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Generating teratoma-derived skeletal muscle stem cells

A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.

Small molecules with antiproliferative activity against pancreatic cancer cells

Small molecules that show antiproliferative activity against the pancreatic cancer cell line MiaPaca-2.

AgRP-Derived melanocortin-5 receptor peptide antagonists

AgRP derived scaffolds composed of natural (Tyr, Ala, Val, Asn) and unnatural amino acids (Dap) with antagonist activity at the mouse MC5R

Treating trauma-induced acute blood loss

Novel formulations of D-β-hydroxybutyrate and melatonin improve survival from hemorrhagic shock.

Pain therapy without the risk of respiratory depression, addiction or abuse

An analgesic combination of peripherally restricted opioids that eliminates the risk of respiratory depression, chemical addiction or abuse.

3D printable bovine head model

AGRP-derived melanocortin receptor ligands

Identifying a selective MC4R antagonist for appetite modulation

Chimeric melanocortin receptor ligands

Melanocortin-4 receptor ligand reduces food intake in mice

Selective melanocortin receptor ligands

Potential dual-ligand approach to weight management

Multi-faceted glue for long-term survival of osseointegrated prosthetic devices

A multi-functional photopolymerizable glue that enhances the physical and biological adhesion between soft skin and a metal prosthetic device.

Risk-free in situ non animal (RISNA) surrogate assay for African swine fever virus

A method of using a surrogate virus to confirm inactivation of African Swine Fever Virus(ASFV)

A novel approach for bioprinting complex tissue models

A new method to align cells in muscle tissue using long, pre-aligned microtissues, which are suspended in a bio-ink and printed using a 3D extrusion bioprinter to form larger macrotissues.

Minimally invasive diagnostic for osteosarcoma in dogs

A panel of six definitive biomarkers that can be isolated from a canine blood sample for the detection of minimal residual disease and monitoring remission in dogs treated for osteosarcoma.

A method to identify cell-free biomarkers of cancers and other diseases

A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.

Assessing tumor behavior and response to therapy

A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.

Machine learning for early cancer detection

A machine learning method to train and validate algorithms to classify cancer risk based on a blood sample.

Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)

An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.

SARS-CoV-2 N-protein for use in COVID-19 serological assays (2020-323)

Full length SARS-CoV-2 Nucleocapsid (N) protein expressed by bacteria for use in serological assays to detect previous COVID-19 infection in humans and animals.

Continuous honey bee cell-line, AmE-711 (2020-240)

The first and only honey bee cell-line available for use in research and experimental testing.

Siderophore-based diagnosis of bacterial infections (20150206)

Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)

A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.

MRI of Amyloid Plaque in the Brain

Mammalian Cell Culture System for Anaplasmosis Vaccine Development

Mutated Opioid Receptors Block Chronic Pain Signals

3D printed deer head and neck model

Chronic wasting disease transmission and progression e-booklet

An informative and captivating e-booklet on chronic wasting disease transmission and progression.

2 licensing options
Selective bromodomain protein inhibitors that reduce cancer cell viability

Small molecules systematically designed as highly selective bromodomain inhibitors for development as cancer and inflammatory disease therapeutics.

3D printed bionic skull for multimodal neural sensing

A synergistic therapy for multi-drug resistant cancers

A synthetic polymer that targets cancer cell membranes and works synergistically with existing chemotherapeutic drugs to treat drug-resistant solid tumors.

CoFe nanowires for remote heating using an alternating magnetic field

A nanowire material for remote, rapid and uniform heating of biological samples.

A TLR-2 stimulatory molecule for use as a vaccine adjuvant

A small molecule that serves as an adjuvant in vaccines through stimulation of the immune receptor, TLR-2

Antibody based treatment for Type 1 Diabetes

A humanized monoclonal antibody against Serpin B13 to treat Type 1 Diabetes.

Immunostimulatory conjugates for targeted delivery as adjuvants

Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure

Novel small molecules for chemotherapy sensitization

Novel phenoxyphenyldeazaflavin compounds that sensitize cancer cells to widely used topoisomerase 2 poisons.

