Male Birth Control Reduces Sperm Motility
A reversible, non-hormonal male birth control method is possible by inhibiting the alpha-4 isoform of the sodium-potassium-transporting ATP-ases of the cells in the male gametes. The alpha-4 isoform is only present in sperm and by specifically inhibiting the alpha-4 isoform the pathway that is responsible for sperm motility becomes blocked and the sperm are unable to fertilize the egg in vitro. Reversibility is a major benefit of this contraception method because the agents are targeting sperm motility rather than trying to reduce the sperm count as in other hormonal methods.
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Reversible Contraception Alternative to Vasectomy Procedures
Currently there are no other options on the market for male contraceptive beyond condoms and vasectomies, two methods that only account for 20% of contraception. Only 500,000 American men each year opt for the vasectomy procedure for their contraceptive method, an invasive procedure that is only 33% irreversible. New options for male birth control have been developed in the form of hormonal and non-hormonal agents. Our non-hormonal contraception method specifically targets sperm motility by blocking the pathway that leads to the reduction in the motility of the sperm and is reversible. The target specificity of the non-hormonal agents is expected to prevent systemic side effects that are often seen with hormonal methods. The male hormonal method is currently the closest to market but has shown depressed levels of good cholesterol (HDL-C), a side effect with potential long term impact on the cardiovascular system.
BENEFITS OF NON-HORMONAL MALE CONTRACEPTIVE AGENT:
- Reduction in sperm motility prevents fertilization of the egg
- Vasectomy and condom alternative
- Effective male contraception method with fewer systemic side effects
Fulfillment Details Licensee will receive rights to practice the intellectual property (patent application) for the purposes of developing and manufacturing a commercial product.
Phase of Development Agent derivatives have been prepared for both in vitro and in vivo studies.