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20130110 – An intraoral radiofrequency (RF) loop coil placed, between the teeth, efficiently images teeth and associated dental structures. The coil is oriented with its axis parallel (coaxial) with the Zeeman field (coil plane perpendicular to B0) and captures B1 information using the coil’s transverse sensitivity volume. This orientation provides one of the most appropriate fields of view (FOV)... Read More
20160388 – Pancreatic ductal adenocarcinoma (PDAC) may be treatable using newly-developed small molecules that show high antiproliferative activity against the pancreatic cancer cell line MiaPaca-2. This technology disrupts the mTOR and autophagy pathways, offering a new mechanism of action for treating pancreatic cancer. The molecules of interest have submicromolar activity, good metabolic... Read More
20170402 – An innovative protein-based scaffold optimizes the spatial connections among multiple enzymes in biocatalytic reactions. This technology uses a new type of self-assembling protein to form the scaffold and a better tagging system for attaching enzymes on the scaffold. This combination significantly improves biosynthetic efficiency with a robust and modular self-assembling protein scaffold... Read More
20130092 – iINTEGRATORS is a single-step, single-solve, unified framework of algorithms encompassing the class of second-order, time-accurate least mean square (LMS) methods for both 1 and 2 order time dependent systems. The framework, which takes a single set of inputs and produces the appropriate output using a single selected algorithm. It could serve as a next generation toolkit for... Read More
20120122 – A magnetic resonance imaging (MRI) method and apparatus amplifies radio frequency (RF) signals from MRI coils. The coils, containing antenna elements, are power amplified by a distributed power amplifier with electronic devices (e.g., field-effect transistors). The approach locates an MRI coil with antenna elements within an MR magnet and amplifies its RF signal to obtain high-power RF... Read More
20120121 – A variable resistance inductance capacitance (R-L-C) technology electrically controls a mechanical movement device (e.g., linear positioner, rotary motor, or pump) that selectively controls an electrical element to vary, and maintain at a selected value, its electrical resistance, inductance, and/or capacitance. The method uses an electrical signal to automatically move a portion of the... Read More
20120123 – A magnetic resonance imaging (MRI) method and apparatus can receive radio frequency (RF) signals while simultaneously transmitting a signal of like frequency. The MRI and spectroscopy technology removes artifacts of the transmitted excitation signal (Tx) from the received signal (Rx), leaving only the desired net received signal (NRx) to generate an image from the MR response if the... Read More
20170291 – A multi-part body coil apparatus can transmit (Tx) and/or receive (Rx) radiofrequency (RF) signals suitable for magnetic resonance imaging (MRI) and/or magnetic-resonance spectroscopy (MRS). The coil is configured as either a circularly polarized transverse-electric-magnetic (TEM) coil or a birdcage coil, and is easily assembled, disassembled (e.g., for easier maintenance, testing, tuning... Read More
20120119 – A new method automatically adjusts electrical performance of radiofrequency (RF) coil assemblies of magnetic resonance imaging (MRI) systems during the medical imaging process of a subject in order to control changes in loading conditions of the RF coil caused by the subject during the imaging process. Automatically tuning the RF coil circuits provides real-time tuning that electrically... Read More
20120060 – A new magnetic resonance imaging (MRI) approach uses a spatiotemporally-encoded MRI pulse sequence (e.g., SWIRLY and/or STEREO) in combination with a smart, adaptive, or phased RF transmit front end. Combining these two components allows highly spatially localized regions of uniform excitation, even in the presence of Band B inhomogeneities. The transmit front end is comprised of a... Read More
20160420 – A new technology allows first-ever in vivo magnetic resonance (MR) imaging with simultaneous transmit and receive (STAR). The process employs a feedback system with real-time load compensation that enables in vivo simultaneous transmit/receive (Tx/Rx) images. The RF front-end and coil subsystem maintains high isolation over variable loading conditions. Phase and gain adjustments... Read More
20170379 – A highly-flexible, solid-state electrolyte with reasonable ionic conductivity for a solid electrolyte offers potential solutions for supercapacitive sensors. The paper-based electrolyte is fabricated by mixing ionic liquid with a photo-curable polymer and then brushing this ionic gel on to filter paper. The gel dissolves the paper and subsequently becomes highly flexible after a short... Read More
