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Novel Antimicrobial Peptide DGL13K

An antimicrobial peptide DGL13 that exhibits several desirable characteristics for a novel antibiotic.

Efficient CRISPR-based gene editing for stem cells

A CRISPR-based gene editing protocol for induced pluripotent stem cells (iPSCs) with improved editing efficiency and cell survival.

Ovarian cancer prognostic test for predicting response to chemotherapy and bevacizumab

A prognostic molecular test for predicting ovarian cancer patient response to platinum-based chemotherapy and/or treatment with bevacizumab.

NOD-2-active carboxamide compounds as vaccine adjuvants

Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.

Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines

A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.

Generating teratoma-derived skeletal muscle stem cells

A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.

Surface Coating with Novel Antimicrobial Peptide DGL13K

Family of antimicrobial peptides, based on the core peptide GL13, that directly attack the bacterial cell membrane.

Methods for Modifying Proteins and Peptides.

Production of alpha-N-methylated peptides for improved pharmacological properties.

Surface markers for identification and isolation of skeletal muscle stem cells

A list of cell surface marker antibodies that can identify and isolate (or purify) human skeletal muscle stem cells.

HUH fusion enzymes for multiplex protein labeling

HUH fusion tags are novel, robust endonucleases that allow proteins and DNA to be linked covalently in one simple step

Cell-free selection of site-specific polypeptide binders via tethering

In vitro selection method for the engineering of protein-based high-affinity binders to targets of interest with potential pharmacological value

Compound with selective inhibition potential against P300 and CBT

A compound to treat pediatric sarcoma through the inhibition of P300 and CBT

Camelid single domain antibody phage display library

Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target

T cell receptors for engineered T cell therapy

Mesothelin-specific T cell receptors for cell engineering and cancer therapy

Nanominne-1: novel virus-like particle (nanoparticle) vaccines to prevent SARS-CoV-2 infections

Series of novel vaccines containing 60 copies of SARS-CoV-2 antigens displayed in ordered array on a virus-like particle scaffold (nanoparticle)

Targeted Artificial DNA Replisome (TADR) a Tool for Targeted Mutagenesis

TADR is a protein-complex designed to target and mutate specific genes on plasmid in vivo

Bacteriophage cocktail for food decontamination

A cocktail of bacteriophages for specific targeting and eradication of foodborne Salmonella and Shiga toxigenic E.coli.

Engineered SARS-CoV-2 spike ectodomain for COVID-19 diagnostic assays

Engineered SARS-CoV-2 spike ectodomain expressed from stably transfected mammalian cell lines to be used as an effective diagnostic antigen against different SARS-CoV-2 variants

Novel anti-cancer agents that target the epigenetic reader protein

Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.

Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction

Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.

SARS-CoV-2 N-protein for use in COVID-19 serological assays (2020-323)

Full length SARS-CoV-2 Nucleocapsid (N) protein expressed by bacteria for use in serological assays to detect previous COVID-19 infection in humans and animals.

A method to genetically engineer monocytes (20180236)

The first and only method available to create genetically modified CD14+ monocytes for use in research or therapy.

Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)

A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.

Antagomir to prevent cardiac arrhythmia (2019-069)

Bactericidal Lanbiotic Inhibits Gram-negative Bacteria

Biological Imaging Provides Full Imaging of Samples

Minnesota Solvation (MNSOL) Database

An extensive and vetted database of free energies of solvation.

1 licensing option
Dental stem cells to treat spinal cord injury

A method of treating nervous tissue damage using dental pulp stem cells that leads to neuro-regeneration with a high safety profile and low probability of patient rejection.

Antibody based treatment for Type 1 Diabetes

A humanized monoclonal antibody against Serpin B13 to treat Type 1 Diabetes.

Immunostimulatory conjugates for targeted delivery as adjuvants

Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure

Real-Time Reporter and Efficient Enzymes for DNA Editing

Unique compounds to treat obesity

Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.

Improved Pertussis Vaccine

Bacterial Biofilms Targeted with Microbial Drone Therapeutics (20140281, Dr. Christine Salomon)

Dystrophin Gene Targeting Method and Tools (20140040, Dr. Perlingeiro, Dr. Daniel Voytas)

Long-term whole organ cryopreservation and transplantation

A method for long-term whole organ cryopreservation and transplantation using vitrification and nanowarming techniques.

Mass Spectrometry Software Improves Data Evaluation (20120293, Dr. Timothy Griffin)

2 licensing options
Sarcoma miRNA Expression Database for Cancer Treatment