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Method for treating P300/CBP-dependent tumors using combined P300/CBP inhibition/ degradation, and senolytic therapy
A method for treating P300/CBP-dependent tumors, such as Ewing sarcoma, by selectively eliminating senescence-induced cancer cells through P300/CBP inactivation.
Derivation of human T-(progenitor) cells from human T-cells derived induced pluripotent stem cells (T-iPSCs)
A method for generating T cells from patient-derived induced pluripotent stem cells, enabling scalable and customizable immunotherapies for cancer and other diseases.
Modified myeloid-derived suppressor cells for treating GvHD
A novel cell therapy and associated methods for treating GvHD after allogenic hematopoietic cell transplantation.
A minipromoter for gene therapies
A mini-promoter to accommodate larger therapeutic genes of interest in gene therapy programs
Allogeneic extracellular vesicles for enhancing CD8+ T cell response in colorectal cancer
Allogeneic tumor-derived extracellular vesicles (TEVs) that stimulate CD8+ T cell response and reduce tumor growth in colorectal cancer.
Compounds that lead to degradation of cancer relevant proteins
Compounds target and degrade kinases, specifically Aurora A and CDK4/6, for effective cancer treatment.
A tau antibody for detecting and treating Alzheimer's disease
An antibody for detecting, screening, and inhibiting Tau products critical in Alzheimer’s disease
Anti-viral phosphoramidates for treating SARS-CoV and influenza
A method for treating an influenza viral infection or a severe acute respiratory syndrome
Novel small molecule inhibitor to target metabolic plasticity
A novel pharmaceutical candidate with potent MPC and MCT1 inhibition.
Zika as an oncolytic virus to treat brain tumors
A method to treat aggressive brain cancers using Zika as an oncolytic virus combined with anti-cancer vaccinations.
Didehydro-nucleoside antiviral agents
A broad-spectrum antiviral agent platform
Stable glutathione analog for the treatment of Alzheimer’s disease
A metabolically stable glutathione analog that resists degradation and offers protection against oxidative stress.
Inhibitors of Cell Adhesion by Nectin Peptides
Peptides that functionally block ovarian cancer cell adhesion by targeting Nectin-4
Therapeutic target for treatment of ataxia
A newly identified pathway that represents a therapeutic target for the prevention and treatment of ataxia.
Glycoengineered mesenchymal stem cells as targeted therapeutic carriers
A targeted therapeutic delivery system utilizing glycoengineered mesenchymal stem cells for reduced toxicity and increased treatment residence time
Hyperstable synthetic miniproteins as ligand scaffolds
Hyperstable synthetic miniproteins as modular ligand scaffolds for advanced therapeutics and diagnostics.
Progesterone receptor detection for breast cancer therapy
A test to detect phosphorylated progesterone receptors for patient stratification
CDK2 inhibitors for cancer therapy and male contraception
CDK2 inhibitors for cancer therapy and non-hormonal male contraception with high selectivity and reduced side effects.
Inhibitory nucleic acid molecules targeting cyclin D1 mRNA
Inhibition of non-canonical functions of cyclin D1 as a potential therapy for liver diseases.
Broadspectrum potentially therapeutic nanobodies against COVID-19
A class of nanobodies (Nanosota-2, -3, and -4) offering broadspectrum therapeutic potential against COVID-19.
Nanorings for cell-mediated drug delivery
Farnesylated chemically self-assembled nanorings that facilitate targeted drug delivery between cells.
Efficient CRISPR-based gene editing for stem cells
A CRISPR-based gene editing protocol for induced pluripotent stem cells (iPSCs) with improved editing efficiency and cell survival.
Single-cell Integration and DrUg Response PrediCtion (scIDUC)
A computational pipeline that predicts drug response scores for individual cells using single-cell RNA sequencing data.
Pharmacological enhancement of CD8 T cell effector function using TEPP46
A clinically viable strategy for preventing mitochondria-mediated T cell exhaustion and enhancing effector T cell function.
First-in-class drug lead candidate (A229) for treating ocular diseases
PPARα agonist, A229, exhibits strong potency and demonstrates efficacy in in-vitro models of diabetic retinopathy.
Bacterial histidine kinase inhibitors for treating Staphylococcus infections
Small molecule bacterial histidine kinase inhibitors that significantly diminish staphylococcal virulence.
Small molecule inhibitors for treating alcoholic hepatitis
Bromodomain inhibitor, UMN627, reduces inflammation in mice models of alcoholic hepatitis.
InTERACCT Program: Occupational health and safety training
Training courses for occupational health and safety workers aimed to equip them to handle risks associated with emerging technologies.
Ovarian cancer prognostic test for predicting response to chemotherapy and bevacizumab
A prognostic molecular test for predicting ovarian cancer patient response to platinum-based chemotherapy and/or treatment with bevacizumab.
Bisubstrate inhibitors for treating SARS-CoV-2 infections
Bisubstrate inhibitors that target the active site of SARS-CoV-2 Nsp14 methyltransferase (MTase) for treating SARS-CoV-2 infections.
Novel compounds for treatment of neurodegenerative disease and chronic pain
Novel alpha2-adrenergic agonists with neuroprotective and/or analgesic properties.