20130311 – CRISPR/Cas systems can be used to create geminivirus resistance in plants. Using this genome editing tool, plants are pre-programmed with a Cas endonuclease and small RNA sequence that essentially give them an immune system that targets both conserved and non-conserved nucleotide sequences within the geminivirus genome. The technology can inhibit the geminivirus life cycle in three ways:... Read More
20180076 – MyStrengths MyHealth™ (MSMH) is a whole-person strengths-based consumer-facing mobile enhanced application designed for individuals, families, and communities to self-identify strengths, challenges, and needs. MSMH leverages the rigor of the Omaha System (Martin, 2005), a multi-disciplinary standardized health terminology and valid, reliable instrument that addresses all of health... Read More
20180072 – An automated model de-identification algorithm applies aggressive de-identification to a word co-occurrence model without sacrificing performance for word sense disambiguation. While some very common words must be included in the model (i.e., names in some of their occurrences, like “white”), the de-identification process removes anything that is not part of the SPECIALIST Lexicon and any... Read More
20170306 – A microfluidic channel structure limits capillary flow to one direction, offering an effective method to control capillary flow in microfluidic channels. This structure is very versatile since unidirectional flow is independent of liquid contact angle and surface tension. Connected small and large channels are designed so a fluid will not flow beyond the joint of the channels (it... Read More
20170326 – An accelerated MRI reconstruction approach, Robust Artificial-neural-networks for k-space Interpolation (RAKI) improves the noise properties of GeneRalized Autocalibrating Partial Parallel Acquisition (GRAPPA), which translates to image acceleration (i.e., faster scan times). This method learns a deep non-linear convolutional neural network (CNN) from limited scan-specific... Read More
20160153 – A 16-channel transceiver array (16LD) that combines loop and dipole elements maintains both the higher transmit and receive performance of the loop elements at shallower depths and the improved performance of the dipole elements at greater depths. The loop-dipole combination increases channel count and density beyond what can be currently achieved with dipole elements alone while reducing... Read More
20160109 – BridGE (Bridging Gene Sets with Epistasis) is an innovative computational method that explicitly searches for disease-specific genetic interactions between single nucleotide polymorphisms (SNPs) in Genome-wide Association Studies (GWAS) data. The algorithm searches for larger, non-random structures of SNP-SNP interactions, guided by established sets of genes belonging to characterized... Read More
20150126 – Acousto-electromagnetic imaging is a hybrid, multimodal neuroimaging technology that fully integrates focused ultrasound with electromagnetic sensing and imaging for mapping dynamic electrophysical (e.g., brain) activation. The noninvasive technology achieves neuroimaging of brain activity with high spatio-temporal resolution (i.e., mm spatial resolution and ms temporal resolution) and... Read More
20170020 – Iteratively reweighted edge sparsity minimization (IRES) is an inverse imaging strategy for estimating extended sources from electroencephalography (EEG) and magnetoencephalography (MEG). IRES can quantitatively and objectively image the extent of electrical sources in an organ system from noninvasive electromagnetic signals measured over the body surface. Source sparsity is exploited in... Read More
20170017 – A new crop assessment tool leverages canopy reflectance and Light Detection and Ranging (LiDAR) sensors for remotely estimating crop height and predicting yield and quality. A spectrophotometer attached to an unmanned aerial vehicle (UAV) or ground vehicle periodically scans alfalfa in the field and measures canopy reflectance values to predict alfalfa yield and quality, while... Read More
20160370 – An injectable liquid embolic agent mixed with piezoelectric crystals enables al method of piezoelectric material delivery and thermal tumor ablation via high intensity focused ultrasound or magnetic resonance imaging (MRI). The mixture can be delivered to a tumor in a minimally invasive manner, and the embolic agent enables specific localization and retention of the piezoelectric material... Read More
20150238 – An automatic flight control system that enables safe and reliable aircraft flight using a subset of aerodynamic control surfaces. A unique feature is that this subset includes cases where only one aerodynamic control surface is functional. The technology, implemented in software, helps prevent loss of aircraft (manned or unmanned) and is not restricted to any particular size. In the event... Read More
