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z06164 – Programmable self-assembly is a breakthrough directed self-assembly method that enables low-cost, highly consistent and high volume manufacturing of complex meso systems and devices (optical and fluidic, integrated circuits, sensors, actuators). Programmable self-assembly enables batch integration both in two and three dimensions, is highly parallel and works up to 1000 times faster than... Read More
z06066 – Compounds have been proven to inhibit a unique enzyme in mycobacterium tuberculosis not found in humans and is not required by the host flora. This mechanism disrupts the activity of the bacteria’s iron chelators known as siderophores. The bacteria that cause TB lose their virulence without the ability to extract iron from the surrounding environment. Since the iron chelators target... Read More
z05221 – Uncooled, focal plane arrays are designed to absorb broadband light with extremely high thermal sensitivity. This causes difficulty for the array to process “hot spots” since the signals are highly uneven. A focal plane array has been designed that combines an etalon with a microbolometer in order to produce continuously tunable infrared detection. Tunable detection is produced by... Read More
z05107 – With an aging population, cost-effective management of chronic heart disease is a high priority. In particular, pacemaker and defibrillator companies are increasingly interested in adding sensors and monitors to implantable devices to monitor for signs of cardiac problems. With early warning, the cardiac patient can seek medical attention prior to a life threatening event, resulting in... Read More
z04220 – Online instructional modules teach complementary therapies and holistic medicine in a timely and relevant method. The modules are written and reviewed by experts from the University of Minnesota Schools of Nursing, Pharmacy, and Medicine and the Center for Spirituality and Healing, which has a national reputation for its research and education on complementary therapies and holistic... Read More
z04117 – Ultra wideband radio (UWB) receivers often use coherent architectures, which require estimation of a radio frequency (RF) carrier signal and the channel response. Synchronization error between incoming signal and template, distorted template signal, or noise in template signal degrade the performance of a coherent receiver. Non-coherent architectures use extremely short duration... Read More
z04067 – One of the major problems facing patients with heart failure is pulmonary edema. It is now possible to monitor the extent of pulmonary edema by measuring impedance from the existing hardware of a cardiac rhythm management (CRM) device such as a cardiac pacemaker, a cardiac resynchronization therapy device (CRT-D) or an implantable cardioverter defibrillator (ICD). By taking advantage of... Read More
z04007 – Microbial biosynthesis of chalcones, stilbenes and flavonoids in engineered microbes offers a production route with greater selectivity and purity than current methods that rely on chemical extraction from plants. In addition, the feedstock for microbial biosynthesis (phenylpropionic acid) can be derived from lignin, an inexpensive agricultural byproduct. Microbial biosynthesis of... Read More
z03098-z08001 – The high resolution xerographic printer uses electrostatic interactions to create high resolution circuits on the nano scale and operates like a laser printer for microelectronics. These devices use a stamp to produce a micro assembly based on deposition. The xerographic printer produces micropatterns on circuits. ** View the Term Sheet ** ** Contact Larry Micek for specific... Read More
z03043 – A single camera system creates 3D data from a 2D video and reduces costs and complexity of traditional systems for obtaining 3D geometry data. Typical methods for obtaining 3D geometry from a 2D video require either a complicated multiple camera system or a single camera system that only has limited uses. For example, some single-camera 3D systems require the target object to be planar... Read More
z02056 – This medical device can close congenital heart defects and is self-centering, can completely occlude defects, and be retrieved back to the catheter in the event of sub-optimal deployment. The device is designed to be bioresorbable and has no metallic components. This simplifies the manufacturing of the device and allows the device to degrade over time and be replaced by natural fibrous... Read More
z00220 – A method using polynucleotide analogues selectively represses the specific genes in the zebrafish, making it possible to ascribe a particular biological function to a known nucleic acid sequence. Similar gene inhibition techniques have proven extremely useful in model systems such as the fruit fly, D. malenogaster, and the nematode, C. elegans, but have previously not been feasible with... Read More
