Bioplastic Polyhydroxyalkanoate (PHA) Microstructures are created in Bacteria
Plastic polyhydroxyalkanoate (PHA) microstructures can be formed in bacterial hosts and have applications in orthopedic devices, orthopedic implants, and other implantable medical devices. These materials are biocompatible and can degrade after being implanted. The biopolymers are synthesized in microbial hosts (bacteria) using a polymerase enzyme within the organisms, the biopolymers are then extracted from the organisms. The microbes are also flexible as they can intake a variety of renewable feedstocks.
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Polyhydroxyalkanoate (PHA) is a Biodegradable and Biocompatible Plastic
The polyhydroxyalkanoates form as core-and-shell biopolymers or copolymers so the created bioplastics can be easily tweaked by controlling the creation of polymer layers in order to tailor the plastics for specific applications. This tailoring of plastic properties, the biopolymers' small sizes, and PHAs' biodegradable and biocompatible nature make these bioplastics especially useful in orthopedic devices, orthopedic implants, and other implantable medical devices. The created biopolymers are water resistant and stable under normal conditions so can they be easily stored.
BENEFITS OF BIOPLASTIC POLYHYDROXYALKANOATE (PHA) FOR USE IN ORTHOPEDIC DEVICES:
- Polyhydroxyalkanoate (PHA) biopolymers are created in bacterial hosts
- Copolymer layers can be tailored to fit application
- Biopolymers are water resistant and stable at normal conditions and are easily stored
- Especially applicable in orthopedic devices, orthopedic implants, and other implantable medical devices
Phase of Development
The method of creating Polyhydroxyalkanoate (PHA) has been demonstrated in laboratory using Ralstonia eutropha bacteria. The bacteria were fed nutrients of fructose and valeric acid to create PHA and related bioplastic. Transmission electron microscopy confirmed the biosynthesis of multi-layer granules.