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20160109 – BridGE (Bridging Gene Sets with Epistasis) is an innovative computational method that explicitly searches for disease-specific genetic interactions between single nucleotide polymorphisms (SNPs) in Genome-wide Association Studies (GWAS) data. The algorithm searches for larger, non-random structures of SNP-SNP interactions, guided by established sets of genes belonging to characterized... Read More
20150126 – Acousto-electromagnetic imaging is a hybrid, multimodal neuroimaging technology that fully integrates focused ultrasound with electromagnetic sensing and imaging for mapping dynamic electrophysical (e.g., brain) activation. The noninvasive technology achieves neuroimaging of brain activity with high spatio-temporal resolution (i.e., mm spatial resolution and ms temporal resolution) and... Read More
20170020 – Iteratively reweighted edge sparsity minimization (IRES) is an inverse imaging strategy for estimating extended sources from electroencephalography (EEG) and magnetoencephalography (MEG). IRES can quantitatively and objectively image the extent of electrical sources in an organ system from noninvasive electromagnetic signals measured over the body surface. Source sparsity is exploited in... Read More
20170017 – A new crop assessment tool leverages canopy reflectance and Light Detection and Ranging (LiDAR) sensors for remotely estimating crop height and predicting yield and quality. A spectrophotometer attached to an unmanned aerial vehicle (UAV) or ground vehicle periodically scans alfalfa in the field and measures canopy reflectance values to predict alfalfa yield and quality, while... Read More
20160370 – An injectable liquid embolic agent mixed with piezoelectric crystals enables al method of piezoelectric material delivery and thermal tumor ablation via high intensity focused ultrasound or magnetic resonance imaging (MRI). The mixture can be delivered to a tumor in a minimally invasive manner, and the embolic agent enables specific localization and retention of the piezoelectric material... Read More
20150238 – An automatic flight control system that enables safe and reliable aircraft flight using a subset of aerodynamic control surfaces. A unique feature is that this subset includes cases where only one aerodynamic control surface is functional. The technology, implemented in software, helps prevent loss of aircraft (manned or unmanned) and is not restricted to any particular size. In the event... Read More
20170293 – The Sliding Windowed Infinite Fourier Transform (SWIFT) algorithm analyzes and extracts frequency amplitude/phase information from digital signals in real time. This spectral analysis technique analyzes any real-time digital signal, from neural signals to accelerometer data to radio waves. The algorithm uses an infinite length causal exponential function as its window, which gives more... Read More
20140230 – An optimal probiotic formulation fed to turkeys uses the latest microbiome profiling techniques to prevent disease, promote growth and increase feed conversion efficiency. The novel defined microbial community contains probiotic bacterial strains targeted at commercial turkeys, and can be administered as an additive to feed or water. This informed, “rationally designed” approach... Read More
20170050 – A 3D printed airway stent and delivery system can be rapidly customized and atraumatically inserted into pediatric airways to provide temporary internal support for the airway (or other duct or plenum) to treat tracheo-bronchomalacia (TBM). The stent is made of silicone, an FDA approved material that is conformable, biocompatible and suitable for additive manufacturing. The length and... Read More
20170040 – A new protein kinase biosensor uses Förster resonance energy transfer (FRET) technology to identify allosteric binders that trigger conformational changes within the activation loop of kinase proteins. The method can identify allosteric small molecule inhibitors or peptide inhibitors using a high-throughput screening method. The unique components of this technology include: ... Read More
20170163 – A new orthopedic meniscus repair system provides orthopedic surgeons the ability to repair meniscus tears in the white-white space and can repair a variety of tear types (e.g., longitudinal, radial, flap, horizontal, bucket handle and degenerative lesions). The tool allows the surgeon to place suture knots in any area of the implant matrix in the same amount of time as a meniscectomy and... Read More
20140165 – A new method produces a high permeance silica (quartz) based support for membranes. The high permeance silica fiber support features superior mechanical strength and is the only silica support with the potential to withstand industrial operating conditions. The silica supports also exhibit low stress in the membrane during thermal treatment and epitaxial growth of zeolite film on silica... Read More
