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Compliant Aortic Stent Graft

Technology #20160398

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Current design is a rigid stent graft around a lumen (L). The new design introduces a compliant inner layer. The space between the rigid and compliant layers is filled with saline solution to allow motion of the compliant wall in response to luminal pressure.
Categories
Researchers
Rumi Faizer, MD
Associate Professor, Vascular Surgery
External Link (www.surgery.umn.edu)
Victor Barocas, PhD
Professor, Biomedical Engineering
External Link (bme.umn.edu)
Filippo Coletti
Assistant Professor, Engineering
External Link (www.aem.umn.edu)
Managed By
Kevin Anderson
Technology Licensing Officer 612-624-8293

Double-walled design mimics compliance of healthy aorta

A double-walled aortic stent graft is compliant to luminal pressure in the aorta. The outer layer of this new design is rigid, similar to current stent grafts, and the inner layer is comprised of a compliant, flexible material that exhibits elastic properties similar to a healthy aorta. The space between the inner and outer layers can be filled (i.e., with sterile saline) to create a volume buffer between the layers so the stent graft becomes compliant to luminal pressure. When blood flows through the lumen of the inner layer, the flexible walls can deform in a similar manner of a healthy vessel. This technology could decrease pressure-induced stresses on the residual native aorta, reduce risk of Stent graft Induced New Entry (SINE) dissections, and potentially result in better systemic hypertension management dissections.

Improves peak systolic pressure, leads to better patient outcomes

Existing aortic endografts offer some flexibility along their length but are rigid across their diameters. Because they press outward against the aortic wall and do expand during systole, they require greater energy from the native aorta to dissipate the systolic pressure wave. While these stent grafts may protect an acutely injured aorta from an aneurysm, they could also damage the native aorta and require aggressive blood pressure management. This new double-walled, compliant design provides flexibility across the stent graft diameter. When the flexible wall of the inner layer deforms, it behaves more like a healthy vessel. Increasing the compliance can improve peak systolic pressure and lead to better patient outcomes.

Phase of Development

  • Proof of concept

Benefits

  • Exhibits elastic properties similar to healthy aorta
  • Mimics compliance of native tissue
  • Could decrease pressure-induced stresses, reduce risk of Stent graft Induced New Entry (SINE) dissections

Features

  • Double-walled aortic stent graft
  • Rigid outer layer; compliant, flexible inner layer
  • Compliant to luminal pressure in the aorta

Applications

  • Thoracic and abdominal aortic aneurysm
  • Aortic repair surgeries
  • Peripheral vascular repair with stent graft
  • Aortic dissection


Interested in Licensing?
The University relies on industry partners to further develop and ultimately commercialize this technology. The license is for the sale, manufacture or use of products claimed by the patents. Please contact Kevin Anderson to share your business needs and licensing and technical interests in this technology.