20170293 – The Sliding Windowed Infinite Fourier Transform (SWIFT) algorithm analyzes and extracts frequency amplitude/phase information from digital signals in real time. This spectral analysis technique analyzes any real-time digital signal, from neural signals to accelerometer data to radio waves. The algorithm uses an infinite length causal exponential function as its window, which gives more... Read More
20140230 – An optimal probiotic formulation fed to turkeys uses the latest microbiome profiling techniques to prevent disease, promote growth and increase feed conversion efficiency. The novel defined microbial community contains probiotic bacterial strains targeted at commercial turkeys, and can be administered as an additive to feed or water. This informed, “rationally designed” approach... Read More
20170050 – A 3D printed airway stent and delivery system can be rapidly customized and atraumatically inserted into pediatric airways to provide temporary internal support for the airway (or other duct or plenum) to treat tracheo-bronchomalacia (TBM). The stent is made of silicone, an FDA approved material that is conformable, biocompatible and suitable for additive manufacturing. The length and... Read More
20170040 – A new protein kinase biosensor uses Förster resonance energy transfer (FRET) technology to identify allosteric binders that trigger conformational changes within the activation loop of kinase proteins. The method can identify allosteric small molecule inhibitors or peptide inhibitors using a high-throughput screening method. The unique components of this technology include: ... Read More
20170163 – A new orthopedic meniscus repair system provides orthopedic surgeons the ability to repair meniscus tears in the white-white space and can repair a variety of tear types (e.g., longitudinal, radial, flap, horizontal, bucket handle and degenerative lesions). The tool allows the surgeon to place suture knots in any area of the implant matrix in the same amount of time as a meniscectomy and... Read More
20140165 – A new method produces a high permeance silica (quartz) based support for membranes. The high permeance silica fiber support features superior mechanical strength and is the only silica support with the potential to withstand industrial operating conditions. The silica supports also exhibit low stress in the membrane during thermal treatment and epitaxial growth of zeolite film on silica... Read More
20180071 – The Reflective Interaction Observation Scale (RIOS) assesses how well a supervisory session demonstrates a reflective process grounded in infant mental health theory and practice. The RIOS describes the content and characteristics of supervisor-supervisee interactions at a given moment in time by identifying “active ingredients” in a reflective supervision session that set it apart from... Read More
20160410-20170196 – Highly potent and selective TLR8 and dual TLR7/TLR8 agonists can stimulate human adaptive immune response. These compounds hold potential as vaccine adjuvants that could augment innate immune response against inflammatory, microbial and/or viral diseases as well as cancer. Toll-like receptors (TLRs) play a crucial role in host defense, inflammation, and immune response, and... Read More
20170066 – A new multi-modal, targeted approach to deep-brain stimulation (DBS) therapy manages multiple symptoms simultaneously to treat various neurological and co-morbid conditions. In particular, the technology can help Parkinson’s disease (PD) patients overcome co-morbid sleep disturbances by using DBS waveforms and stimulation parameters to promote sleep. The technology uses the same... Read More
20140236 – Radiofrequency (RF) pulses for in-vivo magnetic resonance imaging (MRI) are prone to errors due to physiological motion of organs in the torso during the respiratory cycle. Two different strategies mitigate these errors and obtain solutions robust against respiratory changes within an imaging scan or between different scans. Both methods require calibration scans (B1+ and DeltaB0 maps)... Read More
20170298-20170299 – A flexible tactile sensor, 3D printed with electronic inks, can detect and differentiate human movements (e.g., radial pulse and finger pressing/bending). The stretchable sensor consists of a conductive coil placed between two stretchable electrode layers. A custom, multi-functional 3D printing process prints silver-impregnated silicone inks with tunable printability and electrical... Read More
z00179 – A ring-type voltage controlled oscillator (VCO) with a delay stage minimizes phase noise and has an inverter, a memory element and tuning circuitry. The inverter receives a signal from and provides an output to other delay stages. The memory element is coupled to the inverter’s output to delay the time before the output signal begins to switch states in response to switch of states of the... Read More
20170236 – An algorithm that increases signal-to-noise (SNR) ratio in imaging data uses spatial-temporal properties of noise without applying assumptions on the underlying image signal. The technique, which improves already obtained image data and does not require modifying any existing sequences, can be applied to fMRI, diffusion, arterial spin labeling (ASL), and quantitative parameter mapping.... Read More