20180071 – The Reflective Interaction Observation Scale (RIOS) assesses how well a supervisory session demonstrates a reflective process grounded in infant mental health theory and practice. The RIOS describes the content and characteristics of supervisor-supervisee interactions at a given moment in time by identifying “active ingredients” in a reflective supervision session that set it apart from... Read More
20160410-20170196 – Highly potent and selective TLR8 and dual TLR7/TLR8 agonists can stimulate human adaptive immune response. These compounds hold potential as vaccine adjuvants that could augment innate immune response against inflammatory, microbial and/or viral diseases as well as cancer. Toll-like receptors (TLRs) play a crucial role in host defense, inflammation, and immune response, and... Read More
20170066 – A new multi-modal, targeted approach to deep-brain stimulation (DBS) therapy manages multiple symptoms simultaneously to treat various neurological and co-morbid conditions. In particular, the technology can help Parkinson’s disease (PD) patients overcome co-morbid sleep disturbances by using DBS waveforms and stimulation parameters to promote sleep. The technology uses the same... Read More
20140236 – Radiofrequency (RF) pulses for in-vivo magnetic resonance imaging (MRI) are prone to errors due to physiological motion of organs in the torso during the respiratory cycle. Two different strategies mitigate these errors and obtain solutions robust against respiratory changes within an imaging scan or between different scans. Both methods require calibration scans (B1+ and DeltaB0 maps)... Read More
20170298-20170299 – A flexible tactile sensor, 3D printed with electronic inks, can detect and differentiate human movements (e.g., radial pulse and finger pressing/bending). The stretchable sensor consists of a conductive coil placed between two stretchable electrode layers. A custom, multi-functional 3D printing process prints silver-impregnated silicone inks with tunable printability and electrical... Read More
z00179 – A ring-type voltage controlled oscillator (VCO) with a delay stage minimizes phase noise and has an inverter, a memory element and tuning circuitry. The inverter receives a signal from and provides an output to other delay stages. The memory element is coupled to the inverter’s output to delay the time before the output signal begins to switch states in response to switch of states of the... Read More
20170236 – An algorithm that increases signal-to-noise (SNR) ratio in imaging data uses spatial-temporal properties of noise without applying assumptions on the underlying image signal. The technique, which improves already obtained image data and does not require modifying any existing sequences, can be applied to fMRI, diffusion, arterial spin labeling (ASL), and quantitative parameter mapping.... Read More
z01027 – A vertical cavity surface emitting laser (VCSEL) offers single mode confinement. The VCSEL is comprised of a substrate and a lower mirror, active region and upper mirror arranged in a vertical stack to form a laser. Horizontally spaced-apart regions of increased refractive index extend vertically at least partially through the vertical stack to promote single-mode confinement in the... Read More
explic – Licenses are available but not attached to a specific web page.
20170230 – Frequency-swept excitation can be used for 3D imaging to obtain broad bandwidth and sharp slab profiles. Quadratic phase modulation along the slice encoding direction imparts additional spatiotemporal encoding, which better distributes signal content in the slice direction and enables higher acceleration rates robust to slice under-sampling. Sliding the quadratic phase across the... Read More
20170171-20170288 – A magnetic resonance imaging (MRI) sequence acquires cardiac phase resolved native T1 maps of the myocardium, with integrated B1+ quantification at a temporal resolution of up to 40 ms in a single breath-hold. This sequence, TempOrally-resolved Parametric Assessment of Z-magnetization recovery (TOPAZ) is based on contiguous FLASH imaging readout after magnetization inversion from the... Read More
20160298 – “Smart” compression garments can be controlled dynamically using shape changing materials (such as shape memory alloys (SMA)) enables clinical cardiovascular intervention in both healthy and unhealthy populations. The degree of compression, timing of compression, and type and site of compression (pressure) can be controlled dynamically. Controlling compression allows the ability to gait... Read More
20160184-2 – A compact thermally integrated reformer design partially converts alternative fuels to reformate, a gaseous mixture of hydrogen, partially reacted products and some original fuel. This mixture extends the possible diesel engine range of operation with low reactivity fuels like ammonia and increases thermal efficiency through recovering wasted heat from the exhaust. Fumigating... Read More
