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Derivation of human T-(progenitor) cells from human T-cells derived induced pluripotent stem cells (T-iPSCs)
A method for generating T cells from patient-derived induced pluripotent stem cells, enabling scalable and customizable immunotherapies for cancer and other diseases.
Modified myeloid-derived suppressor cells for treating GvHD
A novel cell therapy and associated methods for treating GvHD after allogenic hematopoietic cell transplantation.
A minipromoter for gene therapies
A mini-promoter to accommodate larger therapeutic genes of interest in gene therapy programs
Allogeneic extracellular vesicles for enhancing CD8+ T cell response in colorectal cancer
Allogeneic tumor-derived extracellular vesicles (TEVs) that stimulate CD8+ T cell response and reduce tumor growth in colorectal cancer.
Zika as an oncolytic virus to treat brain tumors
A method to treat aggressive brain cancers using Zika as an oncolytic virus combined with anti-cancer vaccinations.
Hamster CD4 and CD8 antibodies
Monoclonal antibodies against Syrian golden hamster CD4 and CD8
Therapeutic target for treatment of ataxia
A newly identified pathway that represents a therapeutic target for the prevention and treatment of ataxia.
Glycoengineered mesenchymal stem cells as targeted therapeutic carriers
A targeted therapeutic delivery system utilizing glycoengineered mesenchymal stem cells for reduced toxicity and increased treatment residence time
Hyperstable synthetic miniproteins as ligand scaffolds
Hyperstable synthetic miniproteins as modular ligand scaffolds for advanced therapeutics and diagnostics.
Inhibitory nucleic acid molecules targeting cyclin D1 mRNA
Inhibition of non-canonical functions of cyclin D1 as a potential therapy for liver diseases.
Broadspectrum potentially therapeutic nanobodies against COVID-19
A class of nanobodies (Nanosota-2, -3, and -4) offering broadspectrum therapeutic potential against COVID-19.
Nanorings for cell-mediated drug delivery
Farnesylated chemically self-assembled nanorings that facilitate targeted drug delivery between cells.
Efficient CRISPR-based gene editing for stem cells
A CRISPR-based gene editing protocol for induced pluripotent stem cells (iPSCs) with improved editing efficiency and cell survival.
Ovarian cancer prognostic test for predicting response to chemotherapy and bevacizumab
A prognostic molecular test for predicting ovarian cancer patient response to platinum-based chemotherapy and/or treatment with bevacizumab.
NOD-2-active carboxamide compounds as vaccine adjuvants
Benzimidazole-thiophene carboxamide compounds with NOD-2 agonist activity as potential vaccine adjuvants.
Lentivirus for keratinocyte immortalization and immortalized keratinocyte cell lines
A lentivirus for immortalizing human keratinocytes and immortalized keratinocyte cell lines.
Generating teratoma-derived skeletal muscle stem cells
A method for generating teratoma-derived skeletal muscle stem cells with functional regenerative capacity.
Methods for Modifying Proteins and Peptides.
Production of alpha-N-methylated peptides for improved pharmacological properties.
HUH fusion enzymes for multiplex protein labeling
HUH fusion tags are novel, robust endonucleases that allow proteins and DNA to be linked covalently in one simple step
Cell-free selection of site-specific polypeptide binders via tethering
In vitro selection method for the engineering of protein-based high-affinity binders to targets of interest with potential pharmacological value
Compound with selective inhibition potential against P300 and CBT
A compound to treat pediatric sarcoma through the inhibition of P300 and CBT
Camelid single domain antibody phage display library
Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target
T cell receptors for engineered T cell therapy
Mesothelin-specific T cell receptors for cell engineering and cancer therapy
Nanominne-1: novel virus-like particle (nanoparticle) vaccines to prevent SARS-CoV-2 infections
Series of novel vaccines containing 60 copies of SARS-CoV-2 antigens displayed in ordered array on a virus-like particle scaffold (nanoparticle)
Targeted Artificial DNA Replisome (TADR) a Tool for Targeted Mutagenesis
TADR is a protein-complex designed to target and mutate specific genes on plasmid in vivo
Engineered SARS-CoV-2 spike ectodomain for COVID-19 diagnostic assays
Engineered SARS-CoV-2 spike ectodomain expressed from stably transfected mammalian cell lines to be used as an effective diagnostic antigen against different SARS-CoV-2 variants
Novel anti-cancer agents that target the epigenetic reader protein
Small-molecule inhibitors target the bromodomain and PHD finger transcription factor (BPTF) for development as anti-cancer therapeutics.
Analgesic and anti-addictive compositions for treatment of chronic pain and opioid addiction
Strategically substituted agmatine derivatives as selective NMDA receptor subunit 2B (NR2B) antagonists for the treatment of chronic pain and opioid addiction.
Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)
A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.
Antagomir to prevent cardiac arrhythmia (2019-069)
Bactericidal Lanbiotic Inhibits Gram-negative Bacteria
Biological Imaging Provides Full Imaging of Samples
Minnesota Solvation (MNSOL) Database
An extensive and vetted database of free energies of solvation.
Antibody based treatment for Type 1 Diabetes
A humanized monoclonal antibody against Serpin B13 to treat Type 1 Diabetes.
Immunostimulatory conjugates for targeted delivery as adjuvants
Novel vaccine adjuvants composed of TLR7/TLR8 stimulating compounds conjugated to Hyaluronic Acid (HA) to achieve limited systemic exposure
Real-Time Reporter and Efficient Enzymes for DNA Editing
Unique compounds to treat obesity
Unique compounds are the first-ever to target melanocortin receptor 3 in an effort to treat obesity without increasing blood pressure.
Improved Pertussis Vaccine
Bacterial Biofilms Targeted with Microbial Drone Therapeutics (20140281, Dr. Christine Salomon)
Dystrophin Gene Targeting Method and Tools (20140040, Dr. Perlingeiro, Dr. Daniel Voytas)
Long-term whole organ cryopreservation and transplantation
A method for long-term whole organ cryopreservation and transplantation using vitrification and nanowarming techniques.