Controlled Drug Release
New composites for drug release, include silica nanoparticles and a semisolid polymer, are more versatile than the semi-solid polymers alone in terms of accommodating and releasing multiple drugs and active molecules. They are easily injectable, allow more controlled/sustained release, allow different release profiles of a single drug (or for two different drugs from the same composition) and do not require solvents. The semi-solid composite design features shear-reversible properties:
- Shear thinning. The viscosity of the composite can be reduced by mechanical shear, making it easier to inject or process the material.
- Shear recovery. Thinned material regains its viscosity after shear stress is lifted; the material “solidifies” after injection or processing (e.g., releases a drug in a sustained manner).
Injectable Drug Delivery System
Less than half of the high potency, low solubility drugs developed ever reach the market because of inadequate excipients that cannot solubilize a sufficiently high concentration or provide stability. Meanwhile, demand for injectable drug delivery systems capable of long-term delivery with tunable release profiles has steadily risen over the last few years. Injectability and processing of semi-solid polymers for parenteral, oral or topical drug delivery can be challenging due to inherent viscosity of the polymers. These new shear-reversible, semi-solid composites can be injected or processed at shear-induced low viscosity and then "solidify" to high viscosity after injection or processing. This method does not require any solvents, diluents, heating or spray-drying.
BENEFITS AND FEATURES:
- Two-part formulation (polymer and silica components)
- Shear thinning reduces viscosity, making it easier to inject or process
- Shear recovery allows material to “solidify” after injection or processing
- Requires no solvents
- Allow more controlled/sustained release than hydrogels
- Enables different release profiles of a single drug or for two different drugs from the same composition
- Drug delivery platforms
- Oral and parenteral drug delivery
- Pharmaceutical excipients
- 3D printing of oral tablets
Phase of Development - In-vivo testing