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Image processing technique for improved MRI image fidelity

A novel technique to improve MRI image fidelity via the combination of a denoising and deep learning-based reconstruction step.

Nanorings for cell-mediated drug delivery

Farnesylated chemically self-assembled nanorings that facilitate targeted drug delivery between cells.

Wearable ultrasound sensors for imaging and sensing

Novel wearable ultrasound transducers designed to integrate real-time imaging, sensing, and treatment functions for application in therapeutics and diagnostics.

Quantitative ultrasound for fatty tissue imaging

A signal processing method to enhance ultrasound imaging of fatty tissue.

Dual frequency RF coil for magnetic resonance imaging

A novel RF resonant coil that can operate at both X-nuclear and proton frequencies.

Ovarian cancer prognostic test for predicting response to chemotherapy and bevacizumab

A prognostic molecular test for predicting ovarian cancer patient response to platinum-based chemotherapy and/or treatment with bevacizumab.

Early detection of ovarian cancer using a multiprotein classifier

A blood test for detecting ovarian cancer with over 90% accuracy by monitoring key protein levels.

Endotracheal intubation with computer vision

A machine learning-based intubation tube for autonomous or computer-assisted endotracheal intubation.

Autonomous high-accuracy analysis of prostate cancer biopsies

A framework for automated detection of prostate cancer on histopathology slides.

Steerable magneto-photonic particles for targeted delivery and collection of light

An embeddable magneto-photonic microparticle that can be externally positioned and orientated for targeted delivery and collection of light.

Self-navigation to enable efficient 3D DWI SE-EPI multi-slab multi-band imaging

A method for correcting MRI data from corruption due to physiological changes.

Augmented reality transjugular intrahepatic portosystemic shunt (AR-TIPS) set and other interventional devices

An augmented reality (AR) system to assist clinicians in performing medical procedures inside the body where 3D anatomical information is important

Electron paramagnetic resonance (EPR) imaging without magnet

A method which produces low cost EPR imaging with better receiver isolation and no magnet requirement

Engineered SARS-CoV-2 spike ectodomain for COVID-19 diagnostic assays

Engineered SARS-CoV-2 spike ectodomain expressed from stably transfected mammalian cell lines to be used as an effective diagnostic antigen against different SARS-CoV-2 variants

Method for mass production of high performance magnetic nanoparticles for biomedical applications

Iron nitride nanoparticles are post-processed by applying a wet ball milling method in conjunction with different surface-active media and centrifugation steps to obtain ultra-stable, monodispersed, uniformly sized, surface-functionalized, and sub-100-nm iron nitride nanoparticles suitable for biomedical applications

Lateral flow assay for respiratory viruses

CRISPR/Cas9-based point-of-care diagnosis for SARS-CoV-2

AI-enabled support tool for COVID-19 diagnosis using chest x-rays

A deep learning model for screening COVID-19 patients using chest x-rays with >98% accuracy.

Risk-free in situ non animal (RISNA) surrogate assay for African swine fever virus

A method of using a surrogate virus to confirm inactivation of African Swine Fever Virus(ASFV)

MRI RF coil for improved field efficiency and image quality

A novel RF coil design with high dielectric constant materials to improve B1+ efficiency in MRI systems.

Rapid microbial diagnostics

A method for rapid detection of microorganisms using chemiluminescence.

Autonomous, high accuracy classification of cancer in tissue samples

A machine learning-based algorithm for cancer detection and classification.

Quantitative relaxation mapping

Pulse sequence for MRI scanners

1 licensing option
Software for dual-mode ultrasound array driver and imaging platform (DMUA-DIP)

A software to drive dual-mode ultrasound arrays in imaging and therapy modes in a synchronized fashion.

Minimally invasive diagnostic for osteosarcoma in dogs

A panel of six definitive biomarkers that can be isolated from a canine blood sample for the detection of minimal residual disease and monitoring remission in dogs treated for osteosarcoma.

A method to identify cell-free biomarkers of cancers and other diseases

A cost-effective method to discover biomarkers for a variety of cancers that can be measured in a blood sample and can inform risk, diagnosis, prognosis and predict responses to therapy.

Assessing tumor behavior and response to therapy

A method to identify biomarkers for the detection of tumor behavior and/or increased risk for tumor metastasis in order to improve patient outcomes in both humans and animals.

Machine learning for early cancer detection

A machine learning method to train and validate algorithms to classify cancer risk based on a blood sample.

Community-based antibiotic screening method for polymicrobial infections (2020-090)

An improved antibiotic susceptibility test (AST) that determines minimal inhibitory concentration (MIC) with high physiological relevance for polymicrobial infections.

Fast and reliable neutralization antibodies assay for AAV gene therapy (2020-121)

An assay to measure neutralization antibodies for adeno-associated viral vectors in gene therapy, to screen patients for clinical trials and treatment.

SARS-CoV-2 N-protein for use in COVID-19 serological assays (2020-323)

Full length SARS-CoV-2 Nucleocapsid (N) protein expressed by bacteria for use in serological assays to detect previous COVID-19 infection in humans and animals.

