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SARS-CoV-2 N-protein for use in COVID-19 serological assays (2020-323)

Full length SARS-CoV-2 Nucleocapsid (N) protein expressed by bacteria for use in serological assays to detect previous COVID-19 infection in humans and animals.

SARS-CoV-2 spike receptor-binding domain for use in COVID-19 assays (2020-301)

Stably transfected mammalian cell lines that express the receptor-binding domain of the SARS-CoV-2 spike protein for use in assays and research relevant to COVID-19 and potential therapies.

Multifunctional, flexible sensor array for urethral catheters (20140233)

A new urethral catheter for simultaneous measurement of pressure distribution and neural activity.

Wearable laryngeal vibration system for Spasmodic Dysphonia (20170400)

A non-invasive neuromodulation device and method for the treatment of spasmodic dysphonia.

Pharmacological agents to prevent recurrent C. diff infection (20150362)

Cholic and bile acid derivatives that inhibit Clostridium difficile spore germination to prevent or treat C. diff infection.

Circulating tumor biomarkers for meningiomas (2020-164)

A biomarker panel for early diagnosis of meningiomas with the potential to improve patient outcomes.

Siderophore-based diagnosis of bacterial infections (20150206)

Biofeedback Hand Grip Exercise Device for Assessing Muscle Function (20170200)

A method to genetically engineer monocytes (20180236)

The first and only method available to create genetically modified CD14+ monocytes for use in research or therapy.

A streamlined method to isolate Fibroadipogenic progenitor cells from muscle (2020-195)

A method to isolate fibroadipogenic progenitor cells (FAPs) based on the presence of a single surface marker (CD73).

Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)

A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.

Antagomir to prevent cardiac arrhythmia (2019-069)

A novel small molecule screening platform for tauopathies (2019-123)

FRET-based biosensors that identify early toxic states of tau for use in basic research and clinical development of therapeutics for tauopathies including Alzheimer’s Disease.

MRI of Amyloid Plaque in the Brain

Nonlinear Post Beamforming Filter for Imaging

Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ)

The Minnesota LIVING WITH HEART FAILURE® Questionnaire (MLHFQ) is a reliable and valid patient-oriented measure of the adverse effects of heart failure on a patient's life.

7 licensing options
A positive pressure testing booth for sample collection

Design files for a portable testing booth that facilitates safe practice of sample collection procedures on patients with infectious pathogens.

1 licensing option
A Gown for U Project - level 1 isolation gown for emergency use

Design files for a low cost, rapidly producible, one-size-fits-all level 1 isolation gown.

1 licensing option
Storage box to facilitate decontamination and reuse of face masks

A safe and well-ventilated storage box for N95 masks - design files and instruction videos.

1 licensing option
Portable aerosol hood to reduce spread of pathogens during medical procedures

A portable, transparent isolation box that facilitates safe practice of medical procedures on patients with infectious pathogens.

S100A4 inhibitor “Minnetamide” for prostate cancer treatment

Peripheral Artery Disease Quality of Life (PADQOL) Questionnaire

A validated instrument to assess the physical, psychosocial and emotional effects on patients suffering from peripheral artery disease.

3 licensing options
Living with Pulmonary Hypertension Questionnaire (LPHQ)

The Living with Pulmonary Hypertension Questionnaire (LPHQ) is a reliable and validated measure of the adverse effects of pulmonary hypertension on a patient’s life.

1 licensing option
Visualization of intracardiac electrograms on 3D heart model (VIEgram)

A software for easy visualization of intracardiac electrograms on 3D heart models.

1 licensing option
Mouse models of tau variants linked to neurodegenerative disease

An improved and controlled mouse model expressing human tau P301L protein, a common mutation linked to neurodegeneration.

Novel process to obtain large quantities of primary cells for transplantation

A method to isolate large quantities of high quality primary cells for therapeutic transplantation through freezing and thawing organs, including organs typically considered suboptimal for donation.

Nanosota-1: A series of nanobody drugs to combat COVID-19

A series of camelid nanobodies that bind to SARS-CoV-2 (COVID-19) spike protein to block infection of human cells.

Selective bromodomain protein inhibitors that reduce cancer cell viability

Small molecules systematically designed as highly selective bromodomain inhibitors for development as cancer and inflammatory disease therapeutics.

