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20120012 – Certain tumors, such as triple negative breast cancer and gliomas, are especially difficult to treat due to unique metabolic features of these tumors. In particular, tumor hypoxia in these cancers can lead to treatment failure, relapse, and patient mortality as these cells are resistant to standard chemo- and radiation therapy. Hypoxic areas develop when tumor metabolism rate outpaces... Read More
20110171 – The increased miniaturization of CMOS logic devices (complementary metal-oxide semiconductor), which is the dominant technology for constructing integrated circuits, have led to challenges such as increased power dissipation and device variability. Moore’s law for CMOS is approaching fundamental physical limits. There is a concerted effort to identify alternative or hybrid technologies... Read More
20110070 – A vaccine targeting antibiotic resistant Staphylococcus aureus prevents infection by targeting several secreted bacterial toxins. S. aureus produces a family of exotoxins (superantigens and cytolysins) that hyper-activate the immune system and facilitate the organism’s ability to cause infections and death. These toxoid vaccine candidates provide 100% immunity in separate rabbit models of... Read More
20110052 – A method to inhibit ornithine decarboxylase that is suitable for use as a pharmaceutical for the treatment of cancer has been developed. The compound has been shown to be effective at ornithine decarboxylase inhibition potentially without the hearing loss associated with eflornithine. This invention provides a method for treating cancer as well as a method for inhibiting initial cancer... Read More
20110019 – A thermochemical reactor has been developed to produce syngas, a mixture of hydrogen and carbon monoxide from concentrated solar energy, water, and carbon dioxide. The solar reactor efficiently produces affordable hydrogen that can be used directly as fuel. The reactor features dual zones for the simultaneous reduction and oxidation through the continuous cycling of metal oxide to split... Read More
98119 – A method has been developed that utilizes cryopreservative agents for improving the survivability of hematopoietic cells when frozen. Using a balanced electrolyte solution with an arabinogalactan equivalent, a high-survival rate of hematopoietic cells is maintained. It contains a much smaller concentration of glycerol compared to other methods and does not use DMSO, thus decreasing cell... Read More
20130012 – Chronos is a course scheduler that integrates with enterprise information systems such as PeopleSoft and is intended to be used by university students and academic advisors. This technology gives students the means to effectively find university courses and produce a class schedule following the students’ preferences. The system allows students to input their desired university courses... Read More
20100117 – An improved MRI pulse sequence and post processing technique have been developed that dramatically improve MT imaging while improving safety by reducing specific absorption rate (SAR), which is a measure of tissue heating. Clinical usage of magnetization transfer (MT) imaging with MRI scanners has been limited due to radio frequency (RF) heating of the subject, which ultimately limits the... Read More
20100014 – Nanoparticles such as FeCo-FeCoO, FeCo-Au, FeCo-SiO2, Fe-Ag, Co-Au, C, Fe-Au are currently limited to laboratory scale production due to a lack of a system to produce these nanoparticles in large quantities. But a nanoparticle synthesis system has been designed that produces unique nanoparticles including gold shells with high crystallinity and high magnetic moment nanoparticles on an... Read More
20110105 – The highly sensitive magnetic-based biomolecule detection system can identify the presence of antigens, DNA fragments, biomarkers or other biomolecules using magnetic nanoparticles, an applied magnetic field and a giant magnetoresistance (GMR) sensor that detects the presence of nanoparticle tagged biomolecules based on changes in the measured magnetic field. This sensor may provide four... Read More
z00026 – A magnetic grid can be used to separate magnetic material from non-magnetic material in taconite processing, yielding a higher amount of fine, high grade magnetic particles. Hydro separators and flotation plants are commonly used to separate out magnetic material; however, these separation methods often lead to the loss of fine, high grade magnetic particles, therefore lowering the yield... Read More
z05074 – The method for delivering large precursors for chemical vapor deposition (CVD) based on sublimation in a fluidized bed provides more reliable vapor pressure of larger precursor molecules and reduces particle contamination. The fluidized bed consists of either pure precursor or precursor mixed with an inert powder. When operating at a carrier gas flow above the minimum required to fluidize... Read More