z00216 – The single-wire arc spray apparatus and methods yield a narrow beam spray and a controlled width spray pattern having highly defined edges. Current arc spray technologies can suffer from spray divergence of up to 20 degrees, leading to the spray coating having uneven thickness. The described method generates a narrow beam thermal spray of liquid droplets to overcome this problem and... Read More
z00135 – Nuclear magnetic resonance (NMR) spectroscopic quality can be improved by acquiring more half spin echo data and using an iterative numerical method to reconstruct missing data points of the corresponding full symmetrical echo data. This method avoids the degrading effects of noise and provides higher-quality NMR spectrum with sharper peaks. The baseline of this technique is also... Read More
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z00046 – A method of identifying, producing, and using as probiotics certain Bifidobacterium longum strains that inhibit gram positive and gram negative bacteria and promote healthy GI function has been developed. These strains function in the large intestine where they secrete an iron binding molecule that depletes the iron supply for unwanted iron-dependent bacteria and therefore afford... Read More
20130112 – The valve control system results in more consistent decellularized tissue while allowing those working in the lab to effectively cut large amounts of time and effort out of the decellularization and recellularization process of organs. In the process of tissue engineering a large amount of time is spent on changing fluids and carboys manually while the decell/recell process takes place,... Read More
20130033 – The high efficiency hydraulic transformer operates at high efficiency across the full displacement range. Conventional variable displacement pumps suffer from low efficiency when operated at partial loads and low displacements, but the described architecture overcomes these problems. Potential applications for the system include hydraulic hybrid vehicles, hydrostatic transmission for wind... Read More
20120205-20130254 – A real-time active piston motion control acts as the virtual crankshaft in a free piston engine to coordinate the combustion and the load. The control system forces the piston to follow a pre-determined trajectory by sensing the combustion event and the load in real-time. This allows the piston motion to be precisely controlled in real-time, which is difficult with the current free piston... Read More
20120188 – Tests of verbal fluency (VF) are widely used in neurological, psychiatric, mental health, and school settings. There are two main types of VF tests - phonemic and semantic. The phonemic test consists of naming as many words as possible in 60 seconds that begin with a specified letter of the alphabet. The semantic test consists of naming words belonging to a semantic category (e.g.,... Read More
20120134 – A device that can measure the tension placed on tissues during orthopedic and soft tissue surgeries would enhance outcomes for those procedures. During orthopedic surgery, the proper treatment of the surrounding soft tissues, not just the bone, is crucial to a successful surgery. The soft tissues are often manipulated extensively, but there are currently no methods to measure the amount... Read More
20120116 – Nanoparticles for cancer treatment are designed to deliver effective amounts of anticancer agents more directly to tumors so less anticancer agents are needed, reducing the overall toxicity and side effects of the treatment. Current nanoparticle delivery methods use the enhanced permeability and retention (EPR) effect to deliver the agents to a particular depth within the tumor. Due to a... Read More
20120099 – A method of biomass gasification using solar energy produces a higher yield of syngas when compared to traditional combustion methods. The solar-powered biomass gasifier forgoes the traditional method of combusting biomass or fossil fuels and instead uses solar energy to obtain the necessary energy from heat. Using the biomass feedstock as the source of energy to drive the gasification... Read More
20120069 – The microfluidic device can increase recovery and viability of cells, as well as increase extraction of the cryopreservation agent dimethly sulfoxide (DMSO), all at a low cost. Freezing cells such as cord blood, bone marrow, and stem cells require DMSO, but this cryopreservation agent needs to be removed before the cells are used in clinical applications. While current methods of... Read More
20120012 – Certain tumors, such as triple negative breast cancer and gliomas, are especially difficult to treat due to unique metabolic features of these tumors. In particular, tumor hypoxia in these cancers can lead to treatment failure, relapse, and patient mortality as these cells are resistant to standard chemo- and radiation therapy. Hypoxic areas develop when tumor metabolism rate outpaces... Read More
20110171 – The increased miniaturization of CMOS logic devices (complementary metal-oxide semiconductor), which is the dominant technology for constructing integrated circuits, have led to challenges such as increased power dissipation and device variability. Moore’s law for CMOS is approaching fundamental physical limits. There is a concerted effort to identify alternative or hybrid technologies... Read More
