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z01027 – A vertical cavity surface emitting laser (VCSEL) offers single mode confinement. The VCSEL is comprised of a substrate and a lower mirror, active region and upper mirror arranged in a vertical stack to form a laser. Horizontally spaced-apart regions of increased refractive index extend vertically at least partially through the vertical stack to promote single-mode confinement in the... Read More
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20170230 – Frequency-swept excitation can be used for 3D imaging to obtain broad bandwidth and sharp slab profiles. Quadratic phase modulation along the slice encoding direction imparts additional spatiotemporal encoding, which better distributes signal content in the slice direction and enables higher acceleration rates robust to slice under-sampling. Sliding the quadratic phase across the... Read More
20170171-20170288 – A magnetic resonance imaging (MRI) sequence acquires cardiac phase resolved native T1 maps of the myocardium, with integrated B1+ quantification at a temporal resolution of up to 40 ms in a single breath-hold. This sequence, TempOrally-resolved Parametric Assessment of Z-magnetization recovery (TOPAZ) is based on contiguous FLASH imaging readout after magnetization inversion from the... Read More
20160298 – “Smart” compression garments can be controlled dynamically using shape changing materials (such as shape memory alloys (SMA)) enables clinical cardiovascular intervention in both healthy and unhealthy populations. The degree of compression, timing of compression, and type and site of compression (pressure) can be controlled dynamically. Controlling compression allows the ability to gait... Read More
20160184-2 – A compact thermally integrated reformer design partially converts alternative fuels to reformate, a gaseous mixture of hydrogen, partially reacted products and some original fuel. This mixture extends the possible diesel engine range of operation with low reactivity fuels like ammonia and increases thermal efficiency through recovering wasted heat from the exhaust. Fumigating... Read More
20160218 – A novel approach generates monoclonal antibodies (MAb) against peptide presented in major histocompatibility complex II (MHC II). The methodology centers on having a soluble peptide:MHC (p:MHC) Class II complex linked to biotin as the B cell antigenic target. The approach uses recombinant peptide:MHC monomers as immunogens and subsequently relies on multimers to enrich the responding... Read More
20160251 – A new craniotome design helps prevent dural tears during craniotomy procedures. The device uses high pressure liquid (e.g., sterile saline solution) to separate the dura from the cranium ahead of the craniotome in order to minimize the risk of the dura snagging on the dura guard. The concept could be marketed as either an entirely new craniotome design or an attachment to... Read More
20170172 – A magnetic resonance imaging (MRI) method enables imaging with late gadolinium enhancement (LGE) contrast throughout the entire cardiac cycle with high temporal resolution. LGE, the clinical gold standard for assessing focal fibrosis/scars, depicts scar tissue as an enhancement 10-20 minutes after contrast injection. Contrast-agent accumulates in the scar-tissue due to diminished washout... Read More
20170206 – A device with a ferroelectric oxide crystal layer in a capacitive arrangement and a switch converts heat to electric energy in a small temperature difference regime. The method uses oxide crystals that undergo highly reversible phase transformations from a strongly ferroelectric phase to a paraelectric phase upon heating. As the crystal is cooled through the phase transformation it... Read More
20120271 – A new class of oligonucleotides can be used to treat cardiomyopathy. The short, protein-interacting DNAs and RNAs (SPIDRs) are designed to selectively bind to phospholamban (PLN), a compound that inhibits SERCA, which is a necessary function for cardiac health. Results show that ssDNA and RNA interact strongly with PLN, thereby inhibiting its effect on SERCA. Furthermore, the length... Read More
20130259 – A spatial gradient based electrical property tomography (EPT) method uses magnetic resonance imaging (MRI) to produce non-invasive and high spatial resolution in vivo imaging of electrical conductivity and permittivity of biological tissues. Electrical properties are determined based on estimated radiated gradient values of the electrical properties of the object. For example, electrical... Read More
20160260 – A new method designs and implements spatially selective, multidimensional adiabatic radio frequency (RF) pulses for use in magnetic resonance imaging (MRI). Spatially selective inversion is achieved adiabatically in both two- and three-dimensional (2D and 3D) regions of interest. The multidimensional adiabatic pulses are designed by dividing a parent adiabatic pulse into 2D selective... Read More
.jpg?1504640727 "The signal space detector uses a single hyperplane and can be applied to DVD channels.")
