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Associate Professor of Medicine, Division of Rheumatic and Autoimmune Diseases
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20160218 – A novel approach generates monoclonal antibodies (MAb) against peptide presented in major histocompatibility complex II (MHC II). The methodology centers on having a soluble peptide:MHC (p:MHC) Class II complex linked to biotin as the B cell antigenic target. The approach uses recombinant peptide:MHC monomers as immunogens and subsequently relies on multimers to enrich the responding... Read More