SARS-CoV-2 spike receptor-binding domain for use in COVID-19 assays (2020-301)

Stably transfected mammalian cell lines that express the receptor-binding domain of the SARS-CoV-2 spike protein for use in assays and research relevant to COVID-19 and potential therapies.

Multifunctional, flexible sensor array for urethral catheters (20140233)

A new urethral catheter for simultaneous measurement of pressure distribution and neural activity.

Orthodontic teeth aligners enabling deeper analysis and personalized treatment plans (2020-227, Dr. Alex Fok)

A system and method for measuring stress and strain distribution of invisible orthodontic teeth aligners.

3D Spine Registration Software for Computational Thoracic Volume Modeling (20160071)

Circulating tumor biomarkers for meningiomas (2020-164)

A biomarker panel for early diagnosis of meningiomas with the potential to improve patient outcomes.

Siderophore-based diagnosis of bacterial infections (20150206)

Monoclonal Anti-FAP for cancer research and therapeutic development (2019-131)

A plasmid encoding a recombinant monoclonal antibody against tumorigenic protein FAP in the tumor stroma that is ideal for both basic research and therapeutic drug development.

A novel small molecule screening platform for tauopathies (2019-123)

FRET-based biosensors that identify early toxic states of tau for use in basic research and clinical development of therapeutics for tauopathies including Alzheimer’s Disease.

Functional Analysis of Networks in the Neural System

SALSA - Automated Speech Assessment

For Quantitative Neuropsychological Cognitive Assessment

MRI Contrast Software Based on RAFF-n

Algorithm for Non-invasive Source Localization of Neural Activity

MRI of Amyloid Plaque in the Brain

3D Video from 2D Using a Single Camera System

Biological Imaging Provides Full Imaging of Samples

Improved Nuclear Magnetic Resonance Spectroscopy Using Half-Spin Echo Data Recovery

Biological Sample Imaging Device

Machine learning algorithm for 3D particle field reconstruction

A machine learning algorithm for accurately reconstructing 3D particle fields.

Peripheral Artery Disease Quality of Life (PADQOL) Questionnaire

A validated instrument to assess the physical, psychosocial and emotional effects on patients suffering from peripheral artery disease.

4 licensing options
Visualization of intracardiac electrograms on 3D heart model (VIEgram)

A software for easy visualization of intracardiac electrograms on 3D heart models.

1 licensing option
Improving photovoltaic cell efficiency by employing highly stable, earth-abundant nanoparticle system

A novel nanomaterial for applications involving photon upconversion.

3D printed bionic skull for multimodal neural sensing

Machine learning-based sleep quality monitoring

CoFe nanowires for remote heating using an alternating magnetic field

A nanowire material for remote, rapid and uniform heating of biological samples.

Machine Learning-based Dynamic Activity Recommendation System

A deep learning architecture for wearable devices to evaluate, predict, and improve the quality of sleep by recommending personalized activities.

iTorsion - Smartphone App for Ocular Torsion Diagnosis

MRI Pre-Scan Method for Imaging Metallic Devices

3D printing on Moving Freeform Surfaces

CMRR - Center for Magnetic Resonance Research Software for Siemens MRI Scanners

9 licensing options
Referenceless Nyquist Ghost Correction for Echo Planar Imaging (EPI)

Segmenting 3D Bone Computed Tomography Data

Scan-Specific Machine Learning Reconstruction for MRI

Specific kinase biosensors to probe cancer metabolism

Substrate peptides for Ser/Thr kinases to investigate the metabolic processes of cancer cells.

Sliding Windowed Infinite Fourier Transform (SWIFT)

Compressed Sensing Coronary MRI Sequence

Enhanced Resolution Cardiac MRI

Probes for Biosynthesis of Bacterial Cell Wall

Denoising Magnetic Resonance Imaging Data

NOise reduction with DIstribution Corrected (NORDIC) technique for improving MRI imaging.

Faster MRI Acquistion with Motion Robustness

Universal tyrosine kinase substrates

Non-selective, universal substrates for tyrosine kinases that couple with a fluorescent readout mechanism to serve as quantity and quality control (internally and/or between samples). 

Myocardial Viability Functional Assessment

Dynamic Quantification of Myocardial Tissue MRI

Conformable Dual-mode Ultrasound Transducers for Neuromodulation

Single Voxel MR Spectroscopy of Human Brain with Automatic Voxel Positioning

1 licensing option
Magnetization Transfer Contrast Preparation

Particle Swarm Optimization for Programming Neuromodulation Systems

Multi-modal Neuromodulation Therapy Promotes Sleep

Image-Based Fiber Orientation and Alignment Calculator

3 licensing options
Motion-Robust Cardiac B1+ Mapping of the Transmit Field

Imaging Source Distribution from Electromagnetic Signals

Clinical Quality MRI Image under Inhomogeneous Magnetic Field

Black-Blood T1 Myocardial Mapping to Remove Partial Voluming Effects

Kinase assay to aid in development of therapeutics for acute myeloid leukemia

Peptide substrates to sensitively and specifically measure the real-time activity of FLT3, a kinase linked to acute myeloid leukemia.

