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Beam Steering Resonance along a Spatiotemporal Trajectory for MRI

Technology #20120060

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Researchers
Michael Garwood, PhD
Professor, Department of Radiology, Center for Magnetic Research
External Link (www.radiology.umn.edu)
Tommy Vaughan, PhD
Professor, Biomedical Engineering, Columbia University
Managed By
Kevin Nickels
Technology Licensing Officer 612-625-7289
Patent Protection

US Patent Pending 2014/0218028

Combines Spatialtemporal Encoding MR Pulse Sequence with RF Transmit Front End

A new magnetic resonance imaging (MRI) approach uses a spatiotemporally-encoded MRI pulse sequence (e.g., SWIRLY and/or STEREO) in combination with a smart, adaptive, or phased RF transmit front end. Combining these two components allows highly spatially localized regions of uniform excitation, even in the presence of B0 and B1+ inhomogeneities. The transmit front end is comprised of a multichannel transmit array and multiple RF power amplifiers; each amplifier has dynamic phase and gain control over the output waveform. In addition, by exciting only a small region at any given time and allowing more freedom to optimize selected parameters, the technology is expected to reduce specific absorption rate (SAR).

Suppresses Destructive Interference Patterns at Ultrahigh Field Strengths

Beam forming techniques (e.g., B1+ shimming or Transmit SENSE), while previously shown in MRI, use a “static” B1 shim or are based on k-space (Fourier) formalisms. In certain applications, these techniques are not optimal because they cannot avoid exciting signal outside the region of interest. Spatiotemporal imaging methods like STEREO (also known as SWIRLY) can achieve spatially-selective excitation while simultaneously compensating for B1 and B0 inhomogeneities. When combined with an RF front end that dynamically shims the RF B1+ field and dynamically changes the B1+ shim throughout the pulse sequence, these spatiotemporally-encoded MRI methods can further avoid destructive interference patterns typically seen in imaging sequences at ultrahigh field strengths. And as field strength continues to increase, current B1+ shimming techniques for homogeneous transmit pattern will fail in the body (possibly even the head) because of the reduced wavelengths in the body, whereas this method will actually benefit from this better defined basis set.

BENEFITS AND FEATURES:

  • Allows highly spatially localized regions of uniform excitation, even in the presence of B0 and B1+ inhomogeneities
  • Beam-steering improves the ability to compensate inhomogeneities in the radiofrequency (RF) field in spatiotemporally-encoded MRI techniques like STEREO
  • Suppresses destructive interference patterns currently seen in imaging sequences at ultrahigh field strengths
  • Improves image quality
  • Transmit front end comprised of multichannel transmit array and multiple RF power amplifiers
  • Expected to reduce specific absorption rate (SAR), “tissue heating”
  • May reduce the cost of amplifiers
  • Significantly lower power requirements (i.e., as compared to Transmit SENSE)

APPLICATIONS:

  • Magnetic resonance imaging (MRI)
  • MR imaging
  • Potential for ultra high field MRI (≥7T)
  • Low-cost MRI scanners
  • Under-served clinics and hospitals that cannot afford high-cost 1.5T or 3T MRI scanners
  • Imaging at high magnetic fields where B1 and B0 inhomogeneities are particularly challenging
  • Specialized scanner market segments (e.g., breast, dental, extremity, etc.)

Phase of Development - Proof of Concept

Interested in Licensing?
The University relies on industry partners to scale up technologies to large enough production capacity for commercial purposes. The license is available for this technology and would be for the sale, manufacture or use of products claimed by the issued patents. Please contact Kevin Nickels to share your business needs and technical interest in this MRI technology and if you are interested in licensing the technology for further research and development.