Mouse model expressing human APOBEC3B for cancer research
A novel transgenic mouse model expresses human APOBEC3B to study cancer mutagenesis and develop therapeutic strategies.
Technology No. 20150120
IP Status: Research tool
The mouse model has been generated and characterized.
Applications
- Evaluating APOBEC3B's role in tumorigenesis
- Studying point mutations in various cancer types
- Preclinical testing of APOBEC3B inhibitors
- Investigating tumor evolution and metastasis
Technology Overview
Researchers at the University of Minnesota have developed a novel transgenic mouse model that expresses human APOBEC3B, an enzyme implicated as a source of mutation in many cancers. This model is unique as mice naturally lack human APOBEC3B. The mouse strain, designated rosa26::LSL-A3Bi, expresses tumor-like levels of the enzyme, leading to accelerated carcinogenesis and providing a new in vivo platform for studying cancer phenotypes and testing therapeutic agents.
Phase of Development
TRL: 4-5The mouse model has been generated and characterized.
Desired Partnerships
This technology is now available for:- License
- Sponsored research
- Co-development
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Researchers
- Reuben Harris, PhD Position, Department of Biochemistry, Molecular Biology, and Biophysics
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expand_more library_books References (1)
- Cameron Durfee, Nuri Alpay Temiz, Rena Levin-Klein, Prokopios P Argyris, Lene Alsøe, Sergio Carracedo, Alicia Alonso de la Vega, Joshua Proehl, Anna M Holzhauer, Zachary J Seeman, Xingyu Liu, Yu-Hsiu T Lin, Rachel I Vogel, Rocio Sotillo, Hilde Nilsen, Reuben S Harris (2023), Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases, Cell Reports Medicine, 4
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expand_more cloud_download Supporting documents (1)Product brochureMouse model expressing human APOBEC3B for cancer research.pdf