradable pressure sensitive adhesives from by-products of the cashew industry.

Nanoparticle bio-pesticide to improve crop health, germination, and overall yield

A material and method of application for improving crop health and yield.

Selective bromodomain protein inhibitors that reduce cancer cell viability

Small molecules systematically designed as highly selective bromodomain inhibitors for development as cancer and inflammatory disease therapeutics.

Reduce contamination from grains and powdered food

A method for scalable, non-thermal or low temperature pasteurization of powdered or particulate food.

Simplified, Single-Vessel Synthesis and Separation of Ammonia

An apparatus and process for simplified, high yield production of ammonia using a single vessel, isothermal reactor.

Nesocodin: A natural red colorant that’s easily synthesized

A method to synthesize a novel, natural red colorant that is biodegradable and likely non-toxic.

Fluorescence-based assay for probing lipid transfer activity

A sensitive, reproducible and quantitative assay to study lipid transfer using bicelles as model membranes.

A synergistic therapy for multi-drug resistant cancers

A synthetic polymer that targets cancer cell membranes and works synergistically with existing chemotherapeutic drugs to treat drug-resistant solid tumors.

Heart’s Desire™ Brand Redbud Spring Flowering Tree

CoFe nanowires for remote heating using an alternating magnetic field

A nanowire material for remote, rapid and uniform heating of biological samples.

Biodegradable lactose-based hydrogel

A method to produce biodegradable lactose-based hydrogel from lactose-containing dairy waste.

A TLR-2 stimulatory molecule for use as a vaccine adjuvant

A small molecule that serves as an adjuvant in vaccines through stimulation of the immune receptor, TLR-2

Delivery of developmental regulators to whole plants for the induction of genetically altered meristematic tissue (Dr. Voytas)

Research out of the Voytas Lab provides a method for the creation of genetically-altered seeds within one generation via the induction of new plant meristems.

Antibody based treatment for Type 1 Diabetes

A humanized monoclonal antibody against Serpin B13 to treat Type 1 Diabetes.

Immunostimulatory conjugates for targeted delivery as adjuvants

Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure

Plant Biometric Estimation Using 3D Models

3D Plant Reconstruction and Biometric Measurement

Novel small molecules for chemotherapy sensitization

Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.

Patient Controlled Dynamic Therapeutic Compression Tension Garment

MHC Class II Molecules with Enhanced Co-receptor Affinity

High Yield Synthesis of Bio-based Acrylic Acid and Acrylate Monomers from Lactic Acid (20180106, Dr. Marc Hillmyer)

A novel dual-action drug targeting cancer and respiratory syndromes

A novel compound inhibiting translation and inducing p53 independently of DNA damage, with potential for treating both cancer and acute respiratory syndromes.

High Ammonia Absorbing Corn Stover Hydrochar for use in Horse Bedding

Microinjection for Single Cell Gene Manipulation

Referenceless Nyquist Ghost Correction for Echo Planar Imaging (EPI)

Segmenting 3D Bone Computed Tomography Data

Tosedostat (CHR-2797) as a Potential Analgesic

Chewing Simulator Provides Sensory Information

Real-Time Reporter and Efficient Enzymes for DNA Editing

Versatile Biocatalyst System for Synthesizing Chemicals, Pharmaceuticals and Food Ingredients

Optimized Radio Frequency Pulses Generated From Magnetic Resonance User Defined Parameters

Scan-Specific Machine Learning Reconstruction for MRI

Sliding Windowed Infinite Fourier Transform (SWIFT)

3D Microscale Isotropic Metamaterials

Probes for Biosynthesis of Bacterial Cell Wall

Unique compounds to treat obesity

Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.

Denoising Magnetic Resonance Imaging Data

NOise reduction with DIstribution Corrected (NORDIC) technique for improving MRI imaging.

Bacterial Histidine Kinase Inhibitor

Faster MRI Acquistion with Motion Robustness

Tunable Neural Electrodes for MRI-Compatible Brain Signal Recordings

Myocardial Viability Functional Assessment

Dynamic Quantification of Myocardial Tissue MRI

Orthopedic Meniscus Repair Implant, Introducer and Delivery System

Conformable Dual-mode Ultrasound Transducers for Neuromodulation

Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC

Single Voxel MR Spectroscopy of Human Brain with Automatic Voxel Positioning

1 licensing option
Solar UV-Induced Skin Cancer Inhibitor

Magnetization Transfer Contrast Preparation

Multi-modal Neuromodulation Therapy Promotes Sleep

Pediatric Tracheo-bronchomalacia Stent and Deployment System

Mimicked Calcified Annulus Model for Preclinical Assessment of TAVR Devices

1 licensing option
Motion-Robust Cardiac B1+ Mapping of the Transmit Field

Imaging Source Distribution from Electromagnetic Signals

Predicting Crop Yield and Quality Using Canopy Reflectance and LiDAR Sensors

Adaptive Immune Response Stimulated with TLR8 and Dual TLR7/TLR8 Agonists

Black-Blood T1 Myocardial Mapping to Remove Partial Voluming Effects

PDAC Treatment with High Antiproliferative Activity Against MiaPaca-2

Lung Biopsy Tool

Novel inhibitors of HINT1 to treat neuropathic pain and addiction

Small-molecule inhibitors of hHint1 (and their synthesis) for use in basic CNS research and treatment of neuropathic pain and addiction.

Porcine B lymphoma cell lines

Three porcine B cell lines (Murtaugh001, Murtaugh002, Murtaugh003) established by 3 rounds of limiting dilution from splenic and subiliac lymph node lymphomas.

Smart Clothing with Dynamically Controlled Compression

Engineered enzymes to disrupt bacterial communication and reduce virulence

Engineered enzymes that inhibit bacterial virulence factors by breaking down bacterial communication molecules.

