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Magnetization Transfer Using Inversion Recovery

Technology #20100117

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Pulse Sequence MethodsInversion RecoveryMagnetization Transfer
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Researchers
Michael Garwood, PhD
Professor, Department of Radiology, Center for Magnetic Research
External Link (www.radiology.umn.edu)
Managed By
Kevin Nickels
Technology Licensing Officer 612-625-7289
Patent Protection

US Patent Pending 20130069649
Files and Attachments
Non Confidential Summary [PDF]
Magnetization Transfer Term Sheet [PDF]

Magnetization Transfer Imaging Can Lower Specific Absorption Rate

An improved MRI pulse sequence and post processing technique have been developed that dramatically improve MT imaging while improving safety by reducing specific absorption rate (SAR), which is a measure of tissue heating. Clinical usage of magnetization transfer (MT) imaging with MRI scanners has been limited due to radio frequency (RF) heating of the subject, which ultimately limits the sensitivity and specificity of the technique for diagnosis. 

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  • 18 months non-exclusive software license
  • $15,000 Trial Fee waived for MN companies
  • Patent expenses deferred during trial
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  • $5000 Conversion Payment (includes all patent expenses)
  • Royalty: $1500/unit for new MRI installation; $1000/unit for MRI system upgrade
  • Royalty discount for MN companies
  • Royalty holiday on 1st $1M in sales

** View the Term Sheet **
** Contact Kevin Nickels for specific details. **

Inversion Recovery Implemented with Software

Inversion recovery combines a conventional pulse with an inversion pulse, which flips the orientation of the magnetization by 180 degrees. By including the “negative data”, a larger dynamic range is available to accurately calculate the magnetization transfer exchange rate constant with reduced deposition of RF energy in the subject. The MT imaging MRI pulse sequence and post processing is implemented in software on an MRI scanner.

Improves Diagnosis of Multiple Sclerosis

In particular, this technology greatly enhances the ability to identify myelin in the diagnosis and monitoring of disease progression/treatment in demyelinating neuropathies, such as multiple sclerosis (MS). It is expected that this will enable MT imaging MRI scans to become common clinical practice.

FEATURES AND BENEFITS OF MAGNETIZATION TRANSFER WITH INVERSION RECOVERY:

  • Enhanced ability to image demyelination in the brain for diagnosis of certain neuropathies such as multiple sclerosis
  • Improved imaging of other white matter, such as cartilage
  • Larger dynamic range for greater sensitivity and specificity of MT imaging
  • Better resolution and image quality compared to conventional MT imaging MRI
  • Reduced RF power deposition for improved SAR
  • Applicable to all clinical MRI scanners, e.g. 3T, 1.5T, and open-bore low-field scanners