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20170069 – An algorithm using particle swarm optimization (PSO) in programming electrodes in deep brain stimulation arrays (DBSAs) provides clinicians with an intuitive, semi-automated approach for programming multi-electrode neuromodulation systems. The system and methods optimize deep brain stimulation (DBS) therapy by producing a range of optimal electrode configuration solutions that can achieve... Read More
20140289 – A non-toxic cryopreservative solution increases the safety and viability of preserved cells, for many applications, such as cell therapy. The multi-component, cell-optimized solutions contain no dimethyl sulfoxide (DMSO) and have shown significantly higher (more than double) post-thaw recovery of human cells than DMSO. The solutions show promise in storing, preserving and recovering... Read More
20110093 – A new magnetic resonance imaging (MRI) technology for multiband (MB), also known as Simultaneous Multi Slice (SMS), imaging uses multichannel transmit to overcome fundamental limitations in specific absorption rate (SAR). The approach uses multiple coils for radiofrequency (RF) transmit, in which each set of simultaneously excited slices are excited by an optimal combination of the... Read More
20170036 – An innovative annuloplasty ring, used in conjunction with an annuloplasty procedure in large animal models, creates consistent, reproducible models of aortic stenosis for long-term evaluation of transcatheter aortic valve replacement (TAVR) devices. The Calcified Annulus Model (CAM) annuloplasty ring is flexible, circular, planar in shape and covered with a fabric sheath secured to... Read More
20150061 – A new method using parallel transmission radiofrequency (RF) pulses for magnetic resonance imaging (MRI) under strict temperature rise constraints is expected to provide safer and more powerful MRI exams. The method compresses a model for a subject to be scanned by the MRI system into voxel clusters. Each voxel cluster defines a virtual observation point with peak sensitivity to the local... Read More
20170064 – A software program based on Fourier transform methods (FTM) provides accurate image-based fiber orientation and alignment data in tissue samples. FTM surpassed other methods in delivering accurate results, findings confirmed by applying FTM to SEM micrographs of fibrin tissue analogs. The code may also be used to characterize fiber orientation or other microstructural features in a... Read More
20170002 – CG-TARGET (Chemical-Genetic Translation via A Reference Genetic interaction nETwork) software is a pipeline that uses a genetic interaction network for predicting the molecular target of a compound/mode-of-action from chemical-genetic interaction profiles. Three input datasets (chemical-genetic interaction profiles, reference genetic interaction profiles, and a mapping from the query... Read More
20170001 – BEAN-counter (Barcoded Experiment Analysis from Next-generation sequencing) software is a pipeline for quantitative scoring of chemical-genetic interactions from sequencing-based chemical-genetic interaction screens. It provides a complete toolset for processing multiplexed sequencing data from barcoded mutant pools into chemical-genetic interaction profiles, based on these basic inputs:... Read More
z01152 – An unexpected discovery led to a patented technology to synthesize new kappa receptor agonist and delta receptor antagonist therapeutic compounds. Moving the 5'-substituent on naltrindole compounds, which are kappa receptor antagonists, converts the compound into either a kappa receptor agonist or a delta receptor antagonist, depending on where the substituent is moved. These new... Read More
20150194 – HerdIn:Form(er) is a web based mobile questionnaire developed for collecting epidemiological information on livestock in the field. HerdIn:Form(er) data is temporarily stored by a mobile device and can be submitted to another system for analysis. The questions and code can be easily adapted to collect the appropriate information for the disease that will be modeled. This tool is... Read More