Patient Controlled Dynamic Therapeutic Compression Tension Garment

MHC Class II Molecules with Enhanced Co-receptor Affinity

A novel chemotherapy drug with reduced patient side-effects

A novel anti-cancer compound that inhibits translation and induces p53 in a DNA-damage independent manner to cause cell cycle arrest and apoptosis.

Microinjection for Single Cell Gene Manipulation

Referenceless Nyquist Ghost Correction for Echo Planar Imaging (EPI)

Segmenting 3D Bone Computed Tomography Data

Tosedostat (CHR-2797) as a Potential Analgesic

Real-Time Reporter and Efficient Enzymes for DNA Editing

Optimized Radio Frequency Pulses Generated From Magnetic Resonance User Defined Parameters

Scan-Specific Machine Learning Reconstruction for MRI

Sliding Windowed Infinite Fourier Transform (SWIFT)

3D Microscale Isotropic Metamaterials

Probes for Biosynthesis of Bacterial Cell Wall

Unique compounds to treat obesity

Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.

Denoising Magnetic Resonance Imaging Data

NOise reduction with DIstribution Corrected (NORDIC) technique for improving MRI imaging.

Bacterial Histidine Kinase Inhibitor

Faster MRI Acquistion with Motion Robustness

Tunable Neural Electrodes for MRI-Compatible Brain Signal Recordings

Myocardial Viability Functional Assessment

Dynamic Quantification of Myocardial Tissue MRI

Orthopedic Meniscus Repair Implant, Introducer and Delivery System

Conformable Dual-mode Ultrasound Transducers for Neuromodulation

Rationale Design of Inhibitors based on Crystal Structures of ssDNA Bound to APOBEC

Single Voxel MR Spectroscopy of Human Brain with Automatic Voxel Positioning

1 licensing option
Solar UV-Induced Skin Cancer Inhibitor

Magnetization Transfer Contrast Preparation

Multi-modal Neuromodulation Therapy Promotes Sleep

Pediatric Tracheo-bronchomalacia Stent and Deployment System

Mimicked Calcified Annulus Model for Preclinical Assessment of TAVR Devices

1 licensing option
Motion-Robust Cardiac B1+ Mapping of the Transmit Field

Imaging Source Distribution from Electromagnetic Signals

Adaptive Immune Response Stimulated with TLR8 and Dual TLR7/TLR8 Agonists

Black-Blood T1 Myocardial Mapping to Remove Partial Voluming Effects

PDAC Treatment with High Antiproliferative Activity Against MiaPaca-2

Lung Biopsy Tool

Novel inhibitors of HINT1 to treat neuropathic pain and addiction

Small-molecule inhibitors of hHint1 (and their synthesis) for use in basic CNS research and treatment of neuropathic pain and addiction.

Porcine B lymphoma cell lines

Three porcine B cell lines (Murtaugh001, Murtaugh002, Murtaugh003) established by 3 rounds of limiting dilution from splenic and subiliac lymph node lymphomas.

Smart Clothing with Dynamically Controlled Compression

Neuromodulator for Simultaneous Stimulation and Signal Reception

Improved Craniotome to Prevent Dural Tear

Efficient release of affinity-captured cells

A method to effectively release affinity-captured cells.

Developing Highly Specific Monoclonal Antibodies to Peptide in the Context of MHC II

Nonsurgical Method for Restoring Tooth Enamel

Peptide Activation of T Cells for Cancer Immunotherapy

Radiofrequency Antenna Array with Electric Dipole and Loop Elements

Warming of Cryopreserved Biomaterials using Laser Assisted Gold Nanorods

Improved Pertussis Vaccine

Algorithm for Discovering Genetic Interactions in Genome-Wide Association Studies (BridGE)

1 licensing option
Hydrophobic Surfaces for Tooth Tissues

Adaptive Refocusing of Ultrasound Arrays Using Synthetic Aperture Imaging Data

Live Attenuated Viral Vaccines

Catheter System with Guidewire Compartmentalization (20150223, Dr. Rumi Faizer)