20160218 – A novel approach generates monoclonal antibodies (MAb) against peptide presented in major histocompatibility complex II (MHC II). The methodology centers on having a soluble peptide:MHC (p:MHC) Class II complex linked to biotin as the B cell antigenic target. The approach uses recombinant peptide:MHC monomers as immunogens and subsequently relies on multimers to enrich the responding... Read More
20160251 – A new craniotome design helps prevent dural tears during craniotomy procedures. The device uses high pressure liquid (e.g., sterile saline solution) to separate the dura from the cranium ahead of the craniotome in order to minimize the risk of the dura snagging on the dura guard. The concept could be marketed as either an entirely new craniotome design or an attachment to... Read More
20170172 – A magnetic resonance imaging (MRI) method enables imaging with late gadolinium enhancement (LGE) contrast throughout the entire cardiac cycle with high temporal resolution. LGE, the clinical gold standard for assessing focal fibrosis/scars, depicts scar tissue as an enhancement 10-20 minutes after contrast injection. Contrast-agent accumulates in the scar-tissue due to diminished washout... Read More
20170206 – A device with a ferroelectric oxide crystal layer in a capacitive arrangement and a switch converts heat to electric energy in a small temperature difference regime. The method uses oxide crystals that undergo highly reversible phase transformations from a strongly ferroelectric phase to a paraelectric phase upon heating. As the crystal is cooled through the phase transformation it... Read More
20120271 – A new class of oligonucleotides can be used to treat cardiomyopathy. The short, protein-interacting DNAs and RNAs (SPIDRs) are designed to selectively bind to phospholamban (PLN), a compound that inhibits SERCA, which is a necessary function for cardiac health. Results show that ssDNA and RNA interact strongly with PLN, thereby inhibiting its effect on SERCA. Furthermore, the length... Read More
20130259 – A spatial gradient based electrical property tomography (EPT) method uses magnetic resonance imaging (MRI) to produce non-invasive and high spatial resolution in vivo imaging of electrical conductivity and permittivity of biological tissues. Electrical properties are determined based on estimated radiated gradient values of the electrical properties of the object. For example, electrical... Read More
20160260 – A new method designs and implements spatially selective, multidimensional adiabatic radio frequency (RF) pulses for use in magnetic resonance imaging (MRI). Spatially selective inversion is achieved adiabatically in both two- and three-dimensional (2D and 3D) regions of interest. The multidimensional adiabatic pulses are designed by dividing a parent adiabatic pulse into 2D selective... Read More
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z01023 – A signal space detector (SSD) that uses only a single hyperplane offers nearly the same performance as the fixed delay tree search with decision feedback (FDTS/DF). The SSD technology, which can be applied to a variety of systems, including DVD channels, estimates a channel input symbol by detecting input symbols from a finite number of observation samples that define an observation... Read More
20170353 – A biomechanical model of the mouth features a mechanism that interacts with the nipple/areolar complex of the breast by duplicating the rigid body motion of the anterior tongue. The new design was based on analysis of ultrasonic breastfeeding videos, and its camshaft drives a series of followers in constriction circles such that their displacements mimic tongue motion. This model... Read More
20170213 – A 3D printable heat exchanger compatible with selective laser melt metal additive manufacturing has been developed for hydraulic oil cooling applications. The plate-fin tube bank has special features, including non-circular, internally finned tubes, and external angled fins to allow flexibility in the printing process. The design allows additive manufacture commercial-scale heat... Read More
20170084 – Multi-Banded (MB) RF-pulse Enhanced Magnetization Imaging (MBE-MTI) uses multi-banded RF pulses in MT preparation. These multi-banded RF pulses not only provide simultaneous off-resonance saturations of bound water spins on both sides of the central frequency of mobile water, but also increase the coverage of off-resonance frequency range without increasing the potential of direct... Read More
20160397-z07107-z03212 – Three cost effective technologies for creating nanocrystals via a gas-plasma, non-aqueous process are available to license. Gas phase production of these nanocrystals is faster, higher yield and more cost efficient than current processes. The technologies can be optioned for a six month trial period for a $10,000 Try fee to enable testing of the commercial viability of this process to... Read More
20160257 – Cell nanocoating is being used in a food safety application to detect and quantify total microbial content (e.g., bacteria, fungi, viruses, Archaea, protists and gram-negative and gram-positive bacteria). In this technology, a plasmonic nanomaterial interacts with a phylogenetic surface marker (PSM) on a microorganism to coat the microorganism. As the nanoparticles aggregate on the... Read More