20120074 – The DNA aptamers that bind specifically to the human protein fractalkine (FKN) are better suited for targeted drug delivery than other technologies such as antibodies and are non-immunogenic. Fractalkine is a recently discovered chemokine that acts as an adhesion molecule for leukocytes. This feature makes fractalkine a preferred candidate for targeting. Chemokines are a class of... Read More
antibodies – Monoclonal and polyclonal antibodies are available to researchers; the list of available antibodies is in spreadsheet format and can be printed. Monoclonal and polyclonal antibodies are antigen-specific targeting proteins useful as important research tools in the fields of immunology, cell biology, biochemistry, molecular biology, neurology, and medicine. It is possible to create... Read More
96135 – The Sleeping Beauty (SB) Transposon System is a highly efficient and extensively tested system for inserting DNA of interest into chromosomes for high level, long-term gene expression. The SB system involves a “cut and paste” transposon system and can be used for the efficient delivery of DNA to a wide range of cells, including cultured mammalian cells, mouse... Read More
z00105 – This tick cell line includes proteins and genes that are new targets for acaricides and vaccines for the control of the cattle tick Boophilus microplus. The tick Boophilus microplus causes heavy losses of cattle worldwide. This line stems from embryos of B. microplus and is continuously grown in a tissue culture medium (L15B). This is a normal diploid cell line having 22 (female cells) or... Read More
20120126 – Plasmid vectors that incorporate portions of native plasmids from Rickettsia amblyommii, a symbiont of the Lone Star tick. This shuttle vector system has been engineered to be able to replicate in both E. coli (for easy production) and in rickdettsiae. Current technology for transformation of rickettsiae relies on transposon mutagenesis that results in random insertion of genes into the... Read More
z07102 – The Reverse Plug Cytometer combines the positive features of traditional flow cytometers, laser scanning, and imaging cytometers. Specifically, the device enables single cell tracking of large numbers of cells. This creates a valuable tool for unique cell population studies that currently are not feasible. It has utility in the following applications: characterization and isolation of... Read More
z08158 – A mouse model for the study of human brain tumors in a variety of ways, such as generation of "humanized" models for high throughput drug screening and candidate gene validation with exceptional speed and flexibility. The Sleeping Beauty transposable elements are used to achieve chromosomal integration of human oncogenes into endogenous brain cells of immune-competent mice.... Read More
z09100 – This transgenic mouse model can help researchers understand the fundamental biology behind iron deficiency's effects on the brain. It was created by crossing targeted Slc11a2 flox/flox mice in a 129 J1 background strain (20) with CaMKIIα−cre (L7ag#13 line (21)) transgenic mice in a C57BL/6J background to generate double mutant, hippocampal neuron specific knockout of Slc11a2... Read More
20110048 – BAC transgenic mouse that expresses GFP when stimulated through the T or B cell antigen receptor has many applications for basic research on the immune system, infectious disease, autoimmune disease, transplantation, vaccination, and immunotherapy for cancer. It will also be useful in screening compounds designed to activate or inhibit T cell receptor or B cell receptor activation in... Read More
20110168 – Collection of three canine melanoma cell lines for research purposes. Melanoma is the most dangerous type of skin cancer, and is the leading cause of death from skin disease. Melanoma is not the most common form of skin cancer, but rates are steadily increasing. PubMed ID# 9539362 Collection of over 17 canine hemangioma cell lines for research purposes. Hemangiosarcoma is a... Read More
20120137 – This clone is a sub-clone of the well-defined DF-1 cells and is able to produce higher Marek's Disease Virus titers compared to the parental cell line. Marek's Disease Virus is a major poultry pathogen for which there is no known cure. The poultry industry needs a high titer vaccine for Marek's Disease Virus from a well characterized master seed stock in order to vaccinate billions of... Read More
cmrr – The Center for Magnetic Resonance Research (CMRR) at the University of Minnesota develops magnetic resonance imaging, spectroscopy methodologies and instrumentation to non-invasively acquire structural, functional and biochemical information from humans. These capabilities are used to study the function of organs in healthy and diseased states. CMRR has developed pulse sequence software... Read More
z00077 – A method for the fluorination of polymers uses difluorocarbene to produce desired fluorinated polymers. Difluorocarbene is a reactive species that can rapidly react with certain unsaturated parts of the polymer chain. The reaction works under mild conditions and provides a low cost method of synthesizing fluorinated polymers. ** View the Term Sheet ** ** Contact Larry Micek for... Read More
