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Neural Activation Imaging

Technology #z06179

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Bin He
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Kevin Anderson
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Patent Protection

US Patent Pending 2010-0049482

Brain Activation Mapping Algorithm for Surgical Planning

Surgical planning for epileptic patients includes understanding both the brain activation sequence and propagation of the electrical signals. An algorithm to identify the activation sequence and distinguish the primary epileptic sources from the secondary sources has been developed using EEG measurements obtained from noninvasive scalp recordings. The recorded measurements are used to compute the brain activation over the entire brain volume. The technique provides physiological properties rather than the physical properties of neural tissue, which is of clinical relevance. The application of this technology is primarily in diagnostic uses for epileptic patients and, in particular, surgical planning.

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Current Treatment of Epileptic Patients

Close to 200,000 new epilepsy patients are diagnosed in the US annually. If standard drug treatments are unsuccessful, a physician may recommend surgical intervention. The gold standard in localization of the seizure onset zone for surgical planning entails the use of intracranial electrodes placed directly on the brain. The procedure has the risk of infection, requires lengthy EEG monitoring and is expensive, often exceeding $50,000. It is even possible that having gone through this invasive procedure, the patient may discover that s/he is not a suitable candidate for surgery given the location of the seizure onset zone. Moreover, areas identified may not even be the primary sources of electrical disturbance, but rather secondary sources as the electrical disturbances propagate through the brain.


BENEFITS OF NEURAL ACTIVATION IMAGING ALGORITHM:

  • Noninvasively identifies epileptic sources and the brain activation sequence
  • Maps the physiological properties of the brain
  • Guides surgical planning in epileptic patients