Office for Technology Commercialization

Bioplastic for use in Orthopedic Devices, Orthopedic Implants, and Implantable Medical Devices

Technology #99107

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Orthopedic Implant Polyhydroxyalkanoate PHA in Bacterial HostFlexible, Implantable Medical Devices and Orthopedic Devices
Friedrich Srienc, PhD
Professor, Chemical Engineering and Material Sciences, College of Science and Engineering
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Managed By
Larry Micek
Technology Licensing Officer 612-624-9568
Patent Protection
US Patent 6,479,145
US Patent 6,723,800
US Patent 7,026,413
Files and Attachments
Orthopedic Bioplastic Term Sheet [PDF]

Bioplastic Polyhydroxyalkanoate (PHA) Microstructures are created in Bacteria

Plastic polyhydroxyalkanoate (PHA) microstructures can be formed in bacterial hosts and have applications in orthopedic devices, orthopedic implants, and other implantable medical devices. These materials are biocompatible and can degrade after being implanted. The biopolymers are synthesized in microbial hosts (bacteria) using a polymerase enzyme within the organisms, the biopolymers are then extracted from the organisms. The microbes are also flexible as they can intake a variety of renewable feedstocks.

MN-IP Try and Buy
  • Trial fee is $5,000 for a six month license
  • $30,000 conversion fee (TRY to BUY)
  • No patent costs
  • Royalty rate of 3% (2% for MN company)
  • Royalty free for first $1M in sales

** View the Term Sheet **
** Contact Larry Micek for specific details. **

Polyhydroxyalkanoate (PHA) is a Biodegradable and Biocompatible Plastic

The polyhydroxyalkanoates form as core-and-shell biopolymers or copolymers so the created bioplastics can be easily tweaked by controlling the creation of polymer layers in order to tailor the plastics for specific applications. This tailoring of plastic properties, the biopolymers' small sizes, and PHAs' biodegradable and biocompatible nature make these bioplastics especially useful in orthopedic devices, orthopedic implants, and other implantable medical devices. The created biopolymers are water resistant and stable under normal conditions so can they be easily stored.


  • Polyhydroxyalkanoate (PHA) biopolymers are created in bacterial hosts
  • Copolymer layers can be tailored to fit application
  • Biopolymers are water resistant and stable at normal conditions and are easily stored
  • Especially applicable in orthopedic devices, orthopedic implants, and other implantable medical devices

Phase of Development

The method of creating Polyhydroxyalkanoate (PHA) has been demonstrated in laboratory using Ralstonia eutropha bacteria. The bacteria were fed nutrients of fructose and valeric acid to create PHA and related bioplastic. Transmission electron microscopy confirmed the biosynthesis of multi-layer granules.