20120196 – Evacuation route planning to effectively evacuate people in a man-made or natural disaster is of increasing importance with growing populations. The efficient emergency management software produces high quality solutions for emergency evacuation and large event transportation planning. This technology significantly reduces the computational cost compared to existing software because of a... Read More
z04187 – Olefins can be produced from alkanes by partial oxidation with the functional group of the parent alkane intact. Partial oxidation leads to higher yields and lower reaction temperatures than steam cracking; the described invention can be used with wide range of feedstocks, including biomass. ** View the Term Sheet ** ** Contact Larry Micek for specific details. ** Olefins,... Read More
20100059 – The STAT5b-CA x pax5+/- leukemic cell line grows in the presence of interleukin-7. Withdrawal of IL7 results in cell death. We have also treated the STAT5b-CA x pax5+/- cell line with the histone deacetylase inhibitor apicidin. Cell line can be used to identify genes required for transformation and survival of the leukemic cells. Likewise, both the cell line and mouse model can be used to... Read More
20100242 – Annexin II Increases MHC I Expression on Tumor Cells The protein Annexin II can work through a mechanism to boost immunotherapy treatments. Annexin II possesses attributes which makes it desirable as a cancer vaccine adjuvant - it selectively increases the shuttling of exogenous antigen to the major histocompatibility complex class 1 (MHC I) pathway, a key antigen-presenting process... Read More
20120324 – The DBCreate software quickly and accurately updates thermodynamic databases used in geochemical modeling, based on changes in temperatures and pressures. The software facilitates the production of pressure, temperature and problem specific geochemical thermodynamic databases conveniently and quickly while minimizing the possibility of introducing errors caused by manual entry. ... Read More
z08092 – There are no highly sensitive, uncooled mid infrared (IR) thermal sensors on the market. This wavelength is useful for detecting carbon monoxide and generic hyrdrocarbons and has applications in carbon monoxide detection, gas detection, and hydrocarbon detection. In the current generation of broadband detectors, the mid infrared region or MWIR (3-5 microns) is susceptible to... Read More
z03038 – Ethanol and alcohols can be converted into syngas using a robust autothermal reforming process. Syngas is a mixture of carbon monoxide and hydrogen that can be used to synthesize other chemicals or directly as a fuel. The recent advancements in fuel cell technology have spurred an interest in converting alcohols into hydrogen rich gas streams. This robust method enables the conversion... Read More
z01051 – The La Crescent grape is a very cold hardy grape cultivar that produces a white wine of excellent quality, reminiscent of the cultivar Vignoles. Its relatively high sugar and acidity levels have encouraged winemakers to ferment La Crescent in a sweet or semi-sweet style. La Crescent wines commonly have aromas of apricot, peach, citrus and pineapple and lack strong herbaceous aromas or... Read More
z02115 – Frontenac gris wines present aromas of peach and apricot with hints of enticing citrus and tropical fruit. A brilliant balance of fruit and acidity creates lively, refreshing wines. Unique and complex flavors make the Frontenac gris grape excellent for table, dessert and ice wines. Frontenac gris vines are “grower-friendly” due to their winter hardiness, disease resistance, strong vigor,... Read More
z05103 – The Marquette grape is a cold hardy, red wine grape variety with excellent disease resistance. The Marquette grape’s high sugar and moderate acidity make it very manageable in the winery. Finished wines are complex, with attractive ruby color, pronounced tannins, and desirable notes of cherry, berry, black pepper, and spice on both nose and palate. As a red wine, Marquette represents a... Read More
z02120 – Narcotic analgesics such as morphine for chronic pain treatment have been used widely. However, the prolonged used of morphine for such purposes could lead to many unwarranted side effects, two of which are tolerance and addiction to the drug. Instead of developing stronger narcotic analgesic agents, a complex mutant opioid receptor, the target of morphine action, has been characterized... Read More
z05009 – Programmable Reconfigurable Fluid 3D Manufacturing enables the parallel fabrication of three dimensional multi-component microsystems. It can be used to assemble multi-chip modules, hybrid systems, and micro-opto-electro-mechanical systems that consist of non-identical components. Such systems cannot be assembled using conventional self-assembly because the components are only... Read More
