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Enhanced Resolution Cardiac MRI

Technology #20170286-20170315

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Acquisition of full LV short-axis stack in a single heart-beat achieved by imaging at three cardiac phases with three simultaneously acquired slices each.a) Good signal cancellation outside selected area achieved at both sides of selection band. b) Signal ratio between an acquisition with and without multi-band selection slabs. Imaging signal within selection area remains largely unchanged while thorough suppression is achieved within suppression bands.Large LV-coverage shown in 9 slice acquisition in each heart-beat, as depicted for (a) early dynamic during contrast uptake in the RV and (b) late dynamic at end of scan. Depiction of all temporal dynamics shows high image quality during contrast uptake in RV and LV, as well as (c) during later dynamics.
Categories
Researchers
Mehmet Akcakaya, PhD
Assistant Professor, Electrical and Computer Engineering
External Link (ece.umn.edu)
Steen Moeller, PhD
Assistant Professor, Department of Radiology, Center for Magnetic Resonance Research (CMRR)
External Link (www.radiology.umn.edu)
Sebastian Weingartner, PhD
Managed By
Kevin Nickels
Technology Licensing Officer 612-625-7289
Patent Protection

US Patent Pending

Combines outer volume suppression (OVS) and accelerated imaging

This technology is an MRI (magnetic resonance imaging) pulse sequence for cardiac imaging which enables an increased number of slices across the heart volume per heart beat resulting in enhanced temporal and spatial resolution. The method may result in a decrease in overall scan time. The novel method combines outer volume suppression (OVS) and accelerated imaging, such as simultaneous multi-slice (SMS)/compressed sensing (CS), without introducing fold-over artifacts.

Scans more slices per heartbeat, reduces imaging time

Cardiac MRI is often slow and is typically limited to only three slices across the heart per heartbeat. In addition, 3D high resolution cardiac imaging sequences can take up to 10 minutes. Current OVS techniques do not usually allow for a reduction of the FOV, as the residual signal creates fold-over artifacts. This novel method enables increased acceleration rates and reduces fold-over artifacts. Combining OVS with SMS and CS accelerates scan time, particularly for body imaging and improves temporal and spatial resolution.

Multi-band myocardial perfusion imaging

A novel imaging sequence uses the CAIPIRINHA method for multi-band (MB) imaging to allow myocardial perfusion imaging. This method adds an outer-volume suppression module to reduce signals from the chest and back while the heart is imaged. Multi-band imaging may increase the coverage significantly, and adding the OVS module may enable faster multi-band imaging rates.

Phase of Development

  • Prototype developed. Initial evaluations with a small number of healthy subjects.

Benefits

  • Enables faster acceleration rates
  • Increases number of achievable slices across the heart volume per heartbeat
  • Improves temporal and spatial resolution
  • Reduces scan time, particularly for body imaging
  • Reduces fold-over artifacts

Features

  • Combines outer volume suppression (OVS) and accelerated imaging, e.g., simultaneous multi-slice (SMS)/compressed sensing (CS)
  • Multi-band myocardial perfusion imaging
  • CAIPIRINHA method for multi-band imaging
  • Outer-volume suppression module

Applications

  • Magnetic resonance imaging (MRI)
  • Cardiac imaging
  • MRI pulse sequences


Interested in Licensing?
The University relies on industry partners to further develop and ultimately commercialize this technology. The license is for the sale, manufacture or use of products claimed by the patents. Please contact Kevin Nickels to share your business needs and licensing and technical interests in this technology.