High Pressure Liquid Chromatography Using Carbon-Coated Silica

Technology No. 20090028
IP Status: Issued US Patent; Application #: 13/699,992

High Pressure Liquid Chromatography Using Carbon-coated Silica

High pressure liquid chromatography (HPLC) stationary phases based on carbon-coated silica have better mechanical strength and retentivity than pure carbon phases which makes them ideal for two-dimensional liquid chromatography.  Carbon stationary phase results in unique selectivity for polar and non-polar compounds as well as structural and stereoisomers. Carbon coated silica also results in higher loadability for HPLC. This method produces materials with a greater amount of surface area than prior processes that used carbon-coated silica. Carbon-coated silica has applications in HPLC and two-dimensional liquid chromatography.

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  • Due to its increased mechanical strength, the technology can be used at higher pressures than competing carbon adsorbents
  • Improved retentivity and higher loadability due to the high surface area
  • Better separation of stereoisomers when compared to other carbon materials
  • Excellent stability in acid and basic media
  • Applications in two-dimensional liquid chromatography


Peter W. Carr, PhD

Professor, Analytical Chemistry, Environmental Chemistry, Materials Chemistry
External Link (www.chem.umn.edu)

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