20130255 – A new, versatile reagent can make dual, simultaneous site-specific protein modifications in one reaction and a wide range of conjugates, including protein-protein, protein-nucleotide, protein polymers, and protein-small molecule couplings. The reagent uses the enzyme PFTase, which is small, specific, and fast acting. The reagent is non-toxic and allows nearby biological processes to... Read More
20130141 – The Sanfilippo Behavior Rating Scale questionnaire can define Sanfilippo syndrome behavior along a specific pattern and progression of behavioral symptoms. This is the only known scale specifically for the syndrome. Sanfilippo syndrome (also known as Mucopolysaccharidosis type III) is a genetic neurological disease which manifests early in life, generally ending in death in adolescence... Read More
z02049-z01174-99186 – Electronic light detectors can be used to image and/or map biological samples and for DNA chip analysis. In contrast to conventional biological imaging techniques, this method scans across the sample and detects multiple images constructed from light emitted by the biological sample. The detector may be a linear charged-couple device (CCD) or a CMOS image sensor which gathers slices of... Read More
20130323 – A fluorescence resonance energy transfer (FRET) assay method for monitoring and testing the interactions between protein molecules in a high-throughput sample setting has been developed. The FRET system is able to test pharmaceuticals by attaching fluorescent derivatives to pairs of targeted proteins and mixing these with the drug that is being researched. This FRET method is applicable... Read More
20130273 – Researchers at the University of Minnesota have developed a new pacing protocol without feedback to prevent alternans formation and subsequently ventricular fibrillation (VF). This pacing protocol was tested using a physiological ionic model of cardiac myocyte, in the presence or absence of heart rate variability (HRV). They also incorporated the effects of short-term memory on diastolic... Read More
20130320 – Systemic administration of D-serine has been shown to alter blood sugar levels in mice. An acute, high-dose injection of D-serine or a genetic mutation leading to endogenously elevated levels of D-serine resulted in hypoglycemia compared to controls in mice. Human islets secreted more insulin in response to glucose when exposed to D-serine under target activating conditions. Prolonged... Read More
z08015-20110161 – As the magnetic field strength increases in clinical magnetic resonance imaging (MRI) scanners, the images become less sensitive to classic T1-weighting, which is based on T1 relaxation time. T1-weighted images are often used in biomedical imaging since it inherently provides tissue-specific differences that provide contrast in images (darker and lighter areas in the MRI image). **... Read More
20130193-20140051 – A link has been found between a variety of heart and bone illnesses and the dysregulation of sarco/endoplasmic reticulum calcium ATPase (SERCA), the calcium pump in cardiac and skeletal muscles. To test pharmaceuticals aimed at treating and reversing the diseases caused by impaired SERCA regulations, specific assays must be designed. These tests are required to analyze the reactions... Read More
20140040 – A new method and tool have been developed for the genetic therapy of Duchenne muscular dystrophy (DMD) and related genetic disorders. The dystrophin gene sequence has been genetically corrected by inserting a synthetic exon transcript into the gene code prior to the first exon in the natural coding sequence. The inserted construct ends in a stop signal that keeps transcription of mutated... Read More
20140020 – University of Minnesota researchers have developed an amplification method and library preparation process of pico-quantities of RNA. This system is the first of its kind to properly amplify small quantities of RNA as a template while still producing a highly efficient library. The amplification requires only 500pg to 5ng for a template and can capture RNA of 15 nucleotides and longer.... Read More
lsbu-catalog – Click for a printable Life Sciences Research Tools Catalog. View the research tools online. The University of Minnesota provides tools to researchers in the life sciences. These tools include monoclonal and polyclonal antibodies, transgenic mice, cell lines, laboratory reagents and techniques and biomarkers.
