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Black-Blood T1 Myocardial Mapping to Remove Partial Voluming Effects

Technology #20160395

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MRI MappingMyocardial Wall Thickness
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Researchers
Sebastian Weingartner, PhD
Post-doctoral Fellow, Electrical and Computer Engineering, Center for Magnetic Resonance Research
Mehmet Akcakaya, PhD
Assistant Professor, Electrical and Computer Engineering, Center for Magnetic Resonance Research
External Link (ece.umn.edu)
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Kevin Nickels
Technology Licensing Officer 612-625-7289
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Provisional Patent Application Filed
Publications
Black-blood native T1 mapping: Blood signal suppression for reduced partial voluming in the myocardium
Magnetic Resonance in Medicine, 16 September 2016

Improved Quantitative Myocardial Tissue Characterization

A magnetic resonance imaging (MRI) sequence, which allows for complete blood suppression during quantitative imaging, can improve the robustness of quantitative myocardial tissue characterization. The technique, which can be used in commercially available MRI scanners with no additional hardware, improves diagnostic capabilities by suppressing blood signals from quantitative maps. The technique helps reduce partial voluming effects at the myocardium-blood interface and enables robust quantification of myocardial tissue characteristics—independent of myocardial thickness or slice orientation. The sequence may be used for quantitative assessment of the endocardial myocardium, a typical scar area in left ventricular hypertrophy. Eliminating partial voluming further reduces false positives in patients with reduced myocardial wall thickness or young healthy subjects, who commonly have thin myocardial walls.

Blood Signal Supression

Quantitative myocardial tissue characterization is a newer yet crucial technology in cardiac MRI. It provides quantitative insights in myocardial tissue composition in numerous cardiac diseases. The technique provides greater diagnostic and prognostic capabilities, with greater repeatability, and has shown clinical value in diagnosing numerous cardiomyopathies. However, the high signal from blood pools adjacent to the myocardium corrupts these measurements due to partial voluming effects, and this corruption requires careful expert evaluation of the maps to read the results. In addition, partial-voluming effects restricts the tool’s applicability to the mid-myocardium and reduces its applicability to subjects with thin myocardia. This newly-developed black-blood quantitative imaging sequence, when applied to myocardial T1 mapping, completely suppresses the blood signal and therefore improves quantitative characterization of the heart. Furthermore, the results show improved inter- and intra-observer reproducibility for data analysis.

BENEFITS AND FEATURES:

  • Improves robustness of myocardial tissue characterization
  • Reduces false positives
  • Used with commercially available MRI scanners
  • No additional MRI hardware necessary: upgrade distributed with regular vendor software or sequence update routines
  • Advantageous in subjects with myocardial thinning and/or mid-myocardium

APPLICATIONS:

  • Myocardial tissue characterization
  • Conventional MRI scanners
  • Diseases such as aortic valve disease and hyperintensive heart disease; nonischemic cardiomyopathies (hypertrophic, dilated and restrictive) and diabetes; cardiac amyloidosis; myocardial infarction

Phase of Development - Pilot scale demonstration. Have published results on eight healthy volunteers.