20110070 – A vaccine targeting antibiotic resistant Staphylococcus aureus prevents infection by targeting several secreted bacterial toxins. S. aureus produces a family of exotoxins (superantigens and cytolysins) that hyper-activate the immune system and facilitate the organism’s ability to cause infections and death. These toxoid vaccine candidates provide 100% immunity in separate rabbit models of... Read More
20110052 – A method to inhibit ornithine decarboxylase that is suitable for use as a pharmaceutical for the treatment of cancer has been developed. The compound has been shown to be effective at ornithine decarboxylase inhibition potentially without the hearing loss associated with eflornithine. This invention provides a method for treating cancer as well as a method for inhibiting initial cancer... Read More
20110019 – A thermochemical reactor has been developed to produce syngas, a mixture of hydrogen and carbon monoxide from concentrated solar energy, water, and carbon dioxide. The solar reactor efficiently produces affordable hydrogen that can be used directly as fuel. The reactor features dual zones for the simultaneous reduction and oxidation through the continuous cycling of metal oxide to split... Read More
98119 – A method has been developed that utilizes cryopreservative agents for improving the survivability of hematopoietic cells when frozen. Using a balanced electrolyte solution with an arabinogalactan equivalent, a high-survival rate of hematopoietic cells is maintained. It contains a much smaller concentration of glycerol compared to other methods and does not use DMSO, thus decreasing cell... Read More
20130012 – Chronos is a course scheduler that integrates with enterprise information systems such as PeopleSoft and is intended to be used by university students and academic advisors. This technology gives students the means to effectively find university courses and produce a class schedule following the students’ preferences. The system allows students to input their desired university courses... Read More
20100117 – An improved MRI pulse sequence and post processing technique have been developed that dramatically improve MT imaging while improving safety by reducing specific absorption rate (SAR), which is a measure of tissue heating. Clinical usage of magnetization transfer (MT) imaging with MRI scanners has been limited due to radio frequency (RF) heating of the subject, which ultimately limits the... Read More
20100014 – Nanoparticles such as FeCo-FeCoO, FeCo-Au, FeCo-SiO2, Fe-Ag, Co-Au, C, Fe-Au are currently limited to laboratory scale production due to a lack of a system to produce these nanoparticles in large quantities. But a nanoparticle synthesis system has been designed that produces unique nanoparticles including gold shells with high crystallinity and high magnetic moment nanoparticles on an... Read More
20110105 – The highly sensitive magnetic-based biomolecule detection system can identify the presence of antigens, DNA fragments, biomarkers or other biomolecules using magnetic nanoparticles, an applied magnetic field and a giant magnetoresistance (GMR) sensor that detects the presence of nanoparticle tagged biomolecules based on changes in the measured magnetic field. This sensor may provide four... Read More
z00026 – A magnetic grid can be used to separate magnetic material from non-magnetic material in taconite processing, yielding a higher amount of fine, high grade magnetic particles. Hydro separators and flotation plants are commonly used to separate out magnetic material; however, these separation methods often lead to the loss of fine, high grade magnetic particles, therefore lowering the yield... Read More
z05074 – The method for delivering large precursors for chemical vapor deposition (CVD) based on sublimation in a fluidized bed provides more reliable vapor pressure of larger precursor molecules and reduces particle contamination. The fluidized bed consists of either pure precursor or precursor mixed with an inert powder. When operating at a carrier gas flow above the minimum required to fluidize... Read More
20120074 – The DNA aptamers that bind specifically to the human protein fractalkine (FKN) are better suited for targeted drug delivery than other technologies such as antibodies and are non-immunogenic. Fractalkine is a recently discovered chemokine that acts as an adhesion molecule for leukocytes. This feature makes fractalkine a preferred candidate for targeting. Chemokines are a class of... Read More
antibodies – Monoclonal and polyclonal antibodies are available to researchers; the list of available antibodies is in spreadsheet format and can be printed. Monoclonal and polyclonal antibodies are antigen-specific targeting proteins useful as important research tools in the fields of immunology, cell biology, biochemistry, molecular biology, neurology, and medicine. It is possible to create... Read More