Lung Biopsy Tool

3D Shoulder Motion Measurement System

Smart Clothing with Dynamically Controlled Compression

Designing 2D and 3D Adiabatic Pulses

Neuromodulator for Simultaneous Stimulation and Signal Reception

Colorimetric Assay for Microbial Screening

Efficient release of affinity-captured cells

A method to effectively release affinity-captured cells.

Endometrial Cancer Recurrence Risk Biomarker

Radiofrequency Antenna Array with Electric Dipole and Loop Elements

Gut Microbiome Analysis for Detecting Colon Cancer Mutations

Adaptive Refocusing of Ultrasound Arrays Using Synthetic Aperture Imaging Data

Kinase biosensor for individualized cancer therapy (20150289, Dr. Laurie Parker)

A method to sensitively and specifically detect the activity of multiple kinases, from multiple samples in a traceable manner.

Improved Deep Brain Stimulation Target Selectivity (20150170, Dr. Shalom Michaeli)

Improved MRI Quality with Gradient Modulation Pulse Sequence (20150133, Dr. Kobayashi, Dr. Garwood)

Time Efficient Arterial Spin Labeling Imaging with Segmented Multiband-acquisition (20150097, Dr. Greg Metzger)

Improved MRI Method Uses Temperature Rise Contraints (20150061, Dr. Moortele)

Portable Urine Flow Rate Detector (20140342, Dr. Sean Elliott)

Improved Multi-Band Magnetic Resonance Imaging (MRI) (20140303, Dr. Kamil Ugurbil)

Circulating Tumor Cell Detection with New Reagents (20140299, Dr. Jayanth Panyam)

Label-Free Transistor-based Biosensor (20140298, Dr. Dorfman, Dr. Frisbie)

Mapping Prostate Cancer from Multi-parametric MRI with Improved Predictive Models (20140287, Dr. Greg Metzger)

Mesoporous Silica-coated Iron Oxide Nanoparticle (20140249, Dr. Christy Haynes)

In-vivo MRI Radiofrequency Pulses Robust against Respiration Induced Errors (20140236, Dr. Kamil Ugurbil)

Multi-band SWIFT Improves MRI (20140121, Dr. Idiyatullin, Dr. Garwood)

Generalized Multiband Slice Accelerated Imaging (20140093, Dr. Dingxin Wang)

Soft Tissue Elasticity Imaging Method to Assess Pathology (20140062, Dr. Bojan Guzina)

Protein Scaffold for Molecular Targeting Ligands (20140059, Dr. Benjamin Hackel)

Reduced-power SWIFT Magnetic Resonance Imaging (20140052, Dr. Jinjin Zhang, Dr. Garwood)

Mesoporous silica nanoparticles with ultra high porosity

Novel mesoporous silica nanoparticles with high pore volume and open pore structure, displaying high thermal stability and mechanical sturdiness

Cerebral Amyloid Angiopathy and Alzheimer’s Disease Diagnosis and Treatment (20130341, Dr. Karunya Kandimalla)

Anti-arrhythmic Effect of Cardiac Pacing Without Feedback (20130273, Dr. Alena Talkachova)

Magnetic Resonance Electrical Properties Tomography (20130259, Dr. Bin He)

Reagent for Dual Protein Labeling (20130255, Dr. Mark Distefano)

Multislice Multiband Excitation with Parallel Transmission for B1 Homogenization and Power Reduction (20130170)

VnmrJ SWIFT Software for Agilent Varian Systems

1 licensing option
In Vivo Measurement of ATP Hydrolysis (20130111, Dr. Jianyi (Jay) Zhang)

Intraoral Dental MRI Coil (20130110, Dr. Michael Garwood)

MRI Tool is Alternative to Arthroscopy (20130100, Dr. Jutta Ellermann)

MRI Signal Separation using Iterative Calibration (20130079, Dr. Kamil Ugurbil)

Mass Spectrometry Software Improves Data Evaluation (20120293, Dr. Timothy Griffin)

2 licensing options
MRI Method Reduces Peak Power for Multiband Images (20120077, Dr. Kamil Ugurbil)

MRI Pulse Sequence: Steering Resonance over the Object (20120049, Dr. Michael Garwood)

Faster Functional and Diffusion MRI of the Brain (20110139, Dr. Kamil Ugurbil)

Lower Specific Absorption Rate for Multiband MRI (20110093, Dr. Kamil Ugurbil)

Faster Whole Brain Imaging (20110092, Dr. Kamil Ugurbil)

Digital Pathology Virtual Microscope Slides with Online Database (20110025, Dr. Stephen Wiesner)

The Digital Pathology Virtual Microscope Slides allow medical students and allied health professionals to access hematology, body fluids, bacteriology and parasitology microscope slides through an online database for distance learning and enhanced curriculum delivery.

3 licensing options
Magnetization Transfer Using Inversion Recovery (20100117)

Sarcoma miRNA Expression Database for Cancer Treatment