Dental stem cells to treat spinal cord injury

A method of treating nervous tissue damage using dental pulp stem cells that leads to neuro-regeneration with a high safety profile and low probability of patient rejection.

Elderly Mortality After Trauma (EMAT) score

A validated scoring method for predicting mortality after trauma in elderly patients at admission.

Machine learning-based sleep quality monitoring

A Single Device for Vaginal Dilation and Flushing

Fluorescence-based assay for probing lipid transfer activity

A sensitive, reproducible and quantitative assay to study lipid transfer using bicelles as model membranes.

A synergistic therapy for multi-drug resistant cancers

A synthetic polymer that targets cancer cell membranes and works synergistically with existing chemotherapeutic drugs to treat drug-resistant solid tumors.

Novel anticancer compound that targets metabolic plasticity

F-MN-D1 compound targets metabolic plasticity common to many solid tumors through inhibition of glycolysis and oxidative phosphorylation facilitating tumor growth reduction.

3D tumor models for accurate testing of therapeutics

A method to create a 3D tumor model that accurately mimics both tumor behavior and environment for use in anti-cancer drug development.

A TLR-2 stimulatory molecule for use as a vaccine adjuvant

A small molecule that serves as an adjuvant in vaccines through stimulation of the immune receptor, TLR-2

Machine Learning-based Dynamic Activity Recommendation System

A deep learning architecture for wearable devices to evaluate, predict, and improve the quality of sleep by recommending personalized activities.

Unique small molecule modulators of GPCRs

Novel small molecules that bind and modulate G-protein coupled receptors (specifically Sigma 1 and 5-HT7) for therapeutic development.

Point-of-care Concussion Therapy

Immunostimulatory conjugates for targeted delivery as adjuvants

Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure

iTorsion - Smartphone App for Ocular Torsion Diagnosis

Cancer preventative for at risk individuals

An approach to prevent cancers through blocking the transcription factor STAT3 that leads to an 80% tumor reduction in a mouse model of disease.

Drug Delivery Device for Oral Topical Medicine

Select Optimal Therapeutic Parameters for Medical Stimulation Devices

Novel small molecules for chemotherapy sensitization

Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.

Quality Control Test for Pathogenic Bacteria Contaminated Water

New Prodrugs for Preventing and Treating Alzheimer's Disease

Assay to measure intrinsic efficiency of GPCR ligands

FRET-based GPCR biosensors to measure specific ligand activation in a cell independent manner.

Patient Controlled Dynamic Therapeutic Compression Tension Garment

MHC Class II Molecules with Enhanced Co-receptor Affinity

A novel chemotherapy drug with reduced patient side-effects

A novel anti-cancer compound that inhibits translation and induces p53 in a DNA-damage independent manner to cause cell cycle arrest and apoptosis.

Non-invasive Neuromodulation for Reversible Modulation of Neural Activity

A method for targeted modulation of neural activity using transcranial low intensity focused ultrasound.

MyStrengths MyHealth™

2 licensing options
Microinjection for Single Cell Gene Manipulation

Segmenting 3D Bone Computed Tomography Data

Tosedostat (CHR-2797) as a Potential Analgesic

Engineering Human CD64 Chimeric Receptors for Immune Therapy

Integrated Traumatic Brain Injury Catheter (iTBI)

Real-Time Reporter and Efficient Enzymes for DNA Editing

Optimized Radio Frequency Pulses Generated From Magnetic Resonance User Defined Parameters

Scan-Specific Machine Learning Reconstruction for MRI

Augmented non-invasive hearing system

3D Printed Stretchable Tactile Sensors with Electronic Ink

Specific kinase biosensors to probe cancer metabolism

Substrate peptides for Ser/Thr kinases to investigate the metabolic processes of cancer cells.

Sliding Windowed Infinite Fourier Transform (SWIFT)

MRI and Spectroscopy Multi-part Body Coil

3D Microscale Isotropic Metamaterials

Biased Unmatched Bivalent LigandsTargeting Asymmetrically Signaling GPCR Homodimers

One-Year Mortality Risk Estimates from Electronic Medical Record Data

Probes for Biosynthesis of Bacterial Cell Wall

Unique compounds to treat obesity

Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.

