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SARS-CoV-2 N-protein for use in COVID-19 serological assays (2020-323)

Full length SARS-CoV-2 Nucleocapsid (N) protein expressed by bacteria for use in serological assays to detect previous COVID-19 infection in humans and animals.

Continuous honey bee cell-line, AmE-711 (2020-240)

The first and only honey bee cell-line available for use in research and experimental testing.

Pharmacological agents to prevent recurrent C. diff infection (20150362)

Cholic and bile acid derivatives that inhibit Clostridium difficile spore germination to prevent or treat C. diff infection.

Siderophore-based diagnosis of bacterial infections (20150206)

Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)

A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.

MRI of Amyloid Plaque in the Brain

Mammalian Cell Culture System for Anaplasmosis Vaccine Development

Mutated Opioid Receptors Block Chronic Pain Signals

Nonlinear Post Beamforming Filter for Imaging

Turkey Production Improvements

3D printable deer head and neck model

Chronic wasting disease transmission and progression e-booklet

An informative and captivating e-booklet on chronic wasting disease transmission and progression.

2 licensing options
S100A4 inhibitor “Minnetamide” for prostate cancer treatment

Novel process to obtain large quantities of primary cells for transplantation

A method to isolate large quantities of high quality primary cells for therapeutic transplantation through freezing and thawing organs, including organs typically considered suboptimal for donation.

Selective bromodomain protein inhibitors that reduce cancer cell viability

Small molecules systematically designed as highly selective bromodomain inhibitors for development as cancer and inflammatory disease therapeutics.

3D printed bionic skull for multimodal neural sensing

A synergistic therapy for multi-drug resistant cancers

A synthetic polymer that targets cancer cell membranes and works synergistically with existing chemotherapeutic drugs to treat drug-resistant solid tumors.

Novel anticancer compound that targets metabolic plasticity

F-MN-D1 compound targets metabolic plasticity common to many solid tumors through inhibition of glycolysis and oxidative phosphorylation facilitating tumor growth reduction.

CoFe nanowires for remote heating using an alternating magnetic field

A nanowire material for remote, rapid and uniform heating of biological samples.

A TLR-2 stimulatory molecule for use as a vaccine adjuvant

A small molecule that serves as an adjuvant in vaccines through stimulation of the immune receptor, TLR-2

Unique small molecule modulators of GPCRs

Novel small molecules that bind and modulate G-protein coupled receptors (specifically Sigma 1 and 5-HT7) for therapeutic development.

Antibody based treatment for Type 1 Diabetes

A humanized monoclonal antibody against Serpin B13 to treat Type 1 Diabetes.

Immunostimulatory conjugates for targeted delivery as adjuvants

Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure

Cancer preventative for at risk individuals

An approach to prevent cancers through blocking the transcription factor STAT3 that leads to an 80% tumor reduction in a mouse model of disease.

Trotter or Pacer? Accurate Method to Detect Preferred Gait in Standardbred Horses

A genetic testing method to accurately (>99%) predict gait profile of Standardbred horses around the globe.

Novel small molecules for chemotherapy sensitization

Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.

Quality Control Test for Pathogenic Bacteria Contaminated Water

Patient Controlled Dynamic Therapeutic Compression Tension Garment

MHC Class II Molecules with Enhanced Co-receptor Affinity

A novel chemotherapy drug with reduced patient side-effects

A novel anti-cancer compound that inhibits translation and induces p53 in a DNA-damage independent manner to cause cell cycle arrest and apoptosis.

Microinjection for Single Cell Gene Manipulation

Referenceless Nyquist Ghost Correction for Echo Planar Imaging (EPI)

Segmenting 3D Bone Computed Tomography Data

Tosedostat (CHR-2797) as a Potential Analgesic

Engineering Human CD64 Chimeric Receptors for Immune Therapy

Integrated Traumatic Brain Injury Catheter (iTBI)

Real-Time Reporter and Efficient Enzymes for DNA Editing

Optimized Radio Frequency Pulses Generated From Magnetic Resonance User Defined Parameters

Scan-Specific Machine Learning Reconstruction for MRI

Sliding Windowed Infinite Fourier Transform (SWIFT)

MRI and Spectroscopy Multi-part Body Coil

3D Microscale Isotropic Metamaterials

Biased Unmatched Bivalent LigandsTargeting Asymmetrically Signaling GPCR Homodimers

Probes for Biosynthesis of Bacterial Cell Wall

Unique compounds to treat obesity

Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.

