Camelid single domain antibody phage display library
Highly diverse camelid antibody phage library to screen for binders to nearly any molecular target
Applications
- Drug discovery
- Direct evolution of proteins
- Epitope mapping
- Modulation of enzyme activity
Technology Overview
Highly diverse (~710) camelid single domain antibody phage display library constructed from the blood, bone marrow and spleens of a dozen llamas and alpacas. This library has been validated in Professor LeBeau’s lab, positively identifying 6-7 binders to specific proteins. This research tool can be used to isolate novel single domain antibody fragments against recombinant proteins and cell lines for various biotechnology applications in industry and academia. In fact, this library has yielded a possible drug called Nanosota-1C-Fc, which has demonstrated preventive and therapeutic efficacy against live SARS-CoV-2 infection in both hamster and mouse models ( see https://doi.org/10.7554/eLife.64815)
Desired Partnerships
This phage library is fully developed and available for license. Please contact our office to learn more.
Researchers
- Aaron LeBeau, PhD Assistant Professor, Department of Pharmacology
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swap_vertical_circlelibrary_booksReferences (1)
- The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates (2021), Ye, G., Gallant, J., Zheng, J., Massey, C., Shi, K., Tai, W., Odle, A., Vickers, M., Shang, J., Wan, Y. and Du, L, Elife
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