z01023 – A signal space detector (SSD) that uses only a single hyperplane offers nearly the same performance as the fixed delay tree search with decision feedback (FDTS/DF). The SSD technology, which can be applied to a variety of systems, including DVD channels, estimates a channel input symbol by detecting input symbols from a finite number of observation samples that define an observation... Read More
20170213 – A 3D printable heat exchanger compatible with selective laser melt metal additive manufacturing has been developed for hydraulic oil cooling applications. The plate-fin tube bank has special features, including non-circular, internally finned tubes, and external angled fins to allow flexibility in the printing process. The design allows additive manufacture commercial-scale heat... Read More
20170084 – Multi-Banded (MB) RF-pulse Enhanced Magnetization Imaging (MBE-MTI) uses multi-banded RF pulses in MT preparation. These multi-banded RF pulses not only provide simultaneous off-resonance saturations of bound water spins on both sides of the central frequency of mobile water, but also increase the coverage of off-resonance frequency range without increasing the potential of direct... Read More
z07107-z03212 – Three cost effective technologies for creating nanocrystals via a gas-plasma, non-aqueous process are available to license. Gas phase production of these nanocrystals is faster, higher yield and more cost efficient than current processes. The technologies can be optioned for a six month trial period for a $10,000 Try fee to enable testing of the commercial viability of this process to... Read More
20160257 – Cell nanocoating is being used in a food safety application to detect and quantify total microbial content (e.g., bacteria, fungi, viruses, Archaea, protists and gram-negative and gram-positive bacteria). In this technology, a plasmonic nanomaterial interacts with a phylogenetic surface marker (PSM) on a microorganism to coat the microorganism. As the nanoparticles aggregate on the... Read More
20100245 – A simple, robust and scalable method of directed differentiation of human pluripotent stem cells, including embryonic stem (hES) cells and induced pluripotent stem (iPS) cells, generates insulin-producing cells in vitro that have reversed diabetes in vivo and in diabetic mice. A simple, broadly applicable four-step process demonstrates that hES and human iPS cells from dermal fibroblast... Read More
20170198 – An MRI-compatible electrode array records brain physiological signals in animals and humans. The array is manufactured with carbon nanotubes or other nano-structured materials and will be tuned to have a magnetic susceptibility very close to that of brain tissue. Matching the magnetic susceptibilities of the electrode array and brain tissue will highly reduce—or even eliminate—magnetic... Read More
20160195 – The E-Wheel designed at St. Anthony Falls Laboratory (SAFL) is a vertical axis in-stream hydropower generation system that generates clean electricity from renewable sources with minimal impact on the environment. The hydrokinetic energy technology, designed specifically for small to medium sized open channel systems in both warm and cold-weather regions, focuses on single thread... Read More
20150219 – Cell-permeable iron can be used to increase effectiveness of cancer treatments. Whether used alone or when co-administered with chemotherapy and/or radiation therapy, cell-permeable iron sensitizes solid tumor and/or leukemia cells to the therapy, increasing therapeutic effectiveness. Using these methods may decrease the amount of a chemotherapeutic agent needed, thus decreasing costs,... Read More
20150270 – A handheld device used in conjunction with a smartphone can measure three-dimensional angles of the scapula during arm movement. The device attaches to a smartphone with an adjustable mounting apparatus, and a custom smartphone application integrates the phone’s sensors and data recording ability to measure and record scapular angles during arm motion. By measuring all three angles of... Read More
20170123-20180038 – An algorithm and software package for automatic voxel positioning in single voxel magnetic resonance spectroscopy (MRS) improves consistency of tissue coverage between subjects. The software tool quickly identifies the voxel of interest (VOI) in a given scan across a range of patients using an algorithm that maps a VOI from an atlas to a subject’s MR scan data using a nonlinear/non-rigid... Read More
20120049 – Steering Resonance over the Object (STEREO) is a magnetic resonance imaging (MRI) pulse sequence with a frequency and amplitude modulated RF pulse applied in the presence of modulated gradients to excite signals in an entirely spatiotemporal manner. STEREO represents a substantial departure from conventional MRI in which spins contained in the sample, slab, or slice are excited... Read More
