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Tissue-equivalent Biocompatible Rods and Tubes

Technology #95202

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Blood Vessel RepairTissue-equivalent TubeNerve Growth
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Researchers
Robert Tranquillo, Ph.D.
Managed By
Raj Udupa
Technology Licensing Officer 612-624-3966
Patent Protection
US Patent 6,057,137
US Patent 6,461,629
US Patent 6,544,762

Tissue-Equivalent Tubes For Blood Vessel Repair and Nerve Growth

A tissue-equivalent tube made of a reconstituted collagen network has been developed with smooth muscle cells interspersed for use during blood vessel repair. The smooth muscle cells cause the fibrils in the collagen network to orient circumferentially within the tube. This orientation and configuration more accurately mimics an artery. This technology also uses tissue-equivalent rods which help direct nerve growth across the gap between severed nerve endings. The tube is strong enough to withstand tensile forces while also remaining completely biocompatible.

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This technology is available via a standard negotiated license agreement. Contact Raj Udupa for specific details.

Tissue-Equivalent Blood Vessel Grafts

Effective tissue-equivalent tubes for blood vessel repair would be able to withstand typical tensile forces, and direct nerve growth across the repair site. Currently, over 600,000 surgical procedures are performed every year that involve small or large blood vessels. Attempts have been made at creating biopolymer blood vessel for use during repairs. However, these attempts use synthetic, non-biocompatible materials which often lead to blood vessel graft failure. A need exists to develop a tissue-equivalent tube that is suitable for use as a blood vessel graft. Additionally, nerve damage is associated with blood vessel damage. An ideal blood vessel graft would direct nerve growth between the damaged nerve endings.

BENEFITS OF TISSUE-EQUIVALENT BLOOD VESSEL GRAFT:

  • Strong enough to withstand tensile forces
  • Guidance field to direct nerve growth across gap created following nerve damage
  • Inhibits implant rejection and graft failure

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