z02081 – The alterations in Reelin levels occur in significantly specific amounts in schizophrenic, autistic, majorly depressed, and bipolar patients. A Reelin diagnostic blood test aids in the diagnoses and differentiation of autism, major depression, bipolar disorder, and schizophrenia. This test also monitors patient medication compliance, which results in a greater likelihood of patient... Read More
z02209 – Anaplasmosis is a disease caused by Anaplasma phagocytophilium. This intracellular bacterium is transmitted via infected tick bites, and infects humans and animals in North America, Europe, Australia, and Africa. A method of propagating Anaplasma species stably in mammalian cells would assist both industry and academia research and development. A way to propagate Anaplasma species... Read More
z01174 – A method has been developed to acquire digital images and maps of biological samples using an electronic light detector array, for example a CCD or CMOS image sensor. The biological sample may include biological holding structures such as a DNA spot array on a DNA chip and protein bands in a 2D gel. The array allows imaging methods such as fluorescence detection from a biological sample... Read More
20120293 – The Proximity-based Intensity Normalization (PIN) software offers improved evaluation of mass spectrometry data to identify molecules of biological interest. The algorithm dramatically improves the accuracy in the evaluation of mass spectrometry data, making it useful not only for protein identification, but metabolite and peptide identification. In accurately quantifying signals in... Read More
z09185-z09028 – A groundbreaking functional assessment of networks algorithm called Simultaneous Departure from the Equilibrium (SDE) has been developed for the analysis of global interactions in a system. The technology was developed to evaluate how departure from equilibria can be used to assess the stability or health of a complex network. The... Read More
99184 – A potential method for enhancing the lifetime of bone marrow stem cells that uses cyclic ADP-ribose (cADPR) analogs has been developed. This technology works to increase the proliferation of human hemopoietic progenitor cells, more specifically to increase lymphocytes, in order to enhance the efficiency of the immune system without causing cell differentiation. This technology’s... Read More
z02049 – Electronic light detectors can be used to image and/or map biological samples and for DNA chip analysis. In contrast to conventional biological imaging techniques, this method scans across the sample and detects multiple images constructed from light emitted by the biological sample. The detector may be a linear charged-couple device (CCD) which gathers slices of the sample to be... Read More
z03043 – A single camera system creates 3D data from a 2D video and reduces costs and complexity of traditional systems for obtaining 3D geometry data. Typical methods for obtaining 3D geometry from a 2D video require either a complicated multiple camera system or a single camera system that only has limited uses. For example, some single-camera 3D systems require the target object to be planar... Read More
z00220 – A method using polynucleotide analogues selectively represses the specific genes in the zebrafish, making it possible to ascribe a particular biological function to a known nucleic acid sequence. Similar gene inhibition techniques have proven extremely useful in model systems such as the fruit fly, D. malenogaster, and the nematode, C. elegans, but have previously not been feasible with... Read More
20130112 – The valve control system results in more consistent decellularized tissue while allowing those working in the lab to effectively cut large amounts of time and effort out of the decellularization and recellularization process of organs. In the process of tissue engineering a large amount of time is spent on changing fluids and carboys manually while the decell/recell process takes place,... Read More
20110105 – The highly sensitive magnetic-based biomolecule detection system can identify the presence of antigens, DNA fragments, biomarkers or other biomolecules using magnetic nanoparticles, an applied magnetic field and a giant magnetoresistance (GMR) sensor that detects the presence of nanoparticle tagged biomolecules based on changes in the measured magnetic field. This sensor may provide four... Read More
antibodies – Monoclonal and polyclonal antibodies are available to researchers; the list of available antibodies is in spreadsheet format and can be printed. Monoclonal and polyclonal antibodies are antigen-specific targeting proteins useful as important research tools in the fields of immunology, cell biology, biochemistry, molecular biology, neurology, and medicine. It is possible to create... Read More
96135 – The Sleeping Beauty (SB) Transposon System is a highly efficient and extensively tested system for inserting DNA of interest into chromosomes for high level, long-term gene expression. The SB system involves a “cut and paste” transposon system and can be used for the efficient delivery of DNA to a wide range of cells, including cultured mammalian cells, mouse... Read More
z00105 – This tick cell line includes proteins and genes that are new targets for acaricides and vaccines for the control of the cattle tick Boophilus microplus. The tick Boophilus microplus causes heavy losses of cattle worldwide. This line stems from embryos of B. microplus and is continuously grown in a tissue culture medium (L15B). This is a normal diploid cell line having 22 (female cells) or... Read More
20120126 – Plasmid vectors that incorporate portions of native plasmids from Rickettsia amblyommii, a symbiont of the Lone Star tick. This shuttle vector system has been engineered to be able to replicate in both E. coli (for easy production) and in rickdettsiae. Current technology for transformation of rickettsiae relies on transposon mutagenesis that results in random insertion of genes into the... Read More