z04196 – A parity-bit coding strategy detects prescribed error events when detecting error events in code words detected from data signals. The error detection code corresponds to one or more dominant error events for the communication system, thus targeting specific error events. The code provides a substantial performance gain compared to conventional parity-based post processing methods, and... Read More
z01025 – A parallel concatenated parity check (PCPC) coding scheme concatenates, in parallel, multiple single bit parity check block codes for high areal density magnetic recording. The low-density generator matrix coding scheme, decoded as a low density parity check code, obtains results using a Lorentzian channel model (with and without transition noise) modeled as first order position jitter.... Read More
20170069 – An algorithm using particle swarm optimization (PSO) in programming electrodes in deep brain stimulation arrays (DBSAs) provides clinicians with an intuitive, semi-automated approach for programming multi-electrode neuromodulation systems. The system and methods optimize deep brain stimulation (DBS) therapy by producing a range of optimal electrode configuration solutions that can achieve... Read More
20160058 – A new data collection and algorithm system automatically detects nitrogen stress on the leaves of corn plants. Small-scale unmanned aerial vehicles (UAVs) collect high resolution images in the visual (RGB) spectrum by hovering over stressed areas at a low altitude. Computer vision RGB image analysis algorithms eliminate the need of a control/reference plant by analyzing the color and... Read More
20170075 – A newly developed direct synthesis method creates zeolite nanosheets with nanometer thicknesses and a high aspect ratio. The process creates zeolite nanosheets with enhanced mass transport properties within their nanopores, favorable to applications such as catalysis and separation. The nanosheets feature many desirable characteristics: predominant thickness of 5nm (2.5 unit cells), 0.6... Read More
20130079 – A reconstruction algorithm improves separation of signals to generate images in multiband MRI, reducing artifacts that could hinder clinical acceptance due to readability issues. The method iteratively calibrates a reconstruction kernel for use in MRI, reconstructing images from k-space data acquired using accelerated MRI techniques, such as simultaneous multi-slice acquisitions using... Read More
20160259 – A deep brain stimulation (DBS) electrode system allows simultaneous neuromodulation and reception of the neuronal response. The method provides electromagnetic (EM) stimulation (using at least three probes for simultaneous modulation) in pulsed and/or continuous wave configuration with different wave forms. A multi-strip multichannel array electrode generates rotating electric fields, and... Read More
20140093 – A new method performs simultaneous multislice (SMS) MR imaging using multiband RF excitation, enabling generalized multiband slice accelerated imaging for any type of MR pulse sequence (e.g. SE, TSE, HASTE, GRASE, GRE, SSFP, etc.). This method acquires reference scan images and uses balanced gradients to realize CAIPIRINHA FOV (field-of-view) shift. Overlapped signals from simultaneously... Read More
20160374 – A lung biopsy tool features an endobronchial ultrasound (EBUS) sensor, LED illumination, a camera chip, steering capabilities and a flexible biopsy needle. Unique aspects of the device are the integrated camera chip (1x1mm Naneye camera) and LED illumination. The device is less than 2 mm in diameter and can therefore be deployed through the tool port of a standard bronchoscope. While... Read More
20140302 – An approach for channel tracking and transmit beamforming with limited feedback exploits the spatial-temporal channel correlation. These methods considerably reduce computational burden and avoid the limitations of codebook-based feedback and Markov chain modeling. The transmitter periodically transmits a beamformed pilot signal in the downlink, while the receiver quantizes the... Read More
20170087 – A new technique manufactures conductive polymer composites (CPCs) using co-continuous polymer blends with interfacial graphene as the conductive filler. This technology combines two current CPC manufacturing methods with an innovative approach to create CPCs with superior electrical properties. The approach uses polylactic acid (PLA) and polystyrene (PS) co-continuous polymer blends as... Read More
20130170 – A new magnetic resonance imaging (MRI) parallel transmission (pTx) pulse design targets RF homogenization in multiband (MB) excitation and refocusing and other spin manipulations while limiting the specific absorption rate (SAR). These pulses can significantly improve RF uniformity in each image slice while largely reducing global and local SAR. With full pTx hardware capable of... Read More
20160011 – An ultra-high density two-terminal integrated composite capacitor uses a parallel combination of metal oxide metal (MOM), metal oxide silicon (MOS) and metal insulator metal (MIM) capacitors physically laid over one another. This design both conserves area while providing capacitance density comparable to deep trench capacitors. The MOS capacitor, used in accumulation mode, offers high... Read More
