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Lectin Biosensor

Technology #20150324

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LectinRicin DetectionRicin
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Researchers
Christy Haynes, PhD
Professor, Department of Chemistry, College of Science and Engineering
External Link (www.chem.umn.edu)
Theresa Reineke, PhD
Professor, Department of Chemistry, College of Science and Engineering
External Link (www.cems.umn.edu)
Managed By
Kevin Anderson
Technology Licensing Officer 612-624-8293
Patent Protection

US Patent Pending

SERS Selectively Identifies Lectin

Surface-enhanced Raman Spectroscopy (SERS) can selectively detect toxic saccharide-binding proteins (lectins) such as Ricin B Chain (RBC). The technology first attaches glycopolymers to gold-coated nanoparticles as the capture matrix, and then performs SERS to detect any lectins attached to the glycopolymers. These methods could be used for ricin detection, for screening and/or monitoring of food and water supplies, and may even be adapted to detect other poisons.

Selective Ricin Detection

This technology could potentially outperform other methods based on its ease of design, synthesis, and application. It is expected to offer more selective ricin detection than other techniques, such as those using aptamers or thiolated carbohydrates along with SERS, ELISA, electrochemical, or other immunoassays. It is unique in that glycopolymers are used for affinity-based lectin binding.

BENEFITS AND FEATURES:

  • Easy design, synthesis, and application
  • Selective ricin/lectin detection
  • Captured lectins can be detected or removed

APPLICATIONS:

  • Ricin detection
  • Sensing of biohazardous toxins such as RBC
  • Testing food and water supplies
  • Prevention of potentially hazardous outbreak of toxins

Phase of Development Proof of concept