Increase Signal-to-noise Ratio in Imaging Data

Bacterial Histidine Kinase Inhibitor

Faster MRI Acquistion with Motion Robustness

Tunable Neural Electrodes for MRI-Compatible Brain Signal Recordings

Myocardial Viability Functional Assessment

Dynamic Quantification of Myocardial Tissue MRI

Orthopedic Meniscus Repair Implant, Introducer and Delivery System

Conformable Dual-mode Ultrasound Transducers for Neuromodulation

Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC

Single Voxel MR Spectroscopy of Human Brain with Automatic Voxel Positioning

Solar UV-Induced Skin Cancer Inhibitor

Magnetization Transfer Contrast Preparation

Multi-modal Neuromodulation Therapy Promotes Sleep

Pediatric Tracheo-bronchomalacia Stent and Deployment System

Fluorescence-based Detection of Kinase Allostery for High-throughput Allosteric Inhibitor Discovery

Mimicked Calcified Annulus Model for Preclinical Assessment of TAVR Devices

1 licensing option
Motion-Robust Cardiac B1+ Mapping of the Transmit Field

Imaging Source Distribution from Electromagnetic Signals

High-voltage, Fully-integrated, High-density Microstimulator with Charge Balancing

Simultaneous RF Signal Transmission and Reception in MRI (20160420)

Neural Recording under Electrical Microstimulation

Adaptive Immune Response Stimulated with TLR8 and Dual TLR7/TLR8 Agonists

Black-Blood T1 Myocardial Mapping to Remove Partial Voluming Effects

PDAC Treatment with High Antiproliferative Activity Against MiaPaca-2

Lung Biopsy Tool

Treating Tumors with High Intensity Focused Ultrasound

Novel inhibitors of HINT1 to treat neuropathic pain and addiction

Small-molecule inhibitors of hHint1 (and their synthesis) for use in basic CNS research and treatment of neuropathic pain and addiction.

Optimizing Gene Editing in NK Cells for Therapy and Research

Anti-obesity and Weight Control Drugs Target Melanocortin Receptor

Porcine B lymphoma cell lines

Three porcine B cell lines (Murtaugh001, Murtaugh002, Murtaugh003) established by 3 rounds of limiting dilution from splenic and subiliac lymph node lymphomas.

Weight Management Drugs using Selective Melanocortin Ligands

Smart Clothing with Dynamically Controlled Compression

Neuromodulator for Simultaneous Stimulation and Signal Reception

Improved Craniotome to Prevent Dural Tear

Efficient release of affinity-captured cells

A method to effectively release affinity-captured cells.

Developing Highly Specific Monoclonal Antibodies to Peptide in the Context of MHC II

Nonsurgical Method for Restoring Tooth Enamel

Peptide Activation of T Cells for Cancer Immunotherapy

Radiofrequency Antenna Array with Electric Dipole and Loop Elements

Biomarker for Diagnosis of Aggressive Breast Cancer

Warming of Cryopreserved Biomaterials using Laser Assisted Gold Nanorods

Improved Pertussis Vaccine

Algorithm for Discovering Genetic Interactions in Genome-Wide Association Studies (BridGE)

1 licensing option
Hydrophobic Surfaces for Tooth Tissues

Adaptive Refocusing of Ultrasound Arrays Using Synthetic Aperture Imaging Data

Live Attenuated Viral Vaccines

Nucleic Acid Delivery to the Liver for Hemophilia and Lysosomal Storage Disease Treatment (20150339, Dr. Reineke)

Catheter System with Guidewire Compartmentalization (20150223, Dr. Rumi Faizer)

HerdIn:Form(er): Mobile Questionnaire for Livestock Epidemiology Research (20150194, Dr. Andres Perez)

1 licensing option
Lower Extremity Edema Monitor (20150192, Dr. Rajesh Rajamani)

Deep Brain Stimulation Using Magnetic Brain Array (20150177, Dr. Jian-Ping Wang)

Improved Deep Brain Stimulation Target Selectivity (20150170, Dr. Shalom Michaeli)

Increased efficiency of CRISPR-Cas9 genome editing (20150143, Dr. Wendy Gordon)

An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.

