Non-invasive Source Imaging and Brain Mapping for Seizure Localization
This neuroimaging method for seizure source imaging and brain mapping uses high-density EEG and magnetic resonance imaging (MRI) to localize the source. Independent component analysis is used to decompose the data into independent spatial temporal components. The spatial decomposition, together with the time series data, helps segregate the sources of brain activity into separate time and space domains with minimal mutual interference from other activated regions, essentially leading to accurate source imaging.
This method could both decrease cost and morbidity of seizure source imaging, eventually becoming the new gold standard for the 45,000 new refractory seizure patients each year. The software, combined with standard, non-invasive, high-density EEG will both identify candidates for surgical resection and provide source imaging for surgical planning. The algorithms implemented in software have been developed and validated on patients.
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Replaces Risky Invasive Neuroimaging Required for Epilepsy Surgery
Seizures currently affect 40 million people worldwide. Of the roughly 200,000 new epilepsy diagnoses in the US every year, around 45,000 are refractory patients for which drug treatments are ineffective. For these patients surgery is the most effective form of treatment (it can lead to complete seizure freedom), but it requires accurate seizure source localization. Intracranial electroencephalography (iEEG) is currently the gold standard for seizure source imaging and brain mapping prior to epilepsy surgery. However, this method is limited by the discomfort it causes patients and the high morbidity it presents. Additionally, patients may undergo this invasive and risky procedure only to learn that they are not candidates for surgery.
BENEFITS AND FEATURES OF ACCURATE, NON-INVASIVE SOURCE IMAGING FOR SEIZURE LOCALIZATION:
- Decreased risk compared to iEEG neuroimaging
- Reduced OR and ICU time for the patient
- Greatly decreased cost per patient for seizure source imaging
- Compatible with high-density EEG systems already in use
- Avoids unnecessary invasive procedures for patients who are deemed not suitable for epilepsy surgery