z01027 – A vertical cavity surface emitting laser (VCSEL) offers single mode confinement. The VCSEL is comprised of a substrate and a lower mirror, active region and upper mirror arranged in a vertical stack to form a laser. Horizontally spaced-apart regions of increased refractive index extend vertically at least partially through the vertical stack to promote single-mode confinement in the... Read More
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20170230 – Frequency-swept excitation can be used for 3D imaging to obtain broad bandwidth and sharp slab profiles. Quadratic phase modulation along the slice encoding direction imparts additional spatiotemporal encoding, which better distributes signal content in the slice direction and enables higher acceleration rates robust to slice under-sampling. Sliding the quadratic phase across the... Read More
20170171-20170288 – A magnetic resonance imaging (MRI) sequence acquires cardiac phase resolved native T1 maps of the myocardium, with integrated B1+ quantification at a temporal resolution of up to 40 ms in a single breath-hold. This sequence, TempOrally-resolved Parametric Assessment of Z-magnetization recovery (TOPAZ) is based on contiguous FLASH imaging readout after magnetization inversion from the... Read More
20160298 – “Smart” compression garments can be controlled dynamically using shape changing materials (such as shape memory alloys (SMA)) enables clinical cardiovascular intervention in both healthy and unhealthy populations. The degree of compression, timing of compression, and type and site of compression (pressure) can be controlled dynamically. Controlling compression allows the ability to gait... Read More
20160184-2 – A compact thermally integrated reformer design partially converts alternative fuels to reformate, a gaseous mixture of hydrogen, partially reacted products and some original fuel. This mixture extends the possible diesel engine range of operation with low reactivity fuels like ammonia and increases thermal efficiency through recovering wasted heat from the exhaust. Fumigating... Read More
20160218 – A novel approach generates monoclonal antibodies (MAb) against peptide presented in major histocompatibility complex II (MHC II). The methodology centers on having a soluble peptide:MHC (p:MHC) Class II complex linked to biotin as the B cell antigenic target. The approach uses recombinant peptide:MHC monomers as immunogens and subsequently relies on multimers to enrich the responding... Read More
20160251 – A new craniotome design helps prevent dural tears during craniotomy procedures. The device uses high pressure liquid (e.g., sterile saline solution) to separate the dura from the cranium ahead of the craniotome in order to minimize the risk of the dura snagging on the dura guard. The concept could be marketed as either an entirely new craniotome design or an attachment to... Read More
20170172 – A magnetic resonance imaging (MRI) method enables imaging with late gadolinium enhancement (LGE) contrast throughout the entire cardiac cycle with high temporal resolution. LGE, the clinical gold standard for assessing focal fibrosis/scars, depicts scar tissue as an enhancement 10-20 minutes after contrast injection. Contrast-agent accumulates in the scar-tissue due to diminished washout... Read More
20170206 – A device with a ferroelectric oxide crystal layer in a capacitive arrangement and a switch converts heat to electric energy in a small temperature difference regime. The method uses oxide crystals that undergo highly reversible phase transformations from a strongly ferroelectric phase to a paraelectric phase upon heating. As the crystal is cooled through the phase transformation it... Read More
20120271 – A new class of oligonucleotides can be used to treat cardiomyopathy. The short, protein-interacting DNAs and RNAs (SPIDRs) are designed to selectively bind to phospholamban (PLN), a compound that inhibits SERCA, which is a necessary function for cardiac health. Results show that ssDNA and RNA interact strongly with PLN, thereby inhibiting its effect on SERCA. Furthermore, the length... Read More
20130259 – A spatial gradient based electrical property tomography (EPT) method uses magnetic resonance imaging (MRI) to produce non-invasive and high spatial resolution in vivo imaging of electrical conductivity and permittivity of biological tissues. Electrical properties are determined based on estimated radiated gradient values of the electrical properties of the object. For example, electrical... Read More
20160260 – A new method designs and implements spatially selective, multidimensional adiabatic radio frequency (RF) pulses for use in magnetic resonance imaging (MRI). Spatially selective inversion is achieved adiabatically in both two- and three-dimensional (2D and 3D) regions of interest. The multidimensional adiabatic pulses are designed by dividing a parent adiabatic pulse into 2D selective... Read More