z07102 – The Reverse Plug Cytometer combines the positive features of traditional flow cytometers, laser scanning, and imaging cytometers. Specifically, the device enables single cell tracking of large numbers of cells. This creates a valuable tool for unique cell population studies that currently are not feasible. It has utility in the following applications: characterization and isolation of... Read More
z08158 – A mouse model for the study of human brain tumors in a variety of ways, such as generation of "humanized" models for high throughput drug screening and candidate gene validation with exceptional speed and flexibility. The Sleeping Beauty transposable elements are used to achieve chromosomal integration of human oncogenes into endogenous brain cells of immune-competent mice.... Read More
z09100 – This transgenic mouse model can help researchers understand the fundamental biology behind iron deficiency's effects on the brain. It was created by crossing targeted Slc11a2 flox/flox mice in a 129 J1 background strain (20) with CaMKIIα−cre (L7ag#13 line (21)) transgenic mice in a C57BL/6J background to generate double mutant, hippocampal neuron specific knockout of Slc11a2... Read More
20110048 – BAC transgenic mouse that expresses GFP when stimulated through the T or B cell antigen receptor has many applications for basic research on the immune system, infectious disease, autoimmune disease, transplantation, vaccination, and immunotherapy for cancer. It will also be useful in screening compounds designed to activate or inhibit T cell receptor or B cell receptor activation in... Read More
20110168 – Collection of three canine melanoma cell lines for research purposes. Melanoma is the most dangerous type of skin cancer, and is the leading cause of death from skin disease. Melanoma is not the most common form of skin cancer, but rates are steadily increasing. PubMed ID# 9539362 Collection of over 17 canine hemangioma cell lines for research purposes. Hemangiosarcoma is a... Read More
20120137 – This clone is a sub-clone of the well-defined DF-1 cells and is able to produce higher Marek's Disease Virus titers compared to the parental cell line. Marek's Disease Virus is a major poultry pathogen for which there is no known cure. The poultry industry needs a high titer vaccine for Marek's Disease Virus from a well characterized master seed stock in order to vaccinate billions of... Read More
20180139 – The Center for Magnetic Resonance Research (CMRR) at the University of Minnesota develops magnetic resonance imaging, spectroscopy methodologies and instrumentation to non-invasively acquire structural, functional and biochemical information from humans. These capabilities are used to study the function of organs in healthy and diseased states. CMRR has developed pulse sequence software... Read More
20100059 – The STAT5b-CA x pax5+/- leukemic cell line grows in the presence of interleukin-7. Withdrawal of IL7 results in cell death. We have also treated the STAT5b-CA x pax5+/- cell line with the histone deacetylase inhibitor apicidin. Cell line can be used to identify genes required for transformation and survival of the leukemic cells. Likewise, both the cell line and mouse model can be used to... Read More
z04203 – Tooth Explorer is a three dimensional dental software program designed to teach oral anatomy in a highly efficient digital environment. This program provides dentistry students with an interactive, three-dimensional dental library of 32 individual adult teeth. Students are able to engage in self-paced learning by rotating and identifying significant features of individual, anatomically... Read More
20110025 – The Digital Pathology Virtual Microscope Slide database is the only database that offers a high quality resolution of 83X oil immersion, which is necessary for the proper examination of blood cells and microorganisms. The use of virtual microscopes can transform traditional teaching methods by removing the reliance on physical space, equipment, and specimens to a model that is... Read More
z09085a – A fabrication method to obtain ultra-smooth pure metal films with a variety of nanometer sized structural features including grooves, bumps, pyramids, ridges, and holes for sensor and plasmonic applications has been developed. It is a simple, high throughput process that is highly reproducible and produces fewer surface imperfections than other processes. The devices produced using... Read More
z09208 – Researchers at the University of Minnesota have compiled a library of 1,600 analgesics consisting of several classes of molecules and the synthetic intermediates used to create them by chemical reactions. The chemical compounds detailed in the library fall into the following broad categories: agonists, which stimulate a response from cells, antagonists, which obtain a desired outcome... Read More
ndsr87072 – Nutrition Data System for Research (NDSR) is a Windows-based nutrition analysis program designed for the collection and analyses of 24-hour dietary recalls, food records, menus, and recipes. Calculation of nutrient intake occur immediately providing data per ingredient, food, meal, and day in report and analysis file formats. The software includes a dietary supplement assessment module so... Read More
z01136 – Histology is the study of the structure and function of the cells, tissue and organs of the human anatomy as viewed through a microscope. The Histology Time software helps students learn anatomy and cell biology through a computer-based histology atlas of cells, tissues, and organs. The database contains more than 5,000 light microscope images organized into nineteen chapters covering... Read More
