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Superparamagnetic Iron Oxide Nanoparticles Characterization

Technology #20170093

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SPIONs
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Researchers
Jian-Ping Wang, PhD
Professor, Electrical and Computer Engineering
External Link (www.cems.umn.edu)
Kai Wu
Research Assistant, Electrical and Computer Engineering
External Link (www.nanospin.umn.edu)
Managed By
Kevin Nickels
Technology Licensing Officer 612-625-7289
Patent Protection

US Patent Pending
Publications
Characterizing Physical Properties of Superparamagnetic Nanoparticles in Liquid Phase Using Brownian Relaxation
Small Journal, 4 April 2017; 10.1002/smll.201604135

Characterizes SPIONs

A search coil based frequency mixing method characterizes both magnetic and physical properties of superparamagnetic iron oxide nanoparticles (SPIONs). The technology analyzes the harmonic ratios and phase lags from liquid and frozen SPION samples to distinguish between single- and multi-core SPIONs. It also predicts saturation magnetization, average hydrodynamic size and dominating relaxation processes of SPIONs. The technology could be developed into an easy-to-use handheld device or other instruments (e.g., those that characterize saturation magnetization of magnetic particles as well as other physical characteristics such as size and structural data, or existing instruments that measure magnetic susceptibility on magnetic particles/rocks).

Inexpensive SPION Magnetic and Physical Measurement

No single instrument can measure the key magnetic and physical properties of iron oxide nanoparticles, and current techniques face many drawbacks. Vibrating sample magnetometers (VSM) used for saturation magnetization measurements are large and expensive, require equipment maintenance and experienced technicians, and cannot test on magnetic nanoparticles (MNP) in liquid. Transmission electron microscopy (TEM) measurements usually require bulky and highly expensive instrumentation to determine SPION structure. This new approach combines functions from VSM (to estimate saturation magnetization of SPIONs), dynamic light scattering (to measure hydrodynamic volumes of SPIONs), and TEM (to distinguish between single- and multi-core SPIONs). It meets the need for inexpensive, reliable, fast, and easy-to-use ways to characterize MNPs in aqueous solutions and replaces larger and more expensive instruments.

BENEFITS AND FEATURES:

  • Characterizes both magnetic and physical properties of SPIONs
  • Analyzes harmonic ratios and phase lags
  • Able to test liquid samples
  • Replaces larger and more expensive instruments

APPLICATIONS:

  • Measuring properties of nanoparticles
  • Instrumentation
  • Biomedical applications
  • Characterizing saturation magnetization of magnetic particles as well as other physical characteristics, such as size and structural data
  • Measuring magnetic particle/rock magnetic susceptibility

Phase of Development - Working Prototype.