98039 – METIS is a set of serial programs for graph partitioning, finite element analysis, and fill order reduction for sparse matrices. The algorithms implemented in METIS are based on the multilevel recursive-bisection, multilevel k-way, and multi-constraint partitioning schemes developed in the University of Minnesota’s Digital Technology Center (DTC) labs. METIS produces graph... Read More
94087 – A robust, cost effective process for olefin production uses the autothermal reforming method. This process dehydrogenates hydrocarbons to produce a mono-olefin using a catalyst consisting of platinum modified with copper or tin on a ceramic monolith. The worldwide demand for the production of olefins is higher than any other chemical. Traditionally, steam cracking is heavily relied on... Read More
z09049 – The World Health Organization (WHO) reports that corneal blindness affects more than 10 million people worldwide. Despite the increased prevalence, only 100,000 people receive corneal transplants each year through a process called keratoprosthesis. This shortfall is due to inadequate supply of donor corneas along with the unsuitability of some patients to receive a corneal graft due to... Read More
z08156 – The Savvy Caregiver™ is an educational program focused on providing instructional material for Alzheimer’s and dementia caregivers. The Savvy Caregiver™ Program can be used by individual caregivers or in workshops facilitated by service agencies to train both family and professional Alzheimer caregivers. The program teaches the basic knowledge, skills, and attitudes needed to handle the... Read More
99091 – The Virtual Dental Patient is a combination of systems and methods that read digital medical records to create three-dimensional models. This computerized method for dental assessment provides an accurate three-dimensional representation of the surface anatomy of hard and soft tissues, tooth contacts, and motion of the patient’s jaw. The Virtual Dental Patient can accurately and... Read More
z04199 – Fluidic valves are used to control the flow of fluid between two locations. These valves typically have partial openings which can lead to pressure loss. A pulse width modulated fluidic valve has been developed that uses a rotary design in either a fully on or fully off configuration. Since the valve is either on or off, the time the valve is in transition is small. The result is a... Read More
20110133 – Most wireless, charge-based sensors are based upon microelectromechanical systems (MEMS) technology, which are micron-sized electro-mechanical devices. Typically, the capacitance is tuned by changing the mechanical spacing between two electrodes. The resulting sensors are large and not well-suited for in vivo applications. A graphene based variable capacitor varactor has been... Read More
z07178 – Lantibiotics are peptide-based antimicrobial compounds produced by several types of bacteria that inhibit other closely-related bacteria. The most common lantibiotic exhibits a wide range of effectiveness against most Gram-positive bacteria, supporting its common use in extending shelf life. However, this lantibiotic is ineffective in preventing the growth of Gram-negative bacteria such... Read More
20100235 – High-Intensity Focused Ultrasound (HIFU) is a technology that produces high frequency, focused ultrasound beams to destroy diseased tissues. Ablation of tissues occurs when the ultrasound beams locally increase the temperature of diseased tissue in order to destroy the tissue. Presently, it has approval from the FDA as a treatment for uterine fibroids, though it's in clinical... Read More
z06015 – The proliferation of Blu-Ray players has increased the demand for blue LEDs and blue laser diodes that rely on gallium nitride (GaN) and other group III-nitrides. The best solution for producing high quality, long-lived devices is to use bulk GaN substrates, which are expensive. Alternatively, GaN on thin-film, non-GaN substrates can be used as a low cost alternative, but these... Read More
z07191 – A highly precise navigation system uses visual-aided inertial navigation measurements that feeds into a unique Kalman filter based algorithm for pose estimation (position and orientation). The pose estimation algorithm can provide a unified basis for stability control, traction control, slip detection and obstacle avoidance in ground-based applications and navigation and tracking in... Read More
z08062 – Wheeled and tracked vehicles, while cheaper than bipedal or jumping robots, often have problems with slippage. The Loper robotic platform has solved this problem with an innovative wheel design for mobile robots consisting of three lobes connected by to a central hub that essentially act as cogs for the purpose of stair climbing. The design enables fast stair climbing at a reduced... Read More
z06055 – Matrix converters are used to convert an AC signal to an AC signal with a different voltage and phase. Matrix converters do not require capacitor and inductors and offer an all-silicon solution for AC-AC power conversion, which is fundamental in motor drive and other applications. Typically, a matrix converter consists of multiple switches that are controlled using complicated space... Read More
