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Seneca Valley Virus Detection

Technology #20160311

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SwineELISASeneca Valley Virus
Categories
Researchers
Michael Murtaugh, PhD
Professor, Veterinary and Biomedical Sciences
External Link (www.vetmed.umn.edu)
Cheryl Dvorak, PhD
Researcher, Veterinary and Biomedical Sciences
External Link (www.vetmed.umn.edu)
Managed By
BJ Haun
Technology Licensing Officer
Patent Protection

Provisional Patent Application Filed

US Patent Pending
Publications
An indirect enzyme-linked immunosorbent assay for the identification of antibodies to Senecavirus A in swine
BMC Veterinary Research, (2017) 13:50

Seneca Valley Virus Detection and Potential Vaccine

A simple, indirect enzyme-linked immunosorbent assay (ELISA) rapidly and reliably detects Seneca Valley Virus as a cause of idiopathic vesicular disease (IVD) in swine. The ELISA detects serum antibodies to Senecavirus A (SVA) viral protein 2. These methods use the Senecavirus A polypeptide as a capture antigen for detecting antibodies that specifically bind to the Senecavirus A polypeptide, which may also be used as an immunogen to vaccinate against Senecavirus A infection. In addition, the isolated antigens (SVV antigens 1-3) have been cloned and can be easily expressed to obtain antigens for vaccine testing.

Rules Out Foreign Animal Diseases

While IVD itself, sporadically observed in swine, is not debilitating, it closely resembles other devastating foreign animal diseases (e.g., foot and mouth disease). Swine production can be disrupted until such foreign animal diseases, whose presence would be economically devastating to the United States, can be ruled out. This ELISA based detection of antibodies to SVA VP2 will quickly help to differentially diagnose IVD due to SVA, rule out the presence of foreign animal diseases, and reduce industry disruptions.

BENEFITS AND FEATURES:

  • Differentially diagnoses IVD due to SVA
  • Detects serum antibodies to Senecavirus A (SVA) viral protein 2 (VP2)
  • Quickly rules out devastating foreign animal diseases
  • Cloned SVV antigens 1-3 can be expressed to obtain antigens for vaccine testing

APPLICATIONS:

  • Immunodiagnostic testing
  • Vaccines
  • Swine industry

Phase of Development - Serological test with test for strength of binding has been established for use in swine.