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Cancer Treatment Decreases Side Effects of Treatment

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HA 14-1 is a qualified antagonist against Bcl-2 proteins.Bcl-2 Proteins prevent apoptosis in cancer cells, allowing them to survive cancer treatments.  sHA 14-1 increases apoptosis.sHA 14-1 lowers cancer treatment side effects by increasing the cancer cell?s sensitivity to cancer drugs and allowing lower dosages to be effective.Bcl-2 proteins inhibit apoptosis and have been linked to resistance of chemotherapy, radiotherapy, and hormone treatments.
Chengguo (Chris) Xing, Ph.D
Associate Professor, Medicinal Chemistry, College of Pharmacy
Managed By
Raj Udupa
Technology Licensing Officer 612-624-3966
Patent Protection
US Patent 8,394,794

Cancer Treatment with sHA 14-1 Reduces Side Effects by Increasing Programmed Cell Death

Bcl-2 Proteins Inhibit Apoptosis and Increase Drug Resistance to Cancer Treatment

An antagonist that targets anti-apoptotic Bcl-2 proteins has been developed for potential treatment of cancer. The Bcl-2 protein inhibits programmed cell death, or apoptosis, in cancer cells. In tumor cells, over expression of Bcl-2 has been correlated with the development of resistance to chemotherapy, radiotherapy, and hormone treatments. Because of drug resistance due to Bcl-2 proteins, cancer treatment dosages are increased to be more effective, but this leads to greater side effects.

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Bcl-2 Protein Antagonists Improve the Effectiveness of Cancer Treatment

HA 14-1 is a qualified antagonist against the anti-apoptotic Bcl-2 protein. The HA 14-1 molecule is an inhibitor that can sensitize cancer cells to cancer treatments, thereby lowering the effective dosage of anticancer agent and lowering the side effects. New analogs of HA 14-1 have demonstrated improved binding interaction with anti-apoptotic Bcl-2 proteins. One of these analogs, sHA 14-1, has greater stability compared to HA 14-1 but displays similar effectiveness on cancer cells. sHA 14-1 is insensitive to the drug resistance induced by anti-apoptotic Bcl-2 proteins in cancer cells. sHA 14-1 also synergizes the anti-cancer activities of both intrinsic and extrinsic apoptotic stimuli, increasing the potential of sHA 14-1 in cancer therapy.


  • Candidate for the treatment of drug-resistant cancers either as a monotherapy or in combination with current cancer treatments
  • sHA 14-1 analog can sensitize cancers to cancer treatment as an antagonist to Bcl-2
  • Reduces side effects by lowering the effective dosage of anticancer agent

Phase of Development HA14-1 analogues have been synthesized and tested for stability. In vitro binding assays have identified optimum structures and in vivo studies have been completed.