96135 – The Sleeping Beauty (SB) Transposon System is a highly efficient and extensively tested system for inserting DNA of interest into chromosomes for high level, long-term gene expression. The SB system involves a “cut and paste” transposon system and can be used for the efficient delivery of DNA to a wide range of cells, including cultured mammalian cells, mouse... Read More
z00105 – This tick cell line includes proteins and genes that are new targets for acaricides and vaccines for the control of the cattle tick Boophilus microplus. The tick Boophilus microplus causes heavy losses of cattle worldwide. This line stems from embryos of B. microplus and is continuously grown in a tissue culture medium (L15B). This is a normal diploid cell line having 22 (female cells) or... Read More
20120126 – Plasmid vectors that incorporate portions of native plasmids from Rickettsia amblyommii, a symbiont of the Lone Star tick. This shuttle vector system has been engineered to be able to replicate in both E. coli (for easy production) and in rickdettsiae. Current technology for transformation of rickettsiae relies on transposon mutagenesis that results in random insertion of genes into the... Read More
z07102 – The Reverse Plug Cytometer combines the positive features of traditional flow cytometers, laser scanning, and imaging cytometers. Specifically, the device enables single cell tracking of large numbers of cells. This creates a valuable tool for unique cell population studies that currently are not feasible. It has utility in the following applications: characterization and isolation of... Read More
z08158 – A mouse model for the study of human brain tumors in a variety of ways, such as generation of "humanized" models for high throughput drug screening and candidate gene validation with exceptional speed and flexibility. The Sleeping Beauty transposable elements are used to achieve chromosomal integration of human oncogenes into endogenous brain cells of immune-competent mice.... Read More
z09100 – This transgenic mouse model can help researchers understand the fundamental biology behind iron deficiency's effects on the brain. It was created by crossing targeted Slc11a2 flox/flox mice in a 129 J1 background strain (20) with CaMKIIα−cre (L7ag#13 line (21)) transgenic mice in a C57BL/6J background to generate double mutant, hippocampal neuron specific knockout of Slc11a2... Read More
20110048 – BAC transgenic mouse that expresses GFP when stimulated through the T or B cell antigen receptor has many applications for basic research on the immune system, infectious disease, autoimmune disease, transplantation, vaccination, and immunotherapy for cancer. It will also be useful in screening compounds designed to activate or inhibit T cell receptor or B cell receptor activation in... Read More
20110168 – Collection of three canine melanoma cell lines for research purposes. Melanoma is the most dangerous type of skin cancer, and is the leading cause of death from skin disease. Melanoma is not the most common form of skin cancer, but rates are steadily increasing. PubMed ID# 9539362 Collection of over 17 canine hemangioma cell lines for research purposes. Hemangiosarcoma is a... Read More
20120137 – This clone is a sub-clone of the well-defined DF-1 cells and is able to produce higher Marek's Disease Virus titers compared to the parental cell line. Marek's Disease Virus is a major poultry pathogen for which there is no known cure. The poultry industry needs a high titer vaccine for Marek's Disease Virus from a well characterized master seed stock in order to vaccinate billions of... Read More
20180139 – The Center for Magnetic Resonance Research (CMRR) at the University of Minnesota develops magnetic resonance imaging, spectroscopy methodologies and instrumentation to non-invasively acquire structural, functional and biochemical information from humans. These capabilities are used to study the function of organs in healthy and diseased states. CMRR has developed pulse sequence software... Read More
z00077 – A method for the fluorination of polymers uses difluorocarbene to produce desired fluorinated polymers. Difluorocarbene is a reactive species that can rapidly react with certain unsaturated parts of the polymer chain. The reaction works under mild conditions and provides a low cost method of synthesizing fluorinated polymers. ** View the Term Sheet ** ** Contact Larry Micek for... Read More
20120196 – Evacuation route planning to effectively evacuate people in a man-made or natural disaster is of increasing importance with growing populations. The efficient emergency management software produces high quality solutions for emergency evacuation and large event transportation planning. This technology significantly reduces the computational cost compared to existing software because of a... Read More
z04187 – Olefins can be produced from alkanes by partial oxidation with the functional group of the parent alkane intact. Partial oxidation leads to higher yields and lower reaction temperatures than steam cracking; the described invention can be used with wide range of feedstocks, including biomass. ** View the Term Sheet ** ** Contact Larry Micek for specific details. ** Olefins,... Read More