HerdIn:Form(er): Mobile Questionnaire for Livestock Epidemiology Research (20150194, Dr. Andres Perez)

1 licensing option
Lower Extremity Edema Monitor (20150192, Dr. Rajesh Rajamani)

Deep Brain Stimulation Using Magnetic Brain Array (20150177, Dr. Jian-Ping Wang)

Improved Deep Brain Stimulation Target Selectivity (20150170, Dr. Shalom Michaeli)

Increased efficiency of CRISPR-Cas9 genome editing (Dr. Wendy Gordon)

An approach that increases the efficiency of CRISPR/Cas-9 genome editing 30-fold by fusing Cas9 to an HUH endonuclease tethered to the desired donor DNA.

Improved MRI Quality with Gradient Modulation Pulse Sequence (20150133, Dr. Kobayashi, Dr. Garwood)

Time Efficient Arterial Spin Labeling Imaging with Segmented Multiband-acquisition (20150097, Dr. Greg Metzger)

Improved MRI Method Uses Temperature Rise Contraints (20150061, Dr. Moortele)

Therapeutic compound for chronic inflammatory pain without dependence or tolerance (20140357, Dr. Philip Portoghese)

An analgesic compound without side effects that relieves chronic pain associated with arthritis, sickle cell disease, chemotherapy, AIDs and inflammation.

Mapping Prostate Cancer from Multi-parametric MRI with Improved Predictive Models (20140287, Dr. Greg Metzger)

In-vivo MRI Radiofrequency Pulses Robust against Respiration Induced Errors (20140236, Dr. Kamil Ugurbil)

Microbiome Profiling Technique for Improving Commercial Turkey Production (20140230, Dr. Timothy Johnson)

Multi-band SWIFT Improves MRI (20140121, Dr. Idiyatullin, Dr. Garwood)

Generalized Multiband Slice Accelerated Imaging (20140093, Dr. Dingxin Wang)

Bovine Tuberculosis Screening (20140058, Dr. Srinand Sreevatsan)

Reduced-power SWIFT Magnetic Resonance Imaging (20140052, Dr. Jinjin Zhang, Dr. Garwood)

Hay Prices per Ton Calculator App (20130300, Dr. Krishona Martinson)

Healthy Horse App Calculates Weight (20130294, Dr. Krishona Martinson)

Multislice Multiband Excitation with Parallel Transmission for B1 Homogenization and Power Reduction (20130170)

IV Line Lifting Device (20130136, Dr. Mary Hooke)

Intraoral Dental MRI Coil (20130110, Dr. Michael Garwood)

MRI Signal Separation using Iterative Calibration (20130079, Dr. Kamil Ugurbil)

Enhancing Cardiac Function Using Short Protein Inhibiting DNAs and RNAs (20120271, Dr. Michael Bowser)

MRI Method Reduces Peak Power for Multiband Images (20120077, Dr. Kamil Ugurbil)

Synchronized Multi-Modal Tinnitus Therapy (20120070, Dr. Hubert Lim)

A non-invasive or minimally-invasive method for the suppression of tinnitus using synchronized brain stimulation.

Canine Lymphoma Prognostic Classification (20120065, Dr. Jaime Modiano)

MRI Pulse Sequence: Steering Resonance over the Object (20120049, Dr. Michael Garwood)

Faster Functional and Diffusion MRI of the Brain (20110139, Dr. Kamil Ugurbil)

Lower Specific Absorption Rate for Multiband MRI (20110093, Dr. Kamil Ugurbil)

Faster Whole Brain Imaging (20110092, Dr. Kamil Ugurbil)

Generation of NK and Innate Lymphoid Cells from human stem cells (20110085, Dr. Michael Verneris)

Drs. Verneris, Miller and Blazar developed a method to create large numbers of Natural Killer cells and Innate Lymphoid Cells from hematopoietic stem cells.