SERS Selectively Identifies Lectin
Surface-enhanced Raman Spectroscopy (SERS) can selectively detect toxic saccharide-binding proteins (lectins) such as Ricin B Chain (RBC). The technology first attaches glycopolymers to gold-coated nanoparticles as the capture matrix, and then performs SERS to detect any lectins attached to the glycopolymers. These methods could be used for ricin detection, for screening and/or monitoring of food and water supplies, and may even be adapted to detect other poisons.
Selective Ricin Detection
This technology could potentially outperform other methods based on its ease of design, synthesis, and application. It is expected to offer more selective ricin detection than other techniques, such as those using aptamers or thiolated carbohydrates along with SERS, ELISA, electrochemical, or other immunoassays. It is unique in that glycopolymers are used for affinity-based lectin binding.
BENEFITS AND FEATURES:
- Easy design, synthesis, and application
- Selective ricin/lectin detection
- Captured lectins can be detected or removed
- Ricin detection
- Sensing of biohazardous toxins such as RBC
- Testing food and water supplies
- Prevention of potentially hazardous outbreak of toxins
Phase of Development Proof of concept