20150323 – This technology improves upon a previous variable linkage variable displacement machine technology, the high efficiency variable displacement pump, which has a crankshaft-driven adjustable six-bar linkage to vary the displacement of a piston. This new technology is a cam-driven adjustable linkage that also varies the displacement of a piston. This highly efficient mechanism reaches true... Read More
20170018 – A high-voltage, fully-integrated neural stimulator chip for electrical microstimulation features a small chip area and high channel density. Using a feedback-assisted current mirror structure with resource sharing and an efficient chip layout achieves simultaneous high-voltage compliance, high output impedance and high channel count. A foreground current calibration uses a single external... Read More
20160413 – A miniature system on a chip (SoC) device enables continuous, full-duplex neural recording with simultaneous electrical microstimulation. The technology enables precise, closed-loop neuromodulation based on direct neuronal feedback. Scalable and with a small chip area and high channel density, this new design could suppress electrode noise and support high impedance electrodes, especially... Read More
20160323 – A neuro-muscular stimulator implanted inside the mouth stimulates the hypoglossal nerve and the genioglossus muscle to prevent obstructive sleep apnea (OSA) or breathing obstruction caused by inadequate motor tone of the tongue and/or pharyngeal wall muscles. The device consists of an implantable stimulator lead connected to an exposed part, positioned in the lower jaw, that acts as an... Read More
20170091 – A small-scale, hybrid unmanned aerial vehicle (UAV) augments quad-rotor maneuverability with solar-powered fixed-wing energy collection and supply capabilities. Selecting an aerial platform often requires choosing between the flight time and long-range capabilities of a fixed-wing aircraft or the maneuverability and stationary characteristics of a multi-rotor platform. This reconfigurable... Read More
20120077 – A new magnetic resonance imaging (MRI) method for multiband imaging (MB), also known as Simultaneous Multi Slice (SMS) imaging, significantly reduces required peak power. The technology improves MB performance by time shifting the RF pulses of a multiband RF pulse. Normally, all of the multiband pulses (at different frequency bands) are applied at the same time. In this new method, the... Read More
20150170 – Target selectivity of neuromodulation, e.g., deep brain stimulation (DBS) therapy, is critical as the precise locus and pattern of the stimulation dictates the degree to which desired treatment responses are achieved and adverse side effects are avoided. A new concept for neuromodulation generates orientation selective and rotating electric fields that provide more precise and efficient... Read More
20160286 – An effective and economical electrochemical oxidation process for aqueous and gaseous sulfide removal can remove hydrogen sulfide (HS) directly from aqueous environments. The technology uses an electrode system where anodic oxidation directly or indirectly oxidizes sulfide or scavenges sulfide by anodically generated ferrous. By removing HS directly from both liquid (aqueous) and gas... Read More
20140063 – An optical interconnect can be used as the interconnect in spin-based computation and logic systems. The spin-optical interconnect scheme consists of a spin-to-optical transmitter and an optical-to-spin receiver, which are connected with multichannel, integrated optical waveguides or fibers. For data transmission, a spin-based signal is converted to an optical signal and transmitted via... Read More
20140289 – A non-toxic cryopreservative solution increases the safety and viability of preserved cells, for many applications, such as cell therapy. The multi-component, cell-optimized solutions contain no dimethyl sulfoxide (DMSO) and have shown significantly higher (more than double) post-thaw recovery of human cells than DMSO. The solutions show promise in storing, preserving and recovering... Read More
20130219 – Computational-RAM (CRAM) technology featuring a low-power, non-volatile processor architecture produces very high computational performance. The technology conserves power by integrating computational elements into memory arrays so that data no longer needs to move to a separate location for processing. Since data does not have to be accessed sequentially through the interconnect network,... Read More
20160135 – Bordetella pertussis (Bp) is the bacterial agent of pertussis (whooping cough) in humans. Current acellular pertussis vaccines, which target only a narrow range of Bp virulence factors, lack efficacy in preventing respiratory tract colonization or disease transmission. Bp cell surface iron receptors are essential for the uptake of iron and are critical for growth in the host. New methods... Read More
