Office for Technology Commercialization

Neural Recording under Electrical Microstimulation

Technology #20160413

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SoCNeural Activity
Zhi Yang, PhD
Assistant Professor, Biomedical Engineering
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Jian Xu, PhD
Researcher, Biomedical Engineering
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Anh Tuan Nguyen
PhD Candidate, Biomedical Engineering
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Kevin Nickels
Technology Licensing Officer 612-625-7289
Patent Protection

Provisional Patent Application Filed
Neuronix enables continuous, simultaneous neural recording and electrical microstimulation
Engineering in Medicine and Biology Society, Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:4451-4454. doi: 10.1109/EMBC.2016.7591715

System on a Chip Neural Recording Device

A miniature system on a chip (SoC) device enables continuous, full-duplex neural recording with simultaneous electrical microstimulation. The technology enables precise, closed-loop neuromodulation based on direct neuronal feedback. Scalable and with a small chip area and high channel density, this new design could suppress electrode noise and support high impedance electrodes, especially important to ultra-large-scale recording. The device can be used for a wide spectrum of neurological diseases through closed-loop neuromodulation.

Monitoring Neural Activity under Electrical Stimulation

Current electrical stimulation and recording technologies are not able to “talk to the brain” and “hear from the brain” at the same time. Electrical stimulation has been used for probing neural circuitry and identifying networks of neurons for many years, but investigating and understanding the behavior of neural populations under electrical stimulation requires simultaneously monitoring neural activity, which has not been possible until now. Furthermore, current technologies suffer from limitations of scalability as well as poor signal quality, artifacts and noise prone to misinterpretation. This device is the first technology that allows bidirectional communication with a brain and nervous system and features improvements in power, noise, resolution, size, weight, scale and functionality.


  • Neural recording with simultaneous electrical microstimulation
  • Closed-loop neuromodulation based on direct neuronal feedback
  • Support high impedance electrodes
  • Bidirectional communication with a brain and nervous system
  • Improved power, noise, resolution, size, weight, scale and function


  • Electrical stimulation (e.g., vagus nerve stimulation, deep brain stimulation, cortical stimulation)
  • Neural recording
  • Neurological diseases
  • Neuromodulation
  • Implantable devices

Phase of Development - Working prototype, beta tested, in vitro/in vivo data available.