Office for Technology Commercialization

Limiting Cell Apoptosis Using Ursodiol and Its Derivatives

Technology #97080

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ApoptosisProgrammed Cell DeathUrsodiol
Clifford Steer, MD
Professor of Medicine, Associate Dean for Faculty Affairs
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Managed By
Raj Udupa
Technology Licensing Officer 612-624-3966
Patent Protection
US Patent 6,544,972

Ursodiol Derivatives can Reduce Apoptosis in Cells

Methods of utilizing ursodiol and its derivatives to limit cell apoptosis have been developed and can inhibit programmed cell death originating from multiple causes in various body systems. This invention discloses methods to inhibit apoptosis in autoimmune diseases, cardio and cerebrovascular diseases, and neurodegenerative diseases. Ursodiol has also been shown to maintain viability, thereby decreasing the need for more serious interventions. Overall the technology can assist in the treatment of various diseases and the reduction of disease symptoms.

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Programmed Cell Death in Disease and Treatments

Apoptosis is the process of programmed cell death in an organism. Apoptosis plays a role in many diseases and the treatments for many diseases, often contributing to the disease severity or hindering the success of treatments. For example, apoptosis is believed to be the cause for the symptoms associated with many liver diseases, it inhibits success of neural replacement therapies for Parkinson's, and it hinders recovery following ischemic stroke. A need exists for a method to prevent undesired apoptosis in humans.


  • Decreases severity of symptoms associated with many diseases
  • Maintains viability which decreases the need for more serious interventions
  • Applications in various diseases and body symptoms- including neurodegenerative, cardiovascular, cerebrovascular, and autoimmune diseases