Office for Technology Commercialization

Ecdysteroid Biosynthetic Enzyme Inhibitors

Technology #z01201

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Michael O’Connor, Ph.D.
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Managed By
Raj Udupa
Technology Licensing Officer 612-624-3966
Patent Protection
US Patent 7,081,350

Insecticide Molecule Identification

Screening assays have been developed that allow for the discovery and further development of insecticides to reduce the harmful impact of insect pests on crop production. The tests identify agents that target the enzymes involved in ecdysone biosynthesis using the Drosophila P450 enzyme, Shade. By using a product-specific or substrate-specific antibody, it can be determined if candidate inhibitor molecules inhibit enzyme activity.

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This research method is immediately available for a nonexclusive license. Contact Raj Udupa for specific details.

Ecdysteroid Synthesis Inhibitor

Insect pests negatively affect agricultural production by decreasing the quantity and quality of crop yield. It is possible to control these pests via insecticides that disrupt metabolic functions essential to insect development. Ecdysteroids regulate many cellular processes during arthropod growth. There exists a need to target the systems that produce ecdysteroids in order to inhibit harmful insect growth and maximize crop production.


  • Ecdysteroid synthesis inhibitor screening method facilitates the discovery of new enzyme inhibitors in the ecdysone synthesis pathway
  • Ability to determine molecule effect on ecdysteroid biosynthetic enzyme activity
  • Ability to determine insect viability via in vivo phenotypic screening