Nanoparticles Made of Ultra-Porous Silica (20140012, Dr. Christy Haynes)
Nanoparticles for Drug Delivery, Catalysis and Biosensing
Recently, silica nanoparticles have been heavily researched for applications such as drug delivery, catalysis and biosensing. The pharmaceutical industry has been particularly interested in these biodegradable structures that are able to transport drugs to target locations in the body. Research is ongoing to maximize the number of pores and minimize particle diameter.
Mesoporous Silica Nanoparticles
Ultra-porous silica nanoparticles have been developed with an extremely high surface area (about 1200 square meters per gram). The particles are conveniently small at less than 200 nanometers in diameter, and controllable pore size will allow for a variety of drugs or other chemicals to be loaded into the particles. The nanoparticle has a large, empty interior for the storage of compounds surrounded by a shell of mesopores that release the compound in a controlled manner. This will greatly assist in avoiding undesired release during toxic anti-tumor drug delivery.
BENEFITS AND FEATURES OF ULTRA-POROUS NANOPARTICLES:
- Extremely high surface area (~1200 m2/g)
- Ultra-large void volume (>3cm3/g)
- High pore size to particle size ratio allows for a variety of chemicals to be loaded into the pores
Phase of Development Pre-Market Validation: particles have been synthesized and characterized.Researchers