Improved MRI Quality with Gradient Modulation Pulse Sequence (20150133, Dr. Kobayashi, Dr. Garwood)

Acousto-electromagnetic Imaging of the Brain (20150126, Dr. Bin He)

Time Efficient Arterial Spin Labeling Imaging with Segmented Multiband-acquisition (20150097, Dr. Greg Metzger)

Improved MRI Method Uses Temperature Rise Contraints (20150061, Dr. Moortele)

Therapeutic compound for chronic inflammatory pain without dependence or tolerance (20140357, Dr. Philip Portoghese)

An analgesic compound without side effects that relieves chronic pain associated with arthritis, sickle cell disease, chemotherapy, AIDs and inflammation.

Mapping Prostate Cancer from Multi-parametric MRI with Improved Predictive Models (20140287, Dr. Greg Metzger)

In-vivo MRI Radiofrequency Pulses Robust against Respiration Induced Errors (20140236, Dr. Kamil Ugurbil)

Microbiome Profiling Techninque for Improving Commercial Turkey Production (20140230, Dr. Timothy Johnson)

Multi-band SWIFT Improves MRI (20140121, Dr. Idiyatullin, Dr. Garwood)

Generalized Multiband Slice Accelerated Imaging (20140093, Dr. Dingxin Wang)

Bovine Tuberculosis Screening (20140058, Dr. Srinand Sreevatsan)

Reduced-power SWIFT Magnetic Resonance Imaging (20140052, Dr. Jinjin Zhang, Dr. Garwood)

Hay Prices per Ton Calculator App (20130300, Dr. Krishona Martinson)

Healthy Horse App Calculates Weight (20130294, Dr. Krishona Martinson)

Canine Brain MRI Atlas (20130233, Dr. Thomas Fletcher)

Multislice Multiband Excitation with Parallel Transmission for B1 Homogenization and Power Reduction (20130170)

IV Line Lifting Device (20130136, Dr. Mary Hooke)

Intraoral Dental MRI Coil (20130110, Dr. Michael Garwood)

MRI Signal Separation using Iterative Calibration (20130079, Dr. Kamil Ugurbil)

Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)

Immunotherapy for Dogs with Increased Immune Response (20120263, Dr. John Ohlfest)

Simultaneous RF Transmit and Receive in MRI Coils (20120123, Dr. Tommy Vaughan)

MRI Coil Amplifiers (20120122, Dr. Tommy Vaughan)

Human Whole-Body Imaging at 7T (20120120, Dr. Tommy Vaughan)

Electrical Auto-tuning for Ultra-High-Field MRI RF Coils (20120119, Dr. Tommy Vaughan)

MRI Method Reduces Peak Power for Multiband Images (20120077, Dr. Kamil Ugurbil)

Synchronized Multi-Modal Tinnitus Therapy (20120070, Dr. Hubert Lim)

A non-invasive or minimally-invasive method for the suppression of tinnitus using synchronized brain stimulation.

Canine Lymphoma Prognostic Classification (20120065, Dr. Jaime Modiano)

Beam Steering Resonance along a Spatiotemporal Trajectory for MRI (20120060, Dr. Michael Garwood)

MRI Pulse Sequence: Steering Resonance over the Object (20120049, Dr. Michael Garwood)

Faster Functional and Diffusion MRI of the Brain (20110139, Dr. Kamil Ugurbil)

Lower Specific Absorption Rate for Multiband MRI (20110093, Dr. Kamil Ugurbil)

Faster Whole Brain Imaging (20110092, Dr. Kamil Ugurbil)

Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)

Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.

Insulin Producing Cells from Pluripotent Stem Cells (20100245)

Ultrasound System for Characterization and Image-guided Therapy of Blood Vessel Diseases (20100155)

Tracking Deformation of Organs during Minimally Invasive Surgery