Engineered enzymes to disrupt and prevent biofilms

Engineered enzymes that inhibit hazardous and infectious biofilms by breaking down bacterial communication molecules.

Environmentally-friendly, enzymatic anticorrosion and antifouling coating

A method to reduce microbial-caused corrosion and biofouling through the use of an enzymatic coating to disrupt bacterial communication

Designing 2D and 3D Adiabatic Pulses

Neuromodulator for Simultaneous Stimulation and Signal Reception

Colorimetric Assay for Microbial Screening

Improved Craniotome to Prevent Dural Tear

Efficient release of affinity-captured cells

A method to effectively release affinity-captured cells.

Efficient Bio-intensive Gardening Tool Design

Developing Highly Specific Monoclonal Antibodies to Peptide in the Context of MHC II

Nonsurgical Method for Restoring Tooth Enamel

Peptide Activation of T Cells for Cancer Immunotherapy

Radiofrequency Antenna Array with Electric Dipole and Loop Elements

Warming of Cryopreserved Biomaterials using Laser Assisted Gold Nanorods

A method for rapid, uniform warming of cryopreserved biomaterials using laser-assisted gold nanorods.

Improved Pertussis Vaccine

Algorithm for Discovering Genetic Interactions in Genome-Wide Association Studies (BridGE)

1 licensing option
Hydrophobic Surfaces for Tooth Tissues

High Quality Mosaics from UAV Obtained Images

Adaptive Refocusing of Ultrasound Arrays Using Synthetic Aperture Imaging Data

Live Attenuated Viral Vaccines

Catheter System with Guidewire Compartmentalization (20150223, Dr. Rumi Faizer)

HerdIn:Form(er): Mobile Questionnaire for Livestock Epidemiology Research (20150194, Dr. Andres Perez)

1 licensing option
Lower Extremity Edema Monitor (20150192, Dr. Rajesh Rajamani)

Deep Brain Stimulation Using Magnetic Brain Array (20150177, Dr. Jian-Ping Wang)

Improved Deep Brain Stimulation Target Selectivity (20150170, Dr. Shalom Michaeli)

Increased efficiency of CRISPR-Cas9 genome editing (Dr. Wendy Gordon)

An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.

Improved MRI Quality with Gradient Modulation Pulse Sequence (20150133, Dr. Kobayashi, Dr. Garwood)

Phytate Extraction from Corn Ethanol Coproducts (20150123, Dr. Bo Hu)

HILAGE: Haploid Inducer Line for Accelerated Genome Editing (20150117, Dr. Robert Stupar)

Biodiesel from Scum Oil and Waste Oil (20150113, Dr. Roger Ruan)

Time Efficient Arterial Spin Labeling Imaging with Segmented Multiband-acquisition (20150097, Dr. Greg Metzger)

Cold Hardy Itasca Grape Variety

2 licensing options
Improved MRI Method Uses Temperature Rise Contraints (20150061, Dr. Moortele)

LJ-1000 Apple Variety (20150018, Dr. Bedford)

1 licensing option
Therapeutic compound for chronic inflammatory pain without dependence or tolerance (20140357, Dr. Philip Portoghese)

An analgesic compound without side effects that relieves chronic pain associated with arthritis, sickle cell disease, chemotherapy, AIDs and inflammation.

Biofertilizer from Genetically-modified Azotobacter vinelandii (20140348, Dr. Brett Barney)

Mapping Prostate Cancer from Multi-parametric MRI with Improved Predictive Models (20140287, Dr. Greg Metzger)

In-vivo MRI Radiofrequency Pulses Robust against Respiration Induced Errors (20140236, Dr. Kamil Ugurbil)

Microbiome Profiling Technique for Improving Commercial Turkey Production (20140230, Dr. Timothy Johnson)

Physocarpus Opulifolius “Center Glow Ninebark” (20140201, Dr. Harold Pellett)

2 licensing options
Multi-band SWIFT Improves MRI (20140121, Dr. Idiyatullin, Dr. Garwood)

Generalized Multiband Slice Accelerated Imaging (20140093, Dr. Dingxin Wang)

Bovine Tuberculosis Screening (20140058, Dr. Srinand Sreevatsan)

Reduced-power SWIFT Magnetic Resonance Imaging (20140052, Dr. Jinjin Zhang, Dr. Garwood)

Precision Agriculture Drone Algorithms (20140013, Dr. Volkan Isler)

Hay Prices per Ton Calculator App (20130300, Dr. Krishona Martinson)

Healthy Horse App Calculates Weight (20130294, Dr. Krishona Martinson)

Multislice Multiband Excitation with Parallel Transmission for B1 Homogenization and Power Reduction (20130170)

Intraoral Dental MRI Coil (20130110, Dr. Michael Garwood)

MRI Signal Separation using Iterative Calibration (20130079, Dr. Kamil Ugurbil)

Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)

MRI Method Reduces Peak Power for Multiband Images (20120077, Dr. Kamil Ugurbil)

Synchronized Multi-Modal Tinnitus Therapy (20120070, Dr. Hubert Lim)

A non-invasive or minimally-invasive method for the suppression of tinnitus using synchronized brain stimulation.

Canine Lymphoma Prognostic Classification (20120065, Dr. Jaime Modiano)

MRI Pulse Sequence: Steering Resonance over the Object (20120049, Dr. Michael Garwood)

Faster Functional and Diffusion MRI of the Brain (20110139, Dr. Kamil Ugurbil)

Lower Specific Absorption Rate for Multiband MRI (20110093, Dr. Kamil Ugurbil)

Faster Whole Brain Imaging (20110092, Dr. Kamil Ugurbil)

Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)

Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.

Minnesota First Kiss™ Apple (MN55 Variety) (20110037, Dr. David Bedford)