20100245 – A simple, robust and scalable method of directed differentiation of human pluripotent stem cells, including embryonic stem (hES) cells and induced pluripotent stem (iPS) cells, generates insulin-producing cells in vitro that have reversed diabetes in vivo and in diabetic mice. A simple, broadly applicable four-step process demonstrates that hES and human iPS cells from dermal fibroblast... Read More
20170198 – An MRI-compatible electrode array records brain physiological signals in animals and humans. The array is manufactured with carbon nanotubes or other nano-structured materials and will be tuned to have a magnetic susceptibility very close to that of brain tissue. Matching the magnetic susceptibilities of the electrode array and brain tissue will highly reduce—or even eliminate—magnetic... Read More
20160195 – The E-Wheel designed at St. Anthony Falls Laboratory (SAFL) is a vertical axis in-stream hydropower generation system that generates clean electricity from renewable sources with minimal impact on the environment. The hydrokinetic energy technology, designed specifically for small to medium sized open channel systems in both warm and cold-weather regions, focuses on single thread... Read More
20160311 – A simple, indirect enzyme-linked immunosorbent assay (ELISA) rapidly and reliably detects Seneca Valley Virus as a cause of idiopathic vesicular disease (IVD) in swine. The ELISA detects serum antibodies to Senecavirus A (SVA) viral protein 2. These methods use the Senecavirus A polypeptide as a capture antigen for detecting antibodies that specifically bind to the Senecavirus A... Read More
20150219 – Cell-permeable iron can be used to increase effectiveness of cancer treatments. Whether used alone or when co-administered with chemotherapy and/or radiation therapy, cell-permeable iron sensitizes solid tumor and/or leukemia cells to the therapy, increasing therapeutic effectiveness. Using these methods may decrease the amount of a chemotherapeutic agent needed, thus decreasing costs,... Read More
20150270 – A handheld device used in conjunction with a smartphone can measure three-dimensional angles of the scapula during arm movement. The device attaches to a smartphone with an adjustable mounting apparatus, and a custom smartphone application integrates the phone’s sensors and data recording ability to measure and record scapular angles during arm motion. By measuring all three angles of... Read More
20170123-20180038 – An algorithm and software package for automatic voxel positioning in single voxel magnetic resonance spectroscopy (MRS) improves consistency of tissue coverage between subjects. The software tool quickly identifies the voxel of interest (VOI) in a given scan across a range of patients using an algorithm that maps a VOI from an atlas to a subject’s MR scan data using a nonlinear/non-rigid... Read More
20120049 – Steering Resonance over the Object (STEREO) is a magnetic resonance imaging (MRI) pulse sequence with a frequency and amplitude modulated RF pulse applied in the presence of modulated gradients to excite signals in an entirely spatiotemporal manner. STEREO represents a substantial departure from conventional MRI in which spins contained in the sample, slab, or slice are excited... Read More
z04196 – A parity-bit coding strategy detects prescribed error events when detecting error events in code words detected from data signals. The error detection code corresponds to one or more dominant error events for the communication system, thus targeting specific error events. The code provides a substantial performance gain compared to conventional parity-based post processing methods, and... Read More
z01025 – A parallel concatenated parity check (PCPC) coding scheme concatenates, in parallel, multiple single bit parity check block codes for high areal density magnetic recording. The low-density generator matrix coding scheme, decoded as a low density parity check code, obtains results using a Lorentzian channel model (with and without transition noise) modeled as first order position jitter.... Read More
20170069 – An algorithm using particle swarm optimization (PSO) in programming electrodes in deep brain stimulation arrays (DBSAs) provides clinicians with an intuitive, semi-automated approach for programming multi-electrode neuromodulation systems. The system and methods optimize deep brain stimulation (DBS) therapy by producing a range of optimal electrode configuration solutions that can achieve... Read More
20150184 – A next-generation breast pump design offers nursing mothers increased convenience and privacy. The low profile, one piece device can be concealed within a bra and held in place with self-adhesive backing. It conforms to multiple breast sizes and fits comfortably and unobtrusively under clothing. Milk passes through a channel routed along the circumference of the breast into flexible,... Read More