First-generation degraders for class I bromodomain-containing proteins
A bromodomain-targeting degrader of CECR2, an epigenetic regulator that drives cancer metastasis.
NOD-2-active carboxamide compounds as vaccine adjuvants
Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.
Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines
A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.
High-throughput screening assay for sickle cell disease drug discovery
A high-throughput screening assay for discovering small molecules that directly inhibit sickle hemoglobin oligomerization.
Mouse-derived FSHD muscle cell lines
Primary skeletal muscle cell lines isolated from DUX4 expressing FSHD mice.
Generating teratoma-derived skeletal muscle stem cells
A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.
Small molecules with antiproliferative activity against pancreatic cancer cells
Small molecules that show antiproliferative activity against the pancreatic cancer cell line MiaPaca-2.
Steerable magneto-photonic particles for targeted delivery and collection of light
An embeddable magneto-photonic microparticle that can be externally positioned and orientated for targeted delivery and collection of light.
AgRP-Derived melanocortin-5 receptor peptide antagonists
AgRP derived scaffolds composed of natural (Tyr, Ala, Val, Asn) and unnatural amino acids (Dap) with antagonist activity at the mouse MC5R
Methods for Modifying Proteins and Peptides.
Production of alpha-N-methylated peptides for improved pharmacological properties.
Treating trauma-induced acute blood loss
Novel formulations of D-β-hydroxybutyrate and melatonin improve survival from hemorrhagic shock.
Cell-free selection of site-specific polypeptide binders via tethering
In vitro selection method for the engineering of protein-based high-affinity binders to targets of interest with potential pharmacological value
Compound with selective inhibition potential against P300 and CBT
A compound to treat pediatric sarcoma through the inhibition of P300 and CBT
Live cell assay to quantify the activity of SARS-CoV-2 main protease, Mpro
Fluorescence-based method to effectively screen for protease inhibitors
Camelid single domain antibody phage display library
Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target
T cell receptors for engineered T cell therapy
Mesothelin-specific T cell receptors for cell engineering and cancer therapy
A system for unattended delivery of cognitive neuromodulation therapy
Non-invasive interactive system with specialized equipment and customizable stimulation unit to deliver unattended cognitive neuromodulation therapy. The system supports training of prescribers and clinical staff leading to certification
AGRP-derived melanocortin receptor ligands
Identifying a selective MC4R antagonist for appetite modulation
Chimeric melanocortin receptor ligands
Melanocortin-4 receptor ligand reduces food intake in mice
Selective melanocortin receptor ligands
Potential dual-ligand approach to weight management
Lateral flow assay for respiratory viruses
CRISPR/Cas9-based point-of-care diagnosis for SARS-CoV-2
A novel approach for bioprinting complex tissue models
A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.
Novel anti-cancer agents that target the epigenetic reader protein
Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.
Use of sulfanegen and its analogs for prevention and treatment for neurodegenerative disorders
A 3-mercaptopyruvate prodrug, sulfanegen, that reduces neuroinflammation and oxidative stress for therapeutic use in neurodegenerative diseases.
A method to identify cell-free biomarkers of cancers and other diseases
A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.
Assessing tumor behavior and response to therapy
A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.
Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction
Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.
Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)
An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.
A streamlined method to isolate Fibroadipogenic progenitor cells from muscle (2020-195)
A method to isolate fibroadipogenic progenitor cells (FAPs) based on the presence of a single surface marker (CD73).
More Stable and Potent Cyclic ADP-Ribose Analogs
Treating Neurodegenerative Diseases with Nicotine Receptor Ligands
CoFe nanowires for remote heating using an alternating magnetic field
A nanowire material for remote, rapid and uniform heating of biological samples.
Novel small molecules for chemotherapy sensitization
Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.
MHC Class II Molecules with Enhanced Co-receptor Affinity
Microinjection for Single Cell Gene Manipulation
Tosedostat (CHR-2797) as a Potential Analgesic
Real-Time Reporter and Efficient Enzymes for DNA Editing
Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC
Efficient release of affinity-captured cells
A method to effectively release affinity-captured cells.
Peptide Activation of T Cells for Cancer Immunotherapy
Increased efficiency of CRISPR-Cas9 genome editing (Dr. Wendy Gordon)
An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.
Bacterial Biofilms Targeted with Microbial Drone Therapeutics (20140281, Dr. Christine Salomon)
Mesoporous Silica-coated Iron Oxide Nanoparticle (20140249, Dr. Christy Haynes)
ssDNA Amphiphile Self-Assembly Forms DNA Nanotubes (20140227, Dr. Efie Kokkoli)
Small RNA Amplification and Library Preparation (20140020, Dr. Subree Subramanian)
Mesoporous silica nanoparticles with ultra high porosity
Novel mesoporous silica nanoparticles with high pore volume and open pore structure, displaying high thermal stability and mechanical sturdiness
Cerebral Amyloid Angiopathy and Alzheimer’s Disease Diagnosis and Treatment (20130341, Dr. Karunya Kandimalla)
Reagent for Dual Protein Labeling (20130255, Dr. Mark Distefano)
Molecular Probe Measures Nucleosides and Differentiation of ATP and ADP (20120272, Dr. Valerie Pierre)
Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)
Nanoparticle Chemotherapy with Anticancer Prodrugs (20110152, Dr. Thomas Hoye)
Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)
Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.