Increase Signal-to-noise Ratio in Imaging Data

Bacterial Histidine Kinase Inhibitor

Faster MRI Acquistion with Motion Robustness

Tau-targeting Peptides Treat Neurodegenerative Diseases

Tunable Neural Electrodes for MRI-Compatible Brain Signal Recordings

A discrete and effective wearable breast pump for nursing mothers

A quiet and concealed wearable breast pump that mimics infant suckling using mechanical compression and heat; increasing milk expression as well as convenience and comfort.

Myocardial Viability Functional Assessment

Dynamic Quantification of Myocardial Tissue MRI

Skin Care Formulations for Preventing and Treating Skin Cancer

Orthopedic Meniscus Repair Implant, Introducer and Delivery System

Remedy for Heart Failure with Preserved Ejection Fraction

Conformable Dual-mode Ultrasound Transducers for Neuromodulation

Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC

Single Voxel MR Spectroscopy of Human Brain with Automatic Voxel Positioning

Solar UV-Induced Skin Cancer Inhibitor

Magnetization Transfer Contrast Preparation

Particle Swarm Optimization for Programming Neuromodulation Systems

Multi-modal Neuromodulation Therapy Promotes Sleep

Scaffolds for Cancer Cell Ablation

Pediatric Tracheo-bronchomalacia Stent and Deployment System

Fluorescence-based Detection of Kinase Allostery for High-throughput Allosteric Inhibitor Discovery

Mimicked Calcified Annulus Model for Preclinical Assessment of TAVR Devices

1 licensing option
Motion-Robust Cardiac B1+ Mapping of the Transmit Field

Imaging Source Distribution from Electromagnetic Signals

High-voltage, Fully-integrated, High-density Microstimulator with Charge Balancing

Simultaneous RF Signal Transmission and Reception in MRI (20160420)

Neural Recording under Electrical Microstimulation

Adaptive Immune Response Stimulated with TLR8 and Dual TLR7/TLR8 Agonists

Compliant Aortic Stent Graft

Black-Blood T1 Myocardial Mapping to Remove Partial Voluming Effects

Kinase assay to aid in development of therapeutics for acute myeloid leukemia

Peptide substrates to sensitively and specifically measure the real-time activity of FLT3, a kinase linked to acute myeloid leukemia.

PDAC Treatment with High Antiproliferative Activity Against MiaPaca-2

Lung Biopsy Tool

Treating Tumors with High Intensity Focused Ultrasound

Novel inhibitors of HINT1 to treat neuropathic pain and addiction

Small-molecule inhibitors of hHint1 (and their synthesis) for use in basic CNS research and treatment of neuropathic pain and addiction.

3D Shoulder Motion Measurement System

Optimizing Gene Editing in NK Cells for Therapy and Research

Ultrasound-based Hearing Aid

Biosynthetic Route to Serofendic Acid

Anti-obesity and Weight Control Drugs Target Melanocortin Receptor

Smart Clothing with Dynamically Controlled Compression

Improved Lumbar Puncture And Epidural Accuracy

Designing 2D and 3D Adiabatic Pulses

Neuromodulator for Simultaneous Stimulation and Signal Reception

Improved Craniotome to Prevent Dural Tear

Efficient release of affinity-captured cells

A method to effectively release affinity-captured cells.

Developing Highly Specific Monoclonal Antibodies to Peptide in the Context of MHC II

Nonsurgical Method for Restoring Tooth Enamel

Radiofrequency Antenna Array with Electric Dipole and Loop Elements

Biomarker for Diagnosis of Aggressive Breast Cancer

Warming of Cryopreserved Biomaterials using Laser Assisted Gold Nanorods

Catheter Based Targeted Extracorporeal Membrane Oxygenator (ECMO)

Improved Pertussis Vaccine

Algorithm for Discovering Genetic Interactions in Genome-Wide Association Studies (BridGE)

1 licensing option
Multimodal Synchronization, Sound & Electrical Stimulation, Hearing Aid (mSync-hEAR)

Hydrophobic Surfaces for Tooth Tissues

Adaptive Refocusing of Ultrasound Arrays Using Synthetic Aperture Imaging Data

Graphene Formaldehyde Sensor (20150354, Dr. Tianhong Cui)

Pre-surgical Pulmonary Nodule Localization Coil (20150351, Dr. Michael Rosenberg)

Nucleic Acid Delivery to the Liver for Hemophilia and Lysosomal Storage Disease Treatment (20150339, Dr. Reineke)

Kinase biosensor for individualized cancer therapy (20150289, Dr. Laurie Parker)

A method to sensitively and specifically detect the activity of multiple kinases, from multiple samples in a traceable manner.

Dental Mercury Capture Device (20150218, Dr. Sandra Myers)

Lower Extremity Edema Monitor (20150192, Dr. Rajesh Rajamani)

Deep Brain Stimulation Using Magnetic Brain Array (20150177, Dr. Jian-Ping Wang)

Improved Deep Brain Stimulation Target Selectivity (20150170, Dr. Shalom Michaeli)

Soft Catheter Surgical Robot for Heart Disease (20150147, Dr. Tim Kowalewski)

Increased efficiency of CRISPR-Cas9 genome editing (20150143, Dr. Wendy Gordon)

An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.

Improved MRI Quality with Gradient Modulation Pulse Sequence (20150133, Dr. Kobayashi, Dr. Garwood)

Acousto-electromagnetic Imaging of the Brain (20150126, Dr. Bin He)

Time Efficient Arterial Spin Labeling Imaging with Segmented Multiband-acquisition (20150097, Dr. Greg Metzger)

Improved MRI Method Uses Temperature Rise Contraints (20150061, Dr. Moortele)

Therapeutic compound for chronic inflammatory pain without dependence or tolerance (20140357, Dr. Philip Portoghese)

An analgesic compound without side effects that relieves chronic pain associated with arthritis, sickle cell disease, chemotherapy, AIDs and inflammation.

Mapping Prostate Cancer from Multi-parametric MRI with Improved Predictive Models (20140287, Dr. Greg Metzger)

Multi-purpose Arm Ergometer Design (20140266, Dr. Gary Goldish)

In-vivo MRI Radiofrequency Pulses Robust against Respiration Induced Errors (20140236, Dr. Kamil Ugurbil)

Multi-band SWIFT Improves MRI (20140121, Dr. Idiyatullin, Dr. Garwood)

Generalized Multiband Slice Accelerated Imaging (20140093, Dr. Dingxin Wang)

Reduced-power SWIFT Magnetic Resonance Imaging (20140052, Dr. Jinjin Zhang, Dr. Garwood)

Magnetic Resonance Electrical Properties Tomography (20130259, Dr. Bin He)

Multislice Multiband Excitation with Parallel Transmission for B1 Homogenization and Power Reduction (20130170)

IV Line Lifting Device (20130136, Dr. Mary Hooke)

Intraoral Dental MRI Coil (20130110, Dr. Michael Garwood)

MRI Signal Separation using Iterative Calibration (20130079, Dr. Kamil Ugurbil)

Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)

MRI Coil Amplifiers (20120122, Dr. Tommy Vaughan)

Human Whole-Body Imaging at 7T (20120120, Dr. Tommy Vaughan)

Electrical Auto-tuning for Ultra-High-Field MRI RF Coils (20120119, Dr. Tommy Vaughan)

MRI Method Reduces Peak Power for Multiband Images (20120077, Dr. Kamil Ugurbil)

Synchronized Multi-Modal Tinnitus Therapy (20120070, Dr. Hubert Lim)

A non-invasive or minimally-invasive method for the suppression of tinnitus using synchronized brain stimulation.

Beam Steering Resonance along a Spatiotemporal Trajectory for MRI (20120060, Dr. Michael Garwood)

MRI Pulse Sequence: Steering Resonance over the Object (20120049, Dr. Michael Garwood)

Faster Functional and Diffusion MRI of the Brain (20110139, Dr. Kamil Ugurbil)

Lower Specific Absorption Rate for Multiband MRI (20110093, Dr. Kamil Ugurbil)

Faster Whole Brain Imaging (20110092, Dr. Kamil Ugurbil)

Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)

Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.

Insulin Producing Cells from Pluripotent Stem Cells (20100245)

Ultrasound System for Characterization and Image-guided Therapy of Blood Vessel Diseases (20100155)

Digital Pathology Quantitative Immunohistochemistry Software

Digital Pathology Quantitative Immunohistochemistry Software

Tracking Deformation